Exosomal miR-494 from Bone Marrow Mesenchymal Stem Cells Attenuates Ferroptosis and Enhances Spinal Cord Injury Repair by Modulating the SIRT1/HO-1 Pathway.

Spinal cord injury (SCI) is a severe traumatic disorder of the central nervous system, often resulting in partial or complete loss of sensory and motor functions. Ferroptosis, a lipid peroxidation-driven apoptotic process triggered by iron overload, has emerged as a novel form of programmed cell death and a focal point in post-SCI cell death research. Exosomes (Exo), as delivery vehicles, exhibit multiple advantages, including superior encapsulation capacity, high targeting efficiency, and enhanced blood-brain barrier penetration to reach the central nervous system.

Expanding structural insights into DNA packaging apparatus and endolysin LysSA05 function of Epsilon15 bacteriophage.

The rising prevalence of multidrug-resistant (MDR) foodborne pathogens, particularly spp., necessitates alternative antimicrobial solutions. Phage therapy offers a promising solution against MDR Gram-negative infections; however, its clinical application is constrained by the presence of endotoxins, residual cellular debris, the risk of horizontal gene transfer by temperate phages, and an incomplete understanding of how phage structural integrity influences infectivity and enzyme function.

Computed tomography derived FFR and plaque features in prognosis of aortic stenosis combined with coronary artery disease after TAVR.

To assess the value of computed tomography angiography (CTA)-derived fractional flow reserve (CT-FFR) and high-risk plaque characteristics (HRPC) in the prediction of prognosis in patients with concomitant aortic stenosis (AS) and coronary artery disease (CAD) after transcatheter aortic valve replacement (TAVR). The study was a post hoc analysis from a multicenter TAVR registry. Patients with AS and obstructive CAD who underwent successful TAVR treatment were enrolled.

Effects of angiotensin receptor-neprilysin inhibition on myocardial energy metabolism and prognosis in patients with acute myocardial infarction complicated by heart failure.

Objective: This study aims to evaluate the effects of angiotensin receptor-neprilysin inhibitor (ARNI) on myocardial energy metabolism and prognosis in patients with acute myocardial infarction (AMI) complicated by heart failure (HF).

Methods: A retrospective analysis was conducted on data from 244 inpatients admitted to our center, who were diagnosed with AMI complicated by HF. Among these patients, 210 completed a 1-year follow-up.

Genetic correlation and causal relationships between autoimmune thyroid disease and major depressive disorders.

Background: Autoimmune thyroid disease (AITD) and major depressive disorder (MDD) are common genetic diseases. The comorbidity of AITD and MDD has been widely demonstrated by large amounts of epidemiological studies. However, the genetic architectures of the comorbidity remain unknown.

Ligand- and tissue-specific differences in the activation of the aryl hydrocarbon receptor by flavonoids: A focus on baicalein and scutellarein.

Flavonoids are natural dietary modulators of the aryl hydrocarbon receptor (AHR) with considerable therapeutic potential. However, their safety and efficacy remain difficult to predict due to the complex, ligand- and tissue-specific differences of AHR. In this study, we combined transcriptional and protein-level experiments with computational methods, including molecular docking and R-based RNA-seq analyses, to elucidate the patterns of cell type-specific activation of AHR by structurally similar flavonoids.

U-shaped association between ultra-processed food intake and overactive bladder in US adults: a national cross-sectional study.

Background: The association between ultra-processed food (UPF) intake and overactive bladder (OAB) remains unclear. This study aimed to investigate the relationship between UPF consumption and the risk of OAB in U.S.

GGTLC1 Is a Prognostic Biomarker in Renal Clear Cell Carcinoma.

Kidney renal clear cell carcinoma (KIRC), the most common type of renal cell carcinoma, is an immunobiologically and metabolically distinct tumor. Its clinical management is closely related to the tumor microenvironment (TME). Identifying its potential markers is important for improving prognosis.

Efficacy and safety of anrikefon in patients with pruritus undergoing haemodialysis: multicentre, double blind, randomised placebo controlled phase 3 trial.

Objective: To evaluate the efficacy and safety of anrikefon (formerly known as HSK21542), a novel selective peripherally restricted kappa opioid receptor agonist, in patients with chronic kidney disease associated pruritus.

Design: Multicentre, double blind, randomised placebo controlled phase 3 trial.

Setting: 50 centres in China, June 2022 to June 2024.

Polyamine metabolism related gene index prediction of prognosis and immunotherapy response in breast cancer.

Background: Polyamine metabolism is closely associated with tumorigenesis, progression, and the tumor microenvironment (TME). This study aimed to determine whether polyamine metabolism-related genes (PMRGs) could predict prognosis and immunotherapy efficacy in Breast Cancer (BC).

Methods: We conducted a comprehensive multi-omics analysis of PMRG expression profiles in BC.

Development of a carbon nanoparticle-guided nomogram for predicting lateral cervical lymph node metastasis in clinically node-negative papillary thyroid carcinoma.

Objective: To develop and validate a carbon nanoparticle-enhanced nomogram for predicting lateral lymph node (LLN) metastasis in patients with clinically node-negative (cN0) papillary thyroid carcinoma (PTC).

Methods: A retrospective analysis was conducted on 421 cN0 PTC patients treated between 2014 and 2020. Patients were randomly divided into training (n=316) and internal validation (n=105) cohorts.

Association between the psychological frailty index and stroke: a cohort study from CHARLS.

Stroke is a leading cause of death and disability worldwide, especially in the aging population. Psychological vulnerability serves as a multidimensional mental health vulnerability state, but there is a lack of large sample studies on its association with stroke. The aim of this study was to investigate the relationship between psychological vulnerability, as quantified by the Psychological Frailty Index, and stroke.

IL-6 promotes metastasis and EMT of non-small cell lung cancer cells by up-regulating FGL1 via STAT3 pathway.

Background: It has been reported that IL-6 induces the synthesis and secretion of fibrinogen-like protein 1 (FGL1) in liver cells as well as promotes the regeneration of liver cells. FGL1 is upregulated in human cancers, especially in non-small cell lung cancer (NSCLC). FGL1 is involved in the regulation of epithelial-mesenchymal transition (EMT) in gastric cancer (GC) cells.

HSPA9/HMGB1 regulates myocardial fibrosis in atrial fibrillation via TGF-β1/Smad pathway and autophagy.

Background: Atrial fibrillation (AF) is a common arrhythmia often linked to myocardial fibrosis. This study investigates the molecular mechanisms underlying AF, focusing on HSPA9 as a key regulator of fibrosis and its interaction with the TGF-β1/Smad pathway.

Methods: The GSE79768 dataset was employed for differential gene expression analysis.

A differential diagnostic model based on immunological evaluation and routine laboratory tests: distinguishing multiple myeloma from other disorders with aberrant immunoglobulin elevation.

Objective: Develop a diagnostic model using common hematological and immunological indicators to assist in the early screening and differential diagnosis of Multiple Myeloma (MM) in clinical settings, reducing the risk of misdiagnosis.

Methods: A retrospective analysis was conducted on 274 newly diagnosed and treated MM patients and 137 connective tissue disease patients treated at Zhejiang Provincial People's Hospital from January 2008 to August 2023. Laboratory indicators, including complete blood count, biochemistry, coagulation function, and immunoglobulin markers, were collected.

Syringaresinol from Cinnamomum cassia (L.) J.Presl ameliorates cognitive deficits and AD pathology via AMPK in a DM-AD mouse model.

Ethnopharmacological Relevance: Syringaresinol (SYR), a major lignan in food analogous TCM (Cinnamomum cassia (L.) J.Presl) possesses antioxidant, anti-inflammatory, antidiabetic, and antiaging effects.

Brusatol suppresses malignant progression of glioma via modulating the miR-574-5p/USP10/PLK1 axis.

Background: Brusatol (BRU), a compound derived from Brucea javanica, has demonstrated notable antitumour activity across various cancer types. However, its precise mechanisms and functional roles in glioma remain incompletely understood.

Purpose: To explore the role and downstream target of Brusatol in glioma and uncover the potential molecular mechanism.

A distinctive human fatty acid metabolism profile associated with osteoporotic patients.

Evidence indicates a relationship between osteoporosis and nutritional factors. Nevertheless, the correlation between fatty acids and bone health remains not fully elucidated. This research sought to explore the potential associations between fatty acids (FAs) and osteoporosis.

Large metastatic lymph nodes misdiagnosed as a pancreatic tumor: a case report.

Due to the anatomical proximity between pancreatic tumors and the group 8 lymph nodes of the stomach, misdiagnosis can easily occur. The patient's preoperative examination: computed tomography (CT) scan examination indicated an abdominal mass, 3.0T pancreatic magnetic resonance imaging (MRI) with contrast enhancement showed a pancreatic head lesion, possibly a neuroendocrine tumor.

Muscone attenuates myocardial infarction by regulating ferroptosis of cardiomyocytes through Nrf2/system Xc-/GPX4 signaling pathway.

Acute myocardial infarction (MI) is among the diseases with the highest incidences and seriously threatens public health worldwide, with the present clinical treatment methods presenting considerable risks. Ferroptosis, characterized by iron dependence and intracellular oxidative accumulation, is a type of programmed cell death that has opened new avenues for treating MI. Muscone is one of the major active monomers of musk, which can improve ventricular remodeling after MI and myocardial ischemia-reperfusion injury.

Preoperative albumin-bilirubin grade combined with sarcopenia predicts long-term outcomes after laparoscopic gastrectomy for advanced gastric cancer.

Background: This retrospective study evaluated the predictive value of preoperative albumin–bilirubin (ALBI) grade combined with sarcopenia for the long-term prognosis of patients with advanced gastric cancer (AGC) undergoing laparoscopic radical surgery.

Methods: This study analyzed clinical and pathological data from 731 patients who underwent laparoscopic gastrectomy for AGC in 2011–2019. The training and validation datasets comprised 538 and 193 cases, respectively.

The impaired white-matter structural network mediates the relationship between the glymphatic system and emotional abnormalities in patients with chronic kidney disease.

Background: Patients with chronic kidney disease (CKD) tend to have white-matter network and glymphatic system dysfunction, and may experience cognitive decline and psychiatric abnormalities. This study explored the relationships between graph theory-based white-matter networks and diffusion tensor image analysis along the perivascular space (DTI-ALPS) and the choroid plexus volume (CPV).

Methods: Sixty-one CKD patients, including 22 non-dialysis dependent (NDD) and 39 dialysis-dependent (DD) patients, and 43 age-, gender-, and education-matched healthy control (HC) participants were recruited for the study.

The role of UBR2 in triple-negative breast cancer and its implications for immune checkpoint blockade therapy.

Objective: UBR2 (also referred to as n-recognin 2, the E3 component of ubiquitin protein ligase) targets proteins with unstable N-terminal residues for polyubiquitination and proteasome-mediated degradation. It was initially identified as a crucial oncogene during embryonic development. Nevertheless, the function of UBR2 in triple-negative breast cancer (TNBC) and its non-ubiquitination role, particularly in suppressing antitumor immune responses, remain elusive.

Overexpression of SOX4 in MSCs inhibits cellular senescence and enhances therapeutic efficacy in systemic lupus erythematosus.

Background: Mesenchymal stem cells (MSCs) are widely used in treating autoimmune diseases. However, replicative senescence limits the quantity and quality of MSCs during population doublings in vitro. Transcription factor SOX4 is a crucial regulator of cell fate and stemness.