Cardiovascular adverse events associated with epidermal growth factor receptor tyrosine kinase inhibitors in mutated non-small cell lung cancer: systematic review and network meta-analysis.

Objective: To evaluate the risk of cardiovascular adverse events associated with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in patients with mutated non-small cell lung cancer (NSCLC).

Design: Systematic review and network meta-analysis.

Data Sources: PubMed, Embase, Web of Science, Scopus, Cochrane Central Register of Controlled Trials, and three clinical trial registries, from inception to 20 November 2024.

Transcutaneous vagus nerve stimulation modulates fear memory extinction and neural responses in humans.

Previous research has shown that transcutaneous auricular vagus nerve stimulation (tVNS) promotes declarative fear extinction, but its neural mechanisms in this process are still unclear. This study aimed to explore tVNS's impacts on physiological (skin conductance response [SCR]) and neural (event-related potentials, ERP) fear-related responses. Forty healthy participants were randomly assigned to the tVNS or Sham group.

Unveiling causal relationship between white matter tracts and psychiatric disorders.

White matter tracts (WMTs), which mediate information transmission in the brain, are closely associated with the pathogenesis of psychiatric disorders, yet the causality of their associations remain unclear. Thus, we employed two-sample bidirectional Mendelian randomization to explore the causality between WMTs and 10 psychiatric disorders. We found that one standard deviation changes of WMTs metrics modified risks for 8 psychiatric disorders by 2·2% to 71·4%.

Bidirectional Mendelian randomization analysis of inflammatory factors and sleep related traits.

Backgrounds: Observational research has shown significant associations between inflammatory factors and sleep. Experimental studies suggested acute increase in the levels of inflammatory markers following sleep deprivation and sleep restriction. However, the causal association between inflammatory factors and sleep remains unclear in chronic and natural settings.

Role of circadian rhythms in heart failure: insights from myocardial energy metabolism.

Heart failure, which is often the final stage of various cardiovascular diseases, remains a major cause of mortality, challenging the efficacy of current therapeutic advancements. Contemporary pharmacological treatments for heart failure aim to mitigate neurohormonal activation, alleviate volume overload, and provide inotropic support, particularly under conditions of hemodynamic instability. Despite these efforts and advancements in medications and medical technology, the mortality rates associated with heart failure continue to be alarmingly high.

Social isolation, loneliness, genetic risk, and incident dementia in people with type 2 diabetes mellitus: A population-based cohort study.

BackgroundSocial isolation and loneliness, two independent constructs of social disengagement, are becoming increasingly recognized factors for dementia risk.ObjectiveWe aimed to investigate whether these two constructs also associate with dementia risk in individuals with type 2 diabetes mellitus (T2DM), which is becoming more prevalent.MethodsThe longitudinal study included 24,986 participants (mean age: 60.

Heat shock protein 70 mitigates black carbon particles-induced cardiac damage.

Studies have demonstrated the association between black carbon (BC) particles and elevated risk of cardiovascular disease. However, the mechanisms underlying this relationship remain unclear. This study aims to investigate the effects of BC exposure on gene expressions in mice myocardium.

Apnea detection using wrist actigraphy in patients with heterogeneous sleep disorders.

Obstructive sleep apnea (OSA) and related hypoxia are well-established cardiovascular and neurocognitive risk factors. Current multi-sensor diagnostic approaches are intrusive and prone to misdiagnosis when simplified. This study introduces an enhanced single-sensor-based OSA screening method, leveraging novel signal processing and machine learning to ensure accurate detection across diverse populations.

Polysomnographic characteristics of patients with heart failure combined with sleep apnea: A systematic review and meta-analysis.

Aims: Objective sleep parameters in patients with HF and their comorbidity with sleep-disordered breathing (SDB) are not fully understood. We aimed to investigate the polysomnography-measured sleep characteristics in HF patients using a systematic review and meta-analysis.

Methods: PubMed, Embase, and Web of Science databases were searched for studies on PSG in HF patients.

Causal Associations of Insomnia With Chronic Kidney Diseases and Underlying Blood Proteins: An Observational and Mendelian Randomization Study.

Objective: To investigate the causal association between insomnia and chronic kidney disease (CKD) and to explore the underlying protein pathways.

Methods: In primary analyses, multivariate regression and 1-sample mendelian randomization (1SMR) analyses were performed to estimate the associations between insomnia and CKD in the UK Biobank cohort. The study was conducted from March 13, 2006, to November 12, 2021.

The Role of Circulating Fatty Acids in Mediating the Effect of Insomnia on Heart Failure: A Two-Step, Two-Sample Mendelian Randomization Study.

Purpose: Previous studies support the causal effect of insomnia on heart failure. Fatty acid metabolism plays key roles in the occurrence and development of heart failure. It is unclear whether fatty acids play roles in the causal association between insomnia and heart failure.

Device-Measured Physical Activity, Sedentary Behaviour and Risk of Chronic Kidney Diseases Across Levels of Grip Strength.

Background: The study aimed to investigate whether the associations of accelerometer-measured physical activity (PA) and sedentary behaviour (SB) with incident chronic kidney disease (CKD) vary based on different levels of hand grip strength, identifying the modifying role of grip strength in these associations.

Methods: The study included 87 487 adults from the UK Biobank. PA and SB were quantified using accelerometers over 7-day period, while grip strength was assessed using a hand dynamometer.

Association of blood cadmium and physical activity with mortality: A prospective cohort study.

Physical activity (PA) may be considered an alternative method to ameliorate the elevated mortality risks associated with cadmium exposure. In this prospective cohort study, a total of 20,253 participants (weighted mean age, 47.79 years), including 10,247 men (weighted prevalence: 50.

Observational and genetic evidence disagree on the association between loneliness and risk of multiple diseases.

Loneliness-the subjective experience of social disconnection-is now widely regarded as a health risk factor. However, whether the associations between loneliness and multiple diseases are consistent with causal effects remains largely unexplored. Here we combined behavioural, genetic and hospitalization data from the UK Biobank to examine the associations of loneliness with a wide range of non-overlapping diseases.

Accelerometer-measured physical activity, sedentary behavior, and incidence of macrovascular and microvascular events in individuals with type 2 diabetes mellitus and prediabetes.

Background: Physical activity (PA) is considered beneficial for lowering cardiovascular risks following type 2 diabetes mellitus (T2DM) and prediabetes, but existing evidence relies mainly on self-reported measurements. We aimed to describe the intensity-specific dose-response associations of PA and sedentary behavior (SB) with macrovascular and microvascular events among individuals with T2DM and prediabetes.

Methods: This study included 11,474 individuals with T2DM and prediabetes from the UK Biobank.

Associations of objective sleep duration and physical activity with risk of heart failure: A prospective cohort study.

Objective: This study aimed to investigate the independent and joint associations of accelerometer-derived sleep duration and physical activity (PA) in different intensities with the risk of incident heart failure (HF).

Methods: The study included 89,572 participants (mean age 62.2 ± 7.

Associations between insomnia and cardiovascular diseases: a meta-review and meta-analysis of observational and Mendelian randomization studies.

Study Objectives: Observational studies suggest associations between insomnia and cardiovascular diseases (CVDs), but the causal mechanism remains unclear. We investigated the potential causal associations between insomnia and CVDs by a combined systematic meta-review and meta-analysis of observational and Mendelian randomization studies.

Methods: We searched PubMed, Web of Science, and Embase for English-language articles from inception to July 11, 2023.

Associations of accelerometer-measured sleep duration with incident cardiovascular disease and cardiovascular mortality.

Study Objectives: This study aimed to determine the associations between accelerometer-measured sleep durations and the risks of incident cardiovascular disease (CVD) and CVD-related mortality.

Methods: A total of 92 261 participants (mean age: 62.4 ± 7.

Childhood maltreatment, genetic risk, and subsequent risk of arrhythmias: a prospective cohort study.

Emerging evidence has linked childhood maltreatment with cardiovascular disease risk; however, the association between childhood maltreatment and cardiac arrhythmias remains unclear. Moreover, any genetic predispositions to atrial fibrillation (AF), a common cardiac arrhythmia associated with an elevated risk of stroke, heart failure, and mortality, that modify such associations have been undocumented. To examine the associations between childhood maltreatment and incident arrhythmias, and whether a genetic predisposition to arrhythmias modifies these associations.

Evaluation of Changes in Social Isolation and Loneliness with Incident Cardiovascular Events and Mortality.

Background: It remains unknown how the patterns of change of social isolation and loneliness are associated with the onset of cardiovascular disease (CVD) and mortality. We aimed to investigate the longitudinal association of changes in social isolation and loneliness with incident CVD, all-cause mortality, CVD mortality and subsequent cardiac function.

Methods: This prospective cohort study included 18,258 participants aged 38-73 years who participated in visit 0 (2006-2010) and visit 1 (2012-2013) using UK Biobank (mean age 57.