Projecting Global Trends and Inequalities in Adult Overweight and Obesity, 2023-2040: Findings From the NCD-RisC Database.

Objective: This study quantifies the global burden of overweight and obesity, projects future trends, and examines associated health inequalities.

Methods: Overweight and obesity burden data were obtained from the NCD-RisC database. Trends from 1990 to 2022 were analyzed, and a Bayesian model was used to project changes for 2023-2040.

Exploring population and sex-specific disease trajectories for multimorbidities among individuals with overweight or obesity: A retrospective cohort study in UK biobank.

Background: Overweight and obesity are major risk factors for non-communicable diseases (NCDs). This study aimed to explore the pattern of multimorbidity development and disease trajectories in individuals with overweight and obesity.

Methods: We followed a cohort of 392 541 individuals retrospectively from the UK Biobank.

Advances and Challenges in CRISPR/Cas-Based Fungal Genome Engineering for Secondary Metabolite Production: A Review.

Fungi represent an important source of bioactive secondary metabolites (SMs), which have wide applications in many fields, including medicine, agriculture, human health, and many other industries. The genes involved in SM biosynthesis are usually clustered adjacent to each other into a region known as a biosynthetic gene cluster (BGC). The recent advent of a diversity of genetic and genomic technologies has facilitated the identification of many cryptic or uncharacterized BGCs and their associated SMs.

Inhibition of Shigella sonnei-induced epithelial barrier disruption by surface-layer associated proteins of lactobacilli from Chinese fermented food.

Surface-layer associated proteins (SLAP) of Lactobacillus paracasei ssp. paracasei M5-L and Lactobacillus casei Q8-L were examined to identify the functional basis for their protection within intestinal epithelial cells. The results showed that SLAP of M5-L and Q8-L remained active in a trypsin solution and retained a 45-kDa protein band, similar to that observed in controls.

Adhesions of extracellular surface-layer associated proteins in Lactobacillus M5-L and Q8-L.

Surface-layer associated proteins (SLAP) that envelop Lactobacillus paracasei ssp. paracasei M5-L and Lactobacillus casei Q8-L cell surfaces are involved in the adherence of these strain to the human intestinal cell line HT-29. To further elucidate some of the properties of these proteins, we assessed the yields and expressions of SLAP under different incubation conditions.