Non-contact diffuse reflectance spectroscopy using center-illuminated-area-detection modeled by a simple formula for assessing myoglobin.

A convenience that is desirable in diffuse reflectance spectroscopy (DRS) is to recover the spectral absorption by direct model inversion to facilitate decomposition of spectrally significant chromophores. Attaining such convenience that requires a simple forward model has been challenging in non-contact DRS, for assessing myoglobin forms, which is important to the evaluation of discoloration of meat. This work demonstrates that non-contact DRS configured in a center-illuminated-area-detection (CIAD) geometry [Appl.

High diversity of dietary flavonoid intake is associated with a lower risk of all-cause mortality and major chronic diseases.

Higher habitual intakes of dietary flavonoids have been linked with a lower risk of all-cause mortality and major chronic disease. Yet, the contribution of diversity of flavonoid intake to health outcomes remains to be investigated. Here, using a cohort of 124,805 UK Biobank participants, we show that participants who consumed the widest diversity of dietary flavonoids, flavonoid-rich foods and/or specific flavonoid subclasses had a 6-20% significantly lower risk of all-cause mortality and incidence of cardiovascular disease, type 2 diabetes, cancer, respiratory disease and neurodegenerative disease.

Existing food processing classifications overlook the phytochemical composition of processed plant-based protein-rich foods.

According to existing food processing classification systems, plant-based protein-rich (PBPR) foods are often considered 'ultra-processed'-and therefore perceived as unhealthy-despite their ability to provide various bioactive compounds beneficial for human health. Here we used a non-targeted metabolomics approach to analyse the impact of processing on the biochemical composition of PBPR foods. Our results show that existing food classification systems may provide questionable categories for PBPR foods without considering their overall biochemical composition, including phytochemicals.

Diets can be consistent with planetary limits and health targets at the individual level.

Progress towards eliminating hunger and promoting sustainable diets is lagging, with food systems damaging ecosystems and over 700 million people undernourished. Here we develop a linear programming model that identifies food combinations that satisfy both environmental and nutritional constraints. Using US-specific data, the model considers the environmental and nutritional characteristics of more than 2,500 food items consumed in the USA, optimizing diets based on the healthy life gained from the Health Nutritional Index.

Valorization of cocoa pod side streams improves nutritional and sustainability aspects of chocolate.

Chocolate production faces nutritional, environmental and socio-economic challenges present in the conventional cocoa value chain. Here we developed an approach that addresses these challenges by repurposing the often-discarded pectin-rich cocoa pod endocarp and converting it into a gel. This is done using cocoa pulp juice concentrate to replace traditional sugar from sugar beets.

Long-term impact of mediterranean diet on cardiovascular disease prevention: A systematic review and meta-analysis of randomized controlled trials.

Background: Dietary modification plays a pivotal role in the prevention of cardiovascular disease (CVD), with particular emphasis on the potential benefits associated with adopting a Mediterranean diet (MedDiet). Numerous observational studies have explored the impact of the MedDiet on CVD prevention, addressing both primary and secondary prevention. However, a substantial portion of the primary evidence comes from specific Randomized Controlled Trials (RCTs), such as the Lyon Diet Heart Study, the Indo-Mediterranean Diet Heart Study, the PREDIMED Study, and the recent CORDIOPREV Study.

Cortical reactivations predict future sensory responses.

Many theories of offline memory consolidation posit that the pattern of neurons activated during a salient sensory experience will be faithfully reactivated, thereby stabilizing the pattern. However, sensory-evoked patterns are not stable but, instead, drift across repeated experiences. Here, to investigate the relationship between reactivations and the drift of sensory representations, we imaged the calcium activity of thousands of excitatory neurons in the mouse lateral visual cortex.

On-demand entanglement of molecules in a reconfigurable optical tweezer array.

Entanglement is crucial to many quantum applications, including quantum information processing, quantum simulation, and quantum-enhanced sensing. Because of their rich internal structure and interactions, molecules have been proposed as a promising platform for quantum science. Deterministic entanglement of individually controlled molecules has nevertheless been a long-standing experimental challenge.

Motile Living Biobots Self-Construct from Adult Human Somatic Progenitor Seed Cells.

Fundamental knowledge gaps exist about the plasticity of cells from adult soma and the potential diversity of body shape and behavior in living constructs derived from genetically wild-type cells. Here anthrobots are introduced, a spheroid-shaped multicellular biological robot (biobot) platform with diameters ranging from 30 to 500 microns and cilia-powered locomotive abilities. Each Anthrobot begins as a single cell, derived from the adult human lung, and self-constructs into a multicellular motile biobot after being cultured in extra cellular matrix for 2 weeks and transferred into a minimally viscous habitat.

An autonomous laboratory for the accelerated synthesis of novel materials.

To close the gap between the rates of computational screening and experimental realization of novel materials, we introduce the A-Lab, an autonomous laboratory for the solid-state synthesis of inorganic powders. This platform uses computations, historical data from the literature, machine learning (ML) and active learning to plan and interpret the outcomes of experiments performed using robotics. Over 17 days of continuous operation, the A-Lab realized 41 novel compounds from a set of 58 targets including a variety of oxides and phosphates that were identified using large-scale ab initio phase-stability data from the Materials Project and Google DeepMind.

Temporal trends in microplastic accumulation in placentas from pregnancies in Hawai'i.

Microplastics are created for commercial use, are shed from textiles, or result from the breakdown of larger plastic items. Recent reports have shown that microplastics accumulate in human tissues and may have adverse health consequences. Currently, there are no standardized environmental monitoring systems to track microplastic accumulation within human tissues.

A healthy diet, physical activity, or either in relation to cardiovascular and all-cause mortality: A prospective cohort study.

Objectives: The aim of our study was to compare four lifestyles-healthy diet and low activity, unhealthy diet and high activity, unhealthy diet and low activity, and healthy diet and high activity-in relation to the risk of cardiovascular disease (CVD) and all-cause mortality.

Methods: A total of 6504 adults ages ≥35 y were recruited to participate in the Isfahan Cohort Study and followed for 13 y. Diet was assessed using a validated 48-item food frequency questionnaire, and the quality of diet was assessed using the Dietary Quality Index.

Vegans, vegetarians, fish-eaters and meat-eaters in the UK show discrepant environmental impacts.

Modelled dietary scenarios often fail to reflect true dietary practice and do not account for variation in the environmental burden of food due to sourcing and production methods. Here we link dietary data from a sample of 55,504 vegans, vegetarians, fish-eaters and meat-eaters with food-level data on greenhouse gas emissions, land use, water use, eutrophication risk and potential biodiversity loss from a review of 570 life-cycle assessments covering more than 38,000 farms in 119 countries. Our results include the variation in food production and sourcing that is observed in the review of life-cycle assessments.

Diets with higher insulinaemic potential are associated with increased risk of overall and cardiovascular disease-specific mortality.

Hyperinsulinaemia and insulin resistance have been proposed to be associated with mortality risk, and diet can modulate insulin response. However, whether dietary patterns with high insulinaemic potential are associated with mortality remains unknown. We prospectively examined the associations between hyperinsulinaemic diets and the risk of total and cause-specific mortality in a large nationally representative population.

The impact of conflict-driven cropland abandonment on food insecurity in South Sudan revealed using satellite remote sensing.

Armed conflicts often hinder food security through cropland abandonment and restrict the collection of on-the-ground information required for targeted relief distribution. Satellite remote sensing provides a means for gathering information about disruptions during armed conflicts and assessing the food security status in conflict zones. Using ~7,500 multisource satellite images, we implemented a data-driven approach that showed a reduction in cultivated croplands in war-ravaged South Sudan by 16% from 2016 to 2018.

Food Compass is a nutrient profiling system using expanded characteristics for assessing healthfulness of foods.

Nutrient profiling systems (NPS) aim to discriminate the healthfulness of foods for front-of-package labelling, warning labels, taxation, company ratings and more. Existing NPS often assess relatively few nutrients and ingredients, use inconsistent criteria across food categories and have not incorporated the newest science. Here, we developed and validated an NPS, the Food Compass, to incorporate a broader range of food characteristics, attributes and uniform scoring principles.

Fertilizer and grain prices constrain food production in sub-Saharan Africa.

Crop yields across sub-Saharan Africa are much lower than what is attainable given the environmental conditions and available technologies. Closing this 'ecological yield gap' is considered an important food security and rural welfare goal. It is not clear, however, whether it is economically sensible for farmers to substantially increase crop yields.

Global greenhouse gas emissions from animal-based foods are twice those of plant-based foods.

Agriculture and land use are major sources of greenhouse gas (GHG) emissions but previous estimates were either highly aggregate or provided spatial details for subsectors obtained via different methodologies. Using a model-data integration approach that ensures full consistency between subsectors, we provide spatially explicit estimates of production- and consumption-based GHG emissions worldwide from plant- and animal-based human food in circa 2010. Global GHG emissions from the production of food were found to be 17,318 ± 1,675 TgCOeq yr, of which 57% corresponds to the production of animal-based food (including livestock feed), 29% to plant-based foods and 14% to other utilizations.

Small targeted dietary changes can yield substantial gains for human health and the environment.

To identify environmentally sustainable foods that promote health, we combined nutritional health-based and 18 environmental indicators to evaluate, classify and prioritize individual foods. Specifically for nutrition, we developed the Health Nutritional Index to quantify marginal health effects in minutes of healthy life gained or lost of 5,853 foods in the US diet, ranging from 74 min lost to 80 min gained per serving. Environmental impacts showed large variations and were found to be correlated with global warming, except those related to water use.

The COVID-19 crisis will exacerbate maternal and child undernutrition and child mortality in low- and middle-income countries.

The economic crisis and food and health system disruptions related to the COVID-19 pandemic threaten to exacerbate undernutrition in low- and middle-income countries (LMICs). We developed pessimistic, moderate and optimistic scenarios for 2020-2022 and used three modelling tools (MIRAGRODEP, the Lives Saved Tool and Optima Nutrition) to estimate the impacts of pandemic-induced disruptions on child stunting, wasting and mortality, maternal anaemia and children born to women with a low body mass index (BMI) in 118 LMICs. We estimated the cost of six nutrition interventions to mitigate excess stunting and child mortality due to the pandemic and to maximize alive and non-stunted children, and used the human capital approach to estimate future productivity losses.

Role of dietary fiber in the recovery of the human gut microbiome and its metabolome.

Gut microbiota metabolites may be important for host health, yet few studies investigate the correlation between human gut microbiome and production of fecal metabolites and their impact on the plasma metabolome. Since gut microbiota metabolites are influenced by diet, we performed a longitudinal analysis of the impact of three divergent diets, vegan, omnivore, and a synthetic enteral nutrition (EEN) diet lacking fiber, on the human gut microbiome and its metabolome, including after a microbiota depletion intervention. Omnivore and vegan, but not EEN, diets altered fecal amino acid levels by supporting the growth of Firmicutes capable of amino acid metabolism.

Associations of Exercise Types with All-Cause Mortality among U.S. Adults.

Purpose: Exercising benefits physical and mental health as well as longevity. However, the extent to which different types of exercise are differentially associated with the risk of mortality is less clear. This study examined whether 15 different types of exercise were uniquely associated with all-cause mortality in a nationally representative sample of noninstitutionalized American adults between 18 and 84 yr old.