Predicting Treatment Response in Retinal Vein Occlusions Using Baseline Optical Coherence Tomography Biomarkers: A Systematic Review.

This systematic review examines the prognostic value of baseline optical coherence tomography (OCT) biomarkers in predicting visual acuity (VA) outcomes for eyes with macular edema secondary to retinal vein occlusions (RVO) treated with anti-VEGF therapies, steroids, laser photocoagulation, or combination treatments. VA predictions at 6, 12, and 24 months post-treatment were assessed using a narrative synthesis approach and vote counting based on effect direction relative to a minimal clinically important difference. Certainty of evidence was evaluated using GRADE guidelines.

Health-Related Quality-of-Life Outcomes for Upper Blepharoplasty and Blepharoptosis Surgery: A Report by the American Academy of Ophthalmology.

Purpose: To review the literature and identify the health-related quality-of-life (HRQL) outcomes that used a validated instrument in the assessment of upper blepharoplasty, blepharoptosis surgery, or combination surgery.

Methods: A literature search was last conducted in the PubMed database in January 2025 to identify all studies in the English language investigating HRQL outcomes that used a validated instrument in the assessment of upper blepharoplasty, blepharoptosis surgery, or combination surgery. The literature search yielded 773 citations, and 20 studies met the inclusion criteria.

Leveraging port state measures to combat illegal, unreported, and unregulated fishing.

Illegal, unreported, and unregulated (IUU) fishing threatens the sustainability of fisheries and communities dependent on them. The Port State Measures Agreement (PSMA) is a key tool for combatting IUU fishing by foreign fleets, requiring standardized inspections, information sharing, and port denial. Using satellite data, we characterized how PSMA has affected high seas vessel behavior and identify opportunities to strengthen its impact.

Chronic Ocular Surface Pain: An Optometrist and Ophthalmologist Survey.

Introduction: Chronic ocular surface pain (COSP) is defined as ocular pain that is perceived to originate from the ocular surface and persists for more than 3 months. Clear epidemiological data on COSP prevalence are lacking.

Methods: In 2025, a total of 100 eye care providers were surveyed, including 50 optometrists and 50 ophthalmologists.

Exploring Wellness Interventions for Graduate Students: A Pilot Study.

Objective: This mixed-method design pilot study explored healthcare graduate students' perceptions of a two-phase wellness intervention.

Participants: Occupational therapy and physical therapy entry-level graduate students (n=53).

Methods: An initial survey guided content for wellness interventions.

Neurodevelopmental impact of early diagnostic imaging in preterm infants: quantifying risk and the role of point-of-care ultrasound.

Background: Medical imaging is essential in neonatal intensive care units (NICUs), particularly for the management of preterm infants. However, concerns persist regarding the neurodevelopmental impact of repeated low-dose radiation exposure. This study aimed to investigate whether cumulative x-ray exposure in the first month of life is associated with neurodevelopmental outcomes in preterm infants.

Entangled cellular and molecular relationships at the sensory neuron-cancer interface.

Peripheral sensory neurons, once regarded merely as a passive route for nociceptive signals, are now acknowledged as active participants in solid tumor progression. This review explores how sensory neurons influence and are influenced by the tumor microenvironment (TME) through both chemical and electrical signaling, underscoring their pivotal role in the emerging field of cancer neuroscience. We summarize recent findings indicating that cancer-neuron interactions vary among different organs and experimental models, highlighting the ways in which various tumors recruit and reprogram sensory neurons to establish mutual communication loops that foster malignancy.

Structure-function studies of Vibrio cholerae quorum-sensing receptor CqsR signal recognition.

Ethanolamine signaling through the transmembrane quorum-sensing receptor CqsR influences Vibrio cholerae niche recognition and host colonization. In this study, we present a comprehensive structure-function analysis of CqsR. Specifically, we have determined X-ray crystal structures of the CqsR periplasmic domain bound to the signaling agonist ethanolamine and its analogs, serinol and L-alaninol, as well as the ligand-free (apo) form of CqsR.

Single Treatment With MM120 (Lysergide) in Generalized Anxiety Disorder: A Randomized Clinical Trial.

Importance: Effective and well-tolerated pharmacotherapies for generalized anxiety disorder (GAD), which is one of the most common psychiatric disorders, are needed.

Objective: To determine the dose-response relationship of MM120 (lysergide D-tartrate) in adults with moderate to severe GAD.

Design, Settings, And Participants: This phase 2b, multicenter, randomized, double-blind, placebo-controlled study enrolled 198 adults aged 18 to 74 years with a primary GAD diagnosis who presented with moderate to severe symptoms (defined by a Hamilton Anxiety Rating Scale [HAM-A] score ≥20) and was conducted at 22 outpatient psychiatric research sites in the US from August 2022 to August 2023.

Probiotic-Based Cleaning Solutions: From Research Hypothesis to Infection Control Applications.

Novel infection control practices are necessary to reduce the incidence of healthcare-associated infections (HAIs). Since 2007, probiotic-based cleaning solutions have been proposed as an alternative to traditional methods using disinfectants and detergents in healthcare settings, including hospitals. We conducted a comprehensive search across Google Scholar, PubMed, Scopus, and Web of Science resources.

Estimating food availability and self-reliance in island territories: Puerto Rico as a case study.

Introduction: In Small Island Developing States (SIDS), limited statistical capacity and reliance on imports hinder comprehensive assessments of food systems. For island territories, this issue is more pronounced as food production data are disaggregated, inconsistent, and scarce. Most non-independent territories within the SIDS designation are not included in international food availability datasets, and local datasets are not readily available.

Clinically Meaningful Improvements With Vibegron in Men With Overactive Bladder and Benign Prostatic Hyperplasia: A Responder Analysis of the Phase 3 COURAGE Trial.

Objective: To demonstrate the impact of vibegron treatment in the phase 3 COURAGE trial (NCT03902080) on clinically meaningful response parameters in men with overactive bladder (OAB) receiving pharmacological therapy for benign prostatic hyperplasia (BPH) as measured by standard, validated patient-reported outcomes.

Methods: Men >45 years with OAB receiving pharmacotherapy for BPH were randomly assigned 1:1 to vibegron 75 mg or placebo for 24 weeks. Participants completed bladder diaries assessing changes in micturition frequency, nocturia, and urge urinary incontinence (UUI); International Prostate Symptom Score (IPSS); and OAB questionnaire (OAB-q).

Research burden in pediatric cancer: A mixed methods study from the PediQUEST Response Trial.

Context: Research burden in pediatric advanced cancer is understudied.

Objectives: To analyze study burden among parents and children participating in the PediQUEST Response Trial, and explore associated factors, including belonging to historically marginalized (HM) backgrounds or facing economic hardship (EH).

Methods: Mixed-methods secondary analysis of data collected for an RCT.

Inter-evaluator bias and applicability of feline body condition score from visual assessment.

Body Condition Score (BCS) is an effective tool for assessing body weight and fat mass, as well as diagnosing obesity and abnormal weight loss. A method for visual assessment of BCS in cats would be useful to expand access for feline health and research. The goal of this study is to determine whether BCS can be accurately assessed solely from photographs of cats, and to measure inter-evaluator bias in visually assessed BCS.

KCC2 inhibition and neuronal hyperexcitability promote extrinsic apoptosis dependent upon C1q.

Introduction: The potassium chloride co-transporter 2 (KCC2) is the principal Cl extrusion mechanism employed by mature neurons in the central nervous system (CNS) and plays a critical role in determining the efficacy of fast synaptic inhibition mediated by type A -aminobutyric acid receptors (GABARs) to protect against epileptogenesis. It has previously been demonstrated that epileptic seizures down-regulate KCC2 and induce neuronal apoptosis through the extrinsic apoptotic pathway. However, the mechanism by which neuronal death is induced by KCC2 loss remains unknown.

"There's a lot of people who love them, so why call 'em junkies?": clinician and patient perspectives about words used to describe people who use drugs.

Background: There is increasing attention in clinician care to the importance of using person-first language. Clinicians' words can reinforce clinicians' pre-existing stigmas and biases. People who use drugs (PWUD) continue to face stigma from clinicians.

Aligning metrics with meaning: considerations for measurement selection in disability evaluation.

This article explores the role of patient-reported outcome measures (PROMs) in disability evaluation, a measurement domain traditionally dominated by clinical performance-based assessments. While performance tests are valued for their perceived objectivity, PROMs have gained prominence in research for their efficiency, patient-centered orientation, and capacity to capture subjective experiences relevant to functional decline related to potentially disabling conditions. The manuscript underscores the importance of aligning measurement tools with the specific purpose of evaluation-whether clinical, policy-driven, or programmatic.

Peripheral Blood Mononuclear Cell Gene Expression Signatures Predict Long-term Survivorship in Canine DLBCL.

Pet dogs spontaneously develop a form of diffuse large B cell lymphoma (DLBCL) that recapitulates many of the features of double hit () human DLBCL. We recently completed a clinical trial in dogs with DLBCL using a combination of canine anti-CD20 antibody and low dose doxorubicin followed by one of three small molecule immune-modulating agents (KPT-9274, TAK-981 or RV1001). Clinical outcomes and tumor specific biomarkers of response from these dogs have been previously reported.

Hypothermic oxygenated machine perfusion does not increase the risk of infection after liver transplantation: a retrospective cohort study.

Background: Liver transplantation (LT) is a crucial treatment for end-stage liver disease, but the limited organ supply has led to the use of extended criteria donors (ECD). The implementation of dynamic preservation techniques like hypothermic oxygenated machine perfusion (HOPE) is crucial in improving outcomes for ECD grafts. However, graft contamination and infection are a concern.

Analyzing characteristics of immersive virtual reality experiences for chronic pain management: Assessing the interrater reliability of the Virtual Reality Activity Analysis for Pain instrument.

Introduction: Immersive virtual reality is increasingly used to treat chronic pain. Commercial virtual reality experiences offer a way to integrate immersive virtual reality into clinical practice, but selecting appropriate virtual reality experiences for specific patient goals is challenging. We developed the Virtual Reality Activity Analysis for Pain to help occupational therapy professionals assess virtual reality experience physical, sensory, mental, and psychosocial components relevant to chronic pain treatment.

The development of prosocial risk-taking behavior: Mechanisms and opportunities.

Many young people are inclined toward risk taking and also toward helping other people. is a term that can describe different ways that youth provide significant instrumental and emotional support to family members, friends, and strangers, even when it involves a personal risk. In this article, we review research about different types of prosocial risk taking and highlight examples, emphasizing a developmental perspective by examining change across childhood, adolescence, and young adulthood.

Prospective COPD Case Finding in a Lung Cancer Screening Program: A Pilot Study.

Background: Chronic Obstructive Pulmonary Disease (COPD) remains underdiagnosed and undertreated. Because screening asymptomatic individuals for COPD is not recommended, several case-finding tools have been explored. The CAPTURE questionnaire and peak expiratory flow rate (PEFR) (CAPTURE tool) have been tested in the primary care setting, with disappointing results.

The duration and intensity of adolescents' childcare and eldercare responsibilities: Links to short- and long-term educational outcomes.

This longitudinal study documents individual differences in the intensity and duration of adolescents' childcare and eldercare responsibilities from ages 14 to 18. Further, it investigates how adolescents' caregiving responsibilities are associated with socioeconomic background, and educational achievement in high school and at midlife. Participants ( = 1,130, 52% female, 12% Asian, 9% Black, 4% Hispanic) were followed longitudinally from ages 14 to 46.