Publications by authors named "Seanna R Grob"

Purpose: To review the literature and identify the health-related quality-of-life (HRQL) outcomes that used a validated instrument in the assessment of upper blepharoplasty, blepharoptosis surgery, or combination surgery.

Methods: A literature search was last conducted in the PubMed database in January 2025 to identify all studies in the English language investigating HRQL outcomes that used a validated instrument in the assessment of upper blepharoplasty, blepharoptosis surgery, or combination surgery. The literature search yielded 773 citations, and 20 studies met the inclusion criteria.

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Purpose: Innovations in artificial intelligence (AI) have paved the way for automated analysis and detection of various anterior and posterior segment diseases in ophthalmology. The goal of this study is to review the literature surrounding the utilization of AI for oculoplastic diseases or conditions.

Methods: A literature search was conducted on Pubmed and Embase using a combination of terms including AI and oculoplastics, blepharoptosis, eyelid ptosis, brow lift, blepharoplasty, eyelid aesthetics, entropion, eyelid reconstruction, eyelid malposition, periocular cancer, periorbital melanoma, eyelid tumor, eyelid cancer, mohs reconstruction, orbital inflammation, orbital decompression, thyroid eye disease, thyroid ophthalmopathy, giant cell arteritis, lacrimal gland or lacrimal duct, dacryoadenitis, orbital fracture, orbital infections.

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Purpose: To review systematically the literature on the efficacy and safety of the use of patient-specific implants (PSIs) in orbital reconstructive surgery.

Methods: A literature search was last conducted in January 2025 in the PubMed database for English language original research that assessed the use of any PSI reported for orbital reconstructive surgery. Of the 219 articles identified, 51 met the inclusion criteria for this assessment and were selected for full-text review and data abstraction.

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Objective: To review the literature to determine the efficacy and safety of pharmacologic agents for the short-term (minutes to hours) correction of blepharoptosis.

Methods: A literature search was conducted last in the PubMed database in July 2024 to identify all studies in the English language on the use of pharmacologic agents for the correction of blepharoptosis. The search yielded 197 citations, and 26 articles met all of the inclusion criteria for this assessment.

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Objective: To review the literature for protocols and results of patch testing for allergic contact dermatitis (ACD) in patients with noninfectious eyelid dermatitis.

Methods: A literature search of the PubMed database was conducted last in July 2024. Articles were limited to original research for which an English language abstract was available, and in which detailed data were available for at least 25 patients being tested for noninfectious eyelid dermatitis.

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Purpose: To employ a validated survey for evaluation of quality of life (QoL) outcomes and associated factors in a US cohort of adult patients with acquired anophthalmia wearing a prosthesis.

Methods: A retrospective cohort study was performed at a single, US academic institution of patients cared for between 2012 and 2021. The electronic medical record database was queried for adult patients with a history of evisceration or enucleation surgery and placement of an orbital implant.

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Purpose Of Review: In recent years, the field of aesthetic medicine has witnessed a paradigm shift with an increasing demand for minimally invasive cosmetic procedures, including cosmetic injectables. This review aims to delineate the distinctive role played by oculoplastic surgeons in the administration of cosmetic injectables, comparing their expertise to that of nonphysician practitioners.

Recent Findings: Complications arising from cosmetic injections are discussed, including skin discoloration, inflammation, necrosis, vision loss, retinal pathology, and central nervous system adverse effects.

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Purpose: To review the efficacy and safety of the use of intraoperative image guidance (IIG) in orbital and lacrimal surgery.

Methods: A literature search of the PubMed database was last conducted in November 2023 for English-language original research that assessed the use of any image guidance system in orbital and lacrimal surgery that included at least 5 patients. The search identified 524 articles; 94 were selected for full-text analysis by the panel.

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Objective: To investigate whether functional upper eyelid malposition is associated with unrecognized deficits in automated perimetry among glaucoma patients by examining patients undergoing eyelid surgery who had not been identified as requiring eyelid taping during glaucoma field testing.

Methods: In this retrospective pre-post study, an automated database search followed by manual chart review was used to identify eligible patients from January 2012 to March 2020. Included patients had reliable visual field testing within two years before and after functional upper blepharoplasty or ptosis repair and no comorbid ocular diagnoses.

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The NASA human system risk board (HSRB) has long focused on trauma and acute medical illness as a key contributor to high level in-flight medical risk. However, ocular issues, trauma, and complaints during spaceflight are poorly characterized. In a retrospective case series, the NASA data from the life sciences data archieve (LSDA) and the lifetime surveillance of astronaught health (LSAH) was queried for eye related complaints and conditions in spaceflight across international space station (ISS) missions and space shuttle (STS) missions.

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Cutaneous mucormycosis is a rare, opportunistic fungal infection that typically affects immunocompromised hosts. Current treatment consists of systemic antifungal therapy, surgical debridement, and when applicable, restoration of immune function. Despite intervention, the morbidity and mortality of invasive fungal disease remains high.

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Purpose: To evaluate and compare eye and face trauma in mixed martial arts (MMA) and boxing.

Design: Retrospective cohort study.

Methods: Data from boxing and MMA competitions were extracted from the Nevada Athletic Commission (NAC) between 2000 and 2020.

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 Physician diversity is limited in ophthalmology and oculofacial plastic surgery. Determination of barriers within the application process for oculofacial plastic surgery may help target efforts to improve the recruitment of underrepresented groups. This study aimed to illuminate perceived barriers to increasing diversity in oculofacial plastic surgery trainees, according to the American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS) fellows and fellowship program directors (FPDs).

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Purpose: Orbital inflammatory disease (OID) is a heterogeneous group of immunologic disorders whose etiology is often non-specific despite routine investigation. In this proof-of-concept study, metagenomic deep sequencing (MDS) is applied to examine host gene expression in two subtypes of OID.

Methods: Prospectively collected lacrimal gland tissue from patients with OID was processed for MDS.

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Purpose: This study evaluates a web-based tool designed to augment telemedicine post-operative visits after periocular surgery.

Methods: Adult, English-speaking patients undergoing periocular surgery with telemedicine follow-up were studied prospectively in this interventional case series. Participants submitted visual acuity measurements and photographs via a web-based tool prior to routine telemedicine post-operative visits.

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Purpose: To identify initial, preintervention magnetic resonance imaging (MRI) findings that are predictive of visual and mortality outcomes in acute invasive fungal rhinosinusitis (AIFRS).

Design: Retrospective cohort study.

Participants: Patients with histopathologically or microbiologically confirmed AIFRS cared for at a single, tertiary academic institution between January 2000 and February 2020.

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Article Synopsis
  • The study aimed to assess whether antibiotics enhance the treatment effectiveness for chalazions and hordeolums in patients at UCSF between 2012 and 2018.
  • A total of 2,712 patients were analyzed, with 36.5% receiving an antibiotic, particularly in emergency settings, and older patients were more likely to receive antibiotics for hordeolums.
  • The findings suggest that adding antibiotics to other treatments did not significantly improve the chances of successful resolution for either condition.
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Purpose: Tumors of the medial orbital apex can be challenging to resect. Primary endonasal resection can be limited by requirements for fat retraction and poor angulation for lateral orbital dissection. Orbital resection alone can have space limitations and a limited view for dissection of the posterior aspect of the tumor.

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Understanding how periocular nonmelanoma skin cancer (NMSC) impacts quality of life (QoL) provides insight into the patient experience. To prospectively measure QoL of individuals with surgically treated periocular NMSC. Responses to the skin cancer index (SCI) and FACE-Q questionnaires were obtained at preoperative (PRE), postoperative week 1 (POW1), and postoperative month 3 (POM3) visits.

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Purpose: To assess whether a modified treatment ladder algorithm incorporating transcutaneous retrobulbar amphotericin B (TRAMB) for invasive fungal rhino-orbital sinusitis can reduce the risk of exenteration without compromising survival.

Design: Retrospective, comparative clinical study with historical control subjects.

Methods: Fifty consecutive patients with biopsy-proven invasive fungal sinusitis and radiographic evidence of orbital involvement were evaluated at a single tertiary institution from 1999-2020.

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Acute invasive fungal rhinosinusitis is a rare, although highly morbid, infection primarily affecting immunosuppressed individuals. The same population is at particularly high risk of complications and mortality in the setting of SARS-CoV-2 infection and coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome. The authors present a case of acute invasive fungal rhino-orbital mucormycosis in a patient with COVID-19 and discuss the prevalence, diagnosis, and treatment of fungal coinfections in COVID-19.

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Purpose: Opioids may be indicated to mitigate pain after oculofacial surgery. The opioid crisis prompted attention to how these medications are dispensed and disposed. This study aims to characterize opioid usage and handling of patients undergoing oculofacial plastic surgery.

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Purpose: To describe and evaluate the use of a lateral tarsoconjunctival suspension flap (TCSF) for the management of post blepharoplasty lower eyelid retraction.

Methods: Two-center, retrospective chart review of patients who received a lateral TCSF between 2010 and 2018 for correction of post blepharoplasty lower eyelid retraction. The postoperative follow-up was a minimum of 3 months.

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Purpose: To report the characteristic clinical and imaging findings in a series of patients with thrombosed orbital venolymphatic malformations.

Methods: Patients affected by acute thrombosis of an orbital venolymphatic malformation were reviewed. Clinical findings including symptoms and signs of presentation, characteristic imaging features, and clinical course are presented.

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