Publications by authors named "Gizem Gumuskaya"
The Morphological, Behavioral, and Transcriptomic Life Cycle of Anthrobots.
Adv Sci (Weinh)
August 2025
Fascinating aspects of morphogenetic and behavioral plasticity of living material are revealed by novel constructs that self-construct from genetically wild-type cells. Anthrobots arise from cultured adult human airway epithelial cells, developing, becoming self-motile, and acquiring neural repair capabilities without exogenous genetic circuits or inorganic scaffolds. Progress in bioengineering and regenerative medicine depends on developing a predictive understanding of collective cell behavior in novel circumstances.
View Article and Find Full Text PDFMotile Living Biobots Self-Construct from Adult Human Somatic Progenitor Seed Cells.
Adv Sci (Weinh)
January 2024
Article Synopsis
- Fundamental knowledge gaps exist regarding how adult human cells can change and what kinds of shapes and behaviors these genetically normal cells can exhibit when turned into living constructs called anthrobots.
- Anthrobots are bio-robots derived from human lung cells that can form into small spheroid shapes (30-500 microns) and move using cilia, showing diverse behaviors including various movement patterns and speeds.
- These anthrobots can repair damaged human neural cell sheets in lab settings, and their different shapes and structures are linked to their movement types, highlighting the potential of manipulating their environments to discover new biological functions without altering their genetic material directly.