Case Report: Pathological complete response achieved with neoadjuvant immunochemotherapy in synchronous multiple gastric adenocarcinoma.

Synchronous multiple gastric cancers (SMGC) represent a rare clinical entity with no established treatment guidelines. We report a 76-year-old female with two synchronous poorly differentiated adenocarcinomas (dMMR/MSI-H phenotype) in the gastric lesser curvature, clinically staged as cT4bN2M0. Following three cycles of neoadjuvant immunochemotherapy, the patient demonstrated remarkable tumor regression (RECIST 1.

Identification and Validation of Aging-Related Genes in IgA Nephropathy in the Asian Population.

Background: IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Aging is a major risk factor for progression of IgAN to end-stage renal disease. The purpose of this study was to identify and verify aging-related genes associated with IgAN through bioinformatics analysis.

Environmental Change and Hemorrhagic Fever with Renal Syndrome Transmission Risk on the China-Russia Border.

The potential risk of rodent-borne diseases along the China-Russia border necessitates the identification and prediction of rodent distribution from a risk management perspective. In this study, we compile distribution records for Apodemus agrarius, which is the main host of hantavirus responsible for hemorrhagic fever with renal syndrome (HFRS), along the border between China and Russia from various literature sources. We then employ the maximum entropy model (MaxEnt) to assess the influence of climatic and geographic factors on its potential distribution and to predict its current and future habitats.

China's future food demand forecast based on provincial diets and shared socio-economic pathways.

Building on the vast heterogeneity in dietary practices and population size across China, which has contributed to profound regional disparities in food demand, this study incorporated provincial-level dietary preferences and energy needs across different age groups, genders, and residential statuses to project future regional dietary patterns and food demand in China across the five shared socio-economic pathway (SSP) scenarios. The projected diets were proven to be consistent with Chinese dietary practices and fulfilled macronutritrient requirements, compared to dietary guidelines from the EAT-Lancet Commission, the Chinese Nutrition Society, and major peer studies. The dataset covers raw grain demand for 13 major food categories-including rice, wheat, maize, highland barley, tubers, beans, pork, beef, mutton, poultry, aquatic products, eggs, and dairy products-at the provincial level, spanning 2020 to 2100.

Silent but significant: Functional elucidation of a synonymous ATP7B mutation in Wilson's disease pedigrees.

Introduction: Wilson's disease (hepatolenticular degeneration) is a common hereditary neurological disorder. Early diagnosis, particularly the widespread implementation of genetic testing and timely intervention, is crucial for improving the prognosis of this disease. However, limited data exist on genotype-phenotype correlations, thereby impeding accurate early clinical diagnosis.

A novel paradigm for two-degree-of-freedom BCI control based on ERP in-duced by overt and covert visual attention.

This study developed a novel brain-computer interface (BCI) paradigm based on event-related potentials (ERPs) to achieve simultaneous two-degree-of-freedom control through overt and covert visual selective attention.In this paradigm, three stimuli were arranged equidistantly around the cursor. Participants selected two stimuli as attention targets based on the relative position of the cursor and the intended movement destination, focusing overtly on one while covertly attending to the other.

Simulating the effects of drip and flood irrigation on the leaching, migration, and redistribution of heavy metals in contaminated soil.

Background: The extensive adoption of drip irrigation globally has adverse effects on the ecological integrity of soil, leading to significant changes in the distribution of heavy metals and other pollutants across various soil layers. However, the mechanisms underlying such changes are still unclear.

Purpose: This study explores the effects of different irrigation methods (drip and flood irrigation) on the heavy metal behaviors in contaminated soils, including leaching, migration, and redistribution within agricultural practices.

Research on the evolutionary game of reversed online public opinion based on the dual-helix structure mechanism.

This paper employs game theory to examine the impact of the dual-helix structure mechanism on the evolutionary trends of reversed online public opinion, providing a theoretical foundation for public opinion management. Building on the theoretical framework of game theory, the study constructs an evolutionary game model under the dual-helix structure involving online media and opinion leaders as the game participants. It calculates the payoff matrices and replicator dynamics equations of the parties involved and uses numerical simulation methods to assess the stability of various equilibrium points and to deduce the behavioral strategies of the parties under different conditions.

Investigating the impact of the COVID-19 pandemic on the nutritional status of infants and toddlers: insights from China.

Background: A comprehensive understanding of the impact of the COVID-19 pandemic on childhood nutrition is crucial for devising effective mitigation strategies. However, existing knowledge regarding the pandemic's effect on childhood nutritional status remains limited. Furthermore, research focusing on young children aged 0-3 years is scarce.

Assessment of ecological civilization construction from the perspective of environment and health in China.

This study innovatively evaluated ecological civilization in China from the perspective of environment and health. A Composite Environmental Health Index (CEHI) was constructed based on the Driving force-Pressure-State-Impact-Response (DPSIR) and Coupling Coordination Degree (CCD) models. Results showed that significant and sustained improvements were observed in the ecological environment after ecological civilization, while economic development continued to progress at a steady pace.

Circ_0068481 Affects the Human Pulmonary Artery Smooth Muscle Cells' Progression by miR-361-3p/KLF5 Axis.

Background: Uncontrolled proliferation of pulmonary artery smooth muscle cells (PASMCs) contributes to the pathogenesis of pulmonary arterial hypertension (PAH). In this work, we defined the precise part of circ_0068481 in PASMC proliferation and migration induced by hypoxia. We hypothesized that circ_0068481 enhanced hypoxia-induced PASMC proliferation, invasion, and migration through the microRNA (miR)-361-3p/Krüppel-like factor 5 (KLF5) pathway.

Targeted genome mining for microbial antitumor agents acting through DNA intercalation.

Microbial natural products have been one of the most important sources for drug development. In the current postgenomic era, sequence-driven approaches for natural product discovery are becoming increasingly popular. Here, we develop an effective genome mining strategy for the targeted discovery of microbial metabolites with antitumor activities.

Does social capital aid in leveling the income gradient in child mental health? A structural analysis of the left-behind and not-left-behind Chinese children.

Background: Few prior studies have investigated the income gradient in child mental health from a socio-environmental perspective. In an age when child mental health problems in a rapidly changing social environment have become a worldwide issue, an understanding of the socio-environmental mechanisms of the income disparities in child mental health outcomes is imperative and cost-effective.

Methods: By conducting structural equation analyses with Chinese nationally representative survey data, this study explored the family income gradient in child depression and its potential socio-environmental pathways at the neighborhood, family and school levels, differentiating left-behind and not-left-behind children.

The Reasonableness and Spatial Differences of the Food Consumption Structure of Urban and Rural Residents in China, 2015-2021.

Based on residents' food consumption data from 31 provinces in China from 2015-2021, this study analyzes the deviation in food consumption from nutrition targets and the spatial distribution characteristics of urban and rural residents in China from 2015-2021, and finds that there are irrationalities in the structure of food consumption of Chinese residents as well as regional differences in consumption. The food consumption of Chinese residents deviates from the recommended values of the Chinese Food Guide Pagoda to a certain extent, with large differences between urban and rural areas and provinces. Therefore, a new concept of food security with nutrition as the target should be established to guide residents' food consumption scientifically and rationally, and to adopt focused attention and targeted measures for regions with serious imbalances in food consumption.

Selenium and Zinc Intakes of Staple Grains and Their Correlation with Urine Selenium and Zinc in the Tibetan Rural Residents along the Yarlung Zangbo River.

Grains account for a large proportion of the diet of rural residents in Tibet. The lack of selenium (Se) and zinc (Zn) threatens the population's nutrition and health. However, the intakes of selenium and zinc in grains remains unclear.

Organic room-temperature phosphorescence materials for bioimaging.

Organic room-temperature phosphorescence (RTP) materials are currently the focus of research in the field of bioimaging. In comparison with the conventional imaging modalities based on organic fluorescent dyes, RTP materials with long lifetime enable time-resolved imaging to improve the imaging resolution by avoiding autofluorescence. In this review, we will start with summarizing strategies for achieving high performance RTP materials for bioimaging, including the development of RTP-compounds, host-guest doping materials, and supramolecular assemblies.

The spatial-temporal pattern of Japanese encephalitis and its influencing factors in Guangxi, China.

Japanese encephalitis (JE) is a major global public health threat. Using Japanese encephalitis incidence data from 2004 to 2010 in Guangxi Province, China, this study comprehensively explored the driving forces and the interactive effects between environmental and social factors of Japanese encephalitis using the Geo-detector method. The results indicated that the incidence of Japanese encephalitis showed a fluctuating downward trend from 2004 to 2010.

Factors influencing the spatial distribution and individual variation in urinary fluoride levels in Tibet, China.

Nowadays, fluorosis is the most prevalent endemic disease in Tibet and one of the most concerned public health problems in China; urinary fluoride is a common diagnostic indicator of endemic fluorosis. However, the spatial distribution and influencing factors of urinary fluoride content in Tibet remain unclear. This study aims to bridge this gap by geographically weighted regression (GWR), analyses of variance (ANOVAs), Geodetector, and stepwise multiple linear regression (MLR).

Case report: Mild leukoencephalopathy caused by a new mutation of NOTCH3 gene.

Background: Cerebral autosomal dominant arteriosis with subcortical infarction and leukoencephalopathy (CADASIL) is a single-gene small-vessel disease of the brain characterized by migraine, recurrent ischemic stroke, psychiatric disorders, progressive cognitive decline, and occasional intracerebral hemorrhage.[1]NOTCH3 was identified as a pathogenic gene for CADASIL.[2] The NOTCH3 gene encodes a membrane-bound receptor protein, and to date, several different NOTCH3 gene mutations have been identified.

Does Neighborhood Social Capital Longitudinally Affect the Nutritional Status of School-Aged Children? Evidence from China.

Previous research linking social capital to child nutritional status primarily constitutes cross-sectional studies. To investigate whether a longitudinal relationship exists, by conducting fixed-effects analyses with 16,977 repeatedly measured observations of 6193 children from the 2012, 2014, 2016, and 2018 China Family Panel Studies, this study explored the longitudinal effects of neighborhood participation, bonding trust, and bridging trust on the BMI-for-age z-score (BAZ) and BMI categories of school-aged children, differentiating between urban and rural residence. We found an increasing average BAZ, a decreasing prevalence of underweight, an increasing prevalence of overweight/obesity, and a reducing urban/rural gap in nutritional status.

The impact of health resource enhancement and its spatiotemporal relationship with population health.

Objective: This study investigated the impact of health resource enhancement on health and spatiotemporal variation characteristics from 2000 to 2010 at the county level.

Methods: Multiscale Geographically Weighted Regression and curve fitting were used to explore the characteristics of spatiotemporal impact and divergence mechanism of health resource enhancement on population health.

Results: From 2000 to 2010, China's population health continued to rise steadily, and health resource allocation improved.

County level study of the interaction effect of PM and climate sustainability on mortality in China.

Introduction: PM and climate change are two major public health concerns, with majority of the research on their interaction focused on the synergistic effect, particularly for extreme events such as hot or cold temperatures. The climate sustainability index (CLS) was introduced to comprehensively explore the impact of climate change and the interactive effect on human health with air pollution.

Methods: In this study, a county-level panel data in China was collected and used.