Comparative evaluation of root canal morphology in mandibular first premolars with deep radicular grooves using direct vision, dental operating microscope, 2D radiographic visualisation and micro-computed tomography.

Objectives: The objective of this study was to evaluate the effectiveness of clinically applicable diagnostic methods such as Direct Vision (DV), Dental Operating Microscope (DOM), and two-dimensional (2D) radiographs in detecting canal orifices and root canal configurations in mandibular first premolars with deep radicular grooves. The study also aimed to compare these methods with micro-computed tomography (micro-CT) to better understand their diagnostic capabilities and to assess the applicability of the Ahmed et al. (2017) classification system across different imaging modalities.

Emerging trends of injectable hydrogels for vital pulp therapy: A comprehensive review.

Background: Injectable hydrogels are widely used in biomedicine and tissue engineering. Recently, they have been introduced as promising candidates for vital pulp therapy (VPT) owing to their biocompatibility, in situ adaptability, minimal immunogenicity, and ability to modify the cellular activities of dental pulp exposed to caries or accidental injuries. Although injectable hydrogel-based biomaterials facilitate pulp healing and reparative dentine formation, their clinical utility has not been fully explored.

Triazole-functionalized compounds as promising antifungal agents: Synthesis, biological evaluation, and mechanistic insights.

Antimicrobial resistance, particularly in fungal infections, is a major global health problem, aggravated by the misuse of antifungal agents and the emergence of multidrug-resistant strains. This study focused on the synthesis and evaluation of novel 1,2,3-triazole derivatives as potential antifungal agents, capitalizing on the chemical stability and diverse biological activity of the triazole scaffold. Target compounds have been evaluated for their antibacterial and antifungal activity against a panel of Gram positive (e.

Morphology of Accessory Canals in Mandibular First Molar of a Malaysian Subpopulation Using a Novel Coding System: A Micro-computed Tomographic Study.

Objective: This study investigated the morphology of accessory canals in the mandibular first molar of a Malaysian subpopulation.

Methods: A total of 140 mandibular first molars were scanned using micro-computed tomography. The accessory canals for each of the mesial and distal roots were classified according to Ahmed et al.

Anomaly detection using machine learning and adopted digital twin concepts in radio environments.

Reliable and secure wireless communication is essential in Industry 4.0. This work presents an anomaly detection framework using Digital Twin (DT) technology to simulate and monitor dynamic radio environments.

Serum Metabolite Profile in Progressive Versus Nonprogressive Alcohol-Related Liver Disease: A Cross-Sectional Metabolomics Study.

Background And Aims: Alcohol-related liver disease (ALD) is a major cause of mortality and disability-adjusted life years. It is not fully understood why a small proportion of patients develop progressive forms of ALD (e.g.

Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health.

Obesity is associated with alterations in the gut microbiome that may contribute to metabolic and mental health disturbances. Fecal microbiota transplantation (FMT) from humans to mice is a model proposed to study human microbiota-associated disorders. In this study, we investigated whether gut microbiota from human donors with obesity could affect behavior and metabolomic profiles of mice.

Micro-computed tomography analysis and ex-vivo detection of six root canals in a four-rooted mandibular first premolar.

Background: Mandibular first premolar teeth show a wide range of root and canal anatomical variations including accessory roots, deep root proximal grooves and multiple canals. This study provides qualitative and quantitative morphological analysis of a rare four-rooted mandibular first premolar scanned using micro-CT. In addition, it provides clinical implications through endodontic access cavity preparation and negotiation of canals under dental operating microscope (DOM) to assess the difficulty for locating the canals.

Micro-computed tomographic evaluation of root and canal anatomy of maxillary first premolars in Iraqi sub-population.

Successful root canal treatment requires a thorough understanding of root canal morphology. This study investigated the root canal morphology and the fine anatomical characteristics of maxillary first premolars in an Iraqi sub-population using micro-computed tomography (micro-CT) and classified using Vertucci and Ahmed et al. systems.

The Effect of High-intensity Focused Ultrasound on Intracanal Bacterial Reduction, Chemical Structure, and Mechanical Properties of Root Dentine.

Objective: High-intensity focused ultrasound (HIFU) has demonstrated significant efficacy in eradicating bacteria from substrates emerging as a promising solution for root canal disinfection. This in-vitro study investigated the effects of HIFU on reducing intracanal bacteria and its impact on the chemical and mechanical properties of root dentine. It also aimed to demonstrate acoustic wave penetration and distribution within the root canal system (RCS) and characterize the associated temperature changes.

Existing food processing classifications overlook the phytochemical composition of processed plant-based protein-rich foods.

According to existing food processing classification systems, plant-based protein-rich (PBPR) foods are often considered 'ultra-processed'-and therefore perceived as unhealthy-despite their ability to provide various bioactive compounds beneficial for human health. Here we used a non-targeted metabolomics approach to analyse the impact of processing on the biochemical composition of PBPR foods. Our results show that existing food classification systems may provide questionable categories for PBPR foods without considering their overall biochemical composition, including phytochemicals.

Metabolite variations in faba bean ingredients: Unraveling the links between off-flavors and chemical compounds.

Faba bean ingredients are attracting interest for their suitability in producing protein-rich plant-based foods. However, their sensory characteristics (e.g.

Characterisation of Root Canal Configurations and Accessory Canals in Mandibular Incisors: A Micro-Computed Tomography Study on a Malaysian Subpopulation.

This micro-CT study evaluated the root canals of 135 mandibular incisors in a Malaysian subpopulation using Vertucci (1984) and Ahmed et al. (2017), whilst the accessory canals were classified using the Ahmed et al. (2018) system.

Investigating root and canal morphology of anterior and premolar teeth using CBCT with a novel coding classification system in Saudi subpopulation.

Understanding root canal morphology is essential for successful endodontic treatment. This study aimed to investigate morphological variations in root and canal systems of anterior and premolar teeth across different age groups and genders in a Saudi Arabian subpopulation using a novel classification system. A total of 3573 maxillary and mandibular anterior and premolar teeth in 209 patients were examined using cone-beam computed tomography (CBCT) in a Saudi subpopulation.

Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.

Background And Aims: Alcohol Use Disorder (AUD) is a psychiatric disorder characterized notably by gut microbial dysbiosis and insufficient dietary fiber (DF) intake. This study aims to investigate the effect of DF placebo-controlled intervention in patients suffering from AUD during a three-week period of alcohol withdrawal, in order to discover microbial-derived metabolites that could be involved in metabolic and behavioral status.

Methods: A randomized, double-blind, placebo-controlled study was performed with 50 AUD patients supplemented with inulin (prebiotic DF) or maltodextrin (placebo) during 17 days.

Rational design and synthesis of novel phenyltriazole derivatives targeting MRSA cell wall biosynthesis.

Antimicrobial resistance in methicillin-resistant (MRSA) is a major global health challenge. This study reports the design and synthesis of novel phenyltriazole derivatives as potential anti-MRSA agents. The new scaffold replaces the thiazole core with a 1,2,3-triazole ring, enhancing antimicrobial efficacy and physicochemical properties.

Novel bis-benzimidazole-triazole hybrids: anticancer study, in silico approaches, and mechanistic investigation.

Aim: Benzimidazole-triazole conjugates are very active hotspot for design and synthesis of promising anticancer agents. The target analogs showed potent and selective cytotoxicity over different cancer cell lines for breast and lung ones.

Materials & Methods: A new series of bis-1,4-disubstituted-1,2,3-triazoles moieties conjugated with a 2-mercapto-benzimidazole 4a-h and 7a-g was synthesized via the click cycloaddition (CuAAC) reaction.

Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder.

Background: Alcohol use disorder (AUD) is a global health problem with limited therapeutic options. The biochemical mechanisms that lead to this disorder are not yet fully understood, and in this respect, metabolomics represents a promising approach to decipher metabolic events related to AUD. The plasma metabolome contains a plethora of bioactive molecules that reflects the functional changes in host metabolism but also the impact of the gut microbiome and nutritional habits.

Controversial terminology in root and canal anatomy: A comprehensive review.

Discipline-specific terminology is a central element of the vocabulary used by dentists and scientists in the context of their professional activities and plays a critical role in the understanding of dentistry. A number of controversial terms and non-standardized definitions exist in the field of endodontology. For example, in root and canal anatomy, variations exist in the definitions of root morphology (including apical bifurcation, fusion and dilaceration), pulp chamber anatomy (including the outline of the floor, pulp horns and location of the root canal orifice), apical root canal bifurcations, canal isthmuses, accessory canals and apical foramen.

Chemical and physical properties of radiopaque Portland cement formulation with reduced particle size.

This study compared the chemical and physical properties of an experimental radiopaque white Portland cement (REPC) with reduced particle size to ProRoot white mineral trioxide aggregate (WMTA). The particle size distribution of experimental Portland cement (EPC) was examined, and then nano-zirconium oxide (nano-ZrO) was added to produce REPC. Chemical analysis, initial setting time, pH values, and push-out bond strength were evaluated.

Lipophilic and Hydrophilic Metabolites as Descriptors of Different Coffee Beverages.

Coffee is a widely consumed beverage rich in bioactive phytochemicals. This study investigated the effect of brewing method on the profile of potential bioactive compounds in different coffee beverages using metabolomics and lipidomics based on UHPLC-MS/QTOF. The oil contents of the espresso coffee (EC), pot coffee (PC), instant coffee (IC), and filter coffee (FC) beverages studied were 0.

Postpartum family planning among women attending maternal and child health centers in Assiut Governorate, Upper Egypt.

Background: Postpartum family planning (PPFP) is important in helping couples to achieve their reproductive intentions. National surveys have consistently reported higher fertility, lower use of family planning (FP), and higher unmet needs for FP in Upper Egypt. This study aims to identify the factors associated with the use of PPFP in Assiut Governorate, Upper Egypt, and to assess the current status of integration of PPFP counseling in the existing maternal and child health services (MCH).

Exploring of N-phthalimide-linked 1,2,3-triazole analogues with promising -anti-SARS-CoV-2 activity: synthesis, biological screening, and molecular modelling studies.

In this study, a library of phthalimide Schiff base linked to 1,4-disubstituted-1,2,3-triazoles was designed, synthesised, and characterised by different spectral analyses. All analogues have been introduced for assay of their antiviral activity against COVID-19 virus using Vero cell as incubator with different concentrations. The data revealed most of these derivatives showed potent cellular anti-COVID-19 activity and prevent viral growth by more than 90% at two different concentrations with no or weak cytotoxic effect on Vero cells.