Assessing the Efficacy and Immunogenicity of Anticaries Vaccine-A Systematic Review and Meta-Analysis.

Objectives: The current systematic review and meta-analysis aims to assess the safety and immunogenicity of the anticaries vaccines currently available.

Materials And Methods: Electronic searches of PubMed, Scopus, Web of Science and Science Direct were performed. Studies assessing the safety and effectiveness of the anticaries vaccination, including the dose, plasmids, serum IgG and IgA levels after immunization, were included.

Immunohistochemical evaluation of Ki67 in predicting malignant transformation in oral submucous fibrosis.

Oral submucous fibrosis (OSMF) is a potentially malignant disorder with a risk of progressing to oral squamous cell carcinoma. A key indicator of malignant transformation is increased and uncontrolled cell proliferation, which can be evaluated using markers such as Ki67. This study aimed to assess Ki67 expression in OSMF, compare its levels across different associated habits, and correlate expression with clinical and histological grading.

Randomized clinical trial on effectiveness of modified Akinosi technique in mandibular molars with symptomatic irreversible pulpitis during endodontic therapy.

The aim of the study is to investigate the effectiveness of the modified Akinosi technique [MAT] in endodontic management of mandibular molars with symptomatic irreversible pulpitis, and to compare it with the standard inferior alveolar nerve block for effective pulpal anesthesia. A total of 80 clinically healthy patients of both genders, between 16 and 65 years, diagnosed with symptomatic irreversible pulpitis in mandibular first and second molars were included in the study. The subjects were divided into two groups.

Effectiveness of biofilm-targeted therapy in managing and preventing dental caries: protocol for a systematic review and meta-analysis.

Background: Dental caries is a biofilm-dependent disease that continues to challenge conventional preventive strategies, such as fluoride application and mechanical plaque removal. Biofilm-targeted therapies (BTT), including probiotics, photodynamic therapy, enzymatic treatments, and natural compounds, represent promising alternatives to disrupt pathogenic biofilms effectively. However, the available evidence remains fragmented, with inconsistent methodologies and limited clinical data hindering comprehensive conclusions.

Comparative evaluation of root canal morphology in mandibular first premolars with deep radicular grooves using direct vision, dental operating microscope, 2D radiographic visualisation and micro-computed tomography.

Objectives: The objective of this study was to evaluate the effectiveness of clinically applicable diagnostic methods such as Direct Vision (DV), Dental Operating Microscope (DOM), and two-dimensional (2D) radiographs in detecting canal orifices and root canal configurations in mandibular first premolars with deep radicular grooves. The study also aimed to compare these methods with micro-computed tomography (micro-CT) to better understand their diagnostic capabilities and to assess the applicability of the Ahmed et al. (2017) classification system across different imaging modalities.

miRNA regulation of the Akt/mTOR pathway in oral squamous cell carcinoma: a focused review.

Oral squamous cell carcinoma (OSCC) contributes significantly to global cancer mortality, characterized by a progression from hyperplasia to invasive cancer through a series of genetic and epigenetic alterations. Central to this progression is the Akt/mTOR signaling pathway, which regulates cell proliferation and survival. This review examines the role of microRNAs (miRNAs) in modulating the Akt/mTOR pathway and their implications for OSCC.

Navigating the Epidemiology and Complexities of Dental Trauma in Southeast Asia: A Multi-Disciplinary Scoping Review.

Aim: To negotiate the available literature on 'the epidemiology' of dental trauma or DT in Southeast Asia, recognize key patterns, along highlight the gaps in the reporting of data and management.

Background: DT is an important public health problem in Southeast Asia. The differences in socioeconomic situation and healthcare protocol contribute to discrepancies in DT prevalence, along with management.

Role of placental extracts in enhancing periodontal flap surgery healing: insights from periostin biomarker analysis.

Background: The elimination of the causative agent and the facilitation of tissue regeneration are the fundamental objectives of periodontal therapy. Various adjunctive agents have been investigated to optimize treatment outcomes with surgical interventions. Periostin is a matricellular protein predominantly expressed in periodontal tissues, playing a key role in tissue remodeling, inflammation, and wound healing.

Microstructural and elemental characterization of novel bioactive glass bioceramic sealer using Fourier transform infrared and X-ray diffraction analysis.

Introduction: The success of endodontic therapy is primarily determined by effective root canal obturation and complete bacterial eradication. Recently, bioceramic sealers have gained significant attention in root canal treatments due to their bioactive and biocompatible properties. This study aims to characterize a novel bioactive glass-based bioceramic sealer, utilizing X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy to evaluate its bioactivity and hydroxyapatite-forming potential.

Root and canal configurations of maxillary first premolars in 22 countries using two classification systems: a multinational cross-sectional study.

This study aimed to evaluate the root and root canal morphology of maxillary first premolars (M1Ps) globally using cone-beam computed tomography (CBCT), comparing results with Vertucci's and Ahmed et al.'s classification systems. CBCT images were obtained for various purposes such as orthodontic treatment planning, tooth impaction, implant surgery, and trauma cases.

Multinational cross-sectional study and meta-analysis on radicular grooves, C-shaped canals, and taurodontism in mandibular first premolars across 20 countries.

The success of root canal therapy is fully predicated upon a complete understanding of root and canal morphology and all the anatomical variations that can complicate the endodontic treatment. Of these morphological variations, taurodontism, RGs, and C-shaped canals are of note due to their implications on diagnosis, treatment planning, and endodontic success. This study aimed to investigate the prevalence and regional variations of C-shaped canals, RGs, and taurodontism across 20 countries using CBCT imaging and meta-analytic methods.

Rubric system for the evaluation of root canal treatment of single canal tooth performed by preclinical dental students: a cross-sectional study.

The current study aims to investigate the utilization of an analytic rubric system to assess the performance of preclinical dental students in executing root canal treatment for a single canal maxillary anterior tooth. An analytic rubric comprising three parameters was developed for the preparation of root canal treatment of single canal maxillary anterior tooth by 34 fourth-year dental students (17 males and 17 females) in a preclinical endodontic course. Three examiners independently assessed the students' performance on access cavities, cleaning and shaping, and obturation using a 5-point scale.

Predictive analysis of root canal morphology in relation to root canal treatment failures: a retrospective study.

Background: Failure of root canal treatment (RCT) significantly affects patient outcomes and dental practice. Understanding the association between root canal morphology and RCT outcomes can help predict treatment success. This study aimed to analyze the predictive role of root canal morphology in RCT failure.

Chemopreventive effects of chitosan nanogel with thiocolchicoside and lauric acid in chemically induced oral carcinogenesis, in a rodent model.

There is always a quest for newer, more effective chemopreventive agents to prevent and manage oral cancer. A novel nanogel prepared using thiocolchicoside, lauric acid, and chitosan showed promising anticancer activity in KB-1 cell lines. The current manuscript aims to investigate the chemopreventive activity of chitosan nanogel with thiocolchicoside and lauric acid in chemically induced oral carcinogenesis using Wistar rats.

Comparison of pull-out bond strength and microleakage of lithium disilicate onlay with and without immediate dentin sealing.

Background: Effective adhesion between dentin and resin materials is essential for the long-term durability of onlays, as the strength and durability of the tooth-restoration complex hinge on reliable adhesion. This study aims to enhance the adhesion of lithium disilicate onlays by employing immediate dentin sealing (IDS) and evaluates its effectiveness by comparing pull-out bond strength and microleakage with and without IDS.

Methods: Extracted human premolars were prepared and categorized into two distinct groups: Group A (with IDS) and Group B (without IDS).

Effect of allicin-incorporated graphene oxide hydrogel on dentin microhardness.

Objective: The success of root canal treatment and regenerative endodontics relies on thorough disinfection and dentin integrity preservation to ensure long-term tooth survival. This study evaluates the pH stability, material characteristics, microhardness and antimicrobial effects of an allicin-incorporated GO-AgNP hydrogel compared to conventional intracanal medicaments.

Methods: An allicin-incorporated GO-AgNP hydrogel was synthesized using allicin extract, GO-AgNPs, and sodium alginate.

Conventional vs. 3D printed band and loop space maintainers: a fracture strength analysis.

Premature loss of primary teeth is a common occurrence in pediatric dentistry and often necessitates the use of space maintainers to prevent complications. Traditional space maintainers, such as band and loop space maintainers (BLSM), have been widely used, but are fabricated using conventional methods. With advancements in technology, three-dimensional (3D) printing has emerged as a promising alternative for fabricating dental appliances including space maintainers.

Comparative evaluation of microleakage of four restorative materials using confocal laser scanning microscopy: an in vitro study.

Objective: Understanding the sealing ability of restorative materials to prevent microleakage and its consequent complications-such as secondary caries, postoperative sensitivity, and restoration failure-is imperative in clinical dentistry. This study aims to compare the microleakage performance of four restorative materials-bioactive composite resin (Activa Pronto), alkasite restorative (Cention N), compomer (Dyract Flow), and glass ionomer cement (Type 2 GIC)-in Class V cavities of extracted premolar teeth.

Materials And Methods: Forty non-carious, intact premolar teeth were selected and prepared with standardized Class V cavities.

Advancements in osteoblast sourcing, isolation, and characterization for dental tissue regeneration: a review.

Background: Primary osteoblasts are essential for bone formation and regeneration, making them pivotal in dental applications, including periodontal regeneration, ridge augmentation, and implant osseointegration. Sourced from various tissues like alveolar bone, calvarial bone, mandibular and maxillary bones, long bones, and bone marrow-derived stem cells (BMSCs), each type of osteoblast presents unique advantages and limitations related to yield, accessibility, and clinical relevance. Given these variables, selecting an appropriate source is crucial for experimental consistency and translational application in dentistry.

The effects of Shilajit on periodontal ligament cells in wound healing: a comprehensive in vitro study.

Background: Shilajit is a pale-brown to blackish-brown fluid that varies in consistency and is released from rock layers in various mountain ranges across the world. For thousands of years, traditional medical systems in several nations have included shilajit in one form or another as a rejuvenator and adaptogen. Numerous medicinal qualities have been attributed to it, several of which have been confirmed by contemporary scientific analysis.

Molecular insight into histone methylation as a novel target for oral squamous cell carcinoma: future hope in personalised medicine.

Oral squamous cell carcinoma (OSCC) is the most prevalent type of malignant epithelial neoplasm that affects the oral cavity. It has been a significant health concern in many countries for a long time since it was usually treated with surgery, radiation, and/or chemotherapy. Drug resistance is the primary issue in patient populations and scientific research, which promotes OSCC tumour cell invasion and migration.

Scanning Electron Microscopy analysis concerning the effect of 980 nm Diode Laser and Twin Kleen irrigant for the elimination of smear layer off the root canal wall.

Objective: The present research aims to examine the effectiveness of 980 nm Diode Laser and Twin Kleen irrigant individually in addition to the combo for removing the smear layer from tooth canals in single-rooted teeth.

Materials And Methods: 60 single-rooted mandibular premolar teeth were chosen and inspected clinically and by radiography. Protaper was employed to prepare teeth up to F4.

Investigating root and canal morphology of anterior and premolar teeth using CBCT with a novel coding classification system in Saudi subpopulation.

Understanding root canal morphology is essential for successful endodontic treatment. This study aimed to investigate morphological variations in root and canal systems of anterior and premolar teeth across different age groups and genders in a Saudi Arabian subpopulation using a novel classification system. A total of 3573 maxillary and mandibular anterior and premolar teeth in 209 patients were examined using cone-beam computed tomography (CBCT) in a Saudi subpopulation.