Integrating catalytic and fluorescence quenching strategies: A nanozyme-based platform for rutin sensing in complex matrices.

Rutin is a potent antioxidant with therapeutic value in managing vascular and inflammatory conditions. Its accurate quantification is critical for pharmaceutical quality control and food safety. In this study, rutin was employed as a template to construct surface molecularly imprinted magnetic nanozymes (MIPs@FeO-CoNi).

Quantitative Structure-activity Relationship-based Neural Network Model in Screening Potential Inhibitors from Brown Algae against RelA in Oral Squamous Cell Carcinoma.

Introduction And Aim: Oral squamous cell carcinomas (OSCCs) are one of the most frequently diagnosed head and neck cancers with a poor prognosis despite the advancements in diagnostic techniques and treatment strategies. The progression of OSCC is driven by several molecular mechanisms, among them the overexpression of transcription factor RelA, which plays a crucial role by correlating with the clinicopathological characteristics.

Methods: This systematic investigation focused on identifying the top 25 crucial molecular descriptors to predict the RelA inhibitor through the quantitative structure-activity relationship (QSAR)-based artificial neural network model.

Prevalence, safety, and role of nicotine pouches in smoking cessation among smokers and the public in Saudi Arabia.

Nicotine pouches are becoming increasingly popular. However, there's still a lack of comprehensive data on how widespread nicotine pouch use and its side effects in Saudi Arabia. This study aims to investigate the prevalence and associated side effects of the use of nicotine pouches among smokers and the public in Saudi Arabia.

Periodontal Implications of Porphyromonas gingivalis-Derived Metabolites in Host Antioxidant and Anti-Inflammatory Mechanisms: A Computational Analysis.

BACKGROUND Metabolites of Porphyromonas gingivalis (P. gingivalis), a key periodontal pathogen, can interfere with host antioxidant and anti-inflammatory mechanisms. Paraoxonase 1 (PON1) is an enzyme that counteracts oxidative damage and inflammation.

The association between sociodemographic determinants and nomophobia among physiotherapists in the Kingdom of Saudi Arabia: a cross-sectional study.

Nomophobia is a psychological condition characterized by fear or anxiety resulting from being without access to a mobile phone. It is increasingly prevalent among healthcare professionals due to their high reliance on mobile technology. However, limited data exist regarding the prevalence and severity of nomophobia, specifically among physiotherapists in Saudi Arabia.

Smoking prevalence among stroke patients in Saudi Arabia: A systematic review and meta-analysis.

Background: Stroke represents a significant global health issue, consistently identified as one of the leading causes of disability and mortality worldwide. Smoking constitutes a major risk factor for stroke development.

Objectives: This study evaluated the prevalence of smoking among stroke patients in Saudi Arabia.

Paediatrics hospitalization profile in England: A longitudinal ecological study.

Children constitute a large proportion of any population. For the appropriate allocation of resources to promote pediatric health, it is necessary to comprehend the patterns of healthcare usage among pediatric patients. This research aimed to determine the hospitalization among England's pediatric population.

Understanding of Stroke Risk Among Smokers in Saudi Arabia.

: Stroke is a common and fatal condition impacting millions worldwide. Understanding the risk factors, symptoms, and consequences at an earlier stage, specifically in highly at-risk populations such as smokers, is crucial for mitigating the stroke burden. : A cross-sectional study was conducted in Saudi Arabia on more than 1000 smokers.

The Influence of Deep Margin Elevation and Immediate Dentin Sealing on the Fracture Strength of Premolars Restored With Indirect Inlays: An In Vitro Study.

Objective: To evaluate the effect of deep margin elevation (DME) and immediate dentin sealing (IDS) on the fracture strength of premolars restored with lithium disilicate inlay restorations.

Materials And Methods: Standard MOD inlays with proximal box preparations extending 3 mm apical to the cementoenamel junction were prepared on forty sound premolars (n = 10) randomly divided into four groups: inlays without DME and without IDS (G1); inlays without DME but with IDS (G2); inlays with DME but without IDS (G3); and inlays with both techniques applied (G4). Composite resin was applied incrementally to elevate the proximal cervical margin coronally to the cementoenamel junction.

The Associations of Anaemia Status and Body Mass Index with Asthma Severity in Saudi Arabia: A Comparative Study.

Purpose: This study aimed to investigate the associations of anaemia status and body mass index (BMI) with asthma severity in adult subjects.

Methods: The study included 300 adults who had asthma and admitted to King Abdulaziz Medical City from about 2017 to 2022. The subjects' demographic data, BMI, anaemia status, and number of asthma-related hospital admissions were analyzed.

Translation, cross-cultural adaptation, and validation of the arabic version of the foot and ankle ability measure (FAAM-AR).

BackgroundThis study aimed to cross-cultural translate the Foot and Ankle Ability Measure to Arabic version (FAAM-AR) and to assess the psychometric properties of the FAAM-AR in a sample of Arabic-speaking participants.MethodologyThe FAAM-AR was translated according to the International Society for Quality of Life Assessment (IQOLA) guidelines. To determine construct validity, 106 participants with different foot and ankle musculoskeletal pathologies completed the FAAM-AR and SF-36.

Efficacy of Prolotherapy for Temporomandibular Joint Dysfunction: An Interventional Clinical Study.

BACKGROUND This research is aimed at minimizing the patient's discomfort and suffering from temporomandibular joint disorders through less-invasive procedures to evaluate the efficacy of proliferative injection therapy, particularly prolotherapy, in fearful patients with temporomandibular joint (TMJ) disorders. MATERIAL AND METHODS A structured questionnaire covering symptom intensity and presence or absence of TMJ clicking and joint hypermobility in patients with confirmed temporomandibular disorder symptoms was completed by patients. Mouth opening and maximum incisor height was measured in millimeters.

Chemosensitization and Molecular Docking Assessment of Dio-NPs on Resistant Breast Cancer Cells to Tamoxifen.

Diosgenin, a powerful compound found in fenugreek and , has diverse pharmacological effects. This study examines the anticancer potential of diosgenin nanoparticles (Dio-NPs) against DMBA-induced breast cancer in mice in combination with tamoxifen. In the current investigation, characterization of Dio-NPs was performed, including their size, shape, zeta potential, UV-vis, and FT-IR spectra.

Gender differences in patient-reported outcomes and cardiac symptoms in patients with acute coronary syndrome in Riyadh, Saudi Arabia.

Objectives: To measure the gender differences in patient-reported outcomes and cardiac symptoms in patients with acute coronary syndrome (ACS) at King Khalid University Hospital in Riyadh, Saudi Arabia.

Methods: A cross-sectional study was conducted on 240 randomly selected ACS patients aged ≥18 years. Data were collected using validated questionnaires, including Patient-reported outcomes measures, the Rose Dyspnea Scale, Patient Health Questionnaire, and Seattle Angina Questionnaire.

The effects of Shilajit on periodontal ligament cells in wound healing: a comprehensive in vitro study.

Background: Shilajit is a pale-brown to blackish-brown fluid that varies in consistency and is released from rock layers in various mountain ranges across the world. For thousands of years, traditional medical systems in several nations have included shilajit in one form or another as a rejuvenator and adaptogen. Numerous medicinal qualities have been attributed to it, several of which have been confirmed by contemporary scientific analysis.

Association between psychosocial stressors and temporomandibular disorders in clinical dental students: a cross-sectional study.

Background: Temporomandibular disorders (TMDs) comprise an extensive spectrum of conditions that originate from diverse complex components of the temporomandibular joint. It is generally acknowledged that the biopsychosocial model is the preeminent framework for understanding the aetiology of TMDs. Anxiety, depression, and tension are among the psychological disorders that are commonly observed in dental students.

Managing cognitive impairment in patients with chronic obstructive pulmonary disease (COPD) in Saudi Arabia: what are the current practices?

Objective: Cognitive impairment is a common comorbidity, yet overlooked, in patients with chronic obstructive pulmonary disease (COPD). However, little is known about the current practice and perceptions of physicians on recognising and managing cognitive impairment in patients with COPD in Saudi Arabia. This study aimed to investigate current practices and perceptions of physicians in Saudi Arabia regarding the recognition and management of cognitive impairment in COPD patients.

Prevalence of transthyretin cardiac amyloidosis in patients with aortic stenosis.

Background: Transthyretin cardiac amyloidosis (ATTRCA) is a prevalent disease, and it can be associated with heart failure (HF), left ventricle hypertrophy (LVH), atrial fibrillation (AF), and aortic stenosis (AS).

Aim: The study aims to detect the prevalence of ATTRCA in the symptomatic AS population.

Method: A single-center prospective study screening for ATTRCA in patients diagnosed with symptomatic severe AS undergoing aortic valve (AV) intervention.

Current practice of using the airway pressure release ventilation mode in acute respiratory distress syndrome patients among respiratory therapists in Saudi Arabia.

Background: There is a limited data examining the practice of using the airway pressure release ventilation mode for patients with acute respiratory distress syndrome among respiratory therapists.

Objectives: To evaluate the current practice and barriers when using airway pressure release ventilation mode in the management of patients with acute respiratory distress syndrome.

Methods: A cross-sectional online survey was disseminated between November 2022 and April 2023 to respiratory therapists in Saudi Arabia.

Relative Frequency of Primary Salivary Gland Tumors: Multicenter Study of 796 Cases from Riyadh, Saudi Arabia.

Salivary gland tumors (SGTs) are diverse lesions with varying morphological and clinical characteristics. Limited data exist on the distribution of SGTs in Saudi Arabia. We aimed to fill this gap by examining the distribution of SGTs across four tertiary hospitals in Riyadh.

Salivary Nitrate Level and Lipid Profile in Patients with Hypertension: A Cross-Sectional Study in a Saudi Sub-Population.

: The use of salivary biomarkers offers a non-invasive approach to understanding the metabolic and inflammatory status of hypertensive patients. This study aimed to quantify the salivary nitric oxide (NO), total cholesterol, triglycerides, high-density lipoproteins (HDL), and low-density lipoproteins (LDL) levels in hypertensive individuals and healthy controls in a sub-population in Saudi Arabia. : This cross-sectional study comprised 40 hypertensive patients (test group, 40-50 years old) and 40 age-matched healthy controls who visited the dental hospital in the College of Dentistry, King Khalid University, for dental treatment.

Exploring key factors associated with falls in people with multiple sclerosis: The role of trunk impairment and other contributing factors.

Background: Falls are a common and consequential concern for persons with multiple sclerosis (PwMS), with trunk impairment frequently observed even in the early stages of the disease. However, the relationship between falls and trunk impairment using the trunk impairment scale in this population remains unclear. This study aims to explore this association and identify potential factors contributing to falls in PwMS.

Evaluation of the Arabic version of the Asthma Trigger Inventory among asthmatic pediatric patients in Saudi Arabia.

Background: Asthma Trigger Inventory (ATI) is available in English, German, and Spanish languages; however, a version in Arabic language specifically tailored for identifying asthma triggers within Saudi Arabia has been missing.

Objectives: To assess the reliability and validity of the adapted Arabic ATI among parents of asthmatic children in Saudi Arabia.

Methods: A cross-cultural adaptation of the ATI was conducted, adding seven region-specific triggers to reflect cultural and environmental factors.

Comparison Between the Advanced Cardiac Life Support and Adult Advanced Life Support Protocols: A Simulation-Based Pilot Study.

Cardiac arrest is a public health concern associated with unfavorable disease outcomes. Cardiopulmonary resuscitation (CPR) of optimal quality is widely acknowledged as an indispensable technique in restoring spontaneous circulation. In order to perform advanced cardiac life support (ACLS), chest compression must be paused twice: once to assess the rhythm and again to administer the shock.