Publications by authors named "Rodrigo Barbano Weingrill"
Polystyrene microplastics exposition on human placental explants induces time-dependent cytotoxicity, oxidative stress and metabolic alterations.
Ashelley Kettyllem Alves de Sousa
,
Keyla Silva Nobre Pires
,
Isadora Hart Cavalcante
,
Iasmin Cristina Lira Cavalcante
,
Julia Domingues Santos
,
Rodrigo Barbano Weingrill
Front Endocrinol (Lausanne)
December 2024
Article Synopsis
- Microplastics (MPs), specifically 5 μm polystyrene particles, can accumulate in human organs like the placenta and may pose risks to living organisms, which this study aims to assess through placental tissue analysis.
- The research involved exposing placental explants to varying concentrations of PS-MPs, measuring cytotoxicity, oxidative stress, and metabolic changes over 24 to 72 hours, utilizing methods like MTT assays and biochemical evaluations.
- Results showed that exposure to PS-MPs increased cytotoxicity and oxidative stress markers significantly, along with altered metabolomic profiles, indicating potential adverse effects on placental function.
Article Synopsis
- Microplastics are produced for various purposes, shed from clothing, or generated from the decay of larger plastic items, posing potential health risks as they accumulate in human tissues.
- A study using Raman spectroscopy in Hawai'i revealed a noticeable rise in microplastics in discarded placentas over the last 15 years, indicating changes in size and chemical makeup of these pollutants.
- This research highlights the specific vulnerability of Pacific Island communities to plastic pollution and suggests that human tissues could serve as a new method for monitoring environmental plastic contamination.
Hypertensive disorders of pregnancy are closely associated with prematurity, stillbirth, and maternal morbidity and mortality. The onset of hypertensive disorders of pregnancy (HDP) is generally noticed after the 20th week of gestation, limiting earlier intervention. The placenta is directly responsible for modulating local and systemic physiology by communicating using mechanisms such as the release of extracellular vesicles, especially exosomes.
View Article and Find Full Text PDFProblem: We hypothesized that trophoblast expression of Ccl25 attracts a specific leukocyte cell population to the implantation site for local regulation.
Method Of Study: Mice blastocysts, ectoplacental cones, and decidua at gestational days 3.5-7.