How delays in seeking medical care for cervical cancer patients are affected by their health-seeking behaviour: a qualitative study.

Background: Cervical cancer is a global health challenge for women, characterized by high morbidity and mortality rates, along with long-term health consequences and economic burden. Early screening and timely treatment can effectively manage cervical cancer, making it crucial for patients to seek medical attention promptly. Positive health-seeking behaviors (HSB) involve the awareness of health issues, self-assessment of health status, and the proactive gathering of information and taking appropriate actions to maintain health.

Anatomy-aware transformer-based model for precise rectal cancer detection and localization in MRI scans.

Rectal cancer is a major cause of cancer-related mortality, requiring accurate diagnosis via MRI scans. However, detecting rectal cancer in MRI scans is challenging due to image complexity and the need for precise localization. While transformer-based object detection has excelled in natural images, applying these models to medical data is hindered by limited medical imaging resources.

Early Post-discharge Pain Trajectories After Thoracoscopic Sublobar Resection for Stage IA Non-small Cell Lung Cancer.

Background: Thoracoscopic sublobar resection is emerging as a main treatment option for early-stage non-small cell lung cancer (NSCLC). This study aimed to determine whether distinct early post-discharge pain trajectories could be identified in patients with stage IA NSCLC undergoing thoracoscopic sublobar resection.

Methods: The data were collected from a longitudinal prospective observational cohort (CN-PRO-Lung 3).

DeepAIPs-SFLA: Deep Convolutional Model for Prediction of Anti-Inflammatory Peptides Using Binary Pattern Decomposition of Novel Multiview Descriptors with an SFLA Approach.

Inflammation is a vital biological response of the human immune system to harmful stimuli, and it plays a vital role in tissue repair and pathogen elimination. However, chronic inflammation can lead to severe diseases such as arthritis, cancer, cardiovascular disorders, and autoimmune conditions. Anti-inflammatory peptides (AIPs) have emerged as promising therapeutic agents owing to their high selectivity, potency toward target cells, and minimal side effects.

From ownership to custodianship: rethinking human biospecimens data governance in the Chinese context.

As biomedical research shifts from being experiment-driven to data-driven, the importance of human biomedical data (HBD) has been increasingly highlighted. In this context, traditional data governance models face significant challenges. This paper, based on exploring the ontological and moral status of HBD, analyzes the limitations of the current ownership model and proposes a data governance framework centered on custodianship.

Glycosylation in kidney diseases.

Protein glycosylation is a critical post-translational modification that influences protein folding, localization, stability, and functional interactions by attaching glycans to specific sites. This process is crucial for biological functions of glycoproteins, and aberrant glycosylation can lead to genetic disorders, immune system issues, and multi-organ pathologies. Recent advancements in glycoproteomic technologies have made the study of protein glycosylation a key focus for understanding the pathogenesis of kidney diseases.

[Evaluation of reliability and validity of the Chinese version of the Speech, Spatial and Qualities of Hearing Scale].

To sinicize the Speech, Spatial and Qualities of Hearing Scale (SSQ) and to assess its reliability and validity based on the Rasch model and Classical Test Theory (CTT). The acquisition of the Chinese version of the SSQ relies on the systematic translation of the SSQ using the Brislin model. A total of 416 patients who attended the Department of Otorhinolaryngology, Head and Neck Surgery, Chaoyang Hospital, Beijing, between October 2022 and October 2023 were randomly selected using the Chinese version of the SSQ, of which 400 questionnaires were valid, with 281 subjects with hearing impairment [aged 16-92 (59.

Asymmetric hand deformities with limited mobility.

A 52-year-old woman presented to the rheumatology department with a 6-year history of progressively limited hand mobility, bilateral joint pain, and worsening hand deformities. Examination revealed asymmetric deformities of both hands, more pronounced on the left (Fig, A), without joint tenderness, swelling, or Heberden's and Bouchard's nodes. Laboratory tests, including C-reactive protein, rheumatoid factor, anticyclic citrullinated peptide antibody, antinuclear antibody, antidouble-stranded DNA antibody, and anti-Smith antibody, revealed no abnormalities.

Spatially Separated Molecular Activation Over Dual Sites in Sn-Doped ZnGaO/SnO Photocatalysts Toward Complete VOCs Mineralization.

Photocatalysis holds great promise for air pollutant remediation; however, its efficiency is often limited by charge recombination and humidity interference. Herein, Sn-doped ZnGaO loaded SnO nanoparticles (SZGO) is in situ constructed via a one-step hydrothermal method. The doped Sn atoms act as electron-trapping centers and form interfacial Sn─O channels between ZnGaO and SnO, enabling directional electron migration.

Large language models for clinical decision support in gastroenterology and hepatology.

Clinical decision making in gastroenterology and hepatology has become increasingly complex and challenging for physicians. This growing complexity can be addressed by computational tools that support clinical decisions. Although numerous clinical decision support systems (CDSS) have emerged, they have faced difficulties with real-world performance and generalizability, resulting in limited clinical adoption.

Molecular characterization of a new wheat-Thinopyrum ponticum translocation line with resistance to stripe rust.

Stripe rust (Puccinia striiformis f. sp. tritici) is a globally devastating foliar disease affecting common wheat.

Turn Waste into Treasure: Gas-Solid Photoreduction of NO in Flow for Separation-Free Ammonia Synthesis.

Photo/electrocatalytic ammonia (NH) synthesis via nitrous oxide (NO) reduction is challenged by low NO solubility in electrolytes, inefficient electron and proton supply, and the high cost of separating NH from dilute NH product solutions. In this study, we present a continuous, separation-free gas-solid photoreduction strategy for direct NH gas production from flue gas, enabled by dynamic band structure regulation of the photocatalyst. Comprehensive in situ characterization and theoretical analysis demonstrate that this approach utilizes photoexcited oxygen vacancies (PV) in TiO to generate high-energy electrons in deep conduction bands, thereby enhancing the reduction capacity, accelerating electron transfer, and lowering the activation energy for both HO dissociation and NO hydrogenation.

Tegoprazan-based versus esomeprazole-based triple therapy plus bismuth for first-line Helicobacter pylori eradication: A nationwide, multicenter, double-blind, double-dummy, randomized controlled trial.

Background: Although triple therapy plus bismuth (TTPB), comprising a proton pump inhibitor (PPI), two antibiotics, and bismuth, is widely used to eradicate Helicobacter pylori (H. pylori), eradication rates have been suboptimal. Potassium-competitive acid blockers (P-CABs) offer stronger and more stable gastric acid inhibition compared to PPIs.

A multicenter, real-world study analysis: pembrolizumab changes treatment strategy for the patient with recurrent/metastatic head and neck squamous cell carcinoma.

Anti-PD-1/PD-L1 has made breakthrough progress in the treatment of recurrent and metastatic head and neck squamous cell carcinoma (R/M HNSCC). However, the Asian population in KEYNOTE-048 only accounts for 13.2% of the total population, and there is a lack of data on the mainland Chinese population.

Determining the Dipole Orientation of Second Harmonic Generation in 3R-MoS for Enhanced Nonlinear Susceptibility.

As an efficient two-dimensional nonlinear optical crystal, 3R-MoS exhibits intrinsic bulk second-order nonlinearity with substantial second harmonic generation (SHG) due to the interfacial charge transfer induced interlayer dipole and intralayer intrinsic asymmetric dipole. However, how these dipoles determine the SHG emission dipole orientation and intensity in 3R-MoS has not been clearly resolved. Here, we accurately determine the coexistence of in-plane and out-of-plane SHG emission dipoles in few-layer 3R-MoS through radial-/azimuthal-polarization excitation SHG measurements and back focal plane (BFP) imaging combined with numerical simulations, where the SHG emission dipole orientation () in real space for 3L, 4L, 5L, and 6L 3R-MoS is determined to be ∼8°, ∼16°, ∼20°, and ∼32°, respectively.

Recyclable Engineering of Metal-Organic Frameworks toward Sustainable Water Remediation: From Strategies to Applications.

Metal-organic frameworks (MOFs) are extensively used to purify wastewater because of their high specific surface areas and unique photoresponsive electron transport channels. Unfortunately, extensive powder forms of MOFs are challenging to recycle, resulting in additional costs and secondary contamination. Therefore, researchers have attempted to incorporate magnetic components or self-supporting architectures to achieve solid-liquid separation and continuous operation in easy-to-use devices.

Interfacial stability and strain-modulated electronic properties in LaAlO3/SrTiO3 (110) heterostructures: A first-principles study.

Perovskite oxide interfaces exhibit functional properties that are absent in their bulk counterparts. Compared to the well-studied LaAlO3/SrTiO3 (001) interface, the LaAlO3/SrTiO3 (110) interface remains relatively unexplored. Here, we investigate the interfacial properties of n-type LaAlO3/SrTiO3 (110) heterostructures, including cleavage energy, two-dimensional electron gas (2DEG) formation, and the effects of biaxial strain, using first-principles density functional theory calculations.

Comparison of Radiomics and conventional SUVr methods for Alzheimer's disease classification using AV45 PET imaging.

Objective: To compare the diagnostic performance of radiomics-based analysis and the conventional standardized uptake value ratio (SUVr) method in classifying Alzheimer's disease (AD) and non-Alzheimer's disease (NAD) using AV45 PET imaging.

Methods: This retrospective study included 79 patients diagnosed with AD and 34 patients diagnosed with NAD between July 2023 and August 2024. All patients underwent AV45 PET imaging, and the images were registered to a standard template for the extraction of SUVr metrics, including SUVmaxr, SUVmeanr, and SUVmoder, as well as radiomic features (a total of 660 features) from regions of interest (ROIs) in the brain lobes.

Ginsenoside Rg5 enhances Abemaciclib sensitivity in ER+ breast cancer by modulating cell cycle proteins via transcriptional and post-translational levels.

Background: The development of resistance to CDK4/6 inhibitors is a significant challenge in treating estrogen receptor-positive (ER+) breast cancer. This study aimed to explore the regulatory mechanisms of ginsenoside Rg5 in enhancing Abemaciclib sensitivity in ER+breast cancer.

Materials And Methods: Abemaciclib-resistant ER + breast cancer cell lines were established.

Comparison of micro-flow imaging and contrast-enhanced ultrasound in monitoring microwave ablation of papillary thyroid carcinoma: efficacy, safety, and cost-effectiveness.

Objective: To evaluate the value of micro-flow imaging (MFI) in monitoring ultrasound-guided microwave ablation (MWA) of papillary thyroid carcinoma (PTC) by comparing it with contrast-enhanced ultrasound (CEUS).

Methods: This study was conducted on 83 malignant nodules from 79 papillary thyroid carcinoma (PTC) patients treated between June 2022 and September 2023. These cases were divided into a control group (n=37) and an observation group (n=42) based on different guidance modalities during microwave ablation (MWA).

Optimization strategies for ultrasound zoning of cervical lymph nodes in esophageal cancer: a precision medicine approach.

Esophageal cancer is a common malignancy with high incidence and mortality rates. Its pathological types vary by region, with squamous cell carcinoma predominant in Asia and adenocarcinoma in Western countries. Accurate staging before treatment is crucial for selecting appropriate therapeutic strategies.