Transferring the 5Ns chromosome into wheat genetic background to enhance powdery mildew resistance.

Disease resistance is crucial for minimizing agricultural inputs and safeguarding food supply to solve world hunger. The genetic diversity of wild relatives provides a valuable resource for enhancing the disease resistance and yield of crops such as common wheat (Triticum eastivum). Psathyrostachys huashanica (2n = 2x = 14, NsNs) is a valuable wild germplasm for wheat improvement because of its resistance to various diseases and abiotic stresses.

METTL16-dependent GPX4 mA modification links ferroptosis to NSCLC TKIs resistance.

Background: Non-small-cell lung cancer (NSCLC) is a highly aggressive cancer with a poor prognosis, largely due to increasing resistance to Tyrosine Kinase Inhibitors (TKIs). The mechanisms of NSCLC TKI resistance remain unknown. This study aimed to elucidate the molecular mechanism of METTL16-mediated GPX4 mA modification and its underlying function in regulating the proliferation and AZD-9291 resistance of NSCLC.

A self-powered hydration-monitoring and drug-delivery skin patch for closed-loop treatment of atopic dermatitis.

Atopic dermatitis is a chronic inflammatory skin condition that typically manifests in infancy and is characterized by dry, irritated skin. Here, we propose a self-powered hydration-monitoring and drug-delivery skin patch for closed-loop treatment of atopic dermatitis. The patch is composed of piezoelectric generator, hydration sensing unit, microneedle treatment module and flexible circuit.

Analysis wheat wild relatives Thinopyrum intermedium and Roegneria kamoji genomes reveal different polyploid evolution paths.

Many wild relatives of wheat in the Triticeae tribe provide important genetic resources for crop improvement, but their complex, polyploid genomes shaped by hybridization remain poorly understood. Here, we assemble and analyze the genomes of Thinopyrum intermedium and Roegneria kamoji, two species commonly used in wheat hybridization. We show that Th.

Quantum metric third-order nonlinear Hall effect in a non-centrosymmetric ferromagnet.

Berry curvature in the imaginary part of quantum geometry has been confirmed to play a role in the nonlinear Hall effect of Weyl semimetals. However, exploration of the influence of the real component of the quantum geometry, the quantum metrics, on nonlinear Hall transport has primarily focused on second-order effects at lower temperatures, rather than higher-order transport. In this study, we observed a significant third-order nonlinear Hall effect induced by quantum metric in non-centrosymmetric ferromagnetic FeGeTe at room temperature.

Miconazole activates MAPK-driven oligodendrogenesis to promote myelin regeneration and neurological recovery after subarachnoid hemorrhage.

Subarachnoid hemorrhage (SAH) induces multifaceted brain injuries, with white matter injury (WMI) exhibiting dual pathological features resembling traumatic brain injury and cerebral ischemia. Inflammatory responses triggered by SAH lead to extensive axonal and myelin disintegration in white matter, resulting in severe neurological dysfunction. Myelin regeneration post-injury primarily relies on promoting the differentiation of oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes (OLs).

PLNMFG: Pseudo-label guided non-negative matrix factorization model with graph constraint for single-cell multi-omics data clustering.

The development of single-cell multi-omics sequencing technologies has enabled the simultaneous analysis of multi-omics data within the same cell. Accurate clustering of these cells is crucial for downstream analyses of complex biological functions. Despite significant advances in multi-omics integration approaches, current methodologies exhibit two major limitations.

Stapokibart for Severe Uncontrolled Chronic Rhinosinusitis With Nasal Polyps: The CROWNS-2 Randomized Clinical Trial.

Importance: Chronic rhinosinusitis with nasal polyps causes severe symptoms and impaired quality of life. Stapokibart is a novel monoclonal antibody that targets interleukin 4Rα.

Objective: To assess the efficacy and safety of stapokibart as an add-on treatment to intranasal corticosteroids in patients with severe uncontrolled chronic rhinosinusitis with nasal polyps.

Emerging Role of 2D Materials in Photovoltaics: Efficiency Enhancement and Future Perspectives.

The growing global energy demand and worsening climate change highlight the urgent need for clean, efficient and sustainable energy solutions. Among emerging technologies, atomically thin two-dimensional (2D) materials offer unique advantages in photovoltaics due to their tunable optoelectronic properties, high surface area and efficient charge transport capabilities. This review explores recent progress in photovoltaics incorporating 2D materials, focusing on their application as hole and electron transport layers to optimize bandgap alignment, enhance carrier mobility and improve chemical stability.

Dysregulated tRNA-derived fragments impair fatty acid metabolism in intrahepatic cholestasis of pregnancy.

Objective: Intrahepatic cholestasis of pregnancy (ICP) is a common obstetric complication that occurs predominantly in the mid-to-late gestational period, but its exact etiology remains unclear. Recent studies have revealed that transfer RNA-derived fragments (tRFs) are closely associated with various diseases; however, whether tRFs contribute to ICP pathogenesis remains unknown. This study was designed with the objectives of investigating the expression profiles of tRFs in patients with ICP, exploring the potential correlation between tRF expression and maternal-fetal pathophysiological changes, identifying novel early diagnostic biomarkers, and ultimately enhancing clinical management strategies.

Correction: Prevalence of , , and infections in males and females of childbearing age in Chengdu, China.

[This corrects the article DOI: 10.3389/fcimb.2025.

A non-ionic fluorinated p-dopant enables the construction of efficient and stable perovskite solar cells.

The Li-TFSI/-BP system is essential for doping the hole-transporting layer (HTL) to construct efficient perovskite solar cells (PSCs). However, the hygroscopicity and Li migration of Li-TFSI, as well as the corrosiveness and volatility of -BP, can have negative impacts on the efficiency and stability of PSCs. Herein, a novel non-ionic fluorinated p-dopant 1-[bis(trifluoromethanesulfonyl)methyl]-2,3,4,5,6-pentafluorobenzene (PFB-TFSI) is developed to replace the Li-TFSI/-BP system.

The dual role of Piezo1 in tumor cells and immune cells: a new target for cancer therapy.

Piezo1, a mechanosensitive ion channel, plays a pivotal and multifaceted role in tumor progression, immune evasion, and therapeutic resistance by transducing extracellular mechanical stimuli-such as matrix stiffness and fluid shear stress-into intracellular calcium influx. In tumor cells, Piezo1 promotes proliferation, invasion, and metastasis by activating oncogenic signaling and contributes to an immunosuppressive TME through regulation of cancer-associated fibroblasts (CAFs) and extracellular matrix (ECM) remodeling. In the immune compartment, Piezo1 integrates mechanical cues with metabolic and epigenetic reprogramming to orchestrate the functions of T cells, macrophages, and natural killer (NK) cells.

COVID-19: a vascular nightmare unfolding.

The emergence of COVID-19 has been associated with an increased risk of arteriovenous thrombosis, with immune inflammation playing a significant role in the pathogenesis of thrombosis. Numerous drug-related clinical trials have been undertaken to prevent thrombosis, and guidelines for its prevention and treatment are continuously evolving as our understanding of the disease progresses. This article provides a comprehensive review of the mechanisms underlying thrombosis in COVID-19 patients, as well as the advancements in clinical trials and guidelines for thrombosis prevention with pharmacological interventions.

Epidemiologic characteristics of immunoglobulin M antibodies in lower respiratory tract infection pathogens of children: association with severe pneumonia in Chengdu city from 2019 to 2023.

Objective: To analyze the epidemiologic characteristics of serum immunoglobulin M (IgM) antibody aming six pathogens in children with acute lower respiratory tract infections (LRTI) and its association with severe pneumonia, thereby providing a basis for clinical diagnosis and treatment.

Methods: A total of 25,693 children with lower respiratory tract infections who were hospitalized in the Department of Respiratory Medicine at Chengdu Women's and Children's Central Hospital from 2019 to 2023 were included and retrospectively analyzed in the study. The epidemiologic characteristics of serum IgM antibodies for six LRTI pathogens in the enrolled children were analyzed.

Engineered neutrophil, an emerging immune therapeutic strategy.

Neutrophils play a pivotal role in the host immune system, serving as the frontline defense against microbial infections. They eradicate pathogens through diverse mechanisms, encompassing degranulation, phagocytosis, and the release of reactive oxygen species. Moreover, they are acknowledged as crucial contributors to chronic inflammatory pathological processes, including conditions such as cancer and autoimmune diseases.

Identification of Core gene expression alterations regulated by gut microbiota in tumor progression and immunotherapy resistance through integrative pan-cancer analysis.

Gut microbiota has been implicated in various diseases, exerting systemic effects on the host by activating or inhibiting gene expression. However, the precise role of gut microbiota and its downstream targets in hepatocellular carcinoma (HCC) progression remains poorly understood. To address this gap, we developed a computational method, termed the microbial-associated signature (MAS) score, to characterize gut microbiota-induced transcriptional alterations across 33 cancer types and 29 normal tissues.

Neighbourhood greenness might impact thyroid hormone levels in children, adolescents, and young adults.

Background: Growing attention has been paid to the health benefits of neighbourhood greenness in urban cities, whereas the potential impacts on thyroid hormone levels remain unclear, particularly among children, adolescents, and young adults.

Methods: This longitudinal cohort study included 57,198 participants aged 6-25 years from an open cohort in Taiwan, observed from 2000 to 2017. Individual thyroid stimulating-hormone (TSH) and free thyroxine (FT4) levels were measured using immunoassay analysers.

Integrative machine learning models predict prostate cancer diagnosis and biochemical recurrence risk: Advancing precision oncology.

Prostate cancer (PCa) ranks among the most prevalent cancers in men worldwide. Biochemical recurrence (BCR) presents a major clinical challenge in PCa management, with significant prognostic heterogeneity observed among patients post-recurrence. This study aimed to develop machine learning models for predicting both the diagnosis and prognosis of PCa patients.

Microcystin-LR hijacks mitochondrial bioenergetics and Wnt crosstalk: Unveiling a novel dual-pathway mechanism for adipogenesis dysregulation in environmental toxicology.

Cyanobacterial blooms, driven by toxin-producing cyanobacteria, pose significant environmental health risks due to the persistent release of cyanotoxins like microcystin-LR (MC-LR). While much research has focused on its hepatotoxic, nephrotoxic, and neurotoxic effects, its impact on adipose tissue homeostasis remains poorly understood. This study investigates the effects of MC-LR on stromal vascular fraction (SVF) cells, key progenitors in adipogenesis and metabolic regulation.

SOX4-ZIP14-zinc metabolism mediates oncogenesis and suppresses T cell immunity in nasopharyngeal carcinoma.

Subtle variations of micronutrients in the tumor microenvironment often coincide with tumor progression and immune disorders. Nevertheless, the underlying mechanisms of how micronutrients, such as metal ions, influence tumor-intrinsic properties and tumor-immune crosstalk remain inadequately characterized. Here, our integrative analysis of multi-center single-cell, spatial transcriptome sequencing, and bulk RNA sequencing (RNA-seq) cohorts reveals that nasopharyngeal carcinoma (NPC)-specific SRY-box transcription factor 4 (SOX4) governs microenvironmental and cellular zinc metabolism through its downstream target, SLC39A14 (ZIP14), a membrane zinc uptake transporter.

Revealing 1,3-diphenylpropane's coagulation toxicity via infomaxnet-based network toxicology and molecular simulations.

The pervasive use of plastic products has led to environmental contamination by compounds like 1,3-diphenylpropane (SD-1), a polystyrene dimer found in plastic food containers that poses potential health risks. SD-1 can induce coagulation disorder, however, the toxic mechanisms of SD-1 has not been elucidated yet. This study proposes a network toxicology analysis framework-InfomaxNet, which successfully addresses the challenge of lacking prior biological knowledge by analyzing complex biological networks using only network topology.

Effects of Internet-based and mobile device-based cognitive behavioral therapy on tinnitus intervention: a systematic review and meta-analysis.

Background: Tinnitus is a common auditory disorder that seriously affects the quality of life and is often accompanied by psychological problems such as depression and anxiety. Existing therapies have problems such as side effects or high costs. Internet-based cognitive behavioral therapy (i-CBT), due to its low cost and flexibility, has become a new option.

Dysregulated tryptophan metabolism and gut microbiota in chronic hypoxia-induced pulmonary hypertension rats.

Pulmonary hypertension (PH) is a life-threatening disease, mainly caused by pulmonary arterial inflammation and remodeling, which resulted in elevated pulmonary arterial pressure (PAP) and ultimate rightsided heart failure. In the present study, Wistar rats were exposed to hypoxia for four weeks to induce PH. Multiomics approaches integrating 16S rRNA sequencing, untargeted and targeted metabolomics were utilized to identify alterations in gut microbiota and host metabolism associated with hypoxia-induced pulmonary hypertension.

Toward Flexible Low-Voltage Complementary Circuits with Solution-Deposited Organic Semiconductor Single-Crystal Films.

Organic semiconductor single crystals (OSSCs) hold promising prospects in high-performance organic field-effect transistors (OFETs) owing to the advantages of longrange ordering and few defects. However, until now, OSSCs have not shown their strength in flexible complementary integrated circuits, partly due to the lack of high-quality dielectric layers suitable for both large-area crystal growth by solution method and the construction of high-performance n-channel and p-channel transistors simultaneously. Herein, flexible OFETs are fabricated with solution-processed large-area OSSCs and dual-crosslinked bilayer dielectrics, in which the bottom high-k polymer provides key dielectric properties and the top low-k polymer offers improved semiconductor/dielectric interface.