Crystal Facet-Engineered Anion Regulation Enables Fast-Charging Stability in Lithium Metal Batteries.

Lithium metal batteries (LMBs) offer exceptional energy density and output voltage. However, their practical application remains hindered by sluggish ion transport and uncontrolled lithium dendrite formation, particularly under fast-charging conditions. Here, we report a facet-engineered anion-regulating separator based on zeolitic imidazolate framework-8 (ZIF-8) with preferentially crystal-exposed (110) facets.

Engineered neutrophil, an emerging immune therapeutic strategy.

Neutrophils play a pivotal role in the host immune system, serving as the frontline defense against microbial infections. They eradicate pathogens through diverse mechanisms, encompassing degranulation, phagocytosis, and the release of reactive oxygen species. Moreover, they are acknowledged as crucial contributors to chronic inflammatory pathological processes, including conditions such as cancer and autoimmune diseases.

NHANES 2005-2018 data reveal high albumin-bilirubin scores are associated with depression.

Background: Depression has been recognized as a leading global contributor to disease burden and mortality. While the etiology of depression involves a complex interplay of biological, psychological, and social factors, its precise pathophysiological mechanisms remain incompletely understood. The albumin-bilirubin (ALBI) score, originally developed as an objective measure of hepatic function, has demonstrated prognostic value in diverse clinical contexts including liver diseases, brain tumors and chronic heart failure.

Evaluating and modifying the PHDI for depression prevention: insights from NHANES 2005-2018.

Background: Depression is a significant focus in mental health research, emerging as a pressing public health concern globally. The Planetary Health Diet Index (PHDI), recently proposed by The Lancet to balance health and environmental sustainability, remains unclear in its role in preventing depression-our study aims to investigate this association and seeks to optimize this dietary index.

Methods: A cross-sectional analysis was conducted using 2005-2018 NHANES data from 27,868 participants.

Association between arterial stiffness and MASLD in US young adults: base on NHANES 2005-2018.

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) impacts >30 % of the world's population, imposing significant societal and familial burdens. Arterial stiffness is a known risk factor for various metabolic disorders, and early-onset MASLD may be linked to heightened arterial stiffness. However, studies investigating the link between arterial stiffness and MASLD are limited.

Elimination of Concentration Polarization Under Ultra-High Current Density Zinc Deposition by Nanofluid Self-Driven Ion Enrichment.

The commercialization of zinc metal batteries aims at high-rate capability and lightweight, which requires zinc anodes working at high current density, high areal capacity, and high depth of discharge. However, frequent zinc anode fades drastically under extreme conditions. Herein, it is revealed that the primary reason for the anode instability is the severe concentration polarization caused by the imbalanced consumption rate and transfer rate of Zn under extreme conditions.

Electrospun carbon nanofibers loaded with sulfur vacancy CoS as separator coating to accelerate sulfur conversion in Lithium-Sulfur batteries.

Lithium-sulfur batteries (LSBs) have been sought after by researchers owing to their high energy density; however, the inevitable capacity decay and slow reaction kinetics have hindered their advancement. Here, we prepare a Prussian blue analog, Co[Co(CN)] and synthesize carbon nanofibers/S vacancy CoS (CNFs/CoS) as electrocatalysts for separator coating via electrospinning, carbonization, sulfurization, and hydrogen reduction. CNFs/CoS exhibits excellent electrocatalytic activity, wherein S vacancies induce the partial oxidation of Co to Co in CoS and CNFs provide long-range electron transport pathways.

Suppressing Surface Oxidation of Pyrite FeS by Cobalt Doping in Lithium Sulfur Batteries.

Lithium-sulfur batteries have emerged as a promising energy storage device due to ultra-high theoretical capacity, but the slow kinetics of sulfur and polysulfide shuttle hinder the batteries' further development. Here, the 10% cobalt-doped pyrite iron disulfide electrocatalyst deposited on acetylene black as a separator coating in lithium-sulfur batteries is reported. The adsorption rate to the intermediate LiS is significantly improved while surface oxidation of FeS is inhibited: iron oxide and sulfate, thus avoiding FeS electrocatalyst deactivation.

Comprehensive machine learning-based integration develops a novel prognostic model for glioblastoma.

In this study, we developed a new prognostic model for glioblastoma (GBM) based on an integrated machine learning algorithm. We used univariate Cox regression analysis to identify prognostic genes by combining six GBM cohorts. Based on the prognostic genes, 10 machine learning algorithms were integrated into 117 algorithm combinations, and the artificial intelligence prognostic signature (AIPS) with the greatest average C-index was chosen.

The prognostic and immunological role of MCM3 in pan-cancer and validation of prognosis in a clinical lower-grade glioma cohort.

Previous studies have shown that MCM3 plays a key role in initiating DNA replication. However, the mechanism of MCM3 function in most cancers is still unknown. The aim of our study was to explore the expression, prognostic role, and immunological characteristics of MCM3 across cancers.

Identifying the Preoperative Radiological Risk Features in Patients with Leptomeningeal Carcinomatosis Undergoing Cerebrospinal Fluid Drainage.

Background: Patients with leptomeningeal carcinomatosis (LMC) experience a poor prognosis and rapid progression, and cerebrospinal fluid drainage (CSFD) is used to manage intracranial hypertension and hydrocephalus in LMC patients. This study aims to describe a novel discovery of preoperative radiological features in patients who underwent CSFD for LMC.

Methods: A retrospective review was conducted during the past 5 years of LMC patients with intracranial hypertension and hydrocephalus who underwent CSFD.

Identification of prognostic risk score of disulfidptosis-related genes and molecular subtypes in glioma.

Background: Programmed cell death is closely related to glioma. As a novel kind of cell death, the mechanism of disulfidptosis in glioma remains unclear. Therefore, it is of great importance to study the role of disulfidptosis-related genes (DRGs) in glioma.

Quantifying global colonization pressures of alien vertebrates from wildlife trade.

The global trade in live wildlife elevates the risk of biological invasions by increasing colonization pressure (the number of alien species introduced to an area). Yet, our understanding of species traded as aliens remains limited. We created a comprehensive global database on live terrestrial vertebrate trade and use it to investigate the number of traded alien species, and correlates of establishment richness for aliens.

g-CN/MoO composite with optimized crystal face: A synergistic adsorption-catalysis for boosting cathode performance of lithium-sulfur batteries.

The commercial application of lithium-sulfur batteries (LSBs) has been seriously hindered by the shuttle effect of lithium polysulfides (LiPSs) and their slow redox kinetics. In this work, g-CN/MoO composed of graphite carbon nitride (g-CN) nanoflake and MoO nanosheet is designed and applied to modify the separator. The polar MoO can form chemical bond with LiPSs, effectively slowing down the dissolution of LiPSs.

A Nomogram Model for Stratifying the Risk of Recurrence in Patients with Meningioma After Surgery.

Background: Here, we aimed to investigate the clinical parameters affecting the recurrence of meningiomas, and to construct a predictive nomogram model, so as to predict the recurrence-free survival (RFS) of meningiomas more accurately.

Methods: The Clinical, imaging, and pathological data of 155 primary meningioma patients treated surgically from January 2014 to March 2021 were retrospectively analyzed. Independent prognostic factors affecting postoperative recurrence of meningioma were identified by univariate and multivariate Cox regression analyses.

Construction of a pyroptosis-related lncRNAs signature for predicting prognosis and immunotherapy response in glioma.

Recent studies have proved that pyroptosis-related long non-coding RNAs (PRlncRNAs) are closely linked to tumor progression, prognosis, and immunity. Here, we systematically evaluated the correlation of PRlncRNAs with glioma prognosis. This study included 3 glioma cohorts (The Cancer Genome Atlas, Chinese Glioma Genome Atlas, and Gravendeel).

Autophagy regulates inflammation in intracerebral hemorrhage: Enemy or friend?

Intracerebral hemorrhage (ICH) is the second-largest stroke subtype and has a high mortality and disability rate. Secondary brain injury (SBI) is delayed after ICH. The main contributors to SBI are inflammation, oxidative stress, and excitotoxicity.

Global economic costs of mammal invasions.

Invasive alien mammals cause huge adverse ecological impact on human society and natural ecosystems. Although studies have estimated economic costs of mammal invasions at regional scales, there is lacking the large-scale comprehensive assessment of currency costs for this taxon. Here, we estimated the economic cost of invasive alien mammals on a global scale using the most comprehensive global database compiling economic costs of invasive species (InvaCost).

Expression and Prognostic Value of Melanoma-Associated Antigen D2 in Gliomas.

Introduction: The melanoma-associated antigen D2 (MAGED2) is one of the melanoma-associated antigen family members. It is commonly overexpressed in a variety of malignancies. However, the mechanism and function of MAGED2 in glioma remain unknown.

Effects of face shield on an emitter during a cough process: A large-eddy simulation study.

Face shield is a common personal protection equipment for pandemic. In the present work, three-dimensional computational fluid dynamic (CFD) method is used to simulate a cough jet from an emitter who wears a face shield. A realistic manikin model with a simplified mouth cavity is employed.

Identification of an m6A RNA Methylation Regulator Risk Score Model for Prediction of Clinical Prognosis in Astrocytoma.

Astrocytoma (AS) is the most ubiquitous primary malignancy of the central nervous system (CNS). The vital involvement of the N6-methyladenosine (m6A) RNA modification in the growth of multiple human tumors is known. This study entailed probing m6A regulators with AS prognosis to construct a risk prediction model (RS) for potential clinical use.

Integrative Analysis of a Novel Eleven-Small Nucleolar RNA Prognostic Signature in Patients With Lower Grade Glioma.

Objective: The present study used the RNA sequencing (RNA-seq) dataset to identify prognostic snoRNAs and construct a prognostic signature of The Cancer Genome Atla (TCGA) lower grade glioma (LGG) cohort, and comprehensive analysis of this signature.

Methods: RNA-seq dataset of 488 patients from TCGA LGG cohort were included in this study. Comprehensive analysis including function enrichment, gene set enrichment analysis (GSEA), immune infiltration, cancer immune microenvironment, and connectivity map (CMap) were used to evaluate the snoRNAs prognostic signature.

Climate extremes, variability, and trade shape biogeographical patterns of alien species.

Understanding how alien species assemble is crucial for predicting changes to community structure caused by biological invasions and for directing management strategies for alien species, but patterns and drivers of alien species assemblages remain poorly understood relative to native species. Climate has been suggested as a crucial filter of invasion-driven homogenization of biodiversity. However, it remains unclear which climatic factors drive the assemblage of alien species.

Oncogene PLCE1 may be a diagnostic biomarker and prognostic biomarker by influencing cell cycle, proliferation, migration, and invasion ability in hepatocellular carcinoma cell lines.

Hepatocellular carcinoma (HCC) is a lethal malignancy worldwide. HCC has traits of late diagnosis and high recurrence. This study explored potential diagnosis and prognosis significance of phospholipase C epsilon 1 (PLCE1) in HCC.

Diagnostic and prognostic significance of mRNA expressions of apolipoprotein A and C family genes in hepatitis B virus-related hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) is among the most common and lethal malignancies worldwide. Apolipoproteins (APOs) have been reported increasingly for their relationships with tumors. We aim at exploring the potential relationships of apolipoprotein A (APOA) and apolipoprotein C (APOC) family members with HCC.