Evaluation of Short-to-medium Term Efficacy of Guselkumab and Secukinumab in Overweight and Obese Patients with Moderate to Severe Plaque Psoriasis: A 24-Week Single-center Retrospective Study.

Background: Overweight and obesity are common in patients with psoriasis and are associated with increased disease severity and declined treatment response.

Aims: To evaluate the short-to-medium term (24w) efficacy and safety of two biologics, including Guselkumab and Secukinumab, in overweight and obese patients (body mass index [BMI] ≥25 kg/m) with moderate to severe psoriasis.

Materials And Methods: We retrospectively analyzed the data of patients with moderate to severe plaque psoriasis treated with Guselkumab or Secukinumab in Dermatology Hospital of Southern Medical University in 2020.

Reducing PM2.5 Exposure Lowers Dyslipidemia Risk: A Longitudinal Quasi-Experimental Study.

Evidence demonstrating the beneficial effects of improved air quality on lipid health is scarce. This study addresses this gap by examining whether reducing PM2.5 exposure can decrease the risk of dyslipidemia.

The Evolving Global Epidemiology of Presenile Dementia in People Aged Under 65: A 40-year Cross-Sectional Study.

Aim: Despite presenile dementia substantial impact on patients, caregivers, and healthcare systems, comprehensive global assessments of its burden are lacking. This research aims to address this knowledge gap by investigating the trends in the epidemiology of presenile dementia since 1990 and forecast to 2030, providing essential evidence for healthcare policy and resource planning.

Methods: This cross-sectional, population-based study leveraged data for individuals aged 40-64 years of presenile dementia from the GBD study, which performed a detailed evaluation related metrics across 204 countries.

Analysis of the status of leprosy symptom surveillance in Guangdong province: an exploring effort to promote early detection.

Objective: To understand the implementation of leprosy symptom surveillance in Guangdong Province, explore its role in early detection of leprosy, and provide a theoretical basis for leprosy prevention and control.

Methods: Data from the National Leprosy Prevention and Management Information System (LEPMIS) and Guangdong Suspected Leprosy Symptom Surveillance System were collected, including symptom surveillance data (2018-2023) and newly diagnosed leprosy case records (2012-2023). The newly diagnosed leprosy case records were divided into pre-implementation (2012-2017) and post-implementation (2018-2023) of symptom surveillance.

First case report of immune checkpoint inhibitor therapy to treat secretory carcinoma.

Secretory carcinoma (SC) is a newly defined and exceedingly rare pathologic subtype of lung cancer. We present a case of SC that was initially misdiagnosed as stage IIIB (cT2aN3M0) invasive mucinous adenocarcinoma harboring a programmed cell death ligand 1 tumor proportion score of 10% and an - fusion gene. The patient received five cycles of toripalimab and pemetrexed plus carboplatin at a local hospital without treatment-related adverse events.

Causal Effects of Life-Course Adiposity and Metabolic Mediators on the Immune Response to COVID-19 Vaccination.

Despite adiposity's potential role in modulating immune responses, the causal effects of adiposity at different life stages on immune responses to COVID-19 vaccines remain poorly understood. Thus, we aimed to investigate the causal association between life-course adiposity and the immune response to COVID-19 vaccination, and to explore the metabolic mechanisms underlying this association. We used a life-course Mendelian randomization (MR) analytic framework, starting with univariable MR, to estimate the total effects of body mass index (BMI) and obesity in childhood and adulthood on the immune response to COVID-19 vaccination.

Development of a CRISPR/Cas-Based Detection Platform for Tracking Decreased Susceptibility to Cephalosporins in .

Gonorrhea has become an escalating public health issue due to the rapid emergence of antimicrobial resistance (AMR). Developing efficient and accurate detection of resistant strains is urgently needed for their management and treatment. We have developed the Multiplex Integrated RPA-CRISPR/Cas12a detection Assay (MIRCA) for simultaneous detection of () and mutations with decreased susceptibility to cephalosporins.

Emerging epidemic of the predominant clusters of FC428-like Neisseria gonorrhoeae in Guangdong, China.

Objectives: This study aimed to investigate the molecular characteristics of predominant epidemic clusters of FC428-like N. gonorrhoeae in Guangdong, China in 2022.

Methods: Minimum inhibitory concentrations (MICs) were determined for N.

Impact of early-life deprivation and threat on physical, psychological, and cognitive multimorbidity: Evidence from multinational prospective cohorts.

Background: The impact of early-life stressful events on physical-psychological-cognitive multimorbidity needs to be better understood. This study aimed to examine both the prevalence patterns of physical-psychological-cognitive multimorbidity and the associations between specific adverse childhood experiences (ACEs) and multimorbidity among middle-aged and older adults in China, Europe, the US, and the UK.

Methods: Data came from the China Health and Retirement Longitudinal Study (CHARLS) and its partner studies: the US Health and Retirement Study (HRS), the Survey of Health, Ageing and Retirement in Europe (SHARE), and the English Longitudinal Study on Ageing (ELSA).

Cohort profile: China healthy aging cohort study (China-Aging).

BackgroundAs China undergoes a demographic transition towards an aging society, the prevalence and incidence of age-related disabilities, Alzheimer's disease, and various geriatric syndromes are steadily rising.ObjectiveThe China Healthy Aging Cohort Study (China-Aging) aims to investigate the prevalence and associated risk factors of disability and cognitive impairment, and to develop predictive models for these conditions by combining traditional risk factors with artificial intelligence-derived metrics (such as gait, speech, vision, etc.).

Identification of the Critical Life-Stage of Obesity Contributing to Brain Functional Networks.

Aims: Observational studies suggest that obesity impacts brain functional connectivity, but critical developmental periods for these effects remain unclear. Herein, we aimed to investigate the causal relationships between life-course body weight and brain functional connectivity.

Methods: Mendelian randomization (MR) was applied to infer the causality between life-course body weight (birth weight [n = 80,745], childhood body mass index [BMI; n = 39,620], and adulthood BMI [n = 322,154]) and 191 resting-state functional magnetic resonance imaging traits (n = 34,691) using genome-wide association data.

Brominated Flame Retardants Exposure Promotes the Formation of Atherosclerotic Plaque in Aortic Roots of Mice by Increasing Macrophage Recruitment and Foam Cell Formation.

Brominated flame retardants (BFRs) are persistent organic pollutants worldwide. However, the effect of BFRs on the development of atherosclerosis is currently unknown. Here we aimed to investigate the effects of three typical BFRs (BDE-47, BDE-209, and DBDPE) on the development of atherosclerosis and explored the underlying mechanisms using an cell model and mice.

Divergent effects of EDCs on bone maturation: Role of body mass index and puberty.

Exposure to endocrine-disrupting chemical (EDC) mixture and its association with bone maturation in children remain unclear. In this case-control study, the relationship between EDC exposure and accelerated bone maturation in girls aged 6-13 years (n = 501) was investigated using data from the Evaluation and Monitoring on School-based Nutrition and Growth in Shenzhen study. Urinary concentrations of 11 phthalate metabolites, as well as seven bisphenols, nonylphenol (NP), and triclosan, were measured.

Melatonin Mitigates Sarcopenic Obesity via Microbiota and Short-Chain Fatty Acids: Evidence From Epidemiologic and In Vivo Studies.

Introduction: Gut dysbiosis is closely related to the development of sarcopenic obesity (SO). Melatonin (MLT) regulates gut microbiota and promotes the production of short-chain fatty acids (SCFAs). However, whether MLT affects SO through the gut microbiota and SCFAs remains unclear.

Diagnostic efficacy of fecal-based miR-92a for advanced colorectal neoplasia: a prospective multicenter screening trial.

Background: More efficacious, noninvasive screening methods are needed for advanced colorectal neoplasia. miR-92a is a reliable and reproducible biomarker for early colorectal cancer detection in stool samples. We compared the diagnostic efficacies of miR-92a, immunochemical fecal occult blood testing (FIT), and their combination (FIT + miR-92a) in a prospective multicenter screening trial.

A critical role for in negatively impacting metformin response in diabetes.

Metformin has been demonstrated to attenuate hyperglycaemia by modulating the gut microbiota. However, the mechanisms through which the microbiome mediates metformin monotherapy failure (MMF) are unclear. Herein, in a prospective clinical cohort study of newly diagnosed type 2 diabetes mellitus (T2DM) patients treated with metformin monotherapy, metagenomic sequencing of faecal samples revealed that abundance was approximately 12 times higher in nonresponders than in responders.

ALKBH7 mediates the mitigative effect of bismuth drug against cisplatin-induced acute kidney injury.

Cisplatin is a potent chemotherapeutic drug widely used to treat cancers. Unfortunately, its overaccumulation in kidney proximal tubular cell (PTC) results in severe acute kidney injury (AKI). Bismuth drugs have long been used to treat gastrointestinal tract disorder and Helicobacter pylori infection.

A versatile CRISPR/Cas9 system off-target prediction tool using language model.

Genome editing with the CRISPR/Cas9 system has revolutionized life and medical sciences, particularly in treating monogenic genetic diseases by enabling long-term therapeutic effects from a single intervention. However, the CRISPR/Cas9 system can tolerate mismatches and DNA/RNA bulges at target sites, leading to unintended off-target effects that pose challenges for gene-editing therapy development. Existing high-throughput detection and in silico prediction methods are often limited to specifically designed single guide RNAs (sgRNAs) and perform poorly on unseen sequences.

Awareness and attitudes towards children's cigarette card gaming behaviour among adults aged 15 and above in Shenzhen, China: a population representative cross-sectional study.

Introduction: Repurposing cigarette packs for flip-and-win games (cigarette card (CC) gaming) is increasingly popular among Chinese children. We examined adults' awareness and attitudes towards this.

Methods: A population representative survey was conducted in Shenzhen, China, from September to October 2023, involving 4800 adults (aged 15 and above) with a 94.

Secondhand exposure to cigarettes smoke and e-cigarettes aerosols on sidewalks: pattern, public attitudes, and support for tobacco bans.

Objectives: This study investigates exposure patterns, public attitudes towards sidewalk exposure to secondhand cigarettes smoke (SHS) and secondhand e-cigarette aerosols (SHA), and support for a sidewalk cigarette and e-cigarette smoking ban in Shenzhen, China.

Study Design: A cross-sectional study.

Methods: A total of 5003 Shenzhen pedestrians participated in the survey in 2023 using convenience sampling.

Interleukin 33 Promotes Liver Sinusoidal Endothelial Cell Dysfunction and Hepatic Fibrosis in Diabetic Mice.

Background: Interleukin 33 (IL33) drives liver fibrosis, and individuals with type 2 diabetes mellitus are more likely advanced to liver fibrosis. However, the role of IL33 in diabetic liver fibrosis remains unclear, prompting our investigation.

Methods: We developed a diabetes model in wild-type, IL33-/-, and suppression of tumorigenicity 2 (ST2-/-, IL33 receptor) mice.

POSTN Silencing Ameliorates LL37-Induced Rosacea and Inhibits the JAK2/STAT3 and NF-κB Pathways.

Rosacea is a chronic inflammatory skin disease and its pathogenesis remains unclear. Key genes were screened in the GSE155141 and GSE65914 datasets through a bioinformatics approach. To establish a rosacea-like mouse model with periostin (POSTN) knockdown, mice were subcutaneously injected with lentivirus-packaged Lv-shPOSTN, followed by LL37 treatment on the dorsal skin.

Long-Term Exposure to Low-Level Ambient Air Pollution and Mortality among 0.3 Million Chinese Older Adults.

Objective: Evidence that long-term exposure to ambient air pollution increases mortality among older adults, particularly those residing in low-level air pollution locations, remains scarce. This study investigated the potential links between long-term low-level air pollution exposure and mortality among Chinese older adults.

Methods: A population-based study with 317,464 individuals aged ≥ 65 years was conducted in Shenzhen, China during 2018 and 2020.

Ultra-Processed Food Consumption and the Risk of Psoriasis: A Large Prospective Cohort Study.

The sales of ultra-processed food (UPF) are rapidly increasing worldwide, and there have been reports linking UPF consumption to several chronic diseases. However, there is limited prospective evidence exploring the impact of UPF on inflammatory skin diseases. This study investigates the association between UPF intake and the incidence of psoriasis using data from the UK Biobank.