An aptasensor-based fluorescent signal amplification strategy for highly sensitive detection of mycotoxins.

Aflatoxin B1 (AFB1) is one of the most toxic mycotoxins that pose great health threats to humans. Herein, an aptasensor-based fluorescent signal amplification strategy is developed for the detection of AFB1. Initially, the AFB1 aptamers labelled with carboxyfluorescein (FAM) are adsorbed onto graphene oxide (GO), triggering energy transfer.

High-entropy spinel (FeCoNiMnCr)O nanoparticles supported on carbon nanotubes for enhanced electrochemical seawater oxidation.

High-performance, low-cost electrocatalysts are essential for freshwater-independent seawater electrolysis. We design a SWCNT-supported (FeCoNiMnCr)O high-entropy spinel oxide by a hydrothermal method and air-firing, where the conductive network enhances charge transfer and active site exposure. The catalyst achieves 282 mV@10 mA cm with 100 h stability in alkaline seawater.

Antibacterial and antiviral properties of punicalagin (Review).

Punicalagin, a polyphenolic compound extracted from pomegranate peel, has received increasing attention in recent years due to its antibacterial and antiviral properties. Punicalagin is capable of inhibiting bacterial growth at sub-inhibitory concentrations by affecting cell membrane formation, disrupting membrane integrity, altering cell permeability, affecting efflux pumps, interfering with quorum sensing and influencing virulence factors. Additionally, punicalagin inhibits viruses by modulating enzyme activity, interacting with viral surface proteins, affecting gene expression, blocking viral attachment, disrupting virus receptor interaction and inhibiting viral replication.

Clinical manifestations of Oropouche virus infection: A systematic review and meta-analysis.

Oropouche virus (OROV) is emerging as a growing public health concern, with increasing numbers of case, an expanding global spread and the potential for severe clinical outcomes. However, despite the increasing incidence, the clinical features of OROV infections have not yet been thoroughly examined. The present systematic review and meta-analysis aimed to investigate the prevalence of clinical manifestations in OROV infections.

S-glutathionylation modification of proteins and the association with cellular death (Review).

S-glutathionylation (SSG), a redox-sensitive post-translational modification mediated by glutathione, regulates protein structure and function through reversible disulfide bond formation at cysteine residues. Glutaredoxins (GRXs), pivotal antioxidant enzymes, catalyze SSG dynamics to maintain thiol homeostasis. Recent advances in redox proteomics have revealed that SSG dysregulation is intricately linked to neurodegenerative, cardiovascular, pulmonary and malignant diseases.

flavones induce apoptosis in bladder cancer T24 cells via the FAS/TNFR1 pathway: A potential therapeutic candidate.

flavones (PRFs), bioactive components derived from the plant, exhibit anti-inflammatory and anti-tumor properties. However, their therapeutic potential for bladder cancer remains poorly understood. The present study aimed to investigate the anti-tumor effects and molecular mechanisms underlying the effects of PRF on human bladder cancer T24 cells.

Sustained Mg/Sr ion delivery from injectable silk fibroin hydrogels drives SCAP osteogenic differentiation.

This study highlights the biomedical relevance of injectable TS (tannic acid-silk fibroin)-Mg/Sr hydrogels in alveolar bone repair, particularly their prospective role as carriers for stem cells from the apical papilla (SCAPs) in tissue regeneration. By utilizing self-assembling silk material, noted for its favorable handling properties, we present a useful approach for single-wall bone defects, such as bone fenestration and fractures in the oral cavity. Furthermore, our findings regarding the involvement of the TRPM7 ion channel indicate a possible regulatory pathway for improving alveolar bone defect repair.

5-HMF plays an intervention role in ischemic stroke by regulating GluR2 to improve mitochondrial function and promote angiogenesis.

Introduction: 5-Hydroxymethyl furfural (5-HMF) is a furan compound with a molecular formula of CHO. Studies have found that 5-HMF has many pharmacological effects, such as improving hemorheology, anti-inflammatory, antioxidant activity and anti-myocardial ischemia. Identifying the preventive effect of 5-HMF against ischemic stroke and its possible mechanism was the aim of this investigation.

Combined microcatheter and guidewire technique in endovascular coiling of a wide-neck anterior communicating artery aneurysm: A case report.

Wide-necked anterior communicating artery (ACoA) aneurysms pose challenges for endovascular coiling due to the risk of coil protrusion. This case report describes a new endovascular technique for managing ruptured wide-necked ACoA aneurysms, addressing the risk of coil protrusion during embolization. This method employs a combined microcatheter and guidewire-assisted embolization method, enabling coil deployment without needing adjunctive devices such as stents or balloons.

Enhanced SLC2A4 expression mitigates insulin resistance in gestational diabetes mellitus via the FoxO signaling pathway .

Gestational diabetes mellitus (GDM), a type of diabetes mellitus occurring in pregnant women, increases the risk of birth trauma. Solute carrier family 2 member 4 (SLC2A4) polymorphism is notably associated with GDM susceptibility; however, the mechanism is unknown. In the present study, HTR-8/SVneo cells were treated with high glucose concentrations and transfected with SLC2A4 and Forkhead box O (FoxO)1 to investigate their roles in the insulin (INS) resistance of GDM trophoblast cells.

Tetramethylpyrazine alleviates acute kidney injury by activating the Wnt/β-catenin pathway independent of DKK1.

Acute kidney injury (AKI) is a group of common clinical syndromes characterized by a rapid decline in renal function over a short period of time. At present, the treatment methods are limited, and research is needed to identify drugs that could alleviate renal ischemia-reperfusion (I/R) injury. Tetramethylpyrazine (TMP) is a bioactive alkaloid extracted from the Chinese herbal medicine Chuanxiong.

Nanotechnology-driven advancements in organ transplantation: Multifaceted strategies for organ preservation, ischemia reperfusion injury, immunomodulation and post-transplant monitoring.

Organ transplantation faces critical challenges, including donor shortages, suboptimal preservation, ischemia-reperfusion injury (IRI), and immune rejection. Nanotechnology offers transformative solutions by leveraging precision-engineered materials to enhance graft viability and outcomes. This review highlights nanomaterials' roles in revolutionizing organ preservation.

Continuous-flow-enabled intensification in nitration processes: a review of technological developments and practical applications over the past decade.

Flow chemistry technology has demonstrated significant potential in advancing the green transformation of the chemical industry while enhancing inherent process safety. Safety, cost-effectiveness, and operational efficiency serve as pivotal drivers for advancing flow chemistry in nitration processes. This review provides a comprehensive analysis of the continuous-flow nitration technology - a process historically recognized as one of the most hazardous industrial operations - focusing on its technological advancements in process design, reaction kinetics characterization, and practical implementation over the past decade.

Formulating cathode materials based on high-entropy strategies for sodium-ion batteries.

Sodium-ion batteries (SIBs) are promising alternatives to lithium-ion batteries (LIBs) owing to abundant resources and cost-effectiveness. However, cathode materials face persistent challenges in structural stability, ion kinetics, and cycle life. This review highlights the transformative potential of high-entropy (HE) strategies that leveraging multi-principal element synergies to address these limitations entropy-driven mechanisms.

High-entropy metal phosphide nanoparticles for accelerated lithium polysulfide conversion.

To overcome the persistent challenges of sluggish lithium polysulfide (LiPS) conversion kinetics and the shuttle effect in Li-S batteries, this work introduces a novel, cost-effective thermal treatment strategy for synthesizing high-entropy metal phosphide catalysts using cation-bonded phosphate resins. For the first time, we successfully fabricated single-phase high-entropy FeCoNiCuMnP nanoparticles anchored on a porous carbon network (HEP/C). HEP/C demonstrates enhanced electronic conductivity and superior LiPS adsorption capability, substantially accelerating its redox kinetics.

Versatile phenolic composites by in situ polymerization of concentrated dispersions of carbon nanotubes.

Uniform dispersion of carbon nanotubes in a polymer matrix is a prerequisite for high-performance nanotube-based composites. Here, we report an in situ polymerization route to synthesize a range of phenolic composites with high loading of single-wall carbon nanotubes (SWCNTs, >40 wt%) and continuously tunable viscoelasticity. SWCNTs can be directly and uniformly dispersed in cresols through noncovalent charge-transfer interactions without the need for surfactants, and further concentrated before in situ polymerization of the solvent molecules, yielding phenolic composites in the forms of conductive pastes, highly stretchy doughs, and hardened solids with high nanotube loading and much enhanced electrical conductivity (up to 2.

A thermochromic tissue-mimicking phantom for catheter-based radiofrequency ablation of heterogenous lesions.

Background: In catheter-based radiofrequency ablation (RFA), energy is delivered to heterogeneous thin-walled tissues to induce therapeutic heating. Variations in electrical and mechanical properties of tissue contents have a great effect on outcomes.

Purpose: The objective of this study is to develop models that replicate tissue heterogeneity and visualize ablation zones for effective evaluation and optimization.

Photoacoustic-imaging nanomotors enhance tumor penetration and alleviate hypoxia for photodynamic therapy of breast cancer.

Breast cancer is the most prevalent malignancy worldwide, yet conventional therapies are invasive and prone to resistance, recurrence, and metastasis. Photodynamic therapy (PDT) is a promising noninvasive modality, but its efficacy is limited by tumor hypoxia and poor photosensitizer delivery. Here, we report a photoacoustic-imaging nanomotor, PPIC, which addresses these challenges through integrated functions of oxygen production, deep tissue penetration and photoacoustic imaging.

Research status of small molecule inhibitors, probes, and degraders of NSDs: a comprehensive review.

The nuclear receptor binding SET domain (NSD) family of histone methyltransferases, which comprised NSD1, NSD2, and NSD3. They play a pivotal role in catalyzing mono- and dimethylation of histone H3 at lysine 36 (H3K36me1/2), a modification critical for maintaining chromatin structure and transcriptional fidelity. Dysregulation of NSD enzymes, often through overexpression, mutation, or chromosomal translocation, has been implicated in a broad spectrum of malignancies and various diseases.

Harnessing the potential of phytochemicals to design anti-filarial molecules targeting the MurE enzyme of : a hierarchical virtual screening and molecular dynamics simulation study.

, a causative agent of lymphatic filariasis, relies on its endosymbiont for survival. MurE ligase, a key enzyme in peptidoglycan biosynthesis, serves as a promising drug target for anti-filarial therapy. In this study, we employed a hierarchical virtual screening pipeline to identify phytochemical inhibitors targeting the MurE enzyme of the endosymbiont of (MurE).

A directional self-priming continuous-driven compartmentalized microfluidic chip for multiplexed pathogen detection.

Rapid and efficient screening of foodborne pathogens is crucial for preventing bacterial spread and food poisoning. However, developing a multi-detection method that is easy to operate, offers good stability, and achieves high efficiency remains an enormous challenge. Existing multiplexed nucleic acid detection methods suffer from complex designs, leading to complicated operations, and non-robust sample introduction, causing primer/probe crosstalk and false-positive results.

Synthesis and Reactivity of a Crystalline Zinc-cAAC Radical.

Reaction of LZnI [L = BuC(N-DIPP), DIPP = 2,6-Pr-CH] with KC in the presence of cyclic (alkyl)(amino)carbene (cAAC) affords a stable radical complex [LZn(cAAC)] (3). Single-crystal structural analysis of 3 shows a short Zn─C bond and concomitant elongation of C─N bond within the cAAC ligand, indicating a significant π-backbonding from the metal to the cAAC ligand. EPR spectroscopy and DFT calculations reveal that the spin density is mainly localized on the carbenic carbon atom, with a small portion on the zinc center.

Single-Molecule Dual-Anchor Design Enables Extreme-Condition Lithium Metal Batteries Through Solvation Reconstruction and Cathode Polymerization.

Lithium metal batteries (LMBs) have emerged as the most promising candidate for next-generation high-energy-density energy storage systems. However, their practical implementation is hindered by the inability of conventional carbonate electrolytes to simultaneously stabilize the lithium metal anode and LiNiCoMnO (NCM811) cathode interfaces, particularly under extreme operating conditions. Herein, we present a transformative molecular design using 3,5-difluorophenylboronic acid neopentyl glycol ester (DNE), which uniquely integrates dual interfacial stabilization mechanisms in a single molecule.

Inverting the Rhodamine Paradigm: Closed-Form Fluorescence with 280 nm Stokes Shift Drives Plastic Circularity.

Rhodamine derivatives exhibiting inverted open-closed form fluorescence behavior redefines conventional photochemical paradigms while illuminating new structure-property relationships and fascinating application potentials. Herein, we report a donor-acceptor engineering strategy that activates closed form emission in rhodamines, achieving unprecedented Stokes shifts (>280 nm) while overcoming aggregation-caused quenching. The new class of rhodamines with inverted open-close form emission behavior are created through simultaneous substitution of N,N-diethyl groups with indole (donor) and conversion of spiro-lactam to benzene sulfonamide (acceptor).

A single-component white-light-emitting hybrid copper(I) halide constructed using a supramolecular cation for WLEDs.

Single-component white-light-emitters ensure color stability while reducing device complexity, and are ideal candidates for white light-emitting diodes (WLEDs). However, the realization of single-component white-light emission with high efficiency and stability is still a challenge. Herein, a supramolecular cation strategy was used to synthesize the organic-inorganic hybrid copper(I) halide [(AMTA)(18C6)]CuI (1), with AMTA = 1-adamantanamine and 18C6 = 18-crown-6.