DHYZ modulates hippocampal cholinergic pathway acetylation to ameliorate cognitive deficits post-ischemic stroke in rats.

Ischemic stroke is a serious cerebrovascular disease that is often accompanied by debilitating sensorimotor deficits and persistent cognitive deficits, which seriously affect patients' quality of life. DHYZ, a traditional Chinese herbal formula, has shown significant efficacy in restoring neurological function in ischemic regions of the brain, but its potential for improving poststroke cognitive impairment remains underdeveloped. In this study, the middle cerebral artery occlusion/reperfusion (MCAO/R) model was used to reproduce the pathological process of ischemic stroke in humans.

Social appearance anxiety and body checking behavior in the relationship between social media addiction and depressive symptoms among college students.

Background: The relationship between social media addiction and depressive symptoms has been extensively studied; however, the underlying mechanisms remain unexplored. This study examined the mediating roles of social appearance anxiety and body checking behaviors in this relationship. This research aims to address the gap in understanding how social media addiction influences mental health, particularly among college students.

RNF126 suppresses amino acid-mediated mTORC1 signaling pathway by ubiquitinating ILF3 in HEK293T cells.

The mammalian Target of Rapamycin Complex 1 (mTORC1) serves as a metabolic hub that integrates external nutrients to promote cell growth and metabolism, with its activation closely associated with accelerated cancer progression. Interleukin enhancer-binding factor 3 (ILF3) has been identified as a negative regulator of mTORC1 by tethering GATOR1/2 to the lysosomal membrane during amino acid sensing. However, the regulatory mechanisms of the ILF3-mediated mTORC1 signaling pathway remain unclear.

Regulating cell stress responses by nitric oxide to enhance calcium overload-mediated tumor therapy.

Amino acid (AA)-based nanoparticles (NPs) hold promise in cancer therapy due to their excellent biocompatibility and the various therapeutic functions derived from AA monomers. Here, we developed a universal one-step method to synthesize AA-based NPs. We then constructed L-Arginine (L-Arg)/calcium phosphate (CaP) NPs to enhance cancer therapy through synergistic calcium overload to induce apoptosis and immunogenic cell death.

Light-Driven Double-Layer Polydopamine-Coated Flexible Metal-Organic Frameworks: Balancing Antibacterial and Regenerative Functions.

Burns complicated by antibiotic-resistant bacterial infections present a formidable clinical challenge, characterized by key pathological processes, including pathogen colonization, chronic inflammatory responses, and excessive accumulation of reactive oxygen species (ROS). Photocatalytic metal-organic frameworks (MOFs) have emerged as a promising nonantibiotic strategy against antibiotic-resistant bacterial infections. However, the ROS generated by MOF-based photocatalysis is often insufficient for effective antibacterial activity, while excessive ROS may induce tissue injury.

Effect of radical radiotherapy dose on the prognosis of limited-stage thoracic small cell carcinoma of the esophagus: A multicenter retrospective trial from China (CHiSCEC).

Background: The optimal radiation dose for the treatment of small cell carcinoma of the esophagus (SCEC) has not been established. This study aimed to investigate the treatment outcomes and toxicities in patients with limited-stage SCEC (LS-SCEC) treated by radiotherapy.

Methods: Patients with LS-SCEC from 14 institutions were retrospectively identified between December 2000 and October 2021.

Spatial integration of sensory input and motor output in chemotaxis through colocalized distribution.

The opportunistic pathogen serves as a model organism for studying multiple signal transduction pathways. The chemoreceptor cluster, a core component of the chemotaxis pathway, is assembled from hundreds of proteins. The unipolar distribution of receptor clusters has long been recognized, yet the precise mechanism governing their assembly remains elusive.

The graphene oxide/alginate gel loaded with platelet-rich plasma-derived exosomes regulate notch 1 signaling pathway to promote diabetic foot wound healing.

Exosomes have promising applications in accelerating wound healing; however, it remains a challenge for exosomes to effectively promote healing of damaged wounds such as diabetic foot ulcers. The aim of this study was to produce an exosome that promotes wound healing in diabetic foot ulcers and to investigate its potential mechanism. Firstly, graphene oxide/alginate gel loaded with platelet-rich plasma-derived exosomes (GO/Alg + Exo) was prepared and characterized, and then the cytotoxicity and function of the gel were detected in vitro by cell survival, immunofluorescence and scratch test.

Solving multi-scenario hybrid flow shop scheduling problem based on an improved probe machine model.

The hybrid flow-shop scheduling problem is widely present and applied in industries such as production, manufacturing, transportation, and aerospace. In recent years, due to the advantages of nonlinear access and fully parallel processing, the probe machine has shown powerful computing capabilities and promising applications in solving various combinatorial optimization problems. This work firstly proposes an Improved Probe Machine with Multi-Level Probe Operations (IPMMPO) and ingeniously designs general data libraries and probe libraries tailored for multi-scenario HFS problems, including HFS with identical parallel machines and HFS with unrelated parallel machines, no-wait scenario, and standard scenario.

Design, synthesis, and biological evaluation of liver-targeting phosphoric acid thyroid hormone receptor agonists for the treatment of metabolic dysfunction-associated steatohepatitis.

Metabolic dysfunction-associated steatohepatitis (MASH) represents a progressive stage of metabolic dysfunction-associated steatotic liver disease (MASLD) and is characterized by steatosis, inflammation, hepatocyte ballooning, and fibrosis. Resmetirom, a thyroid hormone receptor β (THR-β) agonist, is the first drug approved by the FDA for the treatment of MASH. The beneficial effects of THR-β agonists on lipid levels primarily result from their action on THR-β in the liver, whereas adverse effects, including impacts on cardiac and bone health, are mediated through thyroid hormone receptor α (THR-α).

CT Radiomics-based machine learning approach for the invasiveness of pulmonary ground-glass nodules prediction.

Objective: To develop and validate a machine learning model based on CT radiomics to improve the ability to differentiate pathological subtypes of pulmonary ground-glass nodules (GGN).

Methods: A retrospective analysis was conducted on clinical data and radiological images from 392 patients with lung adenocarcinoma at Binzhou Medical University Hospital between January 1, 2020 to May 31, 2023. All patients underwent preoperative thin-section chest CT scans and surgical resection.

Multimodal MRI characterization of brain injury in heatstroke: integrating gray matter morphometry and advanced diffusion tractometry.

Objective: To investigate gray-white matter injury in heatstroke using multimodal MRI, and precisely localize damaged white matter segments via automated fiber quantification (AFQ) with clinical correlation.

Results: Compared with the healthy control group, VBM revealed reduced volume in bilateral cerebellar anterior lobes and left fusiform gyrus. TBSS showed widespread white matter abnormalities.

circHMGCS1 Promotes the Progression of NSCLC by Regulating the HuR/SFPQ/TNF Pathway.

Among lung cancers, non-small-cell lung cancer (NSCLC) is the most common type. Evidence demonstrates that abnormal expression of circular RNAs (circRNAs) is associated with cancer progression through interactions with RNA-binding proteins (RBPs). Therefore, further elucidation of the role of circular RNAs may provide new therapeutic targets for NSCLC patients.

ORMDL2 Promotes the Growth of Glioma through mTORC1-Mediated Fatty Acid Metabolism.

Fatty acid metabolism is critical for numerous biological processes involved in the pathogenesis of glioma. This study aimed to survey the role of ORMDL sphingolipid biosynthesis regulator 2 (ORMDL2) in fatty acid metabolism of glioma cells. The expression of ORMDL2 in glioma and its association with survival rate was detected using The Cancer Genome Atlas (TCGA) data and Kaplan-Meier survival curve.

Electrospun Nanofibers Loaded with Concentrated Growth Factors and Nanohydroxyapatite for the Healing of Alveolar Bone in Tooth Extraction Wounds.

The healing of tooth extraction wounds is significantly influenced by various factors, including interference from the oral microenvironment, invasion of gingival tissue, and inflammation of the alveolar socket, all of which contribute to the substantial loss of bone tissue in the alveolar socket. This study employed electrospinning technology to fabricate polyvinyl alcohol (PVA)/sodium alginate (SA) nanofiber scaffolds infused with freeze-dried concentrated growth factor (CGF) and nanohydroxyapatite (nHA). The objective was to investigate the repair mechanism of the PVA/SA/CGF/nHA nanofibers for oral alveolar bone defects, thereby offering novel treatment strategies for bone defect repair.

Tenascin-R aggravates Aβ production in the perforant pathway by regulating Nav1.6 activity in APP/PS1 mice.

Introduction: Alzheimer's disease (AD) neuropathology exhibits early accumulation of amyloid beta (Aβ) plaques within the perforant pathway. This study explores how tenascin-R, a myelin-associated protein at nodes of Ranvier (NORs), modulates Aβ generation through Nav1.6 within this cortico-hippocampal circuit.

Investigation of Endodontic Disinfection by Combination of Laser and Nanobubble Technology.

Introduction: To investigate the combined use of laser, nanobubble water (NB-HO), and calcium hydroxide (Ca(OH)) for endodontic disinfection, particularly in regenerative endodontic cases where maximum effectiveness is needed.

Methods: Canal of human teeth were prepared, sterilized and inoculated with Enterococcus faecalis (E. faecalis).

A fluorescent probe for detecting and imaging sulfur dioxide derivatives and .

Sulfur dioxide (SO), an important gaseous signaling molecule, takes part in multiple pathological and physiological processes and plays a vital role in complex biological systems. However, the pathogenesis of many serious diseases, such as respiratory diseases, cardiovascular disorders and neurological diseases, resulting from excessive inhalation of SO remains unclear. Therefore, it is significant to develop reliable analytical methods to effectively and concretely monitor SO derivatives in living systems.

Autophagy-driven modulation of stem cell dynamics in -induced gastric diseases in mice.

Chronic infection is a major contributor to gastric disease progression, with its involvement in autophagy and stem cell dynamics playing a critical role in disease mechanisms. This study investigated how . , particularly in combination with the carcinogen N-nitroso-N-methylurea (NMU), disrupted autophagy and stem cell function, driving gastric pathology.

Altered gray matter networks in the co-occurrence of autism spectrum disorder and attention deficit hyperactivity disorder.

Although the comorbidity of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) (ASD+ADHD) is prevalent, the neurobiological mechanisms underlying this combined condition are not yet fully understood. Both ASD and ADHD have been associated with alterations in gray matter (GM) structural networks, suggesting that such altered GM networks may serve as potential markers for identifying this comorbid disorder. In this study, we compared the GM structural networks in ASD+ADHD, ASD without ADHD (ASD-only), ADHD without ASD (ADHD-only), and typically developing controls (TDc).

Precise copper ion release and recovery in polycaprolactone nanofiber scaffold: an antibacterial and osteogenic synergistic strategy for guided bone regeneration.

Introduction: Infection control and bone regeneration remain major challenges in orthopedic therapy. To address these issues, we developed a multifunctional guided bone regeneration (GBR) nanofibrous material based on electrospun polycaprolactone (PCL). This material combines antibacterial and osteogenic properties using polydopamine (PDA) and copper ions (CuCu).

Structural Changes of Apolipoprotein A-I Caused by Hydroxyethyl Starch 130/0.4 Reveals Potential Toxic Mechanisms.

6% hydroxyethyl starch (HES 130/0.4) is frequently employed to address hypovolemia, ensuring sufficient organ perfusion and oxygen transport. The effects on Apolipoprotein A-I (ApoA-I) were examined at three temperatures-280, 295, and 310 K-through several spectroscopic techniques to explore its possible interaction with the predominant protein in veins.