Mechanistic insights into Shengxian Sanren granules' effects on chronic heart failure: A synergistic study of UPLC-Q-TOF-MS/MS and network pharmacology.

Objective: This study aims to elucidate the pharmacological mechanisms and therapeutic targets of Shengxian Sanren Granules in the treatment of Chronic heart failure (CHF), with particular emphasis on the regulation of the PI3K/AKT/mTOR-mediated autophagy signaling pathway.

Methods: The major blood-absorbed components of Shengxian Sanren Granules were identified using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS). Network analysis was applied to predict potential targets and signaling pathways, revealing 37 core targets predominantly enriched in the PI3K-Akt and mTOR pathways.

Design, synthesis, and biological evaluation of liver-targeting phosphoric acid thyroid hormone receptor agonists for the treatment of metabolic dysfunction-associated steatohepatitis.

Metabolic dysfunction-associated steatohepatitis (MASH) represents a progressive stage of metabolic dysfunction-associated steatotic liver disease (MASLD) and is characterized by steatosis, inflammation, hepatocyte ballooning, and fibrosis. Resmetirom, a thyroid hormone receptor β (THR-β) agonist, is the first drug approved by the FDA for the treatment of MASH. The beneficial effects of THR-β agonists on lipid levels primarily result from their action on THR-β in the liver, whereas adverse effects, including impacts on cardiac and bone health, are mediated through thyroid hormone receptor α (THR-α).

Advances of Chinese herbal medicine-derived polysaccharides as carrier-free and carrier agents in anti-melanoma therapy.

Melanoma, a highly aggressive malignancy with increasing global incidence, faces significant therapeutic challenges due to drug resistance, systemic toxicity, and immunosuppressive tumor microenvironment. Despite advances in targeted therapies and immunotherapies, the need for safer and more effective treatment options remains urgent. Chinese herbal medicine-derived polysaccharides (CHMPs), characterized by their natural origin, biocompatibility, and multifaceted bioactivities, have garnered increasing attention as promising candidates for melanoma therapy due to their low toxicity and multi-targeting capabilities.

Aglycone Polyether Ionophores Affecting Actin Filaments as Broad-Spectrum Antiviral Agents.

RNA viruses have high mutation rates and constitute an increasing global risk. As the viral target approach to develop antiviral drugs is inadequate for responding to an increasing diversity of viruses, an urgent need exists for the development of new antivirals to prevent future outbreaks. Here, we show that aglycone ionophores maduramycin (Mad) and endusamycin (End) from are broadly virucidal against cytoplasmic replicated viruses, including Japanese encephalitis virus (JEV), rabies virus, hepatitis C virus, vesicular stomatitis virus, hantavirus, dengue virus, Zika virus, chikungunya virus, and SARS-CoV-2 in vitro.

Dynamic VOC fingerprinting and mechanistic exploration of medicinal edible fungus Inonotus hispidus: A combination of HS-GC-IMS/MS multivariate analysis and network-based pharmacology.

Inonotus hispidus (IH) is a species of traditional edible and medicinal fungus consumed in China, known for its anti-inflammatory, antioxidant, and anticancer pharmacological effects. IH has garnered widespread attention due to its therapeutic potential in clinical applications. However, despite its widespread use, comprehensive studies on its volatile chemical constituents and pharmacological mechanisms remain limited.

Development and external validation of a model for post-endoscopic retrograde cholangiopancreatography pancreatitis.

Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a common complication in patients undergoing ERCP for choledocholithiasis, yet effective predictive models are lacking. This study included 2,247 patients who underwent ERCP for complete stone removal at the First Affiliated Hospital of USTC from January 2015 to January 2023. Six machine learning algorithms were utilized, incorporating 25 clinical parameters, to develop a predictive model for PEP risk.

Mutational landscapes of NITD008-resistant EV71 variants revealed through population sequencing.

• The mutation spectra between WT population and NITD008-resistant populations during replication are compared. • The 2C protein may be a new target of NITD008 as a nucleotide analogue against EV71 infection. • Antiviral effect of NITD008 against EV71 is associated with increased frequency of U-to-A and U-to-C mutations.

A framework for analyzing EEG data using high-dimensional tests.

Motivation: The objective of EEG data analysis is to extract meaningful insights, enhancing our understanding of brain function. However, the high dimensionality and temporal dependency of EEG data present significant challenges to the effective application of statistical methods. This study systematically addresses these challenges by introducing a high-dimensional statistical framework that includes testing changes in the mean vector and precision matrix, as well as conducting relevant analyses.

APOA1 promotes tumor proliferation and migration and may be a potential pan-cancer biomarker and immunotherapy target.

Introduction: Aberrant expression of APOA1 has been reported in various cancers. However, a comprehensive investigation into its role in cancer is currently lacking.

Methods: Online websites and databases such as TIMER2.

Estimating photosynthetic traits in tea chrysanthemum using high-throughput leaf hyperspectral reflectance.

Hyperspectral remote sensing (RS) has demonstrated to be useful for estimating vegetation photosynthetic traits, such as the maximum carboxylation rate of Rubisco (Vcmax) and the electron transport rate (Jmax). However, the spectral ranges used by RS models for predicting photosynthetic traits vary, and their predictive performance across different crop varieties is poor. This study aimed to investigate whether augmenting the modeling dataset's variability through various nitrogen experiments on tea chrysanthemum could improve RS-based photosynthetic trait models' applicability.

Engineering oxygen vacancies in acid-etched MgMnO for efficiently catalytic benzene combustion: Synergistic activation of gaseous oxygen and surface lattice oxygen.

The synergistic activation of gaseous oxygen and surface lattice oxygen is essential for designing highly efficient catalysts to eliminate VOCs. Herein, an effective acid treatment was carried out to create more oxygen vacancies by modulating the electronic structure of MgMnO spinels and MgMnO mixed oxides. The acid-treated MgMnO exhibited outstanding catalytic performance, with the reaction rate of benzene rising by 8.

Systematic pan-cancer analysis identifies ZBTB11 as a potential pan-cancer biomarker and immunotherapy target in multiple tumor types.

Background: ZBTB11 is a putative transcription factor with an N-terminal BTB domain and tandem C-terminal zinc finger motifs. Recent studies have suggested a potential role for ZBTB11 in tumorigenesis. However, the biological significance of ZBTB11 in different cancer types remains uncertain.

Astragali radix vesicle-like nanoparticles improve energy metabolism disorders by repairing the intestinal mucosal barrier and regulating amino acid metabolism in sleep-deprived mice.

Background: Sleep disorder is widespread and involves a variety of intricate factors in its development. Sleep deprivation is a manifestation of sleep disorder, can lead to energy metabolism disturbances, weakened immune system, and compromised body functions. In extreme situations, sleep deprivation can cause organ failure, presenting significant risks to human health.

A slime-inspired phycocyanin/κ-carrageenan-based hydrogel bandage with ultra-stretchability, self-healing, antioxidative, and antibacterial activity for wound healing.

Hydrogels have attracted extensive attention as wound dressing owing to their excellent multifunctionality, flexibility, and biocompatibility. Due to the frequent movement and stretching of skin as well as complex surface of wound, traditional wound dressings have difficulty to adapt to motion and irregular wounds. Furthermore, excessive reactive oxygen species (ROS) and bacterial infection can induce delayed wound healing.

Analysis of postoperative infection factors of retrograde intrarenal surgery combined with negative pressure equipment for renal stones.

Our study aimed to retrospectively analyze the patients who underwent the combination of negative pressure equipment and RIRS(NP-RIRS) for renal stones, and identified new high-risk factors related to infection. 456 patients with renal stones ≤ 3 cm underwent NP-RIRS in our department, from January 2022 to October 2023. All patients were divided into non-infection group(NIRIRS group) and infection group(IRIRS group) based on infection complications during the perioperative period.

Policy evaluation and optimization for photovoltaic poverty alleviation projects in Anhui Province of China.

To synergize climate mitigation with poverty alleviation, China has implemented photovoltaic poverty alleviation (PVPA) projects since 2014, with Anhui Province being among the initial pilot regions. However, further exploration is needed to determine the extent to which this policy can improve the economic status of poverty-stricken areas. This study aims to evaluate the effects of PVPA projects in Anhui Province from a macroscopic perspective and via the panel data from 11 poverty-stricken counties, including 5 pilot counties, between 2011 and 2018.

Luobitong Potentiates MTX's Anti-Rheumatoid Arthritis Activity via Targeting Multiple Inflammatory Pathways.

Background: The LuoBiTong (LBT) capsule, a novel traditional Chinese medicine formulation, is currently in Phase III clinical trials. Preliminary preclinical and Phase II clinical studies suggest its efficacy and safety in treating rheumatoid arthritis (RA). However, the underlying mechanisms of its action remain to be elucidated.

Application of fused graphical lasso to statistical inference for multiple sparse precision matrices.

In this paper, the fused graphical lasso (FGL) method is used to estimate multiple precision matrices from multiple populations simultaneously. The lasso penalty in the FGL model is a restraint on sparsity of precision matrices, and a moderate penalty on the two precision matrices from distinct groups restrains the similar structure across multiple groups. In high-dimensional settings, an oracle inequality is provided for FGL estimators, which is necessary to establish the central limit law.

Wdr17 Regulates Cell Proliferation, Cell Cycle Progression and Apoptosis in Mouse Spermatocyte Cell Line.

We identified Wdr17 as a highly expressed gene in pachytene spermatocytes by transcriptomic analysis of mouse testis. Germ cell-deficient infertile mouse models had significantly reduced Wdr17 expression. We performed gene interference and overexpression in the mouse spermatocyte cell line GC-2spd(ts) and investigated how Wdr17 affects spermatocyte growth and development.

Case report: A successful clinical experience of transplantation of liver and kidney from a donor with myelodysplastic syndromes.

With a shortage of organs for transplant, the use of marginal donors can be an effective measure to meet the shortfall. Myelodysplastic syndromes (MDS) are considered an absolute contraindication for organ donation because of the high invasive potential. Currently, organ transplantation from donors with a past history of MDS has not been reported.

Bibliometric and visualized analysis of DME from 2012 to 2022.

Background: Diabetic macular edema (DME) is the main cause of irreversible vision loss in patients with diabetes mellitus (DM), resulting in a certain burden to patients and society. With the increasing incidence of DME, more and more researchers are focusing on it.

Methods: The papers related to DME between 2012 and 2022 from the Web of Science core Collection were searched in this study.

[Efficacy and mechanism of Xuefu Zhuyu Decoction on model rats of coronary heart disease with heart blood stasis syndrome based on metabolomics].

This study investigated the effects of Xuefu Zhuyu Decoction on myocardial metabolites in a rat model of coronary heart disease with heart blood stasis syndrome and explored the therapeutic mechanism of blood circulation-promoting and blood stasis-removing therapy. SD rats were randomly divided into a sham operation group, a model group, a Xuefu Zhuyu Decoction group(14.04 g·kg~(-1)), and a trimetazidine group(5.

MUC15 is an independent prognostic factor that promotes metastases of MYCN non-amplified neuroblastoma.

Neuroblastoma (NB) is a cancer that arises from neural-crest-derived sympathoadrenal lineage. Less is known about the pathogenesis and molecular characteristics of MYCN non-amplified (MYCN-NA) NB. We constructed a signature model targeting mucin family according to RNA sequencing data from GSE49710 dataset, and validated the prognostic performance.

Eyes on the Lid: The Impact of Fibroblast Growth Factor Receptor Targeting Drug on Human Meibomian Gland.

Objective: To determine whether fibroblast growth factor receptor (FGFR)-targeting drug could impact human meibomian gland.

Methods: We followed up with three patients who were using pemigatinib for 4 to 10 weeks. The patients were evaluated for their ocular surface disease index, best-corrected visual acuity, Schirmer test, cornea staining, meibum expressibility score, tear meniscus height, noninvasive tear film breakup time, and meibomian gland area.