Dynamics of neutralizing antibodies against COVID-19 Omicron subvariants following breakthrough infection in southwest China between December 2022 and April 2024.

From December 2022 to January 2023, the SARS-CoV-2 Omicron BA.5/BF.7 variant significantly impacted mainland China.

Investigation of human infection with H5N6 avian influenza cases in Sichuan Province from 2014 to 2024: a retrospective study.

Objective: The objective is to examine the epidemiology and clinical features of human cases infected with H5N6 avian influenza in Sichuan Province from 2014 to 2024, and to offer guidance for the prevention and management of human infections with H5N6 avian influenza.

Methods: Epidemiological survey reports of H5N6 avian influenza cases in Sichuan Province from 2014 to 2024 were compiled, and the epidemiological context and characteristics of 16 human cases infected with H5N6 avian influenza in the province were summarized and analyzed using descriptive epidemiological methods.

Results: From 2014, when the initial human case ofH5N6 infection was documented in Sichuan Province, to 2024, there have been 16 human cases of H5N6 avian influenza in the region, resulting in 12 fatalities and a case fatality rate of 75%.

Prenatal arsenic exposure causes cognitive dysfunction in offspring through KDM5-regulated reprogramming of autophagy in developing brain, an effect attenuated by alpha-ketoglutarate.

Prenatal exposure to arsenic has lasting health effects on the developing fetus, including an increased risk of neurological damage in the offspring during adulthood. Epigenetics may be involved in the pathogenic process, but the underlying mechanisms remain unclear. Autophagy, which is involved in nearly all steps of neurodevelopment, is regulated by histones and can be inherited across generations.

The First Imported Case of Lassa Fever - China, 2024.

What Is Already Known About This Topic?: Lassa fever, an acute viral hemorrhagic illness caused by Lassa virus, is primarily transmitted through contact with rodents, particularly species. The disease is endemic to West Africa and is not classified as a notifiable infectious disease in China. Prior to August 2024, no cases of Lassa fever had been reported in China.

A Multi-Regional Epidemiological Evaluation on Post-vaccination Serological Testing in Prevention of Vertical Transmission of Hepatitis B Virus - 10 Counties, 5 Provinces, China, 2019-2024.

What Is Already Known About This Topic?: Post-vaccination serologic testing (PVST) of infants born to hepatitis B virus (HBV) infected mothers is important for evaluating effectiveness of strategies for preventing mother-to-child transmission (MTCT) of HBV.

What Is Added By This Report?: PVST was conducted in 43.7% of 7,425 infants born to HBV-infected mothers and showed that 0.

[Structural equation analysis and modeling of upper limb WMSDs and their adverse ergonomic factors].

To explore the structural relationship between WMSDs in the upper limbs and various risk factors in the occupational population in China, based on a large sample epidemiological survey and structural equation analysis, and to establish a structural equation model, so as to lay a foundation for the prevention and control of such diseases. The Chinese version of the Musculoskeletal Disorders Electronic Questionnaire was used to conduct a nationwide survey on the prevalence of WMSDs in the upper extremity. Six factors related to WMSDs in the upper extremity were extracted by the classification standard of adverse ergonomic factors and their source and confirmatory factor analysis, including work organization, work type, upper extremity work posture, individual factors, upper extremity fatigue and upper extremity WMSDs.

The changing molecular epidemiology of HIV-1 in Liangshan prefecture, China, in 2021-2023.

Introduction: Liangshan Prefecture is one of the areas in China most severely affected by human immunodeficiency virus (HIV), but little is known about the molecular epidemiology of HIV-1 in this area. We aimed to analyze the distribution of HIV-1 genetic variants in Liangshan Prefecture in recent years.

Methods: 8,523 blood samples were collected from people living with HIV with treatment failure and newly diagnosed individuals in all 17 counties and cities in Liangshan Prefecture between 2021 and 2023.

Prevalence and transmission of HIV-1 drug resistance mutations among patients with treatment failure and newly diagnosed people in Liangshan Prefecture, China, in 2021-2023.

Introduction: Despite expanded antiretroviral therapy (ART) in China, HIV transmission persists. Liangshan Prefecture is one of the areas in China most severely affected by HIV, with high levels of drug resistance. A deeper understanding of HIV-1 drug resistance can lead to improvements in current treatment policies.

[Structural equation analysis and modeling of fect and ankles WMSDs and its adverse ergonomic factors].

To explore the structural equation model to explore the levels of work-related musculoskeletal disorders (WMSDs) and various risk factors in the feet and ankle of China's occupational population, providing scientific basis for for preventing WMSDs in feet and ankles. Data of 73497 national occupational epidemiological cases were selected from June 2018 to December 2023 used the Chinese version of the Electronic Questionnaire on Musculoskeletal Disorders. The adverse ergonomic factors and their source classification standard and confirmatory factor analysis were used to investigate foot and ankle WMSDs and their related risk factors (including individual factors, work organization, work posture, work type, fatigue, etc.

[Structural equation analysis of the incidence of shoulder WMSDs and individual and work-related factors].

To investigate the incidence of shoulder work-related musculoskeletal disorders (WMSDs) among occupational population in China, and to explore their intrinsic association with personal and work-related factors. In April 2024, 73497 valid questionnaires of the Chinese version of the Musculoskeletal Disorders Electronic Questionnaire were retrospectively analyzed from June 2018 to December 2023 in 22 provinces and 29 key industries in China, and the general information, occurrence of WMSDs and related risk factors of key occupational populations in different regions in China were collected. By using Chi-square test and confirmatory factor analysis, the relationship between shoulder fatigue and pain in key occupational groups and individual factors, work type, work posture and work organization was discussed, and the internal relationship was analyzed based on structural equation model.

Snail control as a crucial approach to schistosomiasis elimination: evidence from the People's Republic of China.

Background: Asian schistosomiasis is projected to be eliminated by 2030 according to World Health Organization road map for neglected tropical diseases 2021-2030. Snail control is an important measure but has not yet been systematically evaluated at a country scale. Here, we report the findings from a nationwide survey to demonstrate the dynamics of Oncomelania and its potential role in transmission interruption of schistisomiasis in the People's Republic of China (P.

Past, present and future epidemiology of echinococcosis in China based on nationwide surveillance data 2004-2022.

Objectives: We evaluated the epidemiological characteristics of echinococcosis, a global public health threat, in China to inform global control efforts.

Methods: Descriptive, statistical, cluster, spatial, and trend analyses were used to evaluate the epidemiology at national, provincial, and county levels based on 2004-2022 nationwide surveillance data from China.

Results: Between 2004 and 2022, China recorded 72,676 cystic echinococcosis (CE) cases, 11,465 alveolar echinococcosis (AE) cases, and 5703 others, with an average annual cases per million (ANpM) of 3.

Genetic diversity atlas of Brucella melitensis strains from Sichuan Province, China.

Human brucellosis is a re-emerging disease in Sichuan Province, China. In this study, bacteriology, conventional bio-typing, multi-locus sequence typing (MLST), and multiple locus variable-number tandem repeat analysis (MLVA) were applied to preliminarily characterize the strains in terms of genetic diversity and epidemiological links. A total of 101 Brucella strains were isolated from 16 cities (autonomous prefectures) from 2014 to 2021, and all of the strains were identified as Brucella melitensis bv.

A discrete choice experiment on Chinese parents' preferences of vaccine schedules against six childhood infectious diseases.

Background: China's Expanded Program on Immunization (EPI) provides vaccinations against 12 vaccine preventable diseases (VPDs) at no cost to families. For some VPDs, parents may opt to substitute equivalent non-program vaccines, including combination vaccines, for EPI vaccines; substitute vaccines must be paid for by the family. Although parents have several choices for vaccinating their children, their preferences for vaccines and immunization schedules have not been systematically evaluated.

Prevalence and Risk Factors of Lower Extremity Musculoskeletal Disorders Among Occupational Groups in Key Industries - China, 2018-2023.

What Is Already Known About This Topic?: Lower extremity musculoskeletal diseases (LE-MSDs) have emerged as a significant contributor to the global disease economic burden and worker absenteeism, becoming a global public health concern. However, the epidemic characteristics of LE-MSDs among occupational populations in China are unknown.

What Is Added By This Report?: This report finds that the LE-MSDs prevalence rate among key occupational groups in China is 17.

[Structural equation analysis and modeling of wrist WMSDs and its adverse ergonomic factors].

To investigate the relationships and impacts between various occupational ergonomic hazards and hand and wrist fatigue, as well as work-related musculoskeletal disorders (WMSDs) of the hand and wrist, and to propose targeted preventive and intervention measures for adverse occupational ergonomic factors causing WMSDs of the hand and wrist. From 2018 to December 2023, a nationwide epidemiologic survey study of wrist WMSDs was conducted using the Chinese version of the electronic questionnaire system for musculoskeletal disorders.A total of 88, 609 valid questionnaires were collected.

[Study on the epidemiological characteristics of work-related musculoskeletal disorders among 29 industries or occupational groups in China].

To analyze the distribution characteristics of work-related musculoskeletal disorders (WMSDs) among the occupational population in China's key industries during the period from 2018 to 2023, and to provide data support for the formulation of targeted prevention strategies. Between January 1, 2018, and December 31, 2023, a cross-sectional epidemiological survey and a retrospective investigation were conducted in seven geographical regions of North China, East China, Central China, South China, Southwest China, Northwest China, and Northeast China, using a combination of epidemiological cross-sectional and retrospective surveys. The industries were stratified according to the degree of closeness to WMSDs, the size of the occupational population, and the importance of the national economy, and then cluster sampling was conducted according to the size of the enterprises (large, medium, and small) within each stratum.

Indicator-based tuberculosis infection control assessments with knowledge, attitudes, and practices evaluations among health facilities in China, 2017 to 2019.

Background: Tuberculosis Building and Strengthening Infection Control Strategies (TB BASICS) aimed to achieve improvements in TB infection prevention and control (IPC) through structured training and mentorship.

Methods: TB BASICS was implemented in 6 Chinese provinces from 2017 to 2019. Standardized, facility-based risk assessments tailored to inpatient, laboratory, and outpatient departments were conducted quarterly for 18months.

Assessment of compliance and therapeutic efficacy of albendazole treatment in Chinese patients with echinococcosis.

Background: Echinococcosis is an infectious parasitic disease that is extremely harmful to human health. Albendazole is provided free of charge to patients requiring medication under the central government finance transfer payment scheme for echinococcosis control and prevention in China. Our aim is to monitor the state of patient medication and its therapeutic impact, which will help improve medication compliance and the therapeutic effect.

Characterization and Implications of the Regionally Prevalent ST8333 Strains of Serotype 4,[5],12:i: - China, 2017-2023.

What Is Already Known About This Topic?: is a significant foodborne pathogen responsible for millions of infections and thousands of deaths worldwide each year. The increasing prevalence of the ST34 serotype 4,5,12:i:-(. 4,[5],12:i:-) poses a substantial public health threat in China.

A liver CT based nomogram to preoperatively predict lung metastasis secondary to hepatic alveolar echinococcosis.

Purpose: To develop a nomogram based on liver CT and clinical features to preoperatively predict lung metastasis (LM) secondary to hepatic alveolar echinococcosis (HAE).

Methods: A total of 291 consecutive HAE patients from Institution A undergoing preoperative abdominal contrast-enhanced CT and chest unenhanced CT were retrospectively reviewed, and were randomly divided into the training and internal validation sets at the 7:3 ratio. 82 consecutive patients from Institution B were enrolled as an external validation set.

Gastroesophageal reflux disease and risk of incident lung cancer: A large prospective cohort study in UK Biobank.

Background: Some pathogenic mechanisms suggest a potential relationship between gastroesophageal reflux disease (GERD) and respiratory diseases. However, evidence regarding the association between GERD and lung cancer is mixed. We aim to explore this relationship based on data from the large-scale UK Biobank study.

Acceptance of Rubella-Containing Vaccine and Factors Associated with Acceptance among Women of Reproductive Age in China: A Cross-Sectional Study.

: To investigate the acceptance and factors influencing acceptance of rubella-containing vaccine (RCV) among women of reproductive age in Guangdong, Henan, Hubei, Liaoning, Shanxi, Sichuan and Zhejiang provinces of China. : Using a stratified sampling method, we selected one urban and one rural community health services center in each of two cities in seven provinces. From these centers, we recruited women 15-49 years of age to complete a questionnaire on their willingness to receive RCV and factors influencing willingness.