Traceable nanoparticles with mitochondria-targeting pyruvate-Cu induce cuproptosis for enhanced triple-negative breast cancer therapy in a mouse model.

We develop pyruvate with good biocompatibility and mitochondria-targeting ability as a copper ionophore (pyruvate-Cu). To further address its drawbacks, traceable nanoparticles are constructed to deliver pyruvate-Cu for triple negative breast cancer (TNBC) treatment. and results demonstrate that this work provides an efficient platform for enhanced TNBC therapy.

CircRERE promotes myocardial ischemia/reperfusion injury by increasing UHRF1 mRNA decay through targeting PUM2 to reduce Drp1 promoter methylation.

Background: Myocardial ischemia/reperfusion (I/R) injury contributes significantly to cardiac dysfunction following myocardial infarction, mainly due to excessive oxidative stress and mitochondrial injury. Despite advances in reperfusion therapies, secondary injuries remain a challenge, necessitating deeper insight into the molecular mechanisms underlying I/R injury. In the present study, we aim to investigate the roles of circular ribonucleic acid (circRNA) RERE (circRERE) in myocardial I/R injury.

Investigation of human infection with H5N6 avian influenza cases in Sichuan Province from 2014 to 2024: a retrospective study.

Objective: The objective is to examine the epidemiology and clinical features of human cases infected with H5N6 avian influenza in Sichuan Province from 2014 to 2024, and to offer guidance for the prevention and management of human infections with H5N6 avian influenza.

Methods: Epidemiological survey reports of H5N6 avian influenza cases in Sichuan Province from 2014 to 2024 were compiled, and the epidemiological context and characteristics of 16 human cases infected with H5N6 avian influenza in the province were summarized and analyzed using descriptive epidemiological methods.

Results: From 2014, when the initial human case ofH5N6 infection was documented in Sichuan Province, to 2024, there have been 16 human cases of H5N6 avian influenza in the region, resulting in 12 fatalities and a case fatality rate of 75%.

Therapeutic Lipid Nanoparticles Delivery of Small Interfering RNA for the Synergistic Treatment of Hepatic Inflammation.

Small interfering RNA (siRNA) against tumor necrosis factor-alpha (TNF-α) is a valuable therapeutic agent for hepatic inflammation. However, lipid nanoparticles (LNPs), the most clinically advanced vectors for delivering siRNA to the liver, have no therapeutic effect on diseases themselves. Here, therapeutic L-LNPs are developed by replacing the helper lipid in Onpattro with 1,2-dilauryl-sn-glycero-3-phosphocholine (DLPC).

Transverse-mode control in VCSEL with an intra-cavity metalens.

This paper presents a comprehensive numerical analysis of an 850 nm vertical-cavity surface-emitting laser (VCSEL) integrated with intra-cavity metalens. Utilizing the finite-difference time-domain (FDTD) method, we develop a three-dimensional model to examine the impact of an intra-cavity metalens on the modal behavior of the VCSEL. The metalens is designed to converge the fundamental mode towards the central region of the VCSEL cavity.

Rapid Dynamical Pattern Classification via Deterministic Learning From Sampling Sequences.

This article is concerned with the rapid classification issue for dynamical patterns consisting of sampling sequences in a relatively large-scale dynamical dataset constructed by benchmark Rossler systems. Specifically, based on a recently developed deterministic learning mechanism, a rapid dynamical pattern classification method is developed, which contains a modeling stage and a classification stage. In the modeling stage, a deterministic learning scheme is employed to accurately learn/model the inherent dynamics of the training dynamical patterns and store the acquired knowledge in a set of constant radial basis function (RBF) networks.

Forsythoside a as a potential therapeutic agent for non-alcoholic fatty liver disease: from target identification to in vitro and in vivo validation.

Non-alcoholic fatty liver disease (NAFLD) is a long-term metabolic condition marked by unusual fat buildup in the liver, with an increasing occurrence worldwide. (FA), a bioactive component of Forsythia suspensa, has anti-inflammatory, antioxidative, and hepatoprotective effects. This study investigates the mechanisms by which FA may treat NAFLD.

Knowledge, attitudes, and practices regarding intrinsic capacity in the elderly population: A cross-sectional study in Shanghai, China.

To investigate the knowledge, attitudes, and practices (KAP) of the elderly population regarding their intrinsic capacity, as defined by the World Health Organization as a marker of healthy aging. A cross-sectional study was conducted at the Shanghai Traditional Chinese Medicine Hospital from July to November 2023. Participants' socio-demographic information and KAP scores were collected through a self-designed questionnaire.

Correlation and prognosis analysis of human papillomavirus infection and P16 expression in oral and oropharyngeal squamous cell carcinomas.

The incidence of HPV-related oral squamous cell carcinomas (OSCC)and oropharyngeal squamous cell carcinomas (OPSCC) has increased significantly in recent years, but the role of HPV and P16 in OSCC and OPSCC remains controversial. Here, we evaluate the prevalence and prognostic significance of HPV-DNA, HPV E6E7 and P16 protein expression in OSCC and OPSCC patients. Additionally, we explore the correlation between P16 protein expression and HPV infection in these cases.

Distribution and Epidemiological Characteristics of Clinical Isolates of in a Hospital from 2021 to 2023: A Retrospective Study.

Objective: The distribution characteristics of clinical isolates of were analyzed to provide the basis for the prevention and control of infection.

Methods: From January 2021 to December 2023, the First Affiliated Hospital of Nanjing Medical University collected clinical isolates of from hospitalized patients for study. Duplicate strains from the same patient in the same area were eliminated, and community-, hospital-, and colonization infections were grouped.

Enhancing the performance of molecule-based piezoelectric sensors by optimizing their microstructures.

By combining the rigidity of inorganic components with the flexibility of organic components, molecule-based ferroelectrics emerge as promising candidates for flexible, self-powered piezoelectric sensors. While it is well known that the performance of piezoelectric sensor devices depends not only on the materials' piezoelectric properties but also on the device architecture, research into enhancing molecule-based piezoelectric sensor performance through microstructure optimization has never been investigated. Here, we report the synthesis of a molecule-based ferroelectric, [(2-bromoethyl) trimethylammonium][GaBr] ([(CH)NCHCHBr][GaBr]) (1), which exhibits a piezoelectric coefficient ( ) of up to 331 pC N.

Achievement of a giant electromechanical conversion coefficient in a molecule-based ferroelectric.

Molecule-based ferroelectrics are promising candidates for flexible self-powered power supplies (, piezoelectric generators (PEGs)). Although the large electromechanical conversion coefficients ( × ) of piezoelectrics are key to enhancing the performance of PEGs in their nonresonant states, it remains a great challenge to obtain molecule-based piezoelectrics with large × . Here, we report a molecule-based ferroelectric [(CH)NCHCHCl][GaBr] (1) that exhibits the largest piezoelectric coefficient (∼454 pC N) and electromechanical conversion coefficient (4953.

Different effects of air pollutant concentrations on influenza A and B in Sichuan, China.

Background: The detrimental effects of air pollution on the respiratory system are well documented. Previous research has established a correlation between air pollutant concentration and the frequency of outpatient visits for influenza-like illness. However, studies investigating the variations in infection among different influenza subtypes remain sparse.

Reconfigurable aJ-Level Ferroelectric Transistor-Based Boolean Logic for Logic-in-Memory.

Logic-in-memory (LIM) architecture holds great potential to break the von Neumann bottleneck. Despite the extensive research on novel devices, challenges persist in developing suitable engineering building blocks for such designs. Herein, we propose a reconfigurable strategy for efficient implementation of Boolean logics based on a hafnium oxide-based ferroelectric field effect transistor (HfO-based FeFET).

DDAH1 promotes neurogenesis and neural repair in cerebral ischemia.

Choline acetyltransferase (ChAT)-positive neurons in neural stem cell (NSC) niches can evoke adult neurogenesis (AN) and restore impaired brain function after injury, such as acute ischemic stroke (AIS). However, the relevant mechanism by which ChAT neurons develop in NSC niches is poorly understood. Our RNA-seq analysis revealed that dimethylarginine dimethylaminohydrolase 1 (DDAH1), a hydrolase for asymmetric ,-dimethylarginine (ADMA), regulated genes responsible for the synthesis and transportation of acetylcholine (ACh) (, and ) after stroke insult.

Extended-Gate FET Biosensor Based on GaN Micropillar Array and Polycrystalline Layer: Application to Hg Detection in Human Urine.

Owing to the separation of field-effect transistor (FET) devices from sensing environments, extended-gate FET (EGFET) biosensor features high stability and low cost. Herein, a highly sensitive EGFET biosensor based on a GaN micropillar array and polycrystalline layer (GMP) was fabricated, which was prepared by using simple one-step low-temperature MOCVD growth. In order to improve the sensitivity and detection limit of EGFET biosensor, the surface area and the electrical conductivity of extended-gate electrode can be increased by the micropillar array and the polycrystalline layer, respectively.

The Associations of Phosphorylated Tau 181 and Tau 231 Levels in Plasma and Cerebrospinal Fluid with Cognitive Function in Alzheimer's Disease: A Systematic Review and Meta-Analysis.

Background: Cerebrospinal fluid (CSF) or blood biomarkers like phosphorylated tau proteins (p-tau) are used to detect Alzheimer's disease (AD) early. Increasing studies on cognitive function and blood or CSF p-tau levels are controversial.

Objective: Our study examined the potential of p-tau as a biomarker of cognitive status in normal control (NC), mild cognitive impairment (MCI), and AD patients.

Blood Pressure Fluctuation Pattern Associated with 90-Day Ischemic Stroke and Transient Ischemic Attack After Total Knee Arthroplasty-A Retrospective Study.

Objective: Blood pressure (BP) fluctuation has been demonstrated to be closely associated with stroke. However, at present, no attention is paid to the BP fluctuation following total knee arthroplasty (TKA). The aim of this study is to investigate what is BP fluctuation patterns in stroke and transient ischemic attack (TIA) patients after primary TKA, compare clinical characteristics among different BP fluctuation patterns and determine whether it could predict the occurrence of a 90-day stroke.

Metformin regulates chondrocyte senescence and proliferation through microRNA-34a/SIRT1 pathway in osteoarthritis.

Background: Osteoarthritis (OA) is the most common degenerative disease in joints among elderly patients. Senescence is deeply involved in the pathogenesis of osteoarthritis. Metformin is widely used as the first-line drug for Type 2 diabetes mellitus (T2DM), and has great potential for the treatment of other aging-related disorders, including OA.

Associations between constipation, overeating, and depression: A survey of Chinese oldest-old and centenarians.

Objectives: Depression is a common disease of elderly population, with a global prevalence of more than 20%. Few studies have involved the associations of constipation and overeating with depression, especially in the elderly population. We aimed to address these associations in Chinese oldest-old and centenarians.

Clinical outcomes of negative pressure wound therapy with instillation vs standard negative pressure wound therapy for wounds: A meta-analysis of randomised controlled trials.

Negative pressure wound therapy (NPWT) with or without instillation has been extensively applied for patients with multiple wound types. Whether NPWT with instillation is superior to NPWT alone is not known. This study aims to compare the efficacy between negative pressure wound therapy with instillation (NPWTi) and standard negative pressure wound therapy for wounds.

Oscillatory properties of class C notifiable infectious diseases in China from 2009 to 2021.

Background: Epidemics of infectious diseases have a great negative impact on people's daily life. How it changes over time and what kind of laws it obeys are important questions that researchers are always interested in. Among the characteristics of infectious diseases, the phenomenon of recrudescence is undoubtedly of great concern.

A Novel Anatomical Locking Guide Plate for Treating Acetabular Transverse Posterior Wall Fracture: A Finite Element Analysis Study.

Objective: To improve the treatment of the acetabular transverse posterior wall fracture (ATPWF), a novel anatomical locking guidance plate (NALGP) was designed and compared with traditional fixations using finite element analysis.

Methods: The ATPWF model was constructed using the three-dimensional finite element model of the half pelvis via the Mimics software and three internal devices were used to fix this model: the posterior-column locking plate with anterior-column screws (PCLP), double-column locking plates (DCLP), and NALGP. Next, mesh division was conducted by solid 187 tetrahedral elements in the workbench software.