Bruceine A ameliorates ulcerative colitis via macrophage polarization: Targeting HSP90-mediated IL-17 signaling and NF-κB activation.

Background: Bruceine A (BA), a natural quassinoid compound derived from the fruit of Brucea javanica, has demonstrated diverse pharmacological activities. However, the treatment effectiveness of BA against ulcerative colitis (UC) and its underlying mechanisms of action are yet to be fully elucidated.

Purpose: To explore the effects of BA against UC and uncover its underlying mechanisms, with a particular focus on its influence on inhibiting macrophage M1 polarization via the IL-17/NF-κB pathway.

Distinctive clinical and radiological characteristics of persistent super-multiple ground-glass pulmonary nodules.

The clinical characteristics and pathophysiological processes of super-multiple ground-glass nodules (GGNs) remain poorly understood due to their rare incidence. This retrospective-prospective study aimed to elucidate these aspects by analyzing 75 patients with "super-multiple GGNs," having more than five persistent nodules, each measuring at least 5 mm, identified from a larger cohort of 2589 patients. We compared these patients with those having solitary GGNs (N = 691) and 2-5 GGNs (N = 458) to evaluate clinical and radiological characteristics.

The role of Na,K‑ATPase in lung diseases (Review).

Na,K‑ATPase, commonly referred to as the sodium pump, is known for its essential function as an ion pump, which is key for transporting Na and K across plasma cell membranes. Additionally, Na,K‑ATPase has multiple biological functions, independent of ion pumping, which are involved in regulating cell proliferation, apoptosis, differentiation and other processes associated with the development and progression of various diseases; particularly cancer, cardiovascular diseases, nervous system diseases, kidney diseases and lung diseases. As a potential therapeutic target, Na,K‑ATPase may represent a novel strategy for treating these diseases in the future.

A Case Report of Aggressive Angiomyxoma in the Buttock of a Female.

Aggressive angiomyxoma presents distinctive MRI features like "whirl sign" and "layering sign." Laparoscopic combined with perianal incision can minimize bleeding and organ damage risks for pelvic-extending tumors. Surgical excision with negative pressure drainage aids wound healing.

Mesenchymal stem cells in treating human diseases: molecular mechanisms and clinical studies.

Mesenchymal stem cells (MSCs) have emerged as a highly promising strategy in regenerative medicine due to their self-renewal, pluripotency and immunomodulatory properties. MSCs are nonhematopoietic, multipotent stem cells that can differentiate into various mesodermal lineages and modulate the immune system. The therapeutic potential of MSCs from different tissues has been widely explored in preclinical models and clinical trials for human diseases, ranging from autoimmune diseases and inflammatory disorders to neurodegenerative diseases and orthopedic injuries.

The role of microbiota in nonalcoholic fatty liver disease: mechanism of action and treatment strategy.

Non-alcoholic fatty liver disease (NAFLD) is now the most prevalent chronic liver disease worldwide, ranging from simple hepatic steatosis to non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma. It poses a significant public health challenge. Growing evidence indicates that the gut microbiota plays a key role in the development and progression of NAFLD.

Osteocytic vinculin controls bone mass by modulating Mef2c-driven sclerostin expression in mice.

The focal adhesion (FA) is the structural basis of the cell-extracellular matrix crosstalk and plays important roles in control of organ formation and function. Here we show that expression of FA protein vinculin is dramatically reduced in osteocytes in patients with aging-related osteoporosis. Vinculin loss severely impaired osteocyte adhesion and dendrite formation.

Refractory Gout and Metabolic Syndrome in a Chinese Cohort: A Propensity Score Matching and Nonlinear Relationship Analysis.

Objective: The coexistence of refractory gout and metabolic syndrome may worsen patient prognosis, but the association and the nonlinear relationships with clinical parameters have not been fully elucidated. This study aimed to explore this association and reveal its potential nonlinear patterns in a Chinese cohort.

Methods: This retrospective study included clinical data from 4111 gout patients from a single center in Tianjin, China between 2014 and 20234.

Bioinformatic screen with clinical validation for the identification of novel stool based mRNA biomarkers for the detection of colorectal lesions including advanced adenoma.

Messenger RNA (mRNA) stool based biomarkers represent a promising approach for the diagnosis of colorectal cancer (CRC) and advanced adenoma (AA). But it is unclear which mRNA biomarkers have the most clinical utility. This study aims to partially fill this gap by performing an analysis which first ranks genes based on their expression profile in publicly available RNA-seq tissue datasets.

IL-6 Mediated Neurogenic Inflammation Regulated by the DRG Macrophages Exacerbates Imiquimod-Induced Psoriasis-Like Skin Lesions in Mice.

Neuroimmunological mechanisms are essential for maintaining bodily homeostasis. Abnormal activation of these mechanisms is significantly linked to various skin disorders and constitutes a significant component in the development of these diseases. However, the involvement of neuroimmunological interactions in psoriasis pathogenesis is not yet fully understood.

Design and Synthesis of Novel Nitrofurantoin Derivatives as Antibacterial Agents Against Acinetobacter Baumannii.

Acinetobacter baumannii, identified by the World Health Organization (WHO) as one of the first batches of antibiotic-resistant bacteria in urgent need of new antibiotics, poses a great threat to global health. Nitrofurantoin is a kind of broad-spectrum antibacterial drug, which is usually used to treat urinary tract infections (UTIs) in clinics. A.

Glymphatic dysfunction associated with cortisol dysregulation in major depressive disorder.

Cortisol dysregulation plays a critical role in the pathophysiology of depression, but its exact impact on the brain remains unclear. In this cross-sectional study, 210 participants, including 164 depressed patients and 46 healthy controls (HCs), were assessed. Glymphatic circulation was evaluated on Magnetic Resonance Imaging via choroid plexus (CP) volume fraction, perivascular space (PVS) volume fraction, fractional volume of extracellular-free water (FW), and diffusion tensor imaging along the perivascular space (DTI-ALPS) index.

Implication of Bimodal Magnetic Resonance and Fluorescence Imaging Probes in Advanced Healthcare: Enhancing Disease Diagnosis and Targeted Therapy.

Molecular imaging probes hold great promise in disease diagnostics and their therapeutic interventions. However, a single imaging modality sometimes lacks efficiency in all kinds of diseases. Conditions such as cancer, cardiovascular disorders, and neurodegenerative diseases critically require multimodal imaging to characterize complex biological environments accurately.

Repurposing Etalocib suppresses multidrug-resistant Staphylococcus aureus by disrupting the bacterial membrane.

Background: The emergence of multidrug-resistant (MDR) Staphylococcus aureus (S. aureus) seriously poses a serious threat to human health and presents a significant clinical challenge. Therefore, it is urgent to explore alternative treatments and develop novel antimicrobial agents.

PRODH2-Mediated Metabolism in the Bone Microenvironment Promotes Breast Cancer Metastasis.

Breast cancer (BC) frequently metastasizes to the bone, but treatment options for bone metastatic breast cancer are limited. Amino acid metabolism is reprogrammed in the bone metastatic microenvironment, suggesting that it could represent a therapeutic vulnerability. In this study, we focused on metabolism of hydroxyproline (Hyp), a key amino acid resulting from bone collagen degradation, which serves as a critical biomarker for bone metastases.

Identification of SEC16B as a novel regulator of glucose homeostasis.

Aims/hypothesis: Glucose homeostasis, essential for metabolic health, requires coordinated insulin and glucagon activity to maintain blood glucose balance. Dysregulation of glucose homeostasis causes hyperglycaemia and glucose intolerance, hallmark features of type 2 diabetes. While SEC16 homologue B (SEC16B), an endoplasmic reticulum export factor, has been linked to obesity, type 2 diabetes and lipid metabolism, its role in glucose regulation remains poorly defined.

Opto-magnetic optimization enhances the multimodal therapeutic and diagnostic (UCL/- MRI) potential of GdOF against MDA-MB-231.

A novel Yb, Er co-doped GdOF-based nanoprobe with integrated multimodal functionalities has been designed and optimized for simultaneous pH-responsive drug release, photothermal-photodynamic therapy (PTT-PDT), and dual-mode upconversion luminescence and magnetic resonance imaging. The nanoprobe comprises polydopamine (PDA)-coated Yb, Er co-doped GdOF nanoparticles, functionalized with NH-PEG-NH and hyaluronic acid (HA) to provide physical stability and impart CD44-targeting specificity, while doxorubicin (DOX) is loaded for chemotherapy. In this proof-of-concept demonstration, we show that upon 980 nm (0.

Erythropoietin (EPO) Alleviates Chronic Stress-Induced Depression by Modulating SIRT1-Mediated Mitochondrial Function.

Mitochondrial dysfunction is a hallmark of many psychiatric disorders, and SIRT1 signaling plays a critical role in regulating mitochondrial dynamics, function, and autophagy. This study investigated the interplays between erythropoietin (EPO), mitochondrial protection, and SIRT1 signaling in depression. Chronic restraint stress (CRS)- induced depression mouse model and CORT-treated HT22 cells were employed, which were subsequently treated with EPO.

Efficacy of a Novel Continuous Irrigation Mode in Endoscopic Ear Surgery for External Auditory Canal Cholesteatoma.

BACKGROUND Cholesteatoma of the external auditory canal (EACC) is a destructive lesion requiring endoscopic surgical resection, but intraoperative lens contamination and postoperative epithelialization delays remain challenges. The rationale for this study was to investigate whether a novel continuous irrigation system could optimize surgical visibility, reduce procedural burdens, and improve postoperative outcomes in EACC management. MATERIAL AND METHODS A retrospective comparative cohort study of 66 patients undergoing surgery for EACC at Shenzhen Nanshan People's Hospital (January 2022 to December 2024) was conducted.

TMAO regulates OTUB1-mediated SLC7A11 stability to promote NAFLD progression.

Trimethylamine N-oxide (TMAO) is a metabolite of the intestinal microbiota and is closely associated with the occurrence and development of Non-alcoholic fatty liver disease (NAFLD). Ferroptosis is a novel form of cell death and an important pathological mechanism exacerbating NAFLD. However, whether TMAO can promote ferroptosis and worsen NAFLD, as well as its related mechanisms, has not been studied.

Title: clonal hematopoiesis of indeterminate potential and the risk of breast cancer a UK Biobank cohort study.

Objective: This study aims to investigate the association between clonal hematopoiesis of indeterminate potential (CHIP) and the risk of breast cancer.

Methods: We analyzed data from the UK Biobank, initially comprised 502,170 participants who met our inclusion criteria. Baseline data on age, body mass index (BMI), alcohol consumption, smoking habits, diet quality scores, physical activity levels, and health status.

Comprehensive review on emerging nanotechnologies for combating COVID-19 and future pandemic preparedness.

Since its emergence in China in December 2019, the outbreak of COVID-19 caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has escalated into a global pandemic emergency, demanding immediate and coordinated international action. This comprehensive review offers a broad, interdisciplinary perspective, exploring how advancements in nanotechnologies can aid in the battle against COVID-19 and other infectious diseases, with an emphasis on future pandemic preparedness. By analyzing the virus's life cycle, we identify key points where nanotechnology can be effective.

Association between the triglyceride-glucose index and severe left main and/or three-vessel disease in patients with non-ST-segment elevation myocardial infarction: a dual-centre retrospective study.

Objective: This study aimed to investigate the relationship between the triglyceride-glucose (TyG) index and the presence of severe left main and/or three-vessel disease (LM/3VD) evaluated by SYNTAX score.

Design: Cross-sectional study.

Setting: Shenzhen Nanshan People's Hospital and The First Affiliated Hospital of Jinan University.

Clinical and Brain MRI Characteristics of Patients with Anti-N-Methyl-d-Aspartate Receptor Encephalitis: A 10-Year Retrospective Study.

Introduction: The aim of this study was to investigate the diagnostic utility of brain Magnetic resonance imaging (MRI) in anti-N-methyl-d-aspartate receptor encephalitis (anti-NMDAR encephalitis) and analyze the relationship between clinical and brain MRI characteristics and disease prognosis.

Methods: A retrospective analysis was conducted on forty-six (59% female, median age: 24.5 years) clinically identified anti-NMDAR encephalitis patients from December 2012 to April 2022.

Enhanced Detection of Prostate Cancer Lesions on Biparametric MRI Using Artificial Intelligence: A Multicenter, Fully-crossed, Multi-reader Multi-case Trial.

Rationale And Objectives: To assess artificial intelligence (AI)'s added value in detecting prostate cancer lesions on MRI by comparing radiologists' performance with and without AI assistance.

Materials And Methods: A fully-crossed multi-reader multi-case clinical trial was conducted across three institutions with 10 non-expert radiologists. Biparametric MRI cases comprising T2WI, diffusion-weighted images, and apparent diffusion coefficient were retrospectively collected.