Magnetically actuated multimodal bioelectronic catheter for minimally invasive surgery and sensing.

Small-scale magnetically actuated catheters capable of remote active navigation have promising applications in minimally invasive surgeries. However, existing fabrication techniques hinder their integration with multimodal sensing components, especially since embedding rigid electronic components within the catheters may diminish their flexibility and controllability. Here we report a magnetically actuated bioelectronic catheter with the in situ multiplexed biosensing of multiple types of metabolite or ion simultaneously.

Aligning organ-specific toxicities with formulation strategies: a rational design approach to chemotherapy optimization.

Chemotherapy-induced toxicity remains a persistent challenge in oncology, where multi-organ injury continues to limit clinical outcomes despite decades of drug optimization and formulation innovation. Although mechanistic studies have elucidated key pathways of damage, current formulation strategies often overlook organ-specific pathophysiology, resulting in nonspecific mitigation approaches. This review fills a methodological gap by introducing a toxicity-informed framework that integrates organ-specific injury mechanisms with formulation design principles to support rational chemotherapy optimization.

Discovery of novel 1,2,4-triazole schiff bases hybridized with 1,4-naphthoquinones as potent STAT3 inhibitors.

Signal transducer and activator of transcription 3 (STAT3) is closely related to a variety of cancers. The research of novel STAT3 inhibitors is an important and meaningful project for pharmaceutical chemist. In this study, 10 novel 1,4-naphthoquinones carrying 1,2,4-triazole derivatives were synthesized via a four-step synthesis starting from 2-hydroxynaphthalene-1,4-dione.

Development of New Blood Immunoassay and Biomarkers for Tau in the Diagnosis of Alzheimer's Disease.

Post-translational modifications, such as truncation facilitated by proteases and phosphorylation mediated by protein kinases, play pivotal roles in Tau protein function and cellular processes. The detection of distinct Tau forms in plasma has garnered significant interest in the scientific and translational communities. We discovered monoclonal antibodies (mAbs) using the hybridoma technique by immunizing mice with different Tau proteins.

Copper-manganese hybrid nanogel for MRI-guided combined photothermal and chemodynamic tumor theranostics.

Bridging tumor diagnosis and therapy remains a major challenge, largely due to the clinical separation of imaging and treatment, compounded by the low relaxivity of conventional MRI contrast agents. To address these limitations, we developed a copper-manganese hybrid nanogel (CMNG) the incorporation of Mn ions and CuS nanoparticles within a cross-linked polymeric network. This multifunctional design enables -weighted MRI-guided photothermal-chemodynamic therapy.

Microenvironment-Responsive Injectable Microspheres for Osteoarthritis Treatment via Oxidative Stress Inhibition and Sustained Lubrication.

Oxidative stress imbalance and inadequate lubrication are the primary symptoms of osteoarthritis (OA), and they are also significant factors contributing to the progression of OA. Herein, an injectable hydrogel microsphere designed is presented to mitigate the progression of OA, comprising gelatin methacryloyl (GelMA), methacrylated hyaluronic acid (HAMA), 3-acrylamide-phenylboronic acid (3-AAPBA), chitin nanocrystals (ChNCs), and naringin (Nar). Specifically, positively charged ChNCs facilitated adhesion of microspheres to cartilage and enhanced their lubrication function.

Hypoxia and TTR dysregulation in astrocytes from Parkinson's disease with a specific mitochondrial haplogroup: A single-cell analysis.

Mitochondrial DNA variants have been linked to cognitive progression in Parkinson's disease; however, the mechanisms by which mitochondrial DNA variants or haplogroups contribute to this process remain unclear. In the present study, we analyzed single-nucleus RNA sequencing data from 241 post-mortem brain samples across five regions to investigate the dysregulatory mechanisms associated with mitochondrial DNA haplogroup H and haplogroups J, T, and U#. Our findings revealed significant alterations in the proportions of astrocyte subtypes CHI3L1 and GRM3 in the neocortical regions of haplogroup H.

Physio-biochemical regulation of drought resistance in tree species within dryland plantations.

Drought-resistance strategies play a crucial role in determining tree resilience and mortality. During drought, stomatal closure limits photosynthesis and triggers the overproduction of reactive oxygen species (ROS). This process may decrease carbohydrate availability, which is key for antioxidant defense and osmoregulation.

Hyperbaric oxygen augments Doxil antitumor efficacy by reducing tumor-induced lactate.

Compared to healthy individuals, cancer patients exhibit significantly elevated lactate. While numerous studies have revealed the critical role of lactate in fostering an immunosuppressive tumor microenvironment, the effects of lactate on cancer nanomedicine (e.g.

Capsid structure of phage SPO1 reveals novel minor capsid proteins and insights into capsid stabilization.

SPO1-related bacteriophages are promising candidates for phage therapy. We present the 3.0 Å cryo-electron microscopy (cryo-EM) structure of the SPO1 capsid with a triangulation number T = 16, enabling the construction of an atomic model comprising the major capsid protein and three types of minor capsid proteins: gp29.

Global Circulation Dynamics and Its Determinants of Dengue Virus: A Network Evolution and Model Study from 1990 to 2019.

As dengue is an increasing global health threat, a better understanding of the global circulation dynamics and its determinants would be helpful for precise prevention and control of dengue. The dynamics of global circulation of the four dengue virus serotypes were explored utilizing genetic sequences through a network-based method. Four new circulation indicators, including local intensity, betweenness centrality, tip frequency, and persistence time, were defined.

Genome-wide characterization and expression analysis of the growth-regulating factor family in Mikania micrantha.

Background: Growth-regulating factors (GRFs) are plant-specific transcription factors involved in growth, development, and stress responses. Mikania micrantha, a highly invasive weed, displays rapid growth and adaptability, yet the GRF gene family in this species remains largely unexplored.

Results: We identified and characterized 16 GRF genes in M.

Two Cases of Charcot-Marie-Tooth Disease Diagnosed in a 53-Year-Old Mother and a 24-Year-Old Daughter.

BACKGROUND Charcot-Marie-Tooth disease (CMT) is the most common hereditary peripheral neuropathy, affecting an estimated 17.7-40 per 100 000 population. CMT exhibits diverse clinical manifestations, including gradually progressive bilateral atrophy, weakness of the lower-extremity muscles, sensory abnormalities, and abnormal nerve conduction velocities or amplitudes.

Mechanism and function of GPR3 regulated by a negative allosteric modulator.

Allosteric modulators have gained substantial interest in current GPCR drug discovery. Here, we present a mechanism of allosteric modulation involving the dimerization of GPR3, a promising drug target for metabolic diseases and central nervous system disorders. We show that GPR3 forms constitutive homodimers in live cells and reveal that the inhibitor AF64394 functions as a negative allosteric modulator (NAM) specifically targeting dimeric GPR3.

Bioactive Spirocyclic C-Arylglycosides From the Fungal-Fungal Co-Culture of Pestalotiopsis sp. and Nigrospora sp.

Introduction: In this study, two new papulacandin analogs (1-2), together with 12 known compounds (3-14), were identified from the co-culture of two endophytic fungi, Pestalotiopsis sp. J025 and Nigrospora sp. Wn-2-2, which were isolated from Wikstroemia nutans Champ.

Efficacy and safety of immunotherapy in anaplastic thyroid carcinoma: a systematic review and meta-analysis.

Background: Anaplastic thyroid carcinoma (ATC) is a rare, aggressive solid tumor with poor prognosis. Traditional treatment such as surgery, radiotherapy and chemotherapy have limited therapeutic effects. In recent years, immunotherapy is changing the treatment pattern of them.

A copper sulfide/glucose oxidase/elesclomol nanoplatform for photothermal enhanced copper-induced toxicity/chemodynamic tumor combination therapy.

Despite being more effective than single treatments for cancer, combination therapy poses a challenge in integrating multiple modalities. In this study, we propose a nanoplatform (CuS@GOx@ES) that integrates chemodynamic therapy (CDT), starvation therapy (ST), photothermal therapy (PTT), and copper-induced toxicity for enhanced cancer treatment. CuS nanoparticles, with their large surface area, are ideal for CDT, while glucose oxidase (GOx) depletes tumor glucose for ST and catalyzes HO production for a Fenton-like reaction.

Thermodynamic Miscibility-Guided Engineering of Bismuth-Tin Janus Catalysts for Durable Electrocatalytic CO Reduction.

Interfaces in heterogeneous bimetallic catalysts play a pivotal role in providing rich active sites and accelerating charge transfer during reaction process. However, designing an interface-rich catalyst with sufficient exposed active sites is crucial yet challenging. Janus catalysts containing bifunctional surfaces segregated by interfaces can boost the performance of electrochemical CO reduction by optimizing electronic structure and reaction pathway.

Intraoperative pathogen rapid detection on chip.

During surgery, purulent fluid containing pathogens may be found at the surgical site. Pathogens in purulent fluid can cause sepsis if disseminated into the bloodstream. Therefore, intraoperative detection of pathogens in purulent fluid is critical for guiding surgeons in selecting surgical management and antibiotic therapy.

Heterozygous Kctd5 knockout mice exhibit abnormal lipid metabolism.

The KCTD gene family is conserved across species, yet the knowledge of its function is limited. Recently, increasing studies focused on KCTD5 emerged. The functions of KCTD5 and its associations with various diseases were revealed.

Automatic Diagnosis of Left Valvular Heart Disease Based on Artificial Intelligence Stethoscope.

Background: Valvular heart disease (VHD) remains underdiagnosed and results in serious complications. Early screening for VHD facilitates enhanced clinical management.

Objectives: This study aim to develop an artificial intelligence-based stethoscope model for detecting left-sided VHD, including aortic stenosis, aortic regurgitation, mitral stenosis, and mitral regurgitation.

Magnetic Kirigami Metasurfaces with Reprogrammed Multifunctionalities.

Kirigami metasurfaces are two-dimensional engineered structures that leverage the principles of kirigami, the art of paper cutting, to create reconfigurable properties, such as selective transmission tunability, tunable refractive index, and shape-morphing. Although existing kirigami metasurfaces show applications in electromagnetic wave modulation, light and droplet manipulation, crawling locomotion, and actuators, their functionality remains limited, particularly at the nanoscale. Furthermore, reconfiguration of these systems is typically restricted to tethered methods such as mechanical stretching or wired electrical inputs.

Evaluated dietary quality is associated with reduced probability of epilepsy.

Background: The occurrence of epilepsy is significantly associated with the intake of specific nutrients such as calcium. However, the potential association between overall dietary quality and epilepsy remains undetermined.

Methods: Analytical data were retrieved from three consecutive cycles (2013-2018) of the National Health and Nutrition Examination Survey.

Temporal Shifts in Climate-Influenza Dynamics: A Multi-Subtype Analysis in Southern China Spanning the COVID-19 Era.

The COVID-19 pandemic disrupted global influenza transmission. We aimed to elucidate how meteorological and air pollution drivers influenced seasonal influenza A subtypes and B lineage in Southern China pre-, during-, and postpandemic. We analyzed weekly influenza surveillance data from Southern China (2011-2024) and corresponding meteorological data.

Mapping the Global Antigenic Evolution of Human Influenza A/H3N2 Neuraminidase Based on a Machine Learning Model - 1968-2024.

Introduction: Human influenza A/H3N2 imposes a substantial global disease burden. Beyond hemagglutinin (HA), neuraminidase (NA) also plays a critical role in the antigenic evolution of influenza viruses. However, a comprehensive understanding of NA antigenic evolution remains lacking.