Microenvironment-Responsive Injectable Microspheres for Osteoarthritis Treatment via Oxidative Stress Inhibition and Sustained Lubrication.

Oxidative stress imbalance and inadequate lubrication are the primary symptoms of osteoarthritis (OA), and they are also significant factors contributing to the progression of OA. Herein, an injectable hydrogel microsphere designed is presented to mitigate the progression of OA, comprising gelatin methacryloyl (GelMA), methacrylated hyaluronic acid (HAMA), 3-acrylamide-phenylboronic acid (3-AAPBA), chitin nanocrystals (ChNCs), and naringin (Nar). Specifically, positively charged ChNCs facilitated adhesion of microspheres to cartilage and enhanced their lubrication function.

Glucose-Responsive Self-Rolling Antioxidant Hydrogel Actuators for a Cell Culture Platform.

Three-dimensional (3D) cell culture technology can mimic the physiological characteristics of tissues and organs, making it highly suitable for cell therapy, organ chips, and tissue engineering applications. However, achieving a uniform cell distribution within the 3D matrix while mitigating the effects of reactive oxygen species (ROS) accumulation generated during the 3D cell culture remains a critical challenge. Hydrogel actuators, with their excellent bioactivity and controllable self-rolling behavior, provide an optimal microenvironment for the 3D cell culture.