Implication of Bimodal Magnetic Resonance and Fluorescence Imaging Probes in Advanced Healthcare: Enhancing Disease Diagnosis and Targeted Therapy.

Molecular imaging probes hold great promise in disease diagnostics and their therapeutic interventions. However, a single imaging modality sometimes lacks efficiency in all kinds of diseases. Conditions such as cancer, cardiovascular disorders, and neurodegenerative diseases critically require multimodal imaging to characterize complex biological environments accurately.

Opto-magnetic optimization enhances the multimodal therapeutic and diagnostic (UCL/- MRI) potential of GdOF against MDA-MB-231.

A novel Yb, Er co-doped GdOF-based nanoprobe with integrated multimodal functionalities has been designed and optimized for simultaneous pH-responsive drug release, photothermal-photodynamic therapy (PTT-PDT), and dual-mode upconversion luminescence and magnetic resonance imaging. The nanoprobe comprises polydopamine (PDA)-coated Yb, Er co-doped GdOF nanoparticles, functionalized with NH-PEG-NH and hyaluronic acid (HA) to provide physical stability and impart CD44-targeting specificity, while doxorubicin (DOX) is loaded for chemotherapy. In this proof-of-concept demonstration, we show that upon 980 nm (0.

Research Advances in Hydration Status and Kidney, Liver, and Cardiovascular Health, and Tailored Water Intake Recommendations for Chinese Children.

Suboptimal hydration status has increasingly been recognized as a risk factor for the progression of chronic diseases. A nationwide survey conducted in China found that 82% of children aged 6 to 17 years failed to meet the recommended daily total water intake of 1600-2500 mL. On average, boys consumed 1603 ± 731 mL per day, while girls consumed 1487 ± 661 mL per day, placing them at a higher risk of dehydration.

Unraveling the role of deuterium in cancer: mechanisms, detection techniques, and therapeutic potential.

Deuterium, an element recognized for its close association with cancer, is involved in every stage from tumorigenesis and basic research methodologies to clinical diagnosis, therapeutic interventions, and drug development. Several significant findings have emerged in this field. This review explores the potential mechanisms by which deuterons influence cancer initiation and progression in the form of deuterium oxide including deuterium-enriched water (DEW) and deuterium-depleted water (DDW).

Global and regional burden of congenital birth defects, 1990-2021: persistent healthcare disparities and emerging challenges from non-fatal health burden.

Introduction: Approximately 3%-6% of infants were born with congenital birth defects worldwide every year, which ranked as the third leading cause of deaths among the population under 20 years of age in 2021.

Methods: By adopting the methodology from Global Burden of Disease Study 2021, we systematically analysed the burden and temporal trend of congenital birth defects at the global and regional levels. Correlations between these metrics and Healthcare Access and Quality (HAQ) Index were investigated by the Spearman correlation analyses.

Dimensional reduction in CsAgBiBr enables long-term stable Perovskite-based gas sensing.

Halide perovskite gas sensors have a low gas detection limit at room temperature, surpassing the performance of traditional metal oxide chemiresistors. However, they are prone to structural decomposition and performance loss due to the lack of coordination unsaturated surface metal ions and sensitivity to environmental factors such as water, oxygen, heat, and light. To address this issue, we present a general strategy: replacing the cation Cs in inorganic perovskite CsAgBiBr with long-chain alkylamines.

Metabolically healthy abdominal obesity is associated with higher odds of left ventricular geometric remodeling in children: Evidence from two school-based studies in China.

Objectives: The association between metabolically healthy abdominal obesity (MHO) and subclinical cardiovascular outcomes in the general pediatric population remains largely unexplored. We aimed to investigate the relationship of MHO with left ventricular geometric (LVG) remodeling in Chinese children.

Methods: Data were obtained from two school-based cross-sectional studies in China, involving 2866 children aged 6-11 years.

Metagenomics reveals combined effects of microplastics and antibiotics on microbial community structure and function in coastal sediments.

Microplastics and antibiotics are emerging pollutants in marine environments, yet their combined effects on coastal sediments remain poorly understood. This study examined the impacts of microplastics and antibiotics on sediment properties and microbial communities through a 60-day laboratory simulation. Results showed that microplastics significantly reduced carbon, nitrogen, and phosphorus levels in sediments, while both antibiotics and combined pollution decreased phosphorus content.

A Transfer Learning Framework for Predicting and Interpreting Drug Responses via Single-Cell RNA-Seq Data.

Chemotherapy is a fundamental therapy in cancer treatment, yet its effectiveness is often undermined by drug resistance. Understanding the molecular mechanisms underlying drug response remains a major challenge due to tumor heterogeneity, complex cellular interactions, and limited access to clinical samples, which also hinder the performance and interpretability of existing predictive models. Meanwhile, single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for uncovering resistance mechanisms, but the systematic collection and utilization of scRNA-seq drug response data remain limited.

Three Circulating miRNAs Related to Non-Small-Cell Lung Cancer Progression: An Integrative Analysis of Their Biological Roles.

MicroRNAs (miRNAs) are crucial in physiological and pathological processes and serve as biomarkers for various diseases. We previously validated seven miRNA biomarkers and nine in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). In this study, we observed distinct clustering patterns of LUAD or LUSC tissues compared to paired normal tissues based on miRNA expression levels, suggesting the potential involvement of circulating miRNAs in non-small-cell lung cancer (NSCLC) progression.

Genetically Engineered IL12/CSF1R-Macrophage Membrane-Liposome Hybrid Nanovesicles for NIR-II Fluorescence Imaging-Guided and Membrane-Targeted Mild Photothermal-Immunotherapy of Glioblastoma.

It is a big challenge for precision therapy of glioblastoma, mainly due to the existence of blood-brain barrier (BBB), tumor immunosuppressive microenvironment (TIM), and lack of efficient treatment paradigms. Herein, a theranostic nanoplatform for the second near-infrared window (NIR-II) fluorescence imaging-guided membrane-targeted mild photothermal-immunotherapy of glioblastoma using genetically engineered CSF1R/IL12-macrophage membrane (MM)-liposome hybrid nanovesicles, is reported. By mimicking lipophilic membrane probe (Dil) with octadecyl chains, a NIR-II emissive photothermal dye (IRC18), which realizes labeling of nanovesicle lipid bilayers for biodistribution tracing, glioblastoma diagnosis, and molecular imaging of tumoral microenvironment, is synthesized.

The impact of school heavy metal exposure on children's gut microbiota: The mediating role of environmental microorganisms.

Heavy metals are toxic and harmful pollutants that can affect the school environment and the exposed children's health. This study collected dust samples and children's fecal specimens, and performed gene sequencing. We used eXtreme Gradient Boosting to determine the impact of heavy metals on environmental microorganisms and gut microbiota, while using the relative length of the quadrant and Fourth-corner analysis to explore the relationship among the three components.

Sleep quality is associated with stress in secondary school students.

Background: Secondary school students experience notable physiological and psychological changes and academic stressors, rendering them prone to poor sleep quality. We aimed to investigate impact of perceived academic stress and mental stress on sleep quality among secondary school students.

Methods: We conducted a two-stage cluster sampling cross-sectional study among 634 secondary school students in eight schools in Triyuga municipality, Nepal, from February to March 2022.

Deep Clustering-Based Immunotherapy Prediction for Gastric Cancer mRNA Vaccine Development.

Immunotherapy is becoming a promising strategy for treating diverse cancers. However, it benefits only a selected group of gastric cancer (GC) patients since they have highly heterogeneous immunosuppressive microenvironments. Thus, a more sophisticated immunological subclassification and characterization of GC patients is of great practical significance for mRNA vaccine therapy.

Morphology Optimization of Spinel Catalysts for High-Efficiency Photothermal Catalytic Upcycling of Polyethylene Terephthalate.

Thermocatalytic recycling of plastics is typically constrained by high energy input requirements, resulting in poor economic efficiency and necessitating the utilization of light power. Indeed, photothermal catalysis offers several advantages over traditional photocatalysis and enables more efficient use of light energy. In this study, unique octahedral spinel-structured cobalt manganese oxide (CoMnO) catalysts are prepared.

Lead-Free Halide Double Perovskite CsAgBiCl for HS Trace Detection at Room Temperature.

Hydrogen sulfide (HS) is an important respiratory biomarker of many diseases, and thus, developing HS gas sensors with low detection limits at low operating temperatures is essential for the early diagnosis of diseases in low-resource environments. Although lead halide perovskites have unique electronic and optical properties, the high toxicity of lead has prompted the development of alternative materials. In this study, CsAgBiCl was synthesized using a simple method.

Subnational Evidence for the Attributable Burden of Respiratory Infections in China's Population under 20: Challenges from Particulate Matter Pollution.

Respiratory infections and tuberculosis ranked as the second leading global causes of mortality in 2021. Following the methodology from the Global Burden of Disease Study (GBD) 2021, we aimed to estimate the attributable burden and risk factors of respiratory infections and tuberculosis among China's population under 20 from 1990 to 2021. In 2021, there were 652 million new cases and 12 699 deaths of respiratory infections and tuberculosis among people under 20 years old in China.

Exploring urban-rural inequities in older adults life expectancy: a case study in Zhejiang, China for health equity.

This study investigates the inequities in life expectancy among individuals aged 65 and above in urban and rural areas of Zhejiang Province, China, with a primary focus on promoting health equity among the older adults population. The objective is to analyze the trends and factors contributing to the urban-rural gap in life expectancy and to propose strategies for reducing this disparity. Data from the 2010 and 2020 statistical records and census data were analyzed using cohort life tables and gray correlation analysis.

Defect-Engineered Biomimetic Piezoelectric Nanocomposites With Enhanced ROS Production, Macrophage Re-polarization, and Ca Channel Activation for Therapy of MRSA-Infected Wounds and Osteomyelitis.

Antibiotic-resistant bacteria often cause lethal infections in both the surficial and deep organs of humans. Failure of antibiotics in resistant infections leads to more effective alternative therapies, like spatiotemporally controllable piezodynamic therapy (PZDT) with deep penetration. Currently, PZDT demands further investigation for improved treatment outcomes and the corresponding therapeutic mechanisms.

A multi-gene blood-based methylation assay for early diagnosis of colorectal cancer.

Background: Early detection for colorectal cancer (CRC) can enhance the patient prognosis. We aimed to validate the combined multi-gene detection in plasma of , , , and for early diagnosing of CRC in this prospective study.

Methods: Overall, 124 participants including 45 CRC patients, 8 advanced adenoma patients, 34 small polyp patients, and 37 normal controls who underwent colonoscopy were enrolled.

Research on autonomous navigation of mobile robots based on IA-DWA algorithm.

To improve the efficiency of mobile robot movement, this paper investigates the fusion of the A* algorithm with the Dynamic Window Approach (DWA) algorithm (IA-DWA) to quickly search for globally optimal collision-free paths and avoid unknown obstacles in time. First, the data from the odometer and the inertial measurement unit (IMU) are fused using the extended Kalman filter (EKF) to reduce the error caused by wheel slippage on the mobile robot's positioning and improve the mobile robot's positioning accuracy. Second, the prediction function, weight coefficients, search neighborhood, and path smoothing processing of the A* algorithm are optimally designed to incorporate the critical point information in the global path into the DWA calculation framework.

Response of wastewater treatment performance and bacterial community to original and aged polyvinyl chloride microplastics in sequencing batch reactors.

Microplastics (MPs) are prevalent in wastewater treatment systems, and their behavior is further complicated after undergoing aging processes. This study explored the impact of original and aged polyvinyl chloride (PVC) MPs on wastewater treatment performance and bacterial communities. Results revealed that Fenton-aging treatment induced surface roughening of the MPs and altered their chemical properties.

Dynamic Behavior and Energy Absorption of Typical Porous Materials under Impacts.

Porous materials are known for their excellent energy absorption capability and, thus, are widely used in anti-impact applications. However, how the pore shape and size impact the failure mechanism and overall behavior of the porous materials under impact loading is still unclear or limitedly touched. Instead of using homogeneous solids for the porous material model, pores with various shapes and sizes were implanted in a solid to establish the porous materials that have true porous structures, which permits exploration of the local failure mechanism.

Dehydration and Suboptimal Sleep Aggravate Early Renal Impairment in Children: Longitudinal Findings from the PROC Study.

Background: While dehydration is associated with pediatric renal impairment, the regulation of hydration status can be affected by sleep. However, the interaction of hydration and sleep on kidney health remains unclear.

Methods: We conducted a cohort study among 1914 healthy primary school children from October 2018 to November 2019 in Beijing, China.