Opto-magnetic optimization enhances the multimodal therapeutic and diagnostic (UCL/- MRI) potential of GdOF against MDA-MB-231.

A novel Yb, Er co-doped GdOF-based nanoprobe with integrated multimodal functionalities has been designed and optimized for simultaneous pH-responsive drug release, photothermal-photodynamic therapy (PTT-PDT), and dual-mode upconversion luminescence and magnetic resonance imaging. The nanoprobe comprises polydopamine (PDA)-coated Yb, Er co-doped GdOF nanoparticles, functionalized with NH-PEG-NH and hyaluronic acid (HA) to provide physical stability and impart CD44-targeting specificity, while doxorubicin (DOX) is loaded for chemotherapy. In this proof-of-concept demonstration, we show that upon 980 nm (0.

Credentials of chromone based probe as colorimetric sensor for the detection of Cu ion: design of test paper kit and potential anticancer activity.

3-(5-Chloro-2,3-dihydrobenzo[d]thiazol-2-yl)-4H-chromen-4-one (MCF) is spectroscopically characterised (FT-IR, UV-Vis, ESI-MS, NMR) and has been used for the chromogenic selective recognition of Cu ion in EtOH-HO (99:1, v/v) medium in presence of fourteen competitive ions and the limit of detection is 0.6 μM (WHO recommended the permissible limit, 20 μM). The Job's plot identifies the 1:1 M ratio of probe, MCF:Cu.

Kaempferol with Verapamil impeded panoramic chemoevasion pathways in breast cancer through ROS overproduction and disruption of lysosomal biogenesis.

Background: Reactive oxygen species (ROS) at low level promotes cell survival through lysosome induced autophagy induction. Glucose stress induced acidosis, hypoxia, ROS, upregulates markers related to cancer stemness and multidrug resistance. Also, lysosomal upregulation is proposed to be one of the important indicators of cell survival under ROS induced stress.

Interplay of gut microbiome, fatty acids, and the endocannabinoid system in regulating development, progression, immunomodulation, and chemoresistance of cancer.

The roles of gut microorganisms in cancer are diverse. Studies on metagenomics and bioinformatics have documented diverse microbial etiology in different tumors. Evidence supports that a commensal microbiome could provide a promising strategy to treat and prevent cancer through interference in several biologic processes, such as host cell survival and death, host immune function, inflammation, oncogenic signaling, and several hormone receptor signaling and detoxification pathways.

Kaempferol attenuates viability of ex-vivo cultured post-NACT breast tumor explants through downregulation of p53 induced stemness, inflammation and apoptosis evasion pathways.

Early onset of chemotherapy evasion is a therapeutic challenge. Chemotherapy-induced upregulation of stem cell markers imparts invasiveness and metastatic property to the resident tumor. The efficacy of Kaempferol in attenuating epithelial to mesenchymal transition has earlier been established in the breast cancer cell.

Antibiofilm and anticancer activities of unripe and ripe Azadirachta indica (neem) seed extracts.

Background: Antibiotic resistances of pathogens and breast cancer warrant the search for new alternative strategies. Phytoextracts can eradicate microbe-borne diseases as well as cancer with lower side effects compared to conventional antibiotics.

Aim: Unripe and ripe Azadirachta indica (neem) seed extracts were explored as potential antibiofilm and anticancer agents in combating multidrug-resistant infectious bacteria as well as anticancer agents against the MDR breast cancer cell lines.

Deregulation of the CD44-NANOG-MDR1 associated chemoresistance pathways of breast cancer stem cells potentiates the anti-cancer effect of Kaempferol in synergism with Verapamil.

Chemoresistance is an imminent therapeutic challenge for breast cancer. Previous evidence suggests that breast cancer stem cells (BCSC) develop resistance through upregulation of stemness and chemo-evasion markers viz. SOX2, OCT4, NANOG, MDR1 and CD44, following anticancer chemotherapeutic treatments.