Cr-Induced Structure Modulation and Near-Infrared Luminescence in Double Perovskite.

Cr-doped lead-free halide double perovskites (DPs) have recently emerged as promising near-infrared (NIR) phosphors, owing to their tunable optical properties. Herein, we report a Cr-doped CsAgNaInBiCl system exhibiting dual-band luminescence under 405 nm excitation and NIR-only luminescence under 808 nm excitation. Increasing Cr concentration induces a redshift and attenuation in self-trapped excitons (STEs) luminescence, while Cr luminescence first increases and then decreases.

Weight-adjusted waist index and mortality in diabetic retinopathy: a NHANES 1999-2018 cohort study.

Objective: The weight-adjusted waist index (WWI), an innovative indicator of central obesity, is still inadequately researched in relation to diabetic complications. This study sought to elucidate the relationship between WWI and all-cause as well as cardiovascular disease (CVD) mortality in US patients with diabetic retinopathy (DR).

Methods: We performed a retrospective cohort research with 1247 people in the United States diagnosed with diabetic retinopathy (DR).

Emulsifier-Free Emulsion Polymerization-Based Copper-Mediated Molecularly Imprinted Polymer for Vitamin B1 Extraction.

Here, we present a copper-mediated magnetic molecularly imprinted polymer (Cu-mMIP) as dispersive solid-phase extracting material (dSPE) for fast, selective, and specific extraction of a metabolic biomarker vitamin B1 (VB1) in complex biological matrices. With emulsifier-free emulsion polymerization using styrene and itaconic acid as functional co-monomers, Cu as central atom, and FeO nanoparticles (NPs) as core, the resulted Cu-mMIP addresses VB1's structural challenges (conformational flexibility, hydrophilicity) while enabling rapid magnetic separation (< 10 s). The Cu-mMIP demonstrates exceptional specificity for VB1, achieving an imprinting factor of 5.

Erratum: Diffusion MRI biomarkers predict the outcome of irreversible electroporation in a pancreatic tumor mouse model.

[This corrects the article on p. 1615 in vol. 8, PMID: 30210929.

Improving of 6 weeks of repeated sprint training on the aerobic and anaerobic power of college-age male rugby players.

Background: Rugby is characterized by the necessity for athletes to engage in high-intensity efforts followed by rapid recovery phases. Effective training methodologies that enhance both aerobic and anaerobic capacities are crucial for peak athletic performance in this sport. Objective: This study aimed to assess the efficacy of a 6-week repeated sprint training (RST) program in enhancing the aerobic and anaerobic power of collegiate male rugby players, compared to high-intensity interval training (HIIT).

Quantized Channels and Instability Modulation Strategy in Au/PDMS Single-Crack Evolution.

Controllable conductive channels in crack-based sensors are crucial for stable microdeformation detection, yet the random formation of disordered crack networks in conventional sensors hinders the precise analysis of single-crack contributions to sensing performance. We propose a stress-engineered single-crack architecture in Au/PDMS films, achieving control over conductive channel evolution through three distinct regimes: (I) nonpenetrating crack initiation, (II) metal point contact, and (III) fully penetrated fracture. High-resolution in situ monitoring reveals strain-quantized conductance in regime II, demonstrating ballistic transport with reproducible quantum steps (2e/ multiples).

Paclitaxel Attenuates Atherosclerosis by Suppressing Macrophage Ferroptosis and Improving Lipid Metabolism via the Sirt1/Nrf2/GPX4 Pathway.

Atherosclerosis is a leading cause of cardiovascular disorders such as coronary heart disease, heart failure, and stroke. Ferroptosis, a novel type of cell death, plays an important role in atherosclerosis progression, especially macrophage ferroptosis. Paclitaxel (PTX) is an antiproliferative drug that has been developed in recent decades and is helpful in the treatment of atherosclerosis.

Multiscale Dynamics from Picoseconds to Milliseconds: Bridging Spin Coherence and Metastable Photocharging in CsPbX Perovskite Quantum Dots.

All-inorganic lead halide perovskite quantum dots (PQDs) have attracted significant attention due to their exceptional optoelectronic properties and unique spin-related behaviors. This study investigates the interplay between hole spin coherence and photocharging processes in solution-processed CsPbCl PQDs by using time-resolved Faraday rotation spectroscopy. Our research reveals a room-temperature hole spin dephasing time of ∼60 ps and a hole factor of ∼1.

Enhanced Detection of Prostate Cancer Lesions on Biparametric MRI Using Artificial Intelligence: A Multicenter, Fully-crossed, Multi-reader Multi-case Trial.

Rationale And Objectives: To assess artificial intelligence (AI)'s added value in detecting prostate cancer lesions on MRI by comparing radiologists' performance with and without AI assistance.

Materials And Methods: A fully-crossed multi-reader multi-case clinical trial was conducted across three institutions with 10 non-expert radiologists. Biparametric MRI cases comprising T2WI, diffusion-weighted images, and apparent diffusion coefficient were retrospectively collected.

Combining radiomics and deep learning to predict liver metastasis of gastric cancer on CT image.

Objective: Our study aimed to explore the potential of deep learning (DL) radiomics features from CT images of primary gastric cancer (GC) in predicting gastric cancer liver metastasis (GCLM) by establishing and verifying a prediction model based on clinical factors, classical radiomics and DL features.

Methods: We retrospectively analyzed 1001 pathologically confirmed GC patients from June 2014 to May 2024, divided into non-LM (n=689) and LM groups (n=312). CT-based classic radiomics and DL features were extracted and screened to construct a DL-radiomics score.

CT-based deep learning radiomics analysis for preoperative Lauren classification in gastric cancer and explore the tumor microenvironment.

Purpose: This study aimed to investigate the usefulness of CT-based deep learning radiomics analysis (DLRA) for preoperatively differentiating Lauren classification in gastric cancer (GC) patients and explore the tumor microenvironment.

Methods: 578 patients were recruited from January 2015 to June 2024, and divided into the training cohort (n = 311), the internal validation cohort (n = 132), and the external validation cohort (n = 135). Clinical characteristics were collected.

Design of nano charcoal by reshaping inflammatory microenvironment as biofunctional wound nanomedicine.

Hemorrhagic wound management in severe trauma patients remains a vital clinical problem because of uncontrolled bleeding and inflammatory responses. Charcoal drugs have shown great potential for facilitating hemostasis and wound repair for more than two thousand years. Nevertheless, studies on the inherent biological activities of charcoal drugs and their corresponding pharmacological effects are far from satisfactory.

Orphan receptor GPR39: A potential therapeutic target for inflammatory diseases.

G-protein-coupled receptors (GPCRs) play a pivotal role in mediating responses to various hormones, neurotransmitters, and external stimuli, making them essential therapeutic targets for multiple conditions. GPR39, an orphan GPCR that detects changes in extracellular Zn levels, is widely expressed in diverse tissues such as the pancreas, gastrointestinal tract, liver, kidneys, skin, adipose tissue, and brain. Recent studies have increasingly highlighted the involvement of GPR39 in the pathogenesis and progression of inflammatory diseases.

Biocompatible Piezoelectric Elastomer for Self-Powered Electronics.

Piezoelectric elastomers suit the body's curvature and flexibility, making them promising for biomedicine, but they must be biocompatible for tissue contact. Traditional piezoelectric ceramics are rigid and toxic, and synthetic polymers, despite their flexibility, often require harmful organic reagents in fabrication, posing risks to biological safety. To attain a harmonious balance among biocompatibility, piezoelectricity, and elasticity, we designed a biocompatible piezoelectric elastomer by combining HOCH(CF)CHOH (HFPD) with a waterborne polyurethane (WPU) matrix.

CT Radiomics for Predicting Outcomes in HER2-Positive Surgically Resectable Advanced Gastric Cancer: A Preliminary Study.

Rationale And Objectives: Accurate risk stratification in human epidermal growth factor receptor 2-positive surgically resectable advanced gastric cancer (HER2-p SRAGC) can strengthen monitoring for high-risk patients, allowing timely HER2-specific treatment and potentially improving prognosis. Therefore, we aimed to develop a CT radiomics model for predicting outcomes in HER2-p SRAGC and compare it with the 8th edition TNM staging system.

Materials And Methods: 621 HER2-p SRAGC patients who received either radical gastrectomy or radical gastrectomy after neoadjuvant therapy or chemotherapy were retrospectively enrolled in two hospitals and assigned to a training (n=330), an internal validation (n=143) and an external validation (n=148) cohorts.

Amide proton transfer-weighted imaging and T1 mapping as diagnostic tools to evaluate high-risk histopathologic phenotypes before surgery in rectal adenocarcinoma and their correlation with Ki-67 expression:a two-center study.

Objectives: To investigate the application of amide proton transfer (APT)-weighted MRI, T1 mapping in evaluating the preoperative high-risk histopathologic phenotypes of rectal adenocarcinoma and their correlation with Ki-67 expression.

Materials And Methods: Retrospective collection of 178 confirmed cases of rectal adenocarcinoma from two centers (center 1: 97 cases, center 2: 81 cases). High-resolution T2WI, APT, T1 mapping, diffusion-weighted imaging (DWI), and Ki-67 staining were performed in all patients.

Magneto-Optically-Propelled Superhydrophobic Sponge for Efficient Volatile Organic Compounds Adsorption and Evaporation and Water Surface Transport.

As human activities intensify, volatile organic compounds (VOCs) in water pose growing threats to human health, ecosystems, and environmental stability. Conventional photothermal superhydrophobic sponges have shown promise in adsorbing and evaporating VOCs, but their effectiveness is limited by stationary adsorption and relatively low efficiency. Here, we introduce a photothermal-magnetic driven superhydrophobic sponge, synthesized with FeO and TiN nanoparticles, designed to significantly enhance both the mobility and adsorption capacity of VOCs.

Performance of MRI-based radiomics for prediction of residual disease status in patients with nasopharyngeal carcinoma after radical radiotherapy.

The purpose of this study was to determine if habitat radiomic features extracted from pretherapy multi-sequence MRI predict residual status in patients with Nasopharyngeal Carcinoma (NPC) after radical radiotherapy. The retrospective study enrolled 179 primary NPC patients, divided into training and validation cohorts at a 7:3 ratio. K-means clustering was employed to segment T2WI, CE-T1WI and FSCE-T1WI images, creating habitats within the volume of interest.

Reduced DTI-ALPS in H-type hypertension: insights into perivascular space function.

Recent studies suggest that glymphatic dysfunction plays a significant role in vascular cognitive impairment (VCI). Both hypertension and hyperhomocysteinemia are independent risk factors for VCI, and their combination is referred to as H-type hypertension (HHT). However, the impact of HHT on glymphatic function remains unclear.

Enhancing Feammox efficiency through riboflavin and humic acid: Nitrogen and iron transformation, energy metabolism, and microbial response.

Optimizing electron shuttles and revealing their mediating mechanisms are crucial for enhancing the ammonium (NH-N) oxidation coupled with Fe (III) reduction. In this study, anthraquinone-2,6-disulfonate (AQDs), riboflavin (RF), and humic acid (HA) were optimized in batch tests. The optimal dosages of 6, 2, and 8 mg/L for AQDs, RF, and HA resulted in average maximum NH-N removal of 80.

Nicotinamide mononucleotide ameliorates hypertriglyceridemia pancreatitis via NAD/SIRT1-mediated TXNIP suppression and NOTCH pathway for accelerated repair-associated processes.

Background & Aims: Acute pancreatitis (AP) is a life-threatening condition, and hypertriglyceridemia (HTG) is recognized as a factor exacerbating AP and impeding pancreatic regeneration. Nicotinamide mononucleotide (NMN), a precursor in the biosynthesis of nicotinamide adenine dinucleotide (NAD), is extensively utilized to restore NAD levels. However, the impact of NMN on HTG-AP has not been previously addressed, which prompted our investigation into its effects and underlying mechanisms in this study.

Comparison of MRI and CT based deep learning radiomics analyses and their combination for diagnosing intrahepatic cholangiocarcinoma.

Intrahepatic cholangiocarcinoma (iCCA) and other subtypes of primary liver cancer (PLC) have overlapping clinical manifestations and radiological characteristics. The objective of this study was to evaluate the efficacy of deep learning (DL) radiomics analysis, performed using computed tomography (CT) and magnetic resonance imaging (MRI), in diagnosing iCCA within PLC. 178 pathologically confirmed PLC patients (training cohort: test cohort = 124: 54) who underwent both CT and MRI examinations was enrolled.

Slight-Crosslinking: Opening a New Journey for the Intrinsic Elastification of Ferroelectric Polymers.

Elastic electronic materials are essential components in the next generation of wearable devices and soft robots. However, the development of elastic ferroelectric materials has lagged behind that of conductive and semiconductive materials. The successful realization of intrinsically elastic ferroelectrics through slight-crosslinking has opened a new path for making ferroelectric materials elastic.

Bio-inspired organic electrosense transistor for impalpable perception.

Artificial sense technologies predominantly rely on visual and tactile input, which often prove inadequate in obscured or opaque environments. Inspired by the natural electrosensory capabilities of electrogenic fishes, we introduce an organic electrosense transistor designed to detect electric fields generated by nearby objects, facilitating the creation of impalpable perception systems. Unlike traditional sensors, our electrosense transistor perceives bipolar electric fields with high sensitivity and stability.