Probiotics and Diet Modifications: A Holistic Approach to Tackling Helicobacter pylori with the Help of the Gut Microbiota.

Background: Helicobacter pylori (H. pylori) is a common gastrointestinal pathogen that can persist for decades and lead to diseases like gastritis, peptic ulcers, and gastric cancer. Conventional antibiotic treatments have limitations like resistance and side effects, requiring alternative therapies.

Exploration of the mechanism underlying the impact of artificial light on guinea pig ovarian function via proteomics and acetylation analyses.

Objective: This study aims to explore the effects of artificial light on ovarian function in female guinea pigs and the possible mechanism.

Methods: The levels of serum sex hormone expression in the natural light group (N) and LED group (L) were detected via ELISA. The differentially expressed proteins and changes to acetylation levels in the ovaries of female guinea pigs from both groups were analysed via 4D-DIA proteomics and 4D-DIA acetylation quantitative proteomics.

Assembly and characterization of the first mitochondrial genome of Phyllanthaceae: a case study of the ornamental aquatic plant Phyllanthus fluitans.

Phyllanthus fluitans, a member of the Phyllanthaceae, is a unique free-floating aquatic species exhibiting considerable ornamental value. In this study, we assembled the mitochondrial genome of P. fluitans representing the first mitochondrial genome report of the Phyllanthaceae family.

Clinical and Brain MRI Characteristics of Patients with Anti-N-Methyl-d-Aspartate Receptor Encephalitis: A 10-Year Retrospective Study.

Introduction: The aim of this study was to investigate the diagnostic utility of brain Magnetic resonance imaging (MRI) in anti-N-methyl-d-aspartate receptor encephalitis (anti-NMDAR encephalitis) and analyze the relationship between clinical and brain MRI characteristics and disease prognosis.

Methods: A retrospective analysis was conducted on forty-six (59% female, median age: 24.5 years) clinically identified anti-NMDAR encephalitis patients from December 2012 to April 2022.

Clinical science effects of different mydriatics on retinal and choroidal parameters in healthy adults observed by widefield swept-source optical coherence tomography.

Purpose: To assess retinal and choroidal changes following rapid mydriasis in healthy adults.

Methods: Seventy-one volunteers (71 right eyes) participated in a prospective randomised controlled trial. They were divided into two groups: tropicamide (n=36) and a mixture (tropicamide:phenylephrine=1:1, n=35) groups.

Online takeaway food consumption and its association with health among young and middle-aged urban residents in mainland China: a cross-sectional study.

Background: Although ordering food online has become a leading lifestyle factor among the Chinese urban population, its health impact is understudied. This study aims to examine this aspect, focusing on online takeaway food impacts related to foodborne illness, nutrition, and suboptimal health (i.e.

Comprehensive analysis of SPL gene family and miR156a/SPLs in the regulation of terpenoid indole alkaloid biosynthesis in Catharanthus roseus L.

Background: Catharanthus roseus (C. roseus), belongs to the dogbane family Apocynaceae, is the source of various terpenoid indole alkaloids (TIAs) with excellent antitumor properties, including vinblastine, vincristine, ajmalicine, serpentine, vindoline, and catharanthine. However, TIAs are widely used in clinical anticancer research, their content is extremely low in plants, and currently insufficient to meet market demand.

Multi-modal analyses of proteomic measurements associated with type 2 diabetes from the Project Baseline Health Study.

Background: Understanding diabetes at the molecular level can help refine diagnostic approaches and personalized treatment efforts.

Methods: We generated proteomic data from plasma collected from participants enrolled in the longitudinal observational cohort study Project Baseline Health Study (PBHS) (evaluated cohort, n = 738, 27.9% of the total PBHS cohort), and integrated those data with information from their medical history and laboratory tests to determine diabetes status.

Antler base (Cervus nippon Temminck) peptides modulate the NLRP3 inflammatory pyroptosis and Nrf2/HO-1/NQO1 signaling pathways to ameliorate osteoarthritis: a structural and mechanistic study.

Ethnopharmacological Relevance: Antler base (Cervus nippon Temminck), a traditional Chinese medicine, is categorized as deer antler. Antler base extracts can delay osteoarthritis (OA); however, the underlying molecular pathways and effective substances remain unclear.

Aim Of The Study: to clarify the potential mechanism of action and effective substance structure of Cervus nippon Temminck antler base peptides (CNCPs) in improving OA.

Natural killer cell dysfunction is associated with colorectal cancer with severe COVID-19.

Background: Severe acute respiratory syndrome coronavirus 2 induced coronavirus disease 2019 (COVID-19) has posed a great challenge to public health worldwide and also increased susceptibility to colorectal cancer (CRC). Natural killer (NK) cells serve as the first line of defense in the host's innate immune system, performing natural killing functions and mediating cytotoxicity against tumors and viruses. Therefore, a better understanding of NK cell cytotoxicity may facilitate the development of treatment strategies for CRC-associated with COVID-19.

YBX1-driven TUBB6 upregulation facilitates ocular angiogenesis via WNT3A-FZD8 pathway.

Pathological ocular neovascularization, a characteristic feature of proliferative ocular diseases, is a primary contributor to global vision impairment. The dynamics of tubulin are crucial in maintaining ocular homeostasis, closely linked to cellular proliferation and angiogenesis. Elucidating the molecular mechanisms driving this process is vital for formulating effective therapeutic strategies.

Estrogen-related receptor alpha (ERRα) controls the stemness and cellular energetics of prostate cancer cells via its direct regulation of citrate metabolism and zinc transportation.

Compared to most tumors that are more glycolytic, primary prostate cancer is less glycolytic but more dependent on TCA cycle coupled with OXPHOS for its energy demand. This unique metabolic energetic feature is attributed to activation of mitochondrial m-aconitase in TCA caused by decreased cellular Zn level. Evidence suggests that a small subpopulation of cancer cells within prostate tumors, designated as prostate cancer stem cells (PCSCs), play significant roles in advanced prostate cancer progression.

Structural Characterization and Anti-Gouty Nephropathy Potential of Polysaccharides from .

Polysaccharides derived from (DC.) Koidz. (ACP), a traditional Chinese medicine, were extracted and analyzed for their structural characteristics and anti-gouty nephropathy (GN) activity.

Novel progressive rod-cone degeneration mutation causes retinitis pigmentosa.

Retinitis pigmentosa (RP) is a genetic disorder often caused by single or multiple mutations. The progressive rod-cone degeneration (PRCD) gene is linked to retinal degeneration. This study identified a family affected by RP carrying a frameshift mutation (c.

Changes in the effective optical zone following hyperopic keratorefractive lenticule extraction.

Objective: To evaluate the longitudinal changes in the effective optical zone (EOZ) following hyperopic keratorefractive lenticule extraction (KLEx) and investigate factors influencing the EOZ.

Patients And Methods: This retrospective study included 27 patients who underwent hyperopic KLEx. According to the transition zone (TZ) sizes, they were divided into two groups: group A (21 eyes) with a 2.

Effects of Different Light Environments with Varying Spectral Composition on the Axial Lengths and Scleral Specificity Protein 1 and Collagen Type I Expression in Juvenile Guinea Pigs.

The study aimed to investigate changes in the eye axial length in juvenile guinea pigs and the expression of scleral specificity protein 1 (Sp1) and collagen type I (Col-I) under different light environments with varying spectral composition. The animals were randomly divided into five groups: natural light (N), LED light with a low colour temperature (L), E light (E), Fulia light (F), and Gulia light (G). Axial lengths were measured every two weeks, and the expression of Sp1 and Col-I in the sclera was assessed by immunohistochemistry, Western blot and RT-qPCR.

Development and validation of the Post-COVID Symptom Scale for Children/Youth (PCSS-C/Y).

This study aims to develop and validate the Post-COVID Symptom Scale for Children/Youth (PCSS-C/Y), which is a comprehensive tool for measuring the symptom burden of post-COVID-19 conditions-persistent symptoms after SARS-CoV-2 infection, commonly known as Long COVID-and its impact on health-related quality of life among children and adolescents. Parents of children and adolescents, adolescents, and young adults with and without a history of COVID-19 were invited to fill in a questionnaire from October 2022 to June 2023. There were 386 valid parent proxy-reported responses, 433 valid adolescent self-reported responses, and 324 valid young adult self-reported responses included in the final analysis.

Comparison of the Visual Outcomes and Optical Quality of Small Incision Lenticule Extraction and Toric Implantable Collamer Lens Implantation to Correct High Astigmatism.

Purpose: To compare 6-month visual outcomes and optical quality after small incision lenticule extraction (SMILE) and toric Implantable Collamer Lens (ICL) (STAAR Surgical Company) implantation for high myopia astigmatism.

Methods: This was a prospective non-randomized study. Overall, 88 eyes of 88 patients with high astigmatism (≥ 2.

Imbalances of Th1/Th2 and Tc1/Tc2 are Associated With Active Cytomegalovirus Infection in Infant Liver Transplant Recipients.

Background: Because cytomegalovirus (CMV) infection is one of the most common complications following liver transplantation (LT), it is important to analyze the impact of CMV infection on the LT-associated changes in T cells polarization. This study aimed to investigate T helper (Th) and T cytotoxic (Tc) cells polarization and their correlation in infant LT recipients with active CMV infection.

Methods: Twenty infant LT recipients with active CMV infection (the CMV group) and 20 recipients without CMV infection (the stable group) were enrolled.

DcWRKY15 positively regulates anthocyanin biosynthesis during petal coloration in Dianthus caryophyllus.

Petal pigmentation in carnations is closely associated with the biosynthesis of anthocyanins. This biosynthetic process is tightly regulated by transcription factors, which activate or repress key genes involved in anthocyanin production. Here, we aim to explore the mechanisms involved in the transcriptional regulation of anthocyanin biosynthesis in carnation petals.

Unraveling the web of defense: the crucial role of polysaccharides in immunity.

The great potential of polysaccharides in immunological regulation has recently been highlighted in pharmacological and clinical studies. Polysaccharides can trigger immunostimulatory responses through molecular identification, intra- and intercellular communication via direct or indirect interactions with the immune system. Various immunostimulatory polysaccharides or their derivative compounds interacts at cellular level to boost the immune system, including arabinogalactans, fucoidans, mannans, xylans, galactans, hyaluronans, fructans, pectin and arabinogalactans, etc.

AquaticTox: A Web-Based Tool for Aquatic Toxicity Evaluation Based on Ensemble Learning to Facilitate the Screening of Green Chemicals.

The widespread use of chemical products inevitably brings many side effects as environmental pollutants. Toxicological assessment of compounds to aquatic life plays an important role in protecting the environment from their hazards. However, animal testing approaches for aquatic toxicity evaluation are time-consuming, expensive, and ethically limited, especially when there are a great number of compounds.

Diffusiophoretically Mediated Nanopatterning by Solvent Nanodroplets on Polystyrene Surfaces.

Dissolution is a ubiquitous process in nature and industry. However, due to technical difficulties, the detailed dissolution process at the nanoscale has seldom been captured experimentally. In this study, we investigated the dissolution dynamics in the confinement of toluene surface nanodroplets on polystyrene (PS) thin films in oversaturated toluene/water mixture solutions.