Machine Learning for Predicting Thromboembolic Events Following Flow Diverter Treatment of Intracranial Aneurysms: A Multicenter Retrospective Study.

Introduction: Flow diverters (FD) have gradually become the preferred treatment option for complex and large intracranial aneurysms. Postoperative thromboembolic events (TEEs) are among the most common complications associated with endovascular treatment. However, widely applicable predictive tools for the occurrence of TEEs are currently lacking.

orchid: a systematic review.

Background: (L.) R. Br.

Durable Ceramicization-Induced Uncoated Superhydrophobic Surfaces for Anti-Icing Propeller Edges.

The chemical and mechanical instability of conventional coated decorative superhydrophobic anti-icing surfaces on propeller leading edges has been a major limitation for practical applications. Here, a self-starting, uncoated, and ultra-durable superhydrophobic anti-icing surface fabricated on silicone rubber via laser-induced ceramization microstructuring is demonstrated. The laser-processed surface achieves a water contact angle of 168° and a sliding angle of 0.

FUNDC1 drives cholangiocarcinoma progression via RAC1 interaction and ferroptosis suppression.

Cholangiocarcinoma (CCA) is a highly lethal epithelial malignancy that can arise at any site within the biliary tract. Our findings revealed that FUN14 domain-containing protein 1 (FUNDC1) expression was significantly elevated in CCA samples compared to matched peritumoral tissues. Survival analysis indicated that patients with high FUNDC1 expression had shorter overall survival.

[Clinical phenotype and genetic analysis of four cases of Epileptic encephalopathy caused by PCDH19 mutations].

Objective: To investigate the clinical phenotype and genotype features of children with Epileptic encephalopathy caused by PCDH19 mutations.

Methods: Four children with epilepsy caused by PCDH19 gene mutations who were treated at Shanghai Children's Medical Center from August 2015 to May 2024 were selected as study subjects. A retrospective study method was used to collect the clinical data of the patients.

Current research status of dynamic de-icing technology for propellers.

As the core propulsion component of an aircraft, the propeller is highly susceptible to icing in low-temperature and high-humidity environments, leading to aerodynamic performance degradation, compromised flight stability and safety, and even the risk of stall and crash. Therefore, the development of efficient anti-icing and de-icing systems is of critical importance. This paper first examines the dynamic icing characteristics of propellers, analyzing the formation, accumulation, and shedding mechanisms of ice, as well as the influencing factors and their effects on aerodynamic performance.

Multi-omics analysis provides new insights into molecular mechanisms for waterfowl fatty liver formation.

Waterfowl fatty liver has high nutritional value and offers benefits to human health. While previous research on fatty liver has focused on individual organs, this study explored fatty liver by examining the cecum, serum metabolites, and liver gene expression. This study integrated transcriptomic, metabolomic, and 16S rRNA microbiome analyses to analyze the molecular mechanism of waterfowl fatty liver formation.

Efficient utilization of Shuanghuanglian medicine residues by microbial transformation with flavonoid glycosides-hydrolyzing strains.

Shuanghuanglian, a traditional Chinese medicine, is well-known for its bioactive compounds, such as flavonoids, which offer significant health benefits. However, the production of Shuanghuanlian generates substantial pharmaceutical residues, which are often discarded as waste, posing significant environmental and economic challenges. To date, research on repurposing these medicine residues has been limited.

Antimicrobial efficacy of viridicatol derived from P. crustosum S14 against MRSA: Mechanistic insights from a comprehensive multi-omics analysis.

Methicillin-resistant Staphylococcus aureus (MRSA) presents a formidable challenge to public health, necessitating alternative strategies to address the superbug-related infections. This study systematically evaluates the antibacterial efficacy of Viridicatol, a compound isolated from the fermentation products of Penicillium crustosum derived from marine. Special emphasis was placed on its potent activity against MRSA USA300.

Association of serum insulin-like growth factor-1 and adrenocorticotropic hormone therapeutic response in patients with infantile epileptic spasms syndrome.

Background: Infantile epileptic spasm syndrome (IESS), a rare age-specific epileptic encephalopathy, exhibits limited therapeutic efficacy, with approximately 50% of patients showing resistance to adrenocorticotropic hormone (ACTH) monotherapy. Herein, we investigated the association between serum insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein-3 (IGFBP-3), their ratio, and short-term ACTH therapeutic response in IESS, alongside their correlation with video-electroencephalogram (VEEG) characteristics.

Methods: This retrospective study included IESS patients who received ACTH treatment at Shanghai Children's Medical Center from July 2021 to November 2024.

Natural course of unruptured intracranial aneurysms: a case surveillance study in China.

Background: The natural course of unruptured intracranial aneurysms (UIAs) has been well described in developed countries, but there is a lack of large studies on UIAs in China. This article aims to fill this gap by detailing the current status and natural course of UIAs in China and identifying the major risk factors for their rupture, providing a basis for clinical decision-making.

Methods: We included all patients with UIAs consecutively admitted to 12 tertiary care centers in 4 provinces in northern China between January 2017 and December 2020.

Comparative Analysis of Growth Dynamics and Relative Abundances of Gut Microbiota Influenced by Ketogenic Diet.

Unlabelled: Although the compositional alterations of gut bacteria in ketogenic diet (KD) have been intensively investigated, the causal relationship between this extreme diet and the microbiota changes is not fully understood. Here, we studied the growth dynamics of intestinal bacteria in KD. We used the CoPTR method to calculate the peak-to-trough ratio (PTR) based on metagenomic sequencing data, serving as an indicator of bacterial growth rates.

Design of high-performance modular triboelectric nanogenerators for efficient mechanical energy harvesting and electrochemical applications.

Various forms of high-entropy energy (HEE), such as wind energy, ocean tidal energy, mechanical vibrations, and human motion, are widely distributed in nature and our surroundings. Effectively harvesting and utilizing these forms of energy has become a promising solution to address the challenges of sustainable energy development. Triboelectric nanogenerators (TENGs), with their unique advantages in harvesting low-frequency and micro-amplitude mechanical energy, have emerged as a key technology in the field of distributed energy systems and have attracted significant academic attention in recent years.

Proteome of granulosa cells lipid droplets reveals mechanisms regulating lipid metabolism at hierarchical and pre-hierarchical follicle in goose.

Avian hierarchical follicles are formed by selection and dominance of pre-hierarchical follicles, and lipid metabolism plays a pivotal role in this process. The amount of lipid in goose follicular granulosa cells increases with the increase of culture time, and the neutral lipid in the cells is stored in the form of lipid droplets (LDs). LD-associated proteins (LDAPs) collaborate with LDs to regulate intracellular lipid homeostasis, which subsequently influences avian follicle development.

Terramide A: a novel ironophore targeting Acinetobacter baumannii with mechanistic insights into bacterial iron deprivation.

Acetobacter baumannii poses escalating clinical challenges due to its exceptional adaptability, demanding innovative antimicrobial strategies. This study pioneers an investigation into the antibacterial efficacy and molecular mechanism of Terramide A, a hydroxamate siderophore isolated from Aspergillus terreus, against notorious A. baumannii.

16S rRNA and transcriptome analysis revealed the regulatory mechanism of Romboutsia lituseburensis on serum immunoglobulin levels in geese.

Romboutsia is a dominant genus in the goose intestine. Recent studies have suggested that Romboutsia lituseburensis might regulate serum immunoglobulin levels in female geese, although the underlying mechanisms remain unclear. In this study, we administered Romboutsia lituseburensis (R.

Transcriptome analysis of testis and epididymis identifies key genes and pathways regulating gander sperm motility.

Sperm motility is a critical indicator of semen quality and determines the reproduction performance in male poultry. However, compared to chickens and ducks, very little is known about the physiological basis of varying levels of sperm motility as well the underlying regulatory mechanisms in geese. To address this, in the present study, a systematic comparison of semen quality parameters and histomorphological characteristics and genome-wide transcriptomic profiles of testes and epididymis were performed in ganders with high and low sperm motility.

Multi-omics joint analysis and identification of candidate genes for the rate of right ovarian degeneration in geese.

Avian species exhibit a notable asymmetry in their reproductive systems, with the left ovary maturing into a functional organ and the right ovary degenerating. This asymmetry is widespread across bird species, yet the molecular underpinnings of right ovarian degeneration are not fully understood. In this study, we constructed a cellular atlas of the degenerating right ovary in geese through single-cell transcriptome sequencing (scRNA-seq), revealing distinct cellular compositions and gene expression profiles.

Effects of different rearing systems on the development of uropygial gland in three goose breeds.

This study aimed to investigate and compare the age-dependent effects of net-floor mixed rearing system (MRS) and cage rearing system (CRS) on the development-related parameters of uropygial glands among three economically important goose breeds, including Sichuan White goose (SW), Gang goose (GE), and Landes goose (LD). All goslings were reared under the similar environmental conditions during the first 10 post-hatching weeks, and the goslings of each breed were then equally divided into the MRS and CRS groups. At weeks 30 and 43, eight geese from each experimental group per breed were randomly selected for morphometric and histological measurements of the uropygial glands, including Hematoxylin and Eosin (H&E) and oil red O-staining.

Molecular mechanisms underlying the testicular developmental variations among different lines of Tianfu Nonghua duck.

The reproductive and economic performance of male poultry depends on the testicular development and semen quality. However, most previous studies on male duck reproduction have focused on environmental impacts or developmental dynamics within a single breed, so the mechanisms of duck testicular development remain poorly understood. In this study, by taking a total of 240 males from 3 different lines (GF, BGF, and MC) of Tianfu Nonghua duck during the first 24 post-hatch weeks as the experimental objects, we comprehensively analyzed the age-dependent variations in the testicular histomorphological characteristics, serum testosterone (T) contents, and hypothalamic-pituitary-testicular (HPT) axis-related genes expression profiles, aiming to unravel the molecular mechanisms underlying these observed variations.

Identification of the crucial circ-mi-mRNA interaction networks regulating testicular development and spermatogenesis in ganders.

Semen quality has an important impact on the reproductive performance of ganders, and the quantity and quality of spermatozoa in semen are the determinants of semen quality. In our practical work, a small number of azoospermic ganders were observed in adult goose breeding populations, but the underlying regulatory mechanisms remain unknown. In the present study, we firstly compared the morphological and histological differences in the testes of ganders from normozoospermic group (NG) and azoospermic group (AG), and then analyzed the testicular expression patterns of circRNAs, miRNAs, and mRNAs between the two groups by using whole-transcriptome sequencing technology.

Transcriptome Analysis Reveals the Molecular Mechanism of PLIN1 in Goose Hierarchical and Pre-Hierarchical Follicle Granulosa Cells.

, a member of the PAT family, is expressed in both adipocytes and steroidogenic cells. In this study, we used cell transfection technology combined with transcriptome sequencing to investigate the regulatory mechanism of in goose follicular GCs. Gene Ontology (GO) analysis revealed that in the four groups (phGC: over_vs_over-NC; hGC: over_vs_over-NC; phGC: si_vs_si-NC; hGC: si_vs_si-NC), most differentially expressed genes (DEGs) were significantly enriched ( < 0.

N -Acetyl-Tryptophan in Acute Kidney Injury after Cardiac Surgery.

Key Points: -acetyl-tryptophan (NAT) was elevated in plasma of patients with cardiac surgery–associated AKI compared with those who do not develop AKI after surgery. NAT exhibited kidney-protective effects in ischemia-reperfusion–, cisplatin-, and unilateral ureteral obstruction–induced kidney injury mouse models and epithelial cellular models. NAT interacted with Kelch-like ECH-associated protein 1 at 483 and 508 sites, resulting in Nrf2 nuclear translocation and proteasome genes transcription, respectively.

Molecular mechanisms of libido influencing semen quality in geese through the hypothalamic-pituitary-testicular-external genitalia axis.

Libido plays a crucial role in influencing semen quality, yet the underlying regulatory mechanisms remain unclear. As a central axis in male goose reproduction, the hypothalamic-pituitary-testicular-external genitalia (HPTE) axis may contribute to the regulation of this process. In this study, we established a rating scale for goose libido based on average number of massages to erection (ANM) and the erection type, and evaluated semen quality across the entire flock.

Diagnosis and treatment recommendations for glucose transporter 1 deficiency syndrome.

Background: Glucose transporter 1 deficiency syndrome (Glut1DS) was initially reported by De Vivo and colleagues in 1991. This disease arises from mutations in the SLC2A1 and presents with a broad clinical spectrum. It is a treatable neuro-metabolic condition, where prompt diagnosis and initiation of ketogenic dietary therapy can markedly enhance the prognosis.