The novel organoselenium compound 4aa ameliorates osteoporosis by modulating gut microbiota composition and fecal metabolite profiles.

Background: The gut microbiota plays a key role in regulating bone homeostasis. Our previous work demonstrated that the novel organic selenium compound β-trifluoroethoxy dimethyl selenide (4aa alleviates osteoporosis; however, its mechanism remains unclear.

Method: The cytotoxicity of 4aa in osteoblast (MC3T3-E1) and osteoclast precursor (RAW264.

Genetic insights into the mediating role of cardiac function in hypertension-induced brain cortical changes: a Mendelian randomization study with cardiac magnetic resonance imaging.

Background: Hypertension adversely affects both cardiac and cerebral structure and function. However, the underlying mechanisms mediating hypertension-induced brain remodeling remain unclear, particularly the role of cardiac dysfunction in this process. This study aimed to assess the causal association between hypertension and alterations to the cerebral cortex, as well as the mediating effect of heart function, through use of cardiac magnetic resonance (CMR) and mediation Mendelian randomization analysis.

Dentinogenesis imperfecta type II dentin: nanostructural mechanics analysis.

Objectives: This study investigated the nanomechanical properties, microstructure, and composition of dentinogenesis imperfecta type II (DGI-II) peritubular dentin (PTD) and intertubular dentin (ITD) and examined the correlations between them.

Materials And Methods: Six samples from each of the normal and DGI-II groups were prepared by cutting the midcoronal dentin perpendicular to the dentin tubules. The number and morphology of the dentin tubules were then observed by scanning electron microscopy (SEM).

The associations between coping resources and help-seeking intention in a sample of Chinese first-year medical students: mediation effects of coping strategies.

Background: Help-seeking is an adaptive coping process encompassing orientation, intention and actual behaviors. Help-seeking intention which promotes help-seeking behavior is a protective factor for mental health. However, the psychological paths for help-seeking intention in first-year medical students, a population vulnerable to mental health challenges, remain elusive.

Identification of circulating metabolites associated with chronic rhinosinusitis using Mendelian randomization analysis.

Objective: This study aims to employ Mendelian Randomization (MR) analysis to investigate causal relationships between serum metabolites and CRS, identifying key pathogenic and protective factors and analyzing their mechanisms of action.

Methods: Utilizing data from the Genome-Wide Association Studies (GWAS) database, employing two-sample MR analysis to investigate the potential causal relationship between 233 circulating metabolites with the occurrence of CRS. Inverse Variance Weighted (IVW) model, MR-Egger method, Weighted Median, and Weighted model were employed.

Chronic Sinusitis With Nasal Polyps and Olfactory Dysfunction: Comparing Olfactory Training and Glucocorticoid Treatment.

Objective: Few studies have compared the effectiveness of olfactory training (OT) and glucocorticoids (GC) in the phenotype of chronic sinusitis with nasal polyps (CRSwNP) with olfactory dysfunction (OD). To evaluate the effects of GC and OT on OD in patients with eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) and non-eosinophilic chronic rhinosinusitis with nasal polyps (NonECRSwNP).

Methods: After 2 weeks of endoscopic sinus surgery, patients with a composite threshold discrimination identification score (TDIS) of less than 30.

Multi-omics joint analysis and identification of candidate genes for the rate of right ovarian degeneration in geese.

Avian species exhibit a notable asymmetry in their reproductive systems, with the left ovary maturing into a functional organ and the right ovary degenerating. This asymmetry is widespread across bird species, yet the molecular underpinnings of right ovarian degeneration are not fully understood. In this study, we constructed a cellular atlas of the degenerating right ovary in geese through single-cell transcriptome sequencing (scRNA-seq), revealing distinct cellular compositions and gene expression profiles.

Impact of Nasal Glucocorticoid Therapy on Exhaled Nitric Oxide and Symptom Relief in Chronic Rhinosinusitis with Nasal Polyps: A Randomized Prospective Study.

Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a widespread inflammatory disease, classified into eosinophilic (EosCRSwNP) and non-eosinophilic (non-EosCRSwNP) types. Nitric oxide (NO) plays a role in pathophysiological processes, with changing levels in airway diseases like asthma and CRS. Intranasal corticosteroids (INCS) are first-line treatments for CRSwNP, providing anti-inflammatory and immunomodulatory effects pre- and post-endoscopic sinus surgery (ESS).

Single-cell transcriptomic atlas of the chicken cecum reveals cellular responses and state shifts during Eimeria tenella infection.

Eimeria tenella (E. tenella) infection is a major cause of coccidiosis in chickens, leading to significant economic losses in the poultry industry due to its impact on the cecum. This study presents a comprehensive single-cell atlas of the chicken cecal epithelium by generating 7,394 cells using 10X Genomics single-cell RNA sequencing (scRNA-seq).

Cardiac magnetic resonance left atrioventricular coupling index as a prognostic tool in hypertrophic cardiomyopathy.

Aims: A novel marker left atrioventricular coupling index (LACI) has been proved to be associated with cardiovascular events in patients without history of cardiovascular disease. However, the studies on cardiac magnetic resonance-derived LACI in hypertrophic cardiomyopathy (HCM) patients are limited, and the prognostic value of LACI has still not been studied thoroughly, so we aimed to explore the association between LACI and adverse clinical outcomes in HCM patients.

Methods: A total of 206 HCM patients underwent cardiac magnetic resonance examination were retrospectively enrolled.

Comprehensive Genetic Analysis Exploring Sedentary Lifestyle, Physical Activity, and Respiratory Diseases: A Bidirectional Mendelian Randomization with over 500,000 Participants.

Introduction: The association between sedentary lifestyle, physical activity, and risk of respiratory diseases is a crucial area of medical and health research. Despite numerous studies, uncertainties and controversies regarding the causal relationships persist. We utilized Mendelian randomization (MR) analysis, an advanced statistical tool, to further investigate causal links.

Increased expression of epithelial-mesenchymal transition markers associated with recurrence of sinonasal inverted papilloma.

Sinonasal inverted papilloma (SNIP) is a benign epithelial proliferative disease with a high recurrence rate. The role of epithelial-mesenchymal transition (EMT) in the pathogenesis of SNIP remains unclear. EMT marker expression is elevated in SNIP tissues and is associated with its recurrence.

Dissecting the pathogenic effects of smoking in blood DNA methylation on allergic diseases.

Background: Allergic diseases, such as asthma and allergic rhinitis, present significant health challenges globally. Elucidating the genetic and epigenetic foundations is crucial for developing effective interventions.

Methods: We performed two-sample Mendelian Randomization (MR) analyses to investigate the associations between smoking behaviors and various allergic diseases, leveraging data from the FinnGen database.

An investigation of machine learning methods applied to genomic prediction in yellow-feathered broilers.

Machine learning (ML) methods have rapidly developed in various theoretical and practical research areas, including predicting genomic breeding values for large livestock animals. However, few studies have investigated the application of ML in broiler breeding. In this study, seven different ML methods-support vector regression (SVR), random forest (RF), gradient boosting decision tree (GBDT), extreme gradient boosting (XGBoost), light gradient boosting machine (LightGBM), kernel ridge regression (KRR) and multilayer perceptron (MLP) were employed to predict the genomic breeding values of laying traits, growth and carcass traits in a yellow-feathered broiler breeding population.

Causal relationships between allergic and autoimmune diseases with chronic rhinosinusitis.

Chronic rhinosinusitis (CRS) is a prevalent inflammatory airway disease affecting over 10% of the global population, leading to considerable socio-economic impacts, especially in developing countries. The pathogenesis of CRS is multifactorial, involving potential contributions from both genetic and environmental factors. While the influence of allergic and autoimmune diseases on CRS has been observed, the causal relationships between these diseases and CRS remain unclear.

Causal relationships of metabolites with allergic diseases: a trans-ethnic Mendelian randomization study.

Background: Allergic diseases exert a considerable impact on global health, thus necessitating investigations into their etiology and pathophysiology for devising effective prevention and treatment strategies. This study employs a Mendelian randomization (MR) analysis and meta-analysis to identify metabolite targets potentially associated with allergic diseases.

Methods: A two-sample MR analysis was conducted to explore potential causal relationships between circulating and urinary metabolites and allergic diseases.

Regional homogeneity alterations of resting-state functional magnetic resonance imaging of chronic rhinosinusitis with olfactory dysfunction.

Objectives: The aim of this study was to assess the brain functional changes of patients with chronic rhinosinusitis with olfactory dysfunction (CRSwOD) using regional homogeneity (ReHo) of resting-state functional magnetic resonance imaging (MRI) scans, and to better explain the occurrence and development of olfactory decline in patients with chronic sinusitis provides a new idea for the study of more advanced olfactory therapy modalities.

Methods: A total of 28 CRSwOD patients, 24 patients with CRS without olfactory dysfunction (CRSsOD), and 25 healthy controls (HCs) were recruited. All subjects underwent olfactory testing, clinical and brief psychological assessments, and MRI scans.

Long Non-coding RNA LINC00342 Promotes the Proliferation, Invasion, and Migration of Primary Hepatocellular Carcinoma Cells by Regulating the Expression of miRNA-19a-3p, miRNA-545-5p, and miRNA-203a-3p.

This study aimed to investigate the role of the long non-coding RNA (lncRNA) LINC00342-207 (LINC00342) in the development and progression of primary hepatocellular carcinoma (HCC). Forty-two surgically resected HCC tissues and corresponding paracancerous tissues were collected from October 2019 to December 2020 and examined for lncRNA LINC00342, microRNA (miR)-19a-3p, miR-545-5p, miR-203a-3p, cell cycle protein D1 (CyclinD1/CCND1), murine double minute 2 (MDM2), and fibroblast growth factor 2 (FGF2) expression. The disease-free survival and overall survival of patients with HCC were followed up.

Hypoxia induces the production of epithelial-derived cytokines in eosinophilic chronic rhinosinusitis with nasal polyps.

Background: Hypoxia plays a significant role in the pathogenesis of chronic rhinosinusitis (CRS). However, the role and mechanism of hypoxia in the type 2 immune response in eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) remain unclear.

Methods: The expression of hypoxia-inducible factor-1α (HIF-1α) and epithelial-derived cytokines (EDCs), including interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP), was detected in nasal polyps via immunohistochemical analysis.

Epithelial Tight Junction Anomalies in Nasal Inverted Papilloma.

Objectives: As a critical component of the epithelial barrier, tight junctions (TJs) are essential in nasal mucosa against pathogen invasion. However, the function of TJs has rarely been reported in nasal inverted papilloma (NIP). This study aims to investigate the potential factors of TJs' abnormality in NIP.

Diagnostic value and underlying mechanism of nasal nitric oxide in eosinophilic chronic rhinosinusitis with nasal polyps.

Purpose: Nitric oxide (NO) is an important messenger molecule widely present in the human body. However, the role of nasal NO (nNO) in eosinophilic chronic rhinosinusitis with nasal polyps (Eos CRSwNP) remain unclear. This study aimed to investigate the diagnostic value and underlying mechanism of nNO in Eos CRSwNP.

Hypoxia disrupts the nasal epithelial barrier by inhibiting PTPN2 in chronic rhinosinusitis with nasal polyps.

Background: Hypoxia is involved in inflammation and immune response; however, its role in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) is not fully understood. We aimed to investigate the mechanisms by which hypoxia disrupts the nasal epithelial barrier in CRSwNP.

Methods: The expression of hypoxia-inducible factor-1α (HIF-1α), protein tyrosine phosphatase non-receptor type 2 (PTPN2), and tight junction (TJ) components (claudin-4, occludin, and ZO-1) was detected in nasal polyps using immunohistochemistry, western blotting, and qRT-PCR.

Expression and clinical significance of TYRP1, ABCB5, and MMP17 in sinonasal mucosal melanoma.

Background: Sinonasal mucosal melanoma (SNMM) is a lethal malignancy with poor prognosis. Treatment outcomes of SNMM are poor. Novel prognostic or progression markers are needed to help adjust therapy.

Risk factors and survival prediction of pancreatic cancer with lung metastases: A population-based study.

Background: The risk and prognosis of pancreatic cancer with lung metastasis (PCLM) are not well-defined. Thus, this study aimed to identify the risk and prognostic factors for these patients, and establish predictive nomogram models.

Methods: Patients diagnosed with PCLM between 2010 and 2016 were identified from the Surveillance, Epidemiology, and End Results (SEER) database.

Adjuvant Chemotherapy Benefit in Elderly Stage II/III Colon Cancer Patients.

Background: Studies providing more evidence to guide adjuvant chemotherapy decisions in elderly colon cancer patients are expected.

Methods: We obtained data from the Surveillance, Epidemiology and End Results (SEER) database between 2004 and 2012. Kaplan-Meier survival curves were constructed to calculate the cancer-specific survival (CSS) rate, and comparisons of survival difference between different subgroups were performed using the log-rank test.