orchid: a systematic review.

Background: (L.) R. Br.

Spatio-Temporal Pattern and Socio-economic Influencing Factors of Tuberculosis Incidence in Guangdong Province: A Bayesian Spatiotemporal Analysis.

Objective: To investigate the spatiotemporal patterns and socioeconomic factors influencing the incidence of tuberculosis (TB) in the Guangdong Province between 2010 and 2019.

Method: Spatial and temporal variations in TB incidence were mapped using heat maps and hierarchical clustering. Socioenvironmental influencing factors were evaluated using a Bayesian spatiotemporal conditional autoregressive (ST-CAR) model.

The regulatory effects of PD-1/PD-L1 inhibitors on bone metabolism: opportunities and challenges in osteoporosis management.

Programmed death-1 (PD-1) and its ligand PD-L1 inhibitors have become pivotal agents in cancer immunotherapy, demonstrating significant efficacy across multiple malignancies. However, beyond regulating T cell activation, the PD-1/PD-L1 axis also exerts complex and critical effects on bone metabolism. Notably, both clinical observations and mechanistic studies have revealed a paradox: on one hand, PD-1/PD-L1 blockade appears to confer bone-protective benefits; on the other hand, it has been associated with bone-related adverse events (AEs) in up to 69% of patients, including pathological fractures and vertebral compression fractures.

CTLA-4 and PD-1 combined blockade therapy for malignant melanoma brain metastases: mechanisms, challenges, and prospects.

Malignant melanoma brain metastases (MBM) represent one of the deadliest complications of melanoma, with an incidence rate of 7.3%. Among patients with acral and mucosal melanoma, the cumulative 5-year incidence can reach 19.

Heel kicking exercise rapidly improves pain and function in patients with acute lateral ankle sprain: a randomized controlled trial.

Background: Ankle sprain is one of the common traumatic injuries in daily life, and PRICE (protection, rest, ice, compression pressure bandaging, elevation of the affected limb) principle is routinely recommended at its early stage. In traditional Chinese medicine (TCM), bone-setting technique (BST) can quickly relieve ankle pain and improve walking function, but physicians require high skills and physical strength. In this study, we designed an exercise-heel kicking exercise (HKE) based on the principles and methods of BST.

CCR5 gene editing and HIV immunotherapy: current understandings, challenges, and future directions.

Human immunodeficiency virus (HIV) infection remains a major global public health challenge. Although highly active antiretroviral therapy (HAART or ART) can effectively control viral replication, it fails to eradicate latent viral reservoirs and poses limitations such as lifelong medication and cumulative drug toxicity. This study focuses on the pivotal role of C-C chemokine receptor 5 (CCR5) gene editing in HIV immunotherapy, particularly highlighting the natural resistance to R5-tropic HIV strains observed in the "Berlin" and "London" patients carrying the homozygous CCR5-Δ32 mutation.

Inter-cluster-linker-absence-enabled sub-Ångstrom pore modulation in a metal-organic framework for multi-scenario CO capture.

Ultrafine aperture control of carbon capture adsorbents is first and foremost important but inscrutable. Herein, an inter-cluster-linker-absence-enabled sub-Ångstrom pore modulation strategy is proposed through the efficient transitivity of coordination bonds in a metal-organic framework (MOF). The feasibility of this strategy is well-demonstrated in SNNU-98-M materials composed of directly connected [M(TAZ)] (M = Cd or Cu, TAZ = tetrazolate) triangular prism clusters.

[Effect of Low-density Polyethylene Microplastics on Soybean-soil-microbial System].

The widespread use of plastics has led to the prevalence of microplastics in the soil environment, which, as an emerging pollutant, affects plant growth, soil physicochemical properties, and microbial community structure. The effects of different contents of low-density polyethylene microplastics （LDPE-MPs） on soybean growth, soil physicochemical properties, soil enzyme activities, and microbial activities were investigated through pot culture experiments to explore the toxic effects of microplastics on soybean-soil-microbial systems. The results showed that compared with that in the control, microplastics inhibited soybean emergence （14.

Genetically encoding ε-N-methacryllysine into proteins in live cells.

Lysine acylation is a ubiquitous post-translational modification (PTM) that plays pivotal roles in various cellular processes, such as transcription, metabolism, protein localization and folding. Thousands of lysine acylation sites have been identified based on advances in antibody enrichment strategies, highly sensitive analysis by mass spectrometry (MS), and bioinformatics. However, only 27 lysine methacrylation (Kmea) sites have been identified exclusively in histone proteins.

Standardizing classification and assessment methods in clinical frailty scale evaluation for elderly trimalleolar fractures.

In the field of geriatric orthopedics, the correlation between Clinical Frailty Scale (CFS) assessment and postoperative outcomes in elderly trimalleolar fracture patients remains a critical area of investigation. The retrospective study by Zhou et al. examines this relationship through postoperative complication analysis.

Analysis of the Identification Results of Medical Damage in 20 Urological Death Cases.

Objectives: To explore the causes of related medical damage risks and preventive measures by analyzing the identification results of medical damage in 20 urological death cases.

Methods: A retrospective analysis was conducted on 20 death cases of medical damage identification involving urology diagnosis and treatment accepted by the Judicial Appraisal Center, School of Forensic Medicine, Guizhou Medical University, and Academy of Forensic Science from 2010 to 2023.

Results: Among the 20 cases, the male-to-female ratio was 1.

Maximizing Electrostatic Interaction in Ultramicroporous Metal-Organic Frameworks for the One-Step Purification of Acetylene from Ternary Mixture.

Developing efficient adsorbents for acetylene purification from multicomponent mixtures is of critical significance in the chemical industry, but the trade-off between regenerability and selectivity significantly restricts practical industrial applications. Here, we report ultramicroporous metal-organic frameworks with acetylene-affinity channels to enhance electrostatic interaction between CH and frameworks for the efficient one-step purification of CH from CH/CO/CH mixtures, in which the electrostatic interaction led to high regenerability. The obtained exhibits significantly higher adsorption capacity for CH than that for both CH and CO at 298 K and 0.

Rare rectal gastrointestinal stromal tumor case: A case report and review of the literature.

Background: Gastrointestinal stromal tumors (GISTs) are rare tumors of the gastrointestinal tract accounting for less than 1% of all gut tumors. GISTs occurring in the rectum are extremely rare, and these usually present at an advanced stage compared with other sites.

Case Summary: A 60-year-old male who presented with features of sensations of rectal tenesmus was referred to our department with a mass in the lower rectum that was detected during a routine checkup.

[Composition Structure and Influence Factors of Bacterial Communities in the Miyun Reservoir].

As the largest reservoir in North China, the Miyun Reservoir is the most important surface drinking water source in Beijing. Bacteria are key regulators of reservoir ecosystem structure and function, and exploring the community distribution characteristics of bacteria is important for maintaining water quality safety in reservoirs. The spatiotemporal distribution and environmental factors of bacterial communities in the water and sediment of the Miyun Reservoir were explored using the high-throughput sequencing method.

Pore Environmental Modification by Alkoxy Groups in Pore-Space-Partitioned Metal-Organic Frameworks to Achieve Gas Uptake-Selectivity Balance.

Due to the trade-off barrier between high storage capacity and high selectivity, the controllable and systematic design of metal-organic frameworks (MOFs) aiming at performance optimization is still challenging. Herein, considering the effectiveness of alkoxy group functionalization and a pore-space partition strategy, a series of rigid Mg-pacs-MOFs (, = ) with flexible side chains are built for the first time, realizing systematic pore environmental modification. The steric hindrance effects, electron-donating ability, and the flexibility of alkoxy groups are considered as key factors, which lead to a regular change of gas adsorption capacity and selectivity.

[Effects of Heavy Metal Pollution on the Structure of Microbial Communities in Different Habitats].

Heavy metal pollution seriously threatens the diversity and composition of microbial communities in various ecosystems. However, little is known about the effects of heavy metal pollution on the structure of microbial communities in the three habitats of "surface water-sediment-groundwater." Here, with help of 16S rRNA high-throughput sequencing technology, the diversity and composition of microbial communities, as well as the underlying controlling factors, were investigated and compared among the surface water, sediment, and groundwater of the Tanghe sewage reservoir.

Transcriptomic and metabolomic studies on the protective effect of molecular hydrogen against nuclear electromagnetic pulse-induced brain damage.

Background: Excessive doses of electromagnetic radiation pose a negative impact on the central nervous system and lead to mental disorders. Molecular hydrogen can scavenge intracellular hydroxyl radicals, acting as an antioxidant, anti-apoptotic and anti-inflammatory agent. We seek to assess the capability of molecular hydrogen to ameliorate brain damage induced by electromagnetic radiation.