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Neurogenic lower urinary tract dysfunction (NLUTD) is caused by nervous system lesions and characterized by impaired micturition and urinary incontinence. The goal of treatment is to manage these symptoms, improve quality of life, prevent urinary tract infections, and maintain urinary function. Pelvic floor muscle training and medication are commonly used for treating it. Sacral neuromodulation (SNM) has been used in the treatment of NLUTD for >20 years worldwide, and its effectiveness and safety have been verified. Several countries have begun using a rechargeable SNM system, whereas the current sacral SNM system used in China is non-rechargeable. A 29-year-old man with persistent voiding dysfunction for >20 years presented with progressive symptoms 1 year ago. He was admitted to our hospital in August 2022 for a rechargeable SNM system implantation. The patient underwent a video-urodynamic examination and the Short Form of a Urinary Quality of Life Questionnaire (SF-Qualiveen) before and 1 month after surgery. The video-urodynamic examination showed that the maximum bladder capacity significantly increased after surgery, bladder compliance improved, the phenomenon of uninhibited bladder contraction during filling decreased, and urine leakage was reduced. The SF-Qualiveen score showed the patient's quality of life significantly improved. To our knowledge, this is the first case of a rechargeable SNM system implantation in China, which shows that it is safe and effective. More clinical cases and long-term observation are still needed. In conclusion, a rechargeable SNM system has significance for health and the economy and has a broad clinical application prospect.
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Auton Neurosci
August 2025
Univ. Lille, Department of Urology, CHU Lille, F-59000 Lille, France; Univ. Lille, Inserm UMR-S1172 LilNCog, Lille Neuroscience and Cognition, F-59000 Lille, France.
Objectives: Sacral neuromodulation (SNM) is widely used since the 1990's for overactive bladder (OAB) and non-obstructive urinary retention (NOUR) with good clinical results. Though, its mechanisms of action are not fully elucidated.
Materials And Methods: This narrative review intends to explore the various hypotheses of mechanisms of action in SNM, and to propose a theoretical model of action based on the current literature.
Pediatr Res
August 2025
Fetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Neonatologist performed echocardiography (NPE) is fast becoming as an essential tool to provide high-quality patient care in the neonatal intensive care units (NICU), especially to infants with hemodynamic instability. With limited training opportunities in the neonatal intensive care setting, learning echocardiography and implementation of published neonatal echocardiography training guidelines remain a challenge for the vast majority of neonatologists across the world. Hence, these guidelines have recommended the use of simulators for the initial echocardiography training.
View Article and Find Full Text PDFMed Phys
August 2025
Department of Biomedical Engineering, Washington University, St. Louis, Missouri, USA.
Background: Quantitative measures of dopamine transporter (DaT) uptake in the caudate, putamen, and globus pallidus (GP) derived from DaT-single-photon emission computed tomography (SPECT) images are being investigated as biomarkers to diagnose, assess disease status, and track the progression of Parkinsonism. Reliable quantification from DaT-SPECT images requires performing attenuation compensation (AC), typically with a separate x-ray CT scan. Such CT-based AC (CTAC) has multiple challenges, a key one being the non-availability of x-ray CT components on many clinical SPECT systems.
View Article and Find Full Text PDFCurr Biol
July 2025
Biodiversity Research Center, Academia Sinica, 11529 Taipei, Taiwan. Electronic address:
The deeper relationships of major thecostracan (barnacles sensu lato) groups remain contentious due to a lack of genome-scale data of enigmatic lineages. Commonly referred to as y-larvae, Facetotecta is one such example. The group remains one of the few invertebrate groups without known adult stages and almost entirely obscured biodiversity.
View Article and Find Full Text PDFCurr Hypertens Rep
July 2025
Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Purpose Of Review: Heart failure (HF) is characterized by a significant imbalance of the autonomic nervous system (ANS), with chronic sympathetic nervous system (SNS) overactivity leading to maladaptive cardiac remodeling, arrhythmia, and hemodynamic instability. In this review, we aim to discuss current and emerging therapies and the potential path forward for developing future novel neuromodulatory therapies in HF.
Recent Findings: Neuromodulatory therapies including splanchnic nerve modulation (SNM), vagal nerve stimulation (VNS), baroreflex activation therapy (BAT), and renal denervation (RDN) reduce sympathetic output in individuals with HF, leading to improved cardiac function, neurohormonal regulation, and vascular resistance.