Durable Ceramicization-Induced Uncoated Superhydrophobic Surfaces for Anti-Icing Propeller Edges.

The chemical and mechanical instability of conventional coated decorative superhydrophobic anti-icing surfaces on propeller leading edges has been a major limitation for practical applications. Here, a self-starting, uncoated, and ultra-durable superhydrophobic anti-icing surface fabricated on silicone rubber via laser-induced ceramization microstructuring is demonstrated. The laser-processed surface achieves a water contact angle of 168° and a sliding angle of 0.

Metabolic Profiling Reveals Potential Prognostic Biomarkers for SFTS: Insights into Disease Severity and Clinical Outcomes.

Severe fever with thrombocytopenia syndrome (SFTS) is a viral infection primarily found in Asia, with a case fatality rate of about 10%. Despite its increasing prevalence, the underlying pathogenic mechanisms remain poorly understood, limiting the development of effective therapeutic interventions. We employed an untargeted metabolomics approach using liquid chromatography-mass spectrometry (LC-MS) to analyze serum samples from 78 SFTS patients during the acute phase of their illness.

Reversing NK cell exhaustion: a novel strategy combining immune checkpoint blockade with drug sensitivity enhancement in the treatment of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is one of the most common lethal cancers worldwide. Natural killer cells (NK cells) play a key role in liver immunosurveillance, but in the tumor microenvironment, NK cells are readily depleted, as evidenced by down-regulation of activating receptors, reduced cytokine secretion, and attenuated killing function. The up-regulation of inhibitory receptors, such as PD-1, TIM-3, and LAG-3, further exacerbates the depletion of NK cells.

Research on the pharmacognostic characteristics, physicochemical properties and in vitro antioxidant potency of Rosa laxa Retz. flos.

Rosa laxa Retz. is an unexplored Rosaceae plant in Xinjiang, China, and its flower is traditionally used in Kazak to treat the common cold, fever, and epileptic seizures and lessen the effects of aging. In the present study, the pharmacognostic profiles, physicochemical properties, phytochemical characteristics, and in vitro antioxidant potency of Rosa laxa Retz.

Clinical characteristics and influencing factors of severe fever with thrombocytopenia syndrome complicated by viral myocarditis: a retrospective study.

Objective: This study aimed to investigate the clinical characteristics of severe fever with thrombocytopenia syndrome complicated by viral myocarditis (SFTS-VM) and analyze relevant influencing factors.

Methods: Retrospective analysis was conducted on clinical data from 79 SFTS-VM patients, categorized into common (SFTS-CVM, n = 40) and severe groups (SFTS-SVM, n = 39). Clinical manifestations, laboratory results, cardiac ultrasonography, and electrocardiogram features were analyzed.

Systemic inflammatory response syndrome in patients with severe fever with thrombocytopenia syndrome: prevalence, characteristics, and impact on prognosis.

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonosis with a high fatality rate in China. Previous studies have reported that dysregulated inflammatory response is associated with disease pathogenesis and mortality in patients with SFTS. This investigation aimed to evaluate the prevalence and characteristics of systemic inflammatory response syndrome (SIRS), and its impact on prognosis.

Altered bile metabolome and its diagnostic potential for biliopancreatic malignancies.

Background: Due to the difficulty of pathological sampling, the clinical differentiation between benign and malignant biliopancreatic diseases remains challenging. Endoscopic retrograde cholangiopancreatography (ERCP) is used to investigate biliary diseases, enabling the collection of bile. This study assessed potential metabolic alterations in biliopancreatic malignancies by exploring changes in the bile metabolome and the diagnostic potential of bile metabolome analysis.

Preparation methods and research progress of super-hydrophobic anti-icing surface.

The problem of surface icing poses a serious threat to people's economy and safety, especially in the fields of aerospace, wind power generation and circuit transmission. Super-hydrophobic has excellent anti-icing performance, so it has been widely studied. As the most promising anti-icing technology, superhydrophobic anti-icing surface should not only be simple to prepare, but also have excellent comprehensive performance, which can meet the anti-icing task under harsh working conditions and long-term durability.

Clinical characteristics and outcomes of acute kidney injury in patients with severe fever with thrombocytopenia syndrome.

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonosis caused by a novel bunyavirus. Until recently, the SFTS related acute kidney injury (AKI) was largely unexplored. This study aimed to investigate the clinical characteristics and outcomes of AKI in patients with SFTS.

Preparation and Comprehensive Performance Test of Superhydrophobic Paper Mulch Films.

Paper mulch was treated with nano-zinc oxide and nano-silica dispersion by a brushing method, and its mechanical stability, hydrophobicity, impermeability, and wet strength were verified. The experiment shows that the mulch film after brushing has superhydrophobic properties, and it can also have better superhydrophobic properties and stability after being allowed to stand at room temperature for 240 h and drying under a vacuum of 0.03 MPa under negative pressure.

A longitudinal sampling study of transcriptomic and epigenetic profiles in patients with thrombocytopenia syndrome.

Severe fever with thrombocytopenia syndrome (SFTS) is a novel tick-borne infectious disease caused by a new type of SFTS virus (SFTSV). Here, a longitudinal sampling study is conducted to explore the differences in transcript levels after SFTSV infection, and to characterize the transcriptomic and epigenetic profiles of hospitalized patients. The results reveal significant changes in the mRNA expression of certain genes from onset to recovery.

Low-Velocity Impact Experiments and Modeling of TRC Skin-Aerated Concrete Core Sandwich Composites.

Mechanical response of textile-reinforced aerated concrete sandwich panels was investigated using instrumented three-point bending tests under quasi-static and low-velocity impact loads. Two types of core material were compared in the sandwich composite consisting of plain autoclaved aerated concrete (AAC) and fiber-reinforced aerated concrete (FRAC), and the stress skins were alkali-resistant glass (ARG) and textile reinforced concrete (TRC). The textile-reinforced layer promoted distributed cracking mechanisms and resulted in significant improvement in the flexural strength and ductility.

A fluorine-free superhydrophobic silicone rubber surface has excellent self-cleaning and bouncing properties.

Superhydrophobic materials have been widely applied in self-cleaning, anti-fouling, anti-corrosion, anti-freezing. However, simple, efficient, environmentally friendly and large-area preparation is still a great challenge in the field of fabrication of superhydrophobic surfaces. In this paper, a simple physical deposition method is adopted to deposit a layer of alumina oxide (AlO) particles on the surface of the room temperature vulcanized (RTV) silicone rubber, and remove the excess AlO particles on the surface to obtain the superhydrophobic surface of AlO/RTV silicone rubber.

Association Between hMLH1 Promoter Methylation and Risk of Gastric Cancer: A Meta-Analysis.

Human mutL homolog 1 () is located on chromosome 3q21-23. As a classic tumor suppressor gene, many researchers have studied the association between promoter methylation and gastric cancer, but their conclusions were not always consistent. Therefore, we performed a meta-analysis to make a more integrated and precise estimate of the associations.

Hepatitis C Virus Increases Free Fatty Acids Absorption and Promotes its Replication Via Down-Regulating GADD45α Expression.

BACKGROUND Hepatitis C virus (HCV) infection, as a major cause of chronic hepatic diseases, is always accompanied with an abnormality of lipid metabolism. The aim of this study was to investigate the pathogenic role of free fatty acids (FFA) in human HCV infection. MATERIAL AND METHODS Peripheral blood lipid indexes among HCV patients with different viral loads (199 samples) and healthy donors (80 samples) were detected by clinical biochemistry tests.

Clinicopathological significance of forkhead box protein A1 in breast cancer: A meta-analysis.

The aim of the present study was to investigate the associations between the expression of forkhead box protein A1 (FOXA1) and differential clinicopathological characteristics in breast cancer using a meta-analysis method. Eligible studies that investigated the correlation between FOXA1 expression and the clinical characteristics of breast cancer were collected through searching numerous databases, including PubMed, EMBASE, the Chinese National Knowledge Infrastructure and the VIP database. In total, eight studies were included in the meta-analysis.

Small-Molecule-Triggered and Light-Controlled Reversible Regulation of Enzymatic Activity.

The fine control of enzyme activity is essential for the regulation of many important cellular and organismal functions. The light-regulation of proteins serves as an important method for the spatiotemporal control over the production and degradation of an enzyme product. This area is of intense interest for researchers.

Association of the pri- rs531564 polymorphism with cancer risk: A meta-analysis.

Unlabelled: Recently, several studies regarding the association between the pri- rs531564 polymorphism and cancer susceptibility were explored. Owing to inconsistent results of these studies, a meta-analysis was conducted to determine the association of this polymorphism with cancer risk. Relevant studies were identified by a systematic search of PubMed, EMBASE, Web of Science and CNKI on-line databases.

Androgen receptor, EGFR, and BRCA1 as biomarkers in triple-negative breast cancer: a meta-analysis.

Objective: More and more evidences demonstrate that androgen receptor (AR), epidermal growth factor receptor (EGFR), and breast cancer susceptibility gene 1 (BRCA1) have unique clinical implications for targeted therapy or prognosis in triple-negative breast cancer (TNBC). Therefore, we conducted a meta-analysis to summarize the possible associations.

Methods: We retrieved published articles about AR, EGFR, and BRCA1 in TNBC from PubMed and EMBASE.