Cu/Zn superoxide dismutase homologs participate in antiviral responses.

Superoxide dismutases (SODs) serve as the first line of defense against reactive oxygen species. Copper-zinc superoxide dismutase () is an enzyme whose activity depends on copper availability. induction is shown to be involved in the antioxidative and antiviral activity of acetylsalicylic acid in hepatitis C virus (HCV)-expressing cells.

Protein elicitor PeVn1 induces resistance to in strawberry and differential transcriptomic analysis.

is one of the most destructive diseases in strawberry cultivation. The protein elicitor PeVn1 is a secreted protein produced by , and it has been shown to enhance plant resistance against fungal infections. However, the mechanisms by which the protein elicitor acts remain poorly understood.

Resveratrol synthase homologs participate in infection of by pathogenic plant viruses and fungi.

Introduction: Resveratrol synthase (RS) is a key enzyme involved in the synthesis of stilbene and resveratrol. Resveratrol has many biological pharmacological activities that are beneficial to human health including anti-cancer, cardiovascular protection, estrogen regulation, antibacterial, antiviral, and reduction of tissue and organ damage. In plants, RS catalyzes the production of resveratrol, which helps to protect against fungal and bacterial diseases.

A Novel Systemic siDR6 Delivery System Based on DP7-C for the Treatment of Metastatic Lung Cancer.

Background: The treatment of metastatic lung cancer, a common complication of many primary cancers, has historically been a significant clinical challenge. Once lung metastasis occurs, patients' survival is often significantly shortened. Therefore, prevention and treatment of lung metastases is an important aspect of cancer treatment.

Mechanism of N-Acetyl-D-alloisoleucine in Controlling Strawberry Black Root Rot.

China is the largest strawberry producer in the world. Strawberry black root rot is a novel disease that occurs in Hohhot, Inner Mongolia. In the present study, the inhibitory effects of S-16 and its fermented form on strawberry black root rot caused by were tested.

Preparation of a Fluxapyroxad Nanoformulation with Strong Plant Uptake for Efficient Control of Wilt in Potato.

Potato ( L.) is ranked as the fourth largest staple crop in China. However, potato production is increasingly threatened by wilt (VW) caused by the fungus in various provinces.

Antimicrobial peptide DP7 alleviates dextran sulfate sodium (DSS)-induced colitis via modifying gut microbiota and regulating intestinal barrier function.

Inflammatory bowel diseases (IBDs), such as Crohn's disease (CD) and ulcerative colitis (UC), represent a growing global health concern. Restoring the balance of the gut microbiota, a crucial factor in intestinal health, offers potential for treating IBD. DP7, a novel antimicrobial peptide with potent antibacterial activity, was investigated for its anti-inflammatory effects in a dextran sulfate sodium (DSS)-induced UC mouse model.

Genome Sequencing and Comparative Genomic Analysis of Attenuated Strain GnVn.1 Causing Mild Wilt in Sunflower.

, previously classified in the genus until 2007, is an attenuated pathogen known to provide cross-protection against wilt in various crops. To investigate the potential mechanisms underlying its reduced virulence, we conducted genome sequencing, annotation, and a comparative genome analysis of GnVn.1 (GnVn.

Revolutionizing spinal interventions: a systematic review of artificial intelligence technology applications in contemporary surgery.

Leveraging its ability to handle large and complex datasets, artificial intelligence can uncover subtle patterns and correlations that human observation may overlook. This is particularly valuable for understanding the intricate dynamics of spinal surgery and its multifaceted impacts on patient prognosis. This review aims to delineate the role of artificial intelligence in spinal surgery.

3'UTR of tobacco vein mottling virus regulates downstream GFP expression and changes in host gene expression.

Introduction: Tobacco vein mottling virus (TVMV) is a member of the family . The 3' untranslated region (3'UTR) of viral genomic RNA has been reported to significantly impact viral infection. Nevertheless, the role of the TVMV 3'UTR during viral infection remains unknown.

A protein elicitor PeVn1 from HW recognized as a MAMP triggers plant immunity response.

Protein elicitors can induce plant systemic resistance to pathogens. The recognition of a potential elicitor activates intracellular signaling events, leading to plant resistance against pathogens. In this study, a novel protein elicitor was isolated from the culture filtrate of and named PeVn1, which can induce cell death in several plant species.

syn-tasiRnas targeting the coat protein of potato virus Y confer antiviral resistance in .

Trans-acting small interfering RNAs (tasiRNAs) are 21-nt phased (phased siRNAs) resulting from successive DCL-catalyzed processing from the end of a double-stranded RNA substrate originating from the RDR of an AGO-catalyzed cleaved RNA at a micro RNA target site. Plant tasiRNAs have been synthesized to produce synthetic tasiRNAs (syn-tasiRNAs) targeting viral RNAs that confer viral resistance. In this study, we engineered syn-tasiRNAs to target potato virus Y (PVY) infection by replacing five native siRNAs of TAS1c with 210-bp fragments from the coat protein (CP) region of the PVY genome.

Inhibition of Potato Wilt by ZWZ-19 and PT-29: A Comparative Analysis of Non-Targeted Metabolomics.

Potato Wilt is a soil-borne fungal disease that can seriously harm potatoes throughout their growth period and occurs at different degrees in major potato-producing areas in China. To reduce the use of chemical agents and improve the effect of biocontrol agents, the inhibitory effects of the fermentation broth of ZWZ-19 (B) and PT-29 (T) on were compared under single-culture and co-culture conditions. Furthermore, metabolomic analysis of the fermentation broths was conducted.

Transcriptome analysis of genes involved in the pathogenesis mechanism of potato virus Y in potato cultivar YouJin.

Introduction: Potatoes ( L.) can be infected by various viruses, but out of all of viruses, the potato virus Y (PVY) is the most detrimental. Research shows that the potato cultivar YouJin is especially vulnerable to PVY and displays severe symptoms, including leaf vein chlorosis, curled leaf margins, large necrotic spots on the leaf blades, and the growth of small new leaves.

Correlation between bone density, bone metabolism markers with lipid metabolism markers and body mass index.

Purpose: We aimed to explore the relationship between bone mineral density (BMD), bone metabolism markers, and blood lipid-related indicators, body mass index (BMI) in elderly individuals.

Methods: A retrospective analysis was conducted on 710 patients. Patients' gender, age, height, weight, bone density values, T-scores, bone metabolism markers (including serum N-terminal propeptide of type I collagen (s-PINP), serum C-terminal telopeptide of type I collagen (s-CTX) and 1,25-dihydroxyvitamin D (1,25(OH)D) and lipid-related indicators (including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) and Castelli index 1 (TC/HDL-C index) and Castelli index 2 (LDL-C/HDL-C index) were recorded.

Predicting potential distribution of the Rhinoncus sibiricus under climatic in China using MaxEnt.

In recent years, buckwheat (Fagopyrum spp.) is being increasingly damaged by the Siberian tortoise beetle (Rhinoncus sibiricus Faust). Adults and nymphs feed on leaf tissues and caulicles, thus damaging its stems and leaves.

Whole-genome analysis revealed the growth-promoting and biological control mechanism of the endophytic bacterial strain Q2H2, with strong antagonistic activity in potato plants.

Introduction: Endophytes are colonizers of healthy plants and they normally exhibit biocontrol activities, such as reducing the occurrence of plant diseases and promoting plant growth. The endophytic bacterium Q2H2 (Q2H2) was isolated from the roots of potato plants and was found to have an antagonistic effect on pathogenic fungi.

Methods: Q2H2 was identified by morphological observations, physiological and biochemical identification, and 16S rRNA gene sequence analysis.

Transplantation of active nucleus pulposus cells with a keep-charging hydrogel microsphere system to rescue intervertebral disc degeneration.

Background: Cell transplantation has been demonstrated as a promising approach in tissue regeneration. However, the reactive oxygen species (ROS) accumulation and inflammation condition establish a harsh microenvironment in degenerated tissue, which makes the transplanted cells difficult to survive.

Methods: In this study, we constructed a keep-charging hydrogel microsphere system to enable cells actively proliferate and function in the degenerated intervertebral disc.

Formulation and Characterization of Matrine Oil Dispersion to Improve Droplet Wetting and Deposition.

The unreasonable use of chemical pesticides has caused serious damage to crops and the ecological environment. The botanical pesticide matrine has attracted attention as an environmentally friendly pesticide. Compared with traditional spraying methods, unmanned aerial vehicle (UAV) spraying has the advantages of safety, rapidity, uniform droplets, low dosages, and no terrain or crop restrictions.

The Aqueous Extract of L. Exerts Phytotoxicity by Modulating HO and O Levels, Antioxidant Enzyme Activity and Phytohormone Levels.

Allelopathic interactions between plants serve as powerful tools for weed control. Despite the increasing understanding of the allelopathic mechanisms between different plant species, the inhibitory effects of on weed growth remain poorly understood. In this study, we conducted experiments to demonstrate that extract can suppress the germination of L.

11β-Hydroxysteroid Dehydrogenase Type 1 Facilitates Osteoporosis by Turning on Osteoclastogenesis through Hippo Signaling.

11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a key enzyme that transform cortisone to cortisol, which activates the endogenous glucocorticoid function. 11β-HSD1 has been observed to regulate skeletal metabolism, specifically within osteoblasts. However, the function of 11β-HSD1 in osteoclasts has not been elucidated.

Isolation and Identification of Herbicidal Active Compounds from L. and Exploration of the Binding Sites of Brassicanate A Sulfoxide.

L. has strong allelopathic effects on weeds. However, the allelochemicals with herbicidal activity in L.

Indole-3-acetonitrile Is a Critical Molecule with Weed Allopathic Suppression Function in Broccoli (Brassica oleracea var. italica).

Cruciferous plants are frequently used for ecologically benign weed control in agricultural production. Most effective Broccoli varieties were screened using the entropy method-based topsis model at first. Result showed that varieties of Lvwawa and Lvbaoshiwere most effective in allelopathic suppression on radishes.