Metabolism Plasticity on Account of 10 Promotes Poplar Growth under Altered Nitrogen Regimes.

Improving poplar productivity across a wide spectrum of nitrogen conditions is a primary objective in poplar breeding. In this research, we engineered transgenic poplars to overexpress the () gene. The results showed that these transgenic plantlets significantly outperformed the wild-type control in terms of growth under both nitrogen-poor and nitrogen-rich conditions, exhibiting increased biomass, height, and root development.

Photoreaction Drives Efficient, Precise, and Sustainable Additive Manufacturing.

Additive manufacturing, normally referred to as three-dimensional (3D) printing, has been maturing rapidly in recent years and widely utilized in various industrial fields, because it can create predesigned functional products with sophisticated structures that are basically difficult to achieve using traditional methods. Among all 3D printing technologies, vat photopolymerization has attracted much attention because of its outstanding advantages such as fast printing speed, high precision, and ease of formulating. In recent years, many breakthroughs in photopolymerization based 3D printing have been achieved by photoreaction design regarding photopolymerizable monomers, photoinitiating systems, inhibition functions, light sourcs, etc.

Divergent Total Syntheses of Six Crinipellin-Type Diterpenoids through Tandem 4π-Electrocyclization/Dicycloexpansion.

Crinipellins are a significant class of naturally occurring highly congested tetraquinane diterpenoids, with many members exhibiting bio-important antibacterial and anticancer activities. However, their complex structures, particularly their dense 5/5/5/5 tetracyclic frameworks, have made efficient synthesis challenging, leading chemists to attempt to create highly efficient and divergent routes. This study presents a concise, divergent synthesis of six crinipellins, completed in just 9-11 steps using commercially available materials.

Promoted metabolic remolding by overexpression of AspAT9 ameliorates cadmium toxicity in Arabidopsis.

Cadmium (Cd) is a toxic heavy metal that poses a serious threat to crop safety and human health. Aspartate aminotransferase (AspAT) is a prime enzyme engaged in amino acid metabolism, contributing essential metabolic substances for plant growth and acclimatization to various stresses. In this study, we identified a novel AspAT9 gene with high responsiveness to Cd stress from poplar 'Nanlin895' and subsequently transformed it into Arabidopsis.

Preliminary discrimination and evaluation of clinical application value of ChatGPT4o in bone tumors.

•Evaluation of making up ChatGPT4o in the preliminary pathological diagnosis of bone tumors.•ChatGPT-4o's proficiency in analyzing pathological images and providing initial diagnoses of bone tumor characteristics is comparable to that of senior pathologists in the Tertiary hospital doctors group, with both surpassing the Remote grassroots doctors group.•AI, like ChatGPT-4o, has the potential to enhance diagnostic capabilities for remote grassroots doctors and improve sensitivity to reduce missed diagnosis rates among tertiary hospital doctors in identifying bone tumors.

Case report: A novel case of COVID-19 triggered tumefactive demyelinating lesions in one multiple sclerosis patient.

The epidemic of COVID-19 is mainly manifested by respiratory symptoms caused by SARS-CoV-2 infection. Recently, reports of central nervous system diseases caused or aggravated by SARS-CoV-2 infection are also increasing. Thus, the COVID-19 pandemic poses an unprecedented challenge to the diagnosis and management of neurological disorders, especially to those diseases which have overlapping clinical and radiologic features with each other.

Indole-3-acetonitrile Is a Critical Molecule with Weed Allopathic Suppression Function in Broccoli (Brassica oleracea var. italica).

Cruciferous plants are frequently used for ecologically benign weed control in agricultural production. Most effective Broccoli varieties were screened using the entropy method-based topsis model at first. Result showed that varieties of Lvwawa and Lvbaoshiwere most effective in allelopathic suppression on radishes.

A novel report of Cys1298Gly mutation in exon 24 of NOTCH3 gene in a Chinese family with CADASIL.

Objectives: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the most common monogenic hereditary small cerebral vessel disease, which is caused by mutation of the neurogenic locus notch homolog protein 3 gene (NOTCH3). The exon 24 encodes EGF-like repeats, variants on this exon are rare. Here, we report a novel heterozygous variant c.

The More the Better, Only in the Longer Term: A Cluster Randomized Controlled Trial to Evaluate a Compound Intervention Among Mainland Chinese Immigrants in Hong Kong.

Barriers to adaptation faced by mainland Chinese immigrants to Hong Kong can be reduced by improving two targets of adaptation: information about negotiating their new environment and psychological well-being. We developed and evaluated a Compound intervention to address these two domains simultaneously and compared its effects to two separate interventions exclusively targeting either information about Hong Kong or psychological well-being. This cluster randomized controlled trial assigned 251 immigrants to an information provision arm (IP, n = 84) targeting knowledge and adaptation difficulties, a psychological well-being enhancement arm (WBE, n = 80) targeting resilience and mental health, or a Compound arm (i.

Abnormal glucose metabolism is associated with clinical symptoms of adolescent-onset patients with first-episode drug-naive schizophrenia.

Extensive studies have reported alterations in glucose metabolism in adult-onset patients with schizophrenia, but less attention has been paid to adolescent-onset patients with first-episode drug-naive (FEDN) schizophrenia. The purpose of this study was to compare glucose metabolism between adolescent-onset patients with FEDN schizophrenia and healthy controls and to investigate the relationship between glucose metabolism and clinical symptoms in patients with schizophrenia. This study compared the glycometabolism parameters between 51 adolescents-onset patients with FEDN schizophrenia and 51 age- and sex-matched healthy controls.

A novel supramolecular polymer gel-based long-alkyl-chain-functionalized coumarin acylhydrazone for the sequential detection and separation of toxic ions.

A novel approach for the detection and separation of toxic ions was successfully developed via the introduction of competitive reactions into a long-alkyl-chained acylhydrazone-based coumarin supramolecular polymer, chemosensor OGC (3%, n-BuOH/HO), which showed sequential detection and separation of CN, Fe and S, Ag in the gel state with high selectivity and sensitivity. Moreover, the ion-responsive films were prepared for the convenient and continuous detection of CN, Fe and S, Ag in water solution.

[Expression of calponin-1 and its pathogenic role in systemic sclerosis].

Objective: To investigate the expression of calponin-1 (CNN1) in systemic sclerosis (SSc) and its pathogenic role in fibrosis.

Methods: Skin biopsy samples were collected from 19 patients with SSc and 21 healthy subjects. Real-time PCR was used to detect the expression of and mRNAs in the samples, and the protein expression of CNN1 was detected using immunohistochemistry.

A novel long-alkyl-chained acylhydrazone-based supramolecular polymer gel for the ultrasensitive detection and separation of multianalytes.

By rationally introducing multi-self-assembly driving forces and coordination binding sites into the same molecule, a designed functional gelator, G, was synthesized. Next, a novel supramolecular polymer material, OGV (1% DMSO), was constructed and used for the ultrasensitive detection and separation of multianalytes in gel states. Interestingly, OGV showed a fluorescent ultrasensitive response for the Hg2+ and Fe3+ ions in water.

A new colorimetric and fluorescent probe based on Rhodamine B hydrazone derivatives for cyanide and Cu in aqueous media and its application in real life.

A simple selective colorimetric and fluorimetric chemosensor RD based on Rhodamine B hydrazone derivatives was designed and synthesized, which showed both colorimetric and fluorescence responses for cyanide and Cu in aqueous solution with specific selectivity and high sensitivity. In the presence of cyanide, the sensor exhibited a visible color change from colorless to pale yellow by naked-eyes and rapidly produced a strong yellow fluorescence in aqueous solution. The detection limit on fluorescence response of RD sensor to CN is down to 3.

The Brief Intervention Effect of Metaphorical Cognitive Restructuring on Alleviating Mental Distress: A Randomised Controlled Experiment.

Background: Metaphors may provide clarity or identify hidden similarities between two ideas, and their use in cognitive restructuring can help maximise the effect of therapy information. This study aimed to determine whether metaphorical cognitive restructuring would produce a greater intervention effect in targeted mood and cognition than non-metaphorical restructuring.

Methods: Eighty-eight participants chose 25 problems of interest and wrote a self-report distress problem and were then randomly divided into a metaphorical restructuring group (N = 29), a literal restructuring group (N = 30), or a no restructuring problem restating group (N = 29).

A novel colorimetric and "turn-on" fluorimetric chemosensor for selective recognition of CN ions based on asymmetric azine derivatives in aqueous media.

A novel chemosensor 2-((Z)-(((E)-quinolin-2-ylmethylene)hydrazono)methyl)phenol PX has been successfully designed and synthesized, which showed both colorimetric and "turn-on" fluorescence responses for CN in DMSO/HO (3:2, v/v; pH=7.20) solution. The sensor could respond effectively to the stimulation of CN ions via deprotonation and sensing mechanism of intramolecular charge transfer (ICT).

A novel dual-channel chemosensor for CN using asymmetric double-azine derivatives in aqueous media and its application in bitter almond.

In this paper, we have designed and synthesized a novel sensor L1 based on asymmetric double-azine derivatives, which showed both "naked eye" recognition and fluorescence responses for CN in DMSO/HO (v/v=4:1, pH=7.20) solution. This simple sensor L1 could distinguish CN from coexisting anions via the way of deprotonation and sensing mechanism of intramolecular charge transfer (ICT), and the minimum detection limit on fluorescence response of the sensor L1 towards CN was down to 9.

A new unsymmetrical azine derivative based on coumarin group as dual-modal sensor for CN and fluorescent "OFF-ON" for Zn.

A simple chemosensor YS based on coumarin group was designed and synthesized. Its structure was determined by single crystal X-ray diffraction analysis. In the presence of cyanide the sensor showed an immediate visible change in color from colorless to pale yellow by naked-eyes and produced a strong blue fluorescence rapidly in DMSO/HO (3:7, v/v).

A highly selective colorimetric and "turn-on" fluorimetric chemosensor for detecting CN(-) based on unsymmetrical azine derivatives in aqueous media.

A novel highly selective chemosensor S1 for cyanide based on unsymmetrical azine derivative was successfully designed and synthesized, which showed both colorimetric and fluorescence turn-on responses for cyanide ions in aqueous. This structurally simple chemosensor could detect CN(-) anion over other anions in aqueous solution DMSO/H2O (v/v=3:2) undergo deprotonation reaction. Results showed that the chemosensor S1 exhibited 50 fold enhancement in fluorescence at 530nm and showed an obvious change in color from colorless to yellow that could be detected by naked eye under the UV-lamp after the addition of CN(-) in aqueous solution.

Cyanide detection using a benzimidazole derivative in aqueous media.

A novel cyanide selective fluorescent chemosensor S1 based on benzimidazole group and naphthalene group as the fluorescence signal group had been designed and synthesized. The receptor could instantly detect CN(-) anion over other anions such as F(-), Cl(-), Br(-), I(-), AcO(-), H2PO4(-), HSO4(-), SCN(-) and ClO4(-) by fluorescence spectroscopy changes in aqueous solution (H2O/DMSO, 8:2, v/v) with specific selectivity and high sensitivity. The fluorescence color of the solution containing sensor S1 induced a remarkable color change from pale blue to mazarine only after the addition of CN(-) in aqueous solution while other anions did not cause obvious color change.