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The unreasonable use of chemical pesticides has caused serious damage to crops and the ecological environment. The botanical pesticide matrine has attracted attention as an environmentally friendly pesticide. Compared with traditional spraying methods, unmanned aerial vehicle (UAV) spraying has the advantages of safety, rapidity, uniform droplets, low dosages, and no terrain or crop restrictions. In this study, matrine OD was prepared according to the application requirements of flight prevention preparations using three different emulsifiers. The stability, wettability, particle size and distribution, and spraying performance of matrine OD were studied. The results indicated that when the amount of emulsifier was 8%, the three types of matrine OD had good stability. The stability, wettability, particle size and distribution, and spray performance of the suspension prepared using emulsifier VO/03 were better than the other two emulsifiers. Therefore, matrine OD prepared using 8% VO/03 could be used for ultra-low-volume sprays and aerial applications. In this study, we provide a theoretical basis and technical guidance to develop pesticide formulations for aerial applications.
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http://dx.doi.org/10.3390/molecules28196896 | DOI Listing |
J Chem Phys
July 2025
Key Laboratory for Advanced Materials, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China.
Deep eutectic solvents (DESs) have extensive applications in metal processing, organic reaction and extraction, and other fields due to their advantages of facile preparation, environmental compatibility, and non-toxicity. Matrine (Mat) and fatty acids (FAs) are widely used in pharmaceuticals and cosmetics because of their rich biological activities. In this study, Mat-FA DESs (DESs formed by Mat and FAs) are prepared and the corresponding microscopic mechanism for the formation of DESs is elucidated at molecular level systematically by experiments and molecular dynamics (MD) simulations.
View Article and Find Full Text PDFJ Ethnopharmacol
August 2025
School of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, PR China. Electronic address:
Ethnopharmacological Relevance: Qingchang Wenzhong Decoction (QCWZD), a traditional Chinese medicine (TCM) formula, has been clinically utilized for ulcerative colitis (UC) treatment due to its anti-inflammatory and intestinal barrier-protective effects. However, the mechanisms by which its naturally self-assembled supramolecular complexes, formed during aqueous decoction, contribute to therapeutic outcomes remain underexplored, representing a critical gap in understanding TCM's holistic pharmacology.
Aim Of The Study: This study sought to elucidate the self-assembly mechanisms underlying QCWZD's therapeutic effects, with a focus on characterizing the anti-inflammatory properties of its naturally self-assembled complexes formed during decoction and their role in UC intervention.
J Ethnopharmacol
June 2025
Scientific Research and Experimental Center, Yunnan University of Chinese Medicine, Kunming, 650500, China. Electronic address:
Ethnopharmacological Relevance: Compound Kushen Injection (CKI), a traditional Chinese medicine that has been clinically used for the treatment of various malignancies for over two decades, is prepared by purifying two traditional Chinese medicinal herbs: Sophora flavescens Aiton (Kushen) and Heterosmilax japonica Kunth (Baituling). The most abundant active component, matrine, which is derived from Sophora flavescens Aiton, has also been reported in cancer treatment. However, it has effects on breast cancer lung metastasis and underlying molecular mechanisms that remain incompletely understood.
View Article and Find Full Text PDFFront Pharmacol
April 2025
Department of Oncology, Lishui People's Hospital, Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, China.
Introduction: () preparations are widely used to control malignant pleural effusion (MPE) through intrapleural perfusion.
Objectives: This analysis aims to verify the therapeutic values of perfusion with preparations for controlling MPE, reveal the optimal treatment plan, suitable population, and usage, and to demonstrate their clinical effectiveness and safety.
Methods: We performed and reported this systematic review/meta-analysis (PROSPERO: CRD42023430139) following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
Combining ionic liquids with active pharmaceutical ingredients (API-ILs) is an ideal strategy to improve the biopharmaceutical properties of APIs while preserving their efficacy. The appropriate selection of anions and cations for the formation of ILs eliminates the problems of solid drugs and retains the core ideal characteristics of the ionic liquid material state. In this study, API-ILs were prepared using matrine (Mat) as a cation and non-steroidal anti-inflammatory drugs (NSAIDs) as anions to improve the undesirable properties of NSAIDs and prepare API-ILs with dual functions.
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