Kaempferol Plays a Neuroprotection Role by Alleviating Oxidative Stress via AKT/Nrf2/HO-1 Pathway and Inhibiting Apoptosis in Intracerebral Hemorrhage.

Intracerebral hemorrhage (ICH) is a common yet severe cerebrovascular disorder associated with high morbidity, disability, and mortality rates. Kaempferol (Kae), a natural flavonoid with potent antioxidant and anti-inflammatory properties, has shown promise in neuroprotection; however, its therapeutic potential in promoting neurological recovery after ICH remains unclear. In this study, we investigated the neuroprotective effects of Kae in ICH and explored its underlying mechanisms using in vitro and in vivo models.

Efficacy and safety of Belimumab, Rituximab and Voclosporin in the treatment of lupus nephritis based on registered clinical trials: A systematic review and network meta-analysis.

ObjectiveTo systematically compare the clinical effectiveness and safety of Belimumab, Rituximab and Voclosporin in the treatment of lupus nephritis based on network meta-analysis method.MethodsSystematic search of registered clinical trials in four major databases (Pubmed, Embase, Web of Science, The Cochrane Register of Clinical Trials) and ClinicalTrials.gov.

Diagnosis methods for pancreatic cancer with the technique of deep learning: a review and a meta-analysis.

Background: Early diagnosis can significantly improve survival rate of Pancreatic ductal adenocarcinoma (PDAC), but due to the insidious and non-specific early symptoms, most patients are not suitable for surgery when diagnosed. Traditional imaging techniques and an increasing number of non-imaging diagnostic methods have been used for the early diagnosis of pancreatic cancer (PC) through deep learning (DL).

Objective: This review summarizes diagnosis methods for pancreatic cancer with the technique of deep learning and looks forward to the future development directions of deep learning for early diagnosis of pancreatic cancer.

Analysis of Blood Pressure Status and Influencing Factors Among 7218 Emergency Department Nurses: An Observational Cross-Sectional Study.

As frontline healthcare workers, emergency department nurses face high levels of urgency in their work and are exposed to a high risk of contingencies. Their blood pressure status and influencing factors require close attention. This study employed a census method and conducted a cross-sectional survey in 11 cities in Hebei Province from November 2016 to July 2018, measuring blood pressure and collecting questionnaires on influencing factors.

Association between prone position ventilation and tracheal injury score in intensive care unit patients with invasive ventilation: a secondary analysis of a prospective cohort study in China.

Objectives: At present, the available evidence regarding the relationship between prone position ventilation (PPV) and tracheal injury score remains inadequate. This study seeks to gain deeper insights into the relationship between PPV and tracheal injury score in intensive care unit (ICU) patients with invasive ventilation.

Design: A secondary analysis of a prospective cohort study.

Low-intensity transcranial ultrasound stimulation promotes the extinction of fear memory through the BDNF-TrkB signaling pathway.

Synaptic plasticity plays a crucial role in the extinction of fearful memories. Low-intensity transcranial ultrasound stimulation (TUS) can modulate synaptic plasticity and promote the extinction of fear memories. However, the mechanism by which TUS promotes the extinction of fear memory remains unclear.

A case report of tubal-ovarian pregnancy: the fetus in the fallopian tube and the placenta attached to the ovary.

Introduction And Importance: Heterotopic pregnancy (HP), defined as the coexistence of intrauterine and ectopic pregnancies, is a rare occurrence following natural conception or assisted reproductive technology (ART) procedures. Diagnosing HP can be challenging due to its rarity and often asymptomatic presentation.

Case Presentation: We present a case of HP in a woman with unexplained infertility who underwent in vitro fertilization-embryo transfer (IVF-ET).

The Protective Effect of Omeprazole on Vancomycin Cytotoxicity in HK-2 Cells and Renal Injury in Rats.

Vancomycin is the first-line treatment for infection, and high plasma concentration can cause nephrotoxicity. The aim of the study was to determine the correlation between intracellular vancomycin concentration and HK-2 cytotoxicity and explore omeprazole's protective effect. The activity of HK-2 cells was detected, HPLC method was established and verified, and the vancomycin concentrations in the intracellular and extracellular fluids of HK-2 cells were determined.

Study on the relationship between homocysteine and general metabolic indexes in healthy population in Hebei Province, China.

Background: The aging problem is a significant issue and challenge currently faced by the whole world. Hyperhomocysteinemia (HHcy) is a common phenomenon among the older adult. Increasing evidence suggests a link between HHcy and multiple systemic issues in the older adult-related diseases.

Major PM2.5 components promote intracranial aneurysm via TP53: Insights from a comprehensive network analysis.

In this study, we combined network toxicology with two-sample Mendelian randomization (MR) to investigate the potential mechanisms by which major components of PM2.5 influence the development of intracranial aneurysms (IAs). We first identified the target genes of six representative PM2.

Prognostic value of relative enhancement metrics based on preconcurrent chemoradiotherapy magnetic resonance imaging (pre-CCRT MRI) volumetric segmentation in glioblastoma.

Aim: The purpose of this study was to identify the impact of relative contrast enhancement (rCE), based on volumetric segmentation from preconcurrent chemoradiotherapy magnetic resonance imaging (pre-CCRT MRI), in predicting tumour progression and unfavourable survival in glioblastoma (GBM) patients.

Materials And Methods: Seventy-seven GBM patients underwent conventional MRI before and after radiochemotherapy. Residual cavity wall enhancement was segmented using Image J software, and rCE was calculated.

Association between preoperative blood-brain barrier permeability and postoperative delirium in older patients undergoing cardiac surgery: a pilot study.

Background: Postoperative delirium (POD) is a frequent and serious complication in older adults after cardiac surgery. Blood-brain barrier (BBB) dysfunction is implicated in cognitive decline, but its preoperative role in POD remains underexplored. This pilot study aimed to investigate the association between preoperative regional BBB permeability, assessed by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and POD in older patients undergoing off-pump coronary artery bypass grafting (OPCABG).

Oncologic and perioperative outcomes following robot-assisted radical prostatectomy in morbidly obese patients: a systematic review and meta-analysis.

To assess how morbid obesity influences perioperative and oncological outcomes following robot-assisted radical prostatectomy (RARP). A comprehensive literature search was conducted across PubMed, Web of Science, Scopus, and Google Scholar, covering publications up to June 2025. Eligible studies included those that compared outcomes between patients with morbid obesity (defined as BMI ≥ 40 kg/m) and those without.

Targeting FCRLA to induce necrosis in lung adenocarcinoma: a novel strategy for prognosis and therapy via MPT-Driven pathways.

Introduction: The induction of mitochondrial permeability transition-driven necrosis (MPTDN) is therapeutically relevant in various cancers. However, few studies have explored the role of MPTDN-related genes (MPTDNRGs) in lung adenocarcinoma (LUAD). Therefore, this study investigated the regulatory mechanisms of MPTDNRGs in LUAD.

Successful Diagnosis and Treatment of Early Postpartum Choriocarcinoma.

Background: Postpartum placental choriocarcinoma is a rare gestational trophoblastic tumor, with an incidence of approximately one in 50 000. Patients often present with persistent postpartum hemorrhage, which can lead to delayed diagnosis, hematogenous metastasis, and ultimately, a poor prognosis.

Case: A 35-year-old woman was admitted to the Emergency Department 39 days after a cesarean section due to persistent heavy vaginal bleeding.

Gut dysbiosis is associated with increased blood-brain barrier permeability and cognitive impairment in elderlies with coronary heart disease.

Objective: The gut-brain axis is recognized as a critical pathway through which gut microbiota influences neurological health. However, the complex interplay between gut microbiota composition, blood-brain barrier (BBB) integrity, and cognitive function in elderly individuals with coronary heart disease (CHD) experiencing mild cognitive impairment (MCI) remains insufficiently elucidated. This study aimed to investigate these relationships in a cohort of 40 elderlies with CHD, comparing those with MCI to those with normal cognition (NC), focusing on microbial diversity, specific taxa alterations, BBB permeability, and their correlations with cognitive performance.

Phenotypic and genotypic profiles of clinical isolates of various Nocardia species to carbapenems and fluoroquinolones.

Objectives: To establish patterns of the antimicrobial susceptibility of Nocardia species to carbapenems and fluoroquinolones and analysis of phenotypic-genotypic correlations.

Methods: Isolates were identified to the species using 16S rRNA, secA1, or rpoB gene sequencing analysis. The antimicrobial susceptibility testing was performed using the broth microdilution method, and WGS was employed to analyse the presence of resistance genes and/or mutations of Nocardia species against carbapenems and fluoroquinolones.

COL4A1 as a potential prognostic biomarker with functional roles in colon cancer progression.

COL4A1, a key component of the basement membrane, has been increasingly implicated in tumor progression, yet its role in colon cancer remains incompletely understood. In this study, we conducted a comprehensive integrative analysis using transcriptomic data from the TCGA-COAD cohort, combined with functional validation in colon cancer cell lines. Gene set enrichment analysis (GSEA) revealed that high COL4A1 expression was associated with oncogenic pathways including epithelial-mesenchymal transition (EMT), KRAS signaling, and inflammatory responses.

CD9 regulates proliferation, invasion, migration and radioresistance of esophageal squamous cell carcinoma by activating AKT/GSK3β signaling pathway.

Background: Radioresistance poses a major therapeutic challenge in ESCC, significantly impacting patient prognosis. CD9, as a crucial membrane regulatory protein, exhibits dual regulatory roles in various cancers, yet its precise mechanism in ESCC radioresistance remains unclear. This study aims to systematically elucidate the molecular mechanisms by which CD9 regulates malignant phenotypes and radiosensitivity through the AKT/GSK3β signaling pathway in ESCC.

Effect of acid-suppressive drugs on endoscopic transmural drainage of peripancreatic fluid collections-a randomized controlled trial.

Background: Acid-suppressing drugs affect intestinal microbes by inhibiting the secretion of stomach acid. However, it is not clear whether acid suppressive drugs affect the microorganisms in the peripancreatic effusion and affect the postoperative complications.

Methods: This study was a prospective randomized controlled trial.

Relation knowledge distillation 3D-ResNet-based deep learning for breast cancer molecular subtypes prediction on ultrasound videos: a multicenter study.

Background: To develop and test a relation knowledge distillation three-dimensional residual network (RKD-R3D) model for predicting breast cancer molecular subtypes using ultrasound (US) videos to aid clinical personalized management.

Methods: This multicentre study retrospectively included 882 breast cancer patients (2375 US videos and 9499 images) between January 2017 and December 2021, which was divided into training, validation, and internal test cohorts. Additionally, 86 patients was collected between May 2023 and November 2023 as the external test cohort.

Dexmedetomidine attenuates postoperative delirium by activating Nrf2 to reduce oxidative stress and blood-brain barrier disruption.

Background: Postoperative delirium (POD), characterized by cognitive dysfunction, is a prevalent and severe complication following surgery. The blood-brain barrier (BBB) is crucial in maintaining central nervous system (CNS) homeostasis, and its disruption is associated with POD. Dexmedetomidine (DEX), an α2-adrenergic receptor agonist, potentially reduces POD incidence by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, which regulates antioxidant responses and alleviates BBB damage.

The efficacy of augmented reality technology assisted by 3D-CT reconstruction in microvascular decompression for hemifacial spasm craniotomy.

Background: We aimed to assess the efficacy of augmented reality technology assisted by three-dimensional (3D) computed tomography (CT) reconstruction, in facilitating microvascular decompression (MVD) during craniotomy for hemifacial spasm.

Methods: A retrospective analysis was conducted on 80 patients who underwent MVD for hemifacial spasm at Hebei General Hospital between January 2, 2020, and March 24, 2021. Among them, 43 patients received traditional craniotomy (assigned to the traditional group), while 37 patients underwent modified craniotomy (assigned to the modified group).

Canagliflozin Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease via Mitochondrial Protection and Enhanced Mitophagy.

Background: Canagliflozin shows anti-inflammatory and antioxidant properties. However, whether canagliflozin can mitigate metabolic dysfunction-associated steatotic liver disease (MASLD) by modulating mitochondrial dysfunction remains to be explored.

Methods: Canagliflozin was administered daily for MASLD mice at 10 mg/kg from Week 5 to Week 15.