Calcium/Manganese Nanoreactors Enable Triple-Enhanced Chemodynamic/Photodynamic Therapy via Tumor Microenvironment Reprogramming.

While reactive oxygen species (ROS)-dependent chemodynamic therapy (CDT) and photodynamic therapy (PDT) hold promise for cancer treatment, their efficacy remains constrained by tumor microenvironment (TME) barriers: glutathione (GSH) overexpression, insufficient HO supply, and hypoxia. To address these limitations, we engineered a Trojan horse-inspired MnO-shelled CaO nanoreactor (CaO/MnO-Ce6-PEG) by employing a sequential TME reprogramming strategy, triggering a cascading ROS storm for enhanced CDT and PDT. The outer MnO layer first depletes GSH through redox conversion, exposing the CaO core hydrolysis, and subsequently providing HO for CDT and O for ameliorating hypoxia to boost Ce6-mediated PDT.

A Readily Synthesized All-In-One Nanowire Hydrogel: Toward Inhibiting Tumor Recurrence and Postoperative Infection.

Surgical resection remains the frontline intervention for cancer; however, postoperative tumor recurrence and wound infection remain critical unmet challenge in surgical oncology. Herein, an all-in-one nanowired hydrogel (V-Hydrogel) is developed through a facile one-step assembly employing enzyme-mimetic VO nanowires and bactericidal crosslinker THPS. The V-Hydrogel reserves the glutathione peroxidase-, peroxidase-, catalase-, and oxidase-mimetic enzymatic activities derived from vanadium oxide nanowires, thereby exhibiting efficient tumor-specific catalytic therapy.

Comparative Cochlear Transcriptomics in Echolocating Bats and Mouse Reveals Hras as Protector Against Noise-Induced Hearing Loss.

Noise-induced hearing loss (NIHL), caused by irreversible cochlear hair cell (HC) damage, lacks effective therapies due to a limited understanding of endogenous protective mechanisms. The echolocating bats exhibit natural resistance to intense noise, and this suggested novel insights into methods to protect against NIHL. Here, through comparative transcriptomic analysis of noise-exposed cochleae from the eastern bent-winged bats (Miniopterus fuliginosus) and mice, the specific transcriptional dynamics in noise-resistant Miniopterus fuliginosus are revealed, thus highlighting potential mechanisms for preventing cochlear damage that mouse models cannot replicate, with Hras emerging as the most significant hub upregulator.

Research Progress of Mitochondrial Dynamics and Autophagy in Diabetic Complications: New Treatment Strategies.

Diabetes has emerged as a critical global health issue, with its associated complications posing a severe threat to patients' quality of life. Current research demonstrates that imbalance in mitochondrial dynamics and autophagic dysregulation play pivotal roles in the pathogenesis of diabetic complications, particularly in diabetic cardiomyopathy, nephropathy, peripheral neuropathy and retinopathy. Strategic modulation of mitochondrial function and autophagic activity represents a promising therapeutic approach for managing diabetic complications.

Novel pathogenic splicing mutation in in a patient with Stickler syndrome verified by minigene splicing assay.

Background: Stickler syndrome (STL) is a group of related connective tissue disorders characterized by heterogeneous clinical presentations with varying degrees of orofacial, ocular, skeletal, and auditory abnormalities. However, this condition is difficult to diagnose on the basis of clinical features because of phenotypic variability. Thus, expanding the variant spectrum of this disease will aid in achieving a firm definitive diagnosis of STL.

Lightweight rice leaf spot segmentation model based on improved DeepLabv3.

Introduction: Rice is an important food crop but is susceptible to diseases. However, currently available spot segmentation models have high computational overhead and are difficult to deploy in field environments.

Methods: To address these limitations, a lightweight rice leaf spot segmentation model (MV3L-MSDE-PGFF-CA-DeepLabv3+, MMPC-DeepLabv3+) was developed for three common rice leaf diseases: rice blast, brown spot and bacterial leaf blight.

Total ginsenosides enhance γ-globin expression and fetal hemoglobin production in β-thalassemia models.

Introduction: β-thalassemia is a genetic hemoglobinopathy characterized by defective β-globin synthesis and ineffective erythropoiesis. Pharmacological induction of fetal hemoglobin (HbF) via γ-globin gene activation represents a promising therapeutic strategy. Total ginsenosides (TG), the principal active constituents of , have shown epigenetic and transcriptional modulatory properties, yet their role in HbF induction remains unexplored.

Asymmetrical branched PEG-modified liposomes evade anti-PEG antibody recognition to abolish accelerated blood clearance and amplify tumor drug accumulation.

The prevalence of anti-polyethylene glycol (PEG) antibodies poses a significant challenge for the clinical translation of PEGylated liposomes, leading to an accelerated blood clearance (ABC) phenomenon and diminishing therapeutic effectiveness. To address this limitation, we designed an asymmetrical branched PEG derivative (mPEG-DSPE) and prepared mPEG-DSPE-modified liposomes, which included 1,1'-dioctadecyl-3,3,3,3'-tetramethylindo dicarbocyanine iodide liposomes (P-DiR) and mitomycin C lipid prodrug (MSC) liposomes (P-MSC) to minimize the binding of anti-PEG antibodies. Cellular binding assays revealed that the anti-PEG antibody binding rate for P-DiR was only 0.

An electrochemical biosensor for detection of copper(II) based on FeO@Au magnetic nanoparticles and Cu-dependent DNAzyme assisted nicking endonuclease signal amplification.

Copper ions are essential elements in the human body and participate in various physiological activities in the bodies of organisms. Herein, an ultrasensitive electrochemical biosensor was developed for detection of copper ions (Cu) based on FeO@Au magnetic nanoparticles (FeO@Au MNPs) and a Cu-dependent DNAzyme assisted nicking endonuclease signal amplification (NESA) strategy. dsDNA is formed by a hybridization reaction between DNA S2 and S1 immobilized on the surface of FeO@Au MNPs.

Parkin Acetylation-Mediated Mitophagy Orchestrates Periodontal Ligament Stem Cell Osteogenesis and Bone Regeneration During Ageing.

Aim: To investigate the functional significance of mitophagy in age-related osteogenic decline and the underlying mechanisms using in vivo and in vitro models.

Materials And Methods: An alveolar bone defect model in aged mice and a serial passaging-induced ageing model of human periodontal ligament stem cells (PDLSCs) were established. Osteogenic potential in mice was assessed by micro-CT, immunofluorescence, immunohistochemical analyses and histological staining.

OsPIL1 Differentially Modulates Rice Blast Resistance Through Integrating Light or Darkness During Magnaporthe oryzae Infection.

Light and darkness are critical environmental factors that regulate plant immune responses. OsPIL1, a phytochrome-interacting factor-like protein, has been implicated in rice immunity against Magnaporthe oryzae, although its underlying mechanism remains unclear. This study aimed to dissect how OsPIL1 integrates light or darkness to modulate rice immunity.

Polyphenol from walnut septum alleviates DSS-induced colonic injury by regulating the PI3K-AKT pathway signaling and gut microbiota in mice.

Background: Walnut septum, a Juglans regia L. by-product with culinary-medicinal value, is a rich source of bioactive polyphenols. The chemical complexity and anti-colitis activities of these polyphenols remain uncharacterized.

Lithium-Mediated Hydrochloric Acid Dissolution: Enabling Clean and Efficient Recovery of Palladium from Spent Catalysts by Electrodeposition.

To address palladium supply-demand challenges and conventional recovery inefficiencies, this study develops a lithium-mediated electrodeposition process for efficient palladium recycling from spent catalysts. Density functional theory calculations identified a controlled Pd→LiPd (Pd)→LiPdO (Pd) transformation pathway, and experimental verification confirmed that LiPd precursors underwent oxidative transformation into LiPdO with structural inheritance. LiPdO exhibited Pd-O coordination and underwent rapid dissolution in dilute hydrochloric acid.

Functional characterization of odorant binding proteins in Pharsalia antennata provides insights into diverse binding properties and the importance of C-terminal residues.

The cerambycid beetles are important components in the terrestrial ecosystem as they play a dual role in both degrading dying trees and killing healthy plants. The factors including human activity, habitat contraction, climate changes and pesticide use have been shaping the adaptation of beetles to host plants and the environment. As suggested in research on the functions of beetles' olfactory proteins, odorant binding proteins (OBPs) have been found to be involved in insecticide resistance other than chemoreception.

Varroa destructor infestation amplifies imidacloprid vulnerability in Apis mellifera.

Honey bee health is affected by a variety of environmental factors, with Varroa destructor parasitism and pesticide exposure being important factors contributing to colony decline. In this study, we assessed the effects of V. destructor infestation in combination with imidacloprid exposure on honey bees.

Foliar application of selenium nanoparticles enhance quality and mitigate negative plant-soil feedback in Panax notoginseng by modulating plant-microbiota interactions.

Developing a practical strategy to enhance the quality of medicinal herb while alleviating negative plant-soil feedback (NPSF) is critical for agriculture. In this study, we investigated the effects of selenium nanoparticles (SeNPs) on Panax notoginseng through a two-year field experiment. Four treatments were established: a control (SeNPs_0) and three SeNPs concentrations (3, 5, and 10 mg/L), which were foliar-sprayed every 15 days for a total of six applications.

A strain of mycovirus AaVV1 mediates hypovirulence of Alternaria species.

The genus Alternaria comprises a wide range of ubiquitous plant pathogens that affect various host plants. Certain mycoviruses can induce changes in the biological characteristics and virulence of host fungi, offering potential for biocontrol in managing fungal plant diseases. Here, we identified a mycovirus with a high degree of homology to Alternaria arborescens victorivirus 1 (AaVV1), which was previously reported from Alternaria arborescens, in the QRH strain of the heterologous host Alternaria gomphrenae.

Dual sulfur sources redox dynamics guided growth of 〈hk1〉-oriented SbS microrods: lattice strain modulation for ultra-low dark current.

Antimony trisulfide (SbS) has emerged as a promising inorganic semiconductor for optoelectronics due to its distinctive anisotropic crystal structure and suitable bandgap (∼1.7 eV). While hydrothermal synthesis remains challenging for achieving high crystallinity and controlled morphology, we developed an innovative dual‑sulfur precursor strategy utilizing sodium thiosulfate (STS) and thioacetamide (TAA) at a 7:2 M ratio with SbCl.

Dual-functional phthalamide modulation of aging-resistant PbI for efficient perovskite solar cells.

The sequential preparation of perovskite solar cells (PSCs) has received widespread concern for its use in large-scale perovskite modules and perovskite/silicon tandem solar cells. However, the instability of the PbI precursor solution and the incomplete reaction of ammonium salts hinder the industrialization of PSCs. Here, by introducing phthalamide (PA) into PbI solution, the carbonyl oxygen of PA molecules undergoes a bidentate coordination reaction with Pb to form an octahedral coordination structure, and the nitrogen atom in the -NH group exhibits weakly acidic properties due to the conjugation effect.

Effects of camellia seed cake protein on the printability, antioxidant activity and digestive performance of 3D-printed plant protein meat analogues.

This paper aims to explore the feasibility of enhancing the printing performance of 3D-printed meat analogues by varying the substitution amount of camellia seed cake protein (SCP) in the edible ink system based on proteins and polysaccharides. It covers the ink formulation, rheological properties and product analysis. The addition of SCP can significantly enhance the apparent viscosity, mechanical strength, and water retention capacity of the inks.

Highly sensitive detection and mechanism study of tetracycline in water by CuFeO/NiCo-LDH heterojunction electrochemical sensor.

A CuFeO/NiCo-LDH heterojunction electrochemical sensor (LDH: layered double hydroxide) was developed for the sensitive detection of tetracycline (TC). The sensor was constructed by integrating ZIF-67-derived nanocage NiCo-LDH on nickel foam with CuFeO, forming a p-n heterojunction that enhanced electron transfer and TC adsorption. The sensor exhibited bilinear detection ranges (0.

AI-driven and Traditional Radiomic Model for Predicting Muscle Invasion in Bladder Cancer via Multi-parametric Imaging: A Systematic Review and Meta-analysis.

Rationale And Objectives: This study systematically evaluates the diagnostic performance of artificial intelligence (AI)-driven and conventional radiomics models in detecting muscle-invasive bladder cancer (MIBC) through meta-analytical approaches. Furthermore, it investigates their potential synergistic value with the Vesical Imaging-Reporting and Data System (VI-RADS) and assesses clinical translation prospects.

Methods: This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Sustainable bio-based film based on chitosan resin crosslinking with tannin, phytic acid and octadecylamine for food packaging application.

Chitosan and tannin are both promising renewable materials for food packaging; however, their effectiveness is limited by incomplete interactions between them. Therefore, phytic acid and octadecylamine were employed to create chitosan-tannin-phytic acid-octadecylamine (CTPO) films that are flame-retardant, UV-resistant, antibacterial and hydrophobic for food packaging applications. The findings indicate that the CTPO film exhibited excellent hydrophobicity and mechanical properties, with a water contact angle of 133.

Widespread incongruence in the phylogenomics of the ancient land plant lineage, Selaginellaceae (lycophytes).

The advent of high-throughput genomic sequencing has provided unprecedented access to genome-scale data. This deluge of data has yielded new insights into phylogenetic relationships across the tree of life. However, incongruent results arising from different data partitions or from the use of different analyses have often been overlooked or insufficiently explored.

How nutrients and antibiotics shape microbial network patterns: Comparative insights from Erhai Lake bays.

Freshwater lakes are increasingly subject to simultaneous nutrient enrichment and antibiotic pollution, yet the joint effects of these stressors on microbial network structure remain poorly characterized. This study examined the combined effects of nutrients and antibiotics on bacterial communities across eight bays in Erhai Lake, which were classified into high-, moderate-, and low-pollution zones. High-pollution bays (Haichao, Dongsha, and Shuanglang) recorded the region's highest nutrient concentrations, with chemical oxygen demand reaching 33.