Predicting spread through air space of lung adenocarcinoma based on deep learning and machine learning models.

Objective: The aim of this study was to develop a machine learning model that can predict spread through air space (STAS) of lung adenocarcinoma preoperatively. STAS is associated with poor prognosis in invasive lung adenocarcinoma. Therefore non-invasive and accurate pre-surgical prediction of STAS in patients with lung adenocarcinoma is essential for individualised patient management.

Targeted delivery of Bak BH3 peptide to renal myofibroblast for renal fibrosis treatment by activating the mitochondrial-dependent apoptosis pathway.

Background: Renal fibrosis is positively associated with the increased number of renal myofibroblasts with over-expressed platelet-derived growth factor β receptor (PDGFβR). Reducing the number of renal myofibroblasts by inducing cell apoptosis is a novel strategy for treating renal fibrosis. The functional domain BH3 from protein Bak (BH3 peptide) exerts pro-apoptotic activity and the affibody Z shows a superior high affinity for PDGFβR.

The effects of long-term co-exposure to nanocarbon black particles and benzo[a]pyrene on ROS levels and the AKT/P27 signaling pathway in BEAS-2B cells.

Background: Long-term co-exposure to nanocarbon black particles (NCBP) and benzo[a]pyrene (B[a]P), as major components of PM2.5, may contribute to respiratory diseases by inducing oxidative damage. However, the molecular mechanisms underlying their synergistic effects remain unclear.

Highly Efficient Luminescent Solar Concentrators Based on Composition-Tunable ZnCuInSe/ZnSe Quantum Dots.

Luminescent solar concentrators (LSCs) are promising, cost-effective, large-area solar collectors for building-integrated photovoltaics (BIPVs). However, most of the recently reported efficient LSCs contain heavy metal ions, such as Pb or Cd, which limits their potential practical applications. Here we demonstrated eco-friendly ZnCuInSe/ZnSe (ZCISe/ZnSe) core/shell quantum dots (QDs) and integrated them into a poly(methyl methacrylate) (PMMA) polymer matrix to fabricate LSCs (10 × 10 × 0.

Hidden Dangers Within the Rivers of China's Largest Inland Basin: Uncovering the Current Status and Health Risks of BTEX Compounds.

Benzene series (BTEX) pollutants are hazardous organic compounds that are widely distributed in water, air, and soil and pose a significant threat to global public security. The presence of BTEX in surface waters in arid regions and its associated health risks, as well as the primary influencing factors, are crucial concerns that impede the protection and management of water environments in these areas. By employing a combination of the Monte Carlo risk assessment model and the geographical detector model, this study elucidates the health risks associated with benzene-based compounds in surface water within the Tarim Basin (TRB), China's largest inland basin, while identifying the primary driving forces influencing their distribution in the research area.

Cloning and RNA interference indicate that the Na/K-ATPase-β gene helps Hong Kong oysters (Crassostrea hongkongensis) resist short-term hypersalinity stress.

Na/K-ATPase is a carrier protein embedded in the cell membrane. The main function of this protein is to maintain osmotic pressure balance inside and outside the cell. To investigate the role of the Na/K-ATPase gene under high-salt stress in the Hong Kong oyster (Crassostrea hongkongensis), full-length cloning and expression analysis of Na/K-ATPase β subunit (ChNa/K-ATPase-β) were performed.

Unveiling the Nitrogen-Doping Mechanism in Carbon Catalysts for Oxidative Dehydrogenation of Ethanol to Acetaldehyde.

Oxidative dehydrogenation (ODH) of ethanol to acetaldehyde is an important production process. However, it still suffers from low deactivation, selectivity, and high costs. Herein, we developed a new strategy for preparing mesoporous nitrogen-doped carbon catalysts by carbonization of phenolic resin with silica as a hard template.

Genome-wide identification and characterization of the gene family in sorghum under salt-alkali stress.

Fasciclin-like arabinogalactan proteins (FLAs) are crucial for plant growth and development. Utilizing whole genome data, this study delineated the number of genes, gene structure, chromosomal localization, protein structure, evolutionary relationships, and Gene Ontology (GO) annotations of the family in sorghum ( L.).

A gut -derived metabolite impairs neutrophil function to aggravate bacterial lung infection.

The composition of the gut microbiota in patients with bronchiectasis has been proven to be distinct from that of healthy individuals, and this disrupted gut microbiota can exacerbate lung infections. However, the responsible microbes and mechanisms in the "gut-lung" axis in bronchiectasis remain unknown. Here, we report that was enriched in the gut, and taurine ursodeoxycholic acid (TUDCA) was enriched in both the guts and sera of patients with bronchiectasis, with both being associated with disease severity.

Development of single nucleotide polymorphisms in key genes of taurine and betaine metabolism in Crassostrea hongkongensis and their association with content-related traits.

Background: Taurine and betaine are important nutrients in the Hong Kong oyster (Crassostrea hongkongensis) and have many important biological properties. To investigate the characteristics of taurine and betaine and identify single nucleotide polymorphisms (SNPs) associated with traits in C. hongkongensis, we cloned the full-length cDNA of key genes involved in taurine and betaine metabolism (unpublished data), determined taurine and betaine content and gene expression in different tissues and months of the oyster specimen collection, and developed SNPs in the gene coding region.

Enhanced Microwave Absorption of Multi-Interface Core-Shell FeSiAl@MnO@C Composites by Morphology Engineering.

The rational manipulation of interfacial properties, composition, and morphology of materials has emerged as an effective strategy for enhancing their microwave absorption performance. The crystal phase composition, microstructure, and electromagnetic properties can be regulated by varying the thermal treatment temperature. The synergistic integration of heterogeneous interfaces, magnetic materials, microstructures, and defect engineering helps optimize impedance matching and enhance polarization and magnetic losses.

Development of single nucleotide polymorphisms in key genes of taurine and betaine metabolism in Crassostrea hongkongensis and their association with content-related traits.

Background: Taurine and betaine are important nutrients in and have many important biological properties. To investigate the characteristics of taurine and betaine contents and identify SNPs associated with traits in the , we cloned the full-length cDNA of key genes in taurine and betaine (unpublished data) metabolism, determined taurine and betaine content and gene expression in different tissues and months of specimen collection, and developed SNPs in the gene coding region.

Results: We cloned the full-length cDNA of cysteine dioxygenase () and cysteine sulfite decarboxylase (), which are key genes involved in taurine metabolism in , and found that betaine and taurine contents and the expression of key genes were regulated by seawater salinity.

Multimodal prehabilitation to improve functional abilities and reduce the chronic inflammatory response of frail elderly patients with gastric cancer: A prospective cohort study.

Background: Population ageing and cancer burden are important global public health problems that pose unprecedented threats to health systems worldwide. Frailty is a common health problem among elderly patients with cancer. In recent years, the use of prehabilitation to improve frailty has received widespread attention.

One-Step Synthesis Strategy for a Platinum-Based Alloy Catalyst Designed via Crystal-Structure Prediction.

The industrial application of polymer electrolyte membrane fuel cells is limited by the high cost of platinum catalysts. In this study, we developed a one-step synthesis strategy for low-platinum alloy catalysts based on crystal-structure predictions. Using this method, we successfully prepared a low-platinum alloy catalyst, i.

PCBM Constructing Heterojunction for Efficient CsPbI Perovskite Quantum Dot Solar Cells.

CsPbI perovskite quantum dots (PQDs) have emerged as promising photovoltaic materials for third-generation solar cells, owing to their superior optoelectronic properties. Nevertheless, the performance of CsPbI PQD solar cells is primarily hindered by low carrier extraction efficiency, largely due to the insulative ligands. In this study, we introduced a semiconductor molecule, [6,6]-phenyl C butyric acid methyl ester (PCBM), onto the surfaces of CsPbI PQDs as surface ligands to enhance photogenerated charge extraction.

O-methyltransferase CbzMT catalyzes iterative 3,4-dimethylations for carbazomycin biosynthesis.

Carbazomycins (-) are a subgroup of carbazole derivatives that contain oxygen at the C3 and C4 positions and an unusual asymmetric substitution pattern. Several of these compounds exhibit antifungal and antioxidant activities. To date, no systematic biosynthetic studies have been conducted on carbazomycins.

Deciphering the driving factors and probabilistic health risks of potentially toxic elements in arid surface water: Insights from the Tarim River Basin.

Potentially toxic elements (PTEs) in surface water in arid areas pose a serious threat to environmental safety and human health within a basin. It is important to determine the factors controlling PTEs and to assess the likelihood that they will pose a risk to human health in order to support the development of environmental protection and risk management strategies. In this study, a structural equation model and Bayesian method were combined to discuss the distribution and probabilistic health risks of PTEs in surface water in arid area, and the Tarim River Basin was taken as a case study.

Biocontrol and growth promotion potential of NT35 on based on the multifunctional effect.

The strain NT35, which has strong biocontrol ability, was isolated from the rhizosphere soil of . The antifungal effects of the NT35 strain against the mycelium and spore growth of , which causes ginseng rusty root rot, were determined. The inhibitory rate of mycelial growth was 94.

Distribution characteristics of antinuclear antibodies in Guillain-Barré syndrome and its relationship with disease severity.

Background: Guillain-Barré syndrome (GBS), an acquired immune-mediated autoimmune disorder affecting the peripheral nervous system (PNS), is associated with autoimmunity. The presence of autoantibodies in the blood is an important feature of autoimmune diseases. Herein, we explored the distribution characteristics of the antinuclear antibodies (ANAs) in GBS and the correlation between ANAs and disease severity.

Accurate 3D LiDAR SLAM System Based on Hash Multi-Scale Map and Bidirectional Matching Algorithm.

Simultaneous localization and mapping (SLAM) is a hot research area that is widely required in many robotics applications. In SLAM technology, it is essential to explore an accurate and efficient map model to represent the environment and develop the corresponding data association methods needed to achieve reliable matching from measurements to maps. These two key elements impact the working stability of the SLAM system, especially in complex scenarios.

Transcutaneous Electrical Acupoint Stimulation Combined with Moderate Sedation of Remimazolam Tosilate in Gastrointestinal Endoscopy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Introduction: Further clinical validation is required to determine whether transcutaneous electrical acupoint stimulation (TEAS) can replace opioids and be used in combination with remimazolam for sedation during gastrointestinal endoscopy.

Methods: A total of 108 outpatients who underwent diagnostic gastrointestinal endoscopy were randomly divided into three groups: fentanyl plus remimazolam group (group C), TEAS plus remimazolam group (group E), and placebo-TEAS plus remimazolam group (group P). The assessments of patient satisfaction, physician satisfaction, and pain scale score during the examination constituted the primary endpoints of the study.

Posterior mediastinal leiomyosarcoma: Case report and literature review.

Background: Posterior mediastinal leiomyosarcoma is an extremely rare malignant mesenchymal tumor with no special clinical symptoms, which is easily confused with some common tumors in the posterior mediastinum, affecting the accuracy of the first diagnosis by clinicians and delaying the treatment of patients.

Case Summary: We report a 59-year-old woman with a space-occupying lesion in the posterior mediastinum. The patient was mistakenly diagnosed with lumbar muscle or vertebral body lesions due to chest and back pain and underwent conservative treatment, but her symptoms did not improve significantly and she gradually developed pain in both lower limbs.

STGIC: A graph and image convolution-based method for spatial transcriptomic clustering.

Spatial transcriptomic (ST) clustering employs spatial and transcription information to group spots spatially coherent and transcriptionally similar together into the same spatial domain. Graph convolution network (GCN) and graph attention network (GAT), fed with spatial coordinates derived adjacency and transcription profile derived feature matrix are often used to solve the problem. Our proposed method STGIC (spatial transcriptomic clustering with graph and image convolution) is designed for techniques with regular lattices on chips.