Overcoming ACQ: DPA-modified TICT-type AIEgens for high-resolution and multilevel latent fingerprint visualization.

Latent fingerprints (LFPs), as critical carriers of personal identification information, present a long-standing challenge for high-resolution imaging in forensic science. Aggregation-induced emission luminogens (AIEgens), known for their superior luminescence in aggregated or high-viscosity environments, have emerged as ideal candidates for high-contrast fingerprint visualization. In this study, we designed a series of novel AIEgens by introducing diphenylamine (DPA) donor groups at the 3- and 11-positions of a quinazolinone core, effectively constructing twisted intramolecular charge transfer (TICT) systems.

PGC-1α-mediated mitochondrial homeostasis imbalance aggravated gingival lesions of diabetic periodontitis by disrupting ECM remodeling of human gingival fibroblast.

Diabetic periodontitis (DP) usually has more severe clinical symptoms compared with chronic periodontitis (CP), especially the worsened gingival lesions. Mitochondrial homeostasis plays an important role in both diabetes and periodontitis, and some studies have already confirmed its role in DP. However, there are few reports on whether mitochondrial homeostasis is involved in regulating DP gingival lesions.

Rhus chinensis Mill Derived Anti-Allergic Ingredients Screening Using MAS-Related G Protein-Coupled Receptor X2 Cell Membrane Chromatography.

Mas-related G-protein coupled receptor member X2 (MrgprX2) serves as a potential therapeutic target for pseudoallergic reactions. Cell membrane chromatography (CMC) is an efficient and reliable technique for screening active components from complex systems, which can be used to search for MrgprX2 antagonists in herbs. Therefore, we used a previously constructed MrgprX2-HALO-tag/CMC-HPLC-MS system specifically for identifying natural antagonists.

Association between marital status and dementia among older adults population: the Chinese longitudinal healthy longevity survey.

Objective: This paper describes the association between marital status and dementia in older Chinese adults.

Methods: Using the 2018 Chinese Longitudinal Healthy Longevity Survey dataset, we conducted a cross-sectional study involving 13,982 older adults with dementia. Marital status was categorized as married and unmarried (divorced, widowed, or never married).

Effects of artificial humic acid on rhizosphere ecology and microbial regulation in a ryegrass-Bacillus cereus symbiotic system for remediating Cr(VI)-contaminated soil.

Pollution by heavy metals, particularly hexavalent chromium (Cr(VI)), has become a significant environmental threat. This study aimed to evaluate the synergistic effects of artificial humic acid (A-HA) and Bacillus cereus Q-0 on Cr(VI) remediation in a ryegrass-soil system. A-HA was synthesized, and B.

Multifunctional copper-light synergistic prodrug nanosystems for specific reprogramming of tumour immunogenic endoplasmic reticulum stress.

Inducing lethal endoplasmic reticulum (ER) stress is a key initiative to counteract tumour resistance and induce anti-tumour immunity. However, conventional ER stress inducers are largely limited by hypoxia and off-target effects to induce tumour-lethal ER stress. Here, we encapsulated Cu-bridged eosin Y (CuBY) in ER-targeting peptide (pardaxin)-modified mesoporous silica and successfully constructed an oxygen-independent multifunctional copper-light synergistic prodrug nanosystems (MP@CuBY).

Electroacupuncture Intervention Improves Post-Stroke Dysphagia by Modulating NMDAR1 and GABABR1.

Introduction: Post-stroke dysphagia (PSD) is a common complication after acute stroke. It can be effectively alleviated by electroacupuncture (EA) stimulation at the Baihui acupoint; however, the underlying mechanism remains unclear.

Methods: Male ICR mice were used, and the suture occlusion method was employed to establish the middle cerebral artery occlusion (MCAO) mouse model.

Rapid detection of aspartame in beverages using a molecularly imprinted polymer-based fluorescence sensor.

With growing concerns about aspartame safety in beverages, we present a novel fluorescent molecularly imprinted polymer (FMIP) sensor designed for rapid, low-cost aspartame detection. By strategically selecting functional monomers and cross-linkers, and optimizing polymerization conditions, the FMIP sensor achieved high specificity for aspartame with ultrafast response (10 min, faster than conventional methods). The sensor demonstrated a wide linear range (1-100 μM), low detection limit (0.

Development of fluorescent artificial receptors for specific recognition and rapid detection of Escherichia coli O157:H7.

Development of rapid, low-cost, and sensitive sensors for monitoring Escherichia coli (E. coli) O157:H7 is very necessary and urgent to ensure food safety. In this study, we developed two fluorescent artificial receptor-based sensors via a boronate affinity molecular imprinting strategy targeting E.

Controlling T cell-tumor cell interaction with a biomimetic physical barrier for cancer immunotherapy.

Cancer immunotherapy has shown tremendous promise in various cancers. However, current strategies, such as immune checkpoint blockade, primarily restore exhausted T cells but provide only transient efficacy, as the rapid clearance of antibodies. Their limited durability is further hindered by persistent T cell-tumor cell interactions that accelerate T cell exhaustion.

Photoresponsive tetracoordinate arylboron smart molecules: Strategies for molecular design and photoresponse mechanisms.

Photoresponsive smart materials, which exhibit swift or instantaneous responses to external light stimuli, are pivotal for advancing the development of novel smart devices. Among these materials, photoresponsive tetracoordinate arylboron compounds emerge as prominent molecular systems, owing to their captivating photochemical mechanisms and photophysical transformations. In recent years, these molecules have experienced notable progress, leading to the emergence of numerous organic boron photoresponsive molecular systems with innovative structures and exceptional performance.

Mechanism of the effect of fixation degrees on the volatile and non-volatile metabolites in green tea using targeted and non-targeted metabolomics analyses and the flavor objective quantification technique.

Fixation plays a crucial role in green tea processing; however, the impact of different fixation degrees on the conversion of non-volatile and volatile metabolites remains unclear. This study explored the effects of mild, moderate, and severe fixation on green tea quality and identified 53 non-volatile metabolites, 60 volatile metabolites, and 17 objective flavor indicators. Moderate fixation (55 % leaf moisture) enhanced the umami and greenness of liquor by 38.

Enhancing Luminescence Efficiency of Solvated Europium(III) via Electronic-Vibrational Decoupling: An Unconventional Aggregation-Induced Emission System.

Europium(III) (Eu) ions are renowned for their exceptional photophysical properties, making them invaluable in applications such as energy-efficient lighting, display technologies, and advanced laser systems. However, transitioning Eu from solid-state matrices to solution-based environments typically results in a significant decline in luminescence efficiency due to strong vibrational coupling and dynamic coordination interactions with solvents. These issues have hindered the broader application of rare earth ions in solution-based technologies such as biological imaging probes and optical sensors.

Broadening the Na diffusion degree of freedom to unlock a rapid sodium storage potential in fluorophosphate cathode.

High safety and high energy-density sodium-ion batteries require the promising polyanionic insertion-type cathode possessing fast dis-/charging capability, yet persistent challenges remain in the kinetic optimization to accelerate their intrinsically low Na diffusivity. Exampled by the representative NaV(PO)OF (NVPOF) with considerable theoretical energy density, structural distortion results in a one-dimensional sluggish Na diffusion out of the two-dimensional Na pathway provided structurally. Previous endeavors with Na site or transition-metal site regulation successfully optimize the Na diffusion energy barrier of the available one-dimensional path.

PAM-free hairpin target binding activates trans-cleavage activity of Cas12a.

CRISPR-Cas12a has been demonstrated to be activated for its trans-cleavage activity by single- and double-stranded DNA containing a protospacer adjacent motif (PAM), but other types of activators have remained undiscovered. In this work, we found that a hairpin-structured substrate can activate the trans-cleavage activity of Cas12a without a PAM, and the parameters of the hairpin loop obviously affect the activity. Cas12a exhibits sequence preference for proximal loops, preferring to recognize polyadenine hairpin loop activators.

Efficacy of 3% diquafosol sodium eye drops at different frequencies in the treatment of dry eye after FS-LASIK.

Aim: To compare the efficacy of 3% diquafosol sodium (DQS) eye drops at different frequencies in dry eye (DE) after femtosecond laser-assisted keratomileusis (FS-LASIK).

Methods: In this prospective study, DE patients after FS-LASIK were randomly divided into two groups. All patients were administered routine anti-inflammatory and anti-infective drugs after FS-LASIK.

RNA Editing-Mediated Correction of TP53 Nonsense Mutations via Lipid Nanoparticle-Delivered Circular ADAR-Recruiting RNAs.

Nonsense mutations account for over 20% of disease-associated mutations, which refer to the occurrence of premature termination codons (PTCs) in gene sequences, resulting in truncated and dysfunctional proteins. Nonetheless, due to poor accessibility of precise target sites and the limitations of gene editing tools, there is still a lack of safe, effective, and site-specific approach for correction of nonsense mutations. Here, we designed a circular ADAR-recruiting RNA (Circ-arRNA) for the in vivo RNA editing-mediated repair of the nonsense mutation.

Specific and sensitive detection of capsaicin for edible oils authentication using fluorescent molecularly imprinted silica particles.

In this study, we developed two fluorescent molecularly imprinted polymers (FMIPs) for sensitive detection of capsaicin to distinguish the recycled edible oils. Utilizing a catalyst-free molecular imprinting approach and N-vanillylnonanamide (capsaicin analog) as the template, two types of FMIPs were synthesized utilizing fluorescent monomers coupled with fluorescein isothiocyanate (FFMIP) and rhodamine B isothiocyanate (RFMIP). Both FFMIP and RFMIP showed high selectivity (imprinting factors of 2.

Tissue-resident immune cells in cervical cancer: emerging roles and therapeutic implications.

The favorable prognosis of "hot" tumors is widely acknowledged in oncology. Recently, the concept of tertiary lymphoid structures (TLS) has renewed appreciation for local immune cells within tumor tissues. Tissue-resident immune cells, a newly identified subset of tumor-infiltrating lymphocytes, are emerging as potential key players in tumor infiltration and TLS formation, due to their ability to reside indefinitely within tissues and mount effective responses to local antigens.

[Research progress of the dopamine system in neurological diseases].

The etiology of nervous system diseases is complicated, posing significant harm to patients and often resulting in poor prognoses. In recent years, the role of dopaminergic system in nervous system diseases has attracted much attention, and its complex regulatory mechanism and therapeutic potential have been gradually revealed. This paper reviews the role of dopaminergic neurons, the neurotransmitter dopamine, dopamine receptors and dopamine transporters in neurological diseases (including Alzheimer's disease, Parkinson's disease and schizophrenia), with a view to further elucidating the disease mechanism and providing new insights and strategies for the treatment of neurological diseases.

Managing non-motor symptoms of Parkinson disease in China: clinical perspectives.

Background: Parkinson's disease (PD) is a complex neurodegenerative disorder with both motor and non-motor symptoms (NMS), the latter having a profound impact on patients' quality of life (QoL). Increased recognition of NMS underscores the need for comprehensive approaches. The study aimed to evaluate healthcare professionals' awareness and management practices of NMS in PD in China.

Preparation and Application of Core-Shell Nanocarbon-Based Slow-Release Foliar Fertilizer.

The application of nanotechnology offers a promising solution to improve fertilizer utilization efficiency by mitigating the losses and volatilization of conventional fertilizers, contributing to sustainable agriculture. In this study, a core-shell nanocarbon-based slow-release foliar fertilizer (CN@mSiO-NH@Urea@PDA) was synthesized using nanocarbon (CN) as the core, amino-functionalized mesoporous silica (mSiO-NH) as the shell, and polydopamine (PDA) as the coating layer. BET analysis revealed a 3.

Non-volatile and volatile metabolite analyses and objective quantitative technique reveal the effect of fixation methods on the flavor quality and metabolites of green tea.

Fixation methodology serves as the critical determinant in shaping green tea's multi-dimensional quality attributes; however, the impact of different fixation methods and the corresponding combinations on the overall metabolites and quality of in green tea remains unclear. In this study, non-volatile metabolites (NVMs) and volatile metabolites (VMs) analyses and objective quantitative techniques were used to determine the effects of electromagnetic roller-hot air coupling fixation (ROHF), electromagnetic roller-steam coupling fixation (ROSF), electromagnetic roller-hot air-steam coupling fixation (RHSF), electromagnetic single roller fixation (ROLF), and carding fixation (CDF) on the quality of green tea. Forty-four NVMs, 99 VMs, and 15 flavor objective quantitative indexes were identified, with 12 differential NVMs and 9 differential VMs statistically screened.

Agronomic characteristics, objective quantitative, metabolome and transcriptome analysis reveal the influence of fertilization treatments on fresh leaf characteristics and finished tea quality.

Fertilization is important for tea garden management and tea flavor improvement; however, the effects of different ratios of organic and chemical fertilizer on fresh tea leaf quality and finished tea flavor remain unclear. Therefore, four fertilization treatments were used to elucidate the underlying mechanisms. Fertilization treatments increased tea yield, and organic fertilizer increased bud density.