Highly sensitive detection and mechanism study of tetracycline in water by CuFeO/NiCo-LDH heterojunction electrochemical sensor.

A CuFeO/NiCo-LDH heterojunction electrochemical sensor (LDH: layered double hydroxide) was developed for the sensitive detection of tetracycline (TC). The sensor was constructed by integrating ZIF-67-derived nanocage NiCo-LDH on nickel foam with CuFeO, forming a p-n heterojunction that enhanced electron transfer and TC adsorption. The sensor exhibited bilinear detection ranges (0.

Widespread incongruence in the phylogenomics of the ancient land plant lineage, Selaginellaceae (lycophytes).

The advent of high-throughput genomic sequencing has provided unprecedented access to genome-scale data. This deluge of data has yielded new insights into phylogenetic relationships across the tree of life. However, incongruent results arising from different data partitions or from the use of different analyses have often been overlooked or insufficiently explored.

How nutrients and antibiotics shape microbial network patterns: Comparative insights from Erhai Lake bays.

Freshwater lakes are increasingly subject to simultaneous nutrient enrichment and antibiotic pollution, yet the joint effects of these stressors on microbial network structure remain poorly characterized. This study examined the combined effects of nutrients and antibiotics on bacterial communities across eight bays in Erhai Lake, which were classified into high-, moderate-, and low-pollution zones. High-pollution bays (Haichao, Dongsha, and Shuanglang) recorded the region's highest nutrient concentrations, with chemical oxygen demand reaching 33.

CsWRKY15 from tea plant promotes its auto-resistance when intercropped with chestnut.

To explore the role of WRKY transcription factors in resistance, a WRKY15 homologous gene, CsWRKY15, and its promoter were isolated from tea plants when intercropped with chestnut. CsWRKY15 expression was significantly induced by ethephon, polyethylene glycol (PEG), and low temperature. Notably, its expression was strongly induced by exogenous gibberellic acid (GA3).

C/N-Driven Synergies: Earthworms Optimize CO/NO Mitigation and Soil Quality in Floral Waste Recycling.

The expansion of floriculture has increased the need for sustainable floral waste management to support agricultural carbon neutrality. This study assessed the impact of carnation, lily, and rose straw amendments (with varying C/N ratios, lignin, and cellulose) on GHG emissions and soil quality with earthworm (Eisenia fetida). Controlled microcosm experiments were conducted to examine the effects of straw types and earthworms on CO and NO fluxes, as well as soil properties, enzyme activities, and microbial functions.

PathTGSeg: The pathologic image segmentation of breast cancer via template matching and graphic calculation.

Pathologic image analysis is important for providing fundamental references for the clinical diagnosis of breast cancer. Although many methods have achieved outstanding performance in the pathologic image segmentation of breast cancer, there are still two issues limiting further development in this task. First, diverse and complex appearances exist within the observed scope for the same type of breast cancer.

Electrochemical Oxidation of C(sp)-H Bonds for the Construction of C-S Bonds: Access to 9-Thioxanthenes.

Radical-radical cross-coupling offers an efficient strategy for constructing C-S bonds, yet existing methods typically rely on stoichiometric oxidants or metal catalysts. The lack of sustainable approaches for C(sp)-H sulfenylation at the C9 position of xanthene derivatives limits their functionalization. Herein, we developed an electrochemical method enabling direct C(sp)-H sulfenylation/selenylation of oxa/thia/aza-xanthenes under metal- and chemical-oxidant-free conditions.

Transformation of a covalent organic framework from dual pores to single pores and their different properties.

We have achieved a controllable transformation of covalent organic framework (COF) isomers from BATD-Dma-COF-K (dual pores) to BATD-Dma-COF-R (single pores). The fluorescence of BATD-Dma-COF-K was enhanced by clinafloxacin (CFN). After transformation from dual pores to single pores, BATD-Dma-COF-R can effectively adsorb CFN, but cannot fluoresce to detect CFN.

Yttrium-Doped Zinc Oxide (ZnYO) Electron Transport Layers: A Pathway to Enhanced Efficiency in PbS Colloidal Quantum Dot Solar Cells.

Significant progress has been achieved in PbS colloidal quantum dot solar cells (CQDSCs) by concentrating on structural engineering, band-alignment engineering, and enhancing the interfacial functionality of colloidal quantum dots (CQDs). Nonetheless, designing a durable and efficient photovoltaic device still represents a considerable obstacle for scientists in this domain. The present work demonstrates that the photovoltaic performance of PbS CQDSCs can be increased by adding 1-5 wt % yttrium into the zinc oxide (YZO) ETL.

Analysis of the quadruple evolutionary game of ecosystem service payment empowered by farmers' cooperatives.

Payments for Ecosystem Services (PES) are essential for ecosystem restoration and promoting sustainable economic development. Farmer cooperatives serve as key intermediaries in implementing PES. This study constructs a game model involving four stakeholders-local government, enterprises, cooperatives, and cooperative members-while considering their bounded rationality.

Orthogonally polarized dual-wavelength Nd:LaMgAl11O19/Nd:SrAl12O19 laser at 1297 and 1306 nm with adjustable ratio of output powers.

Using tunable in-band laser diode (LD) pumping (791.1-798.2 nm), an orthogonally polarized dual-wavelength (OPDW) Nd:LaMgAl11O19/Nd:SrAl12O19 (Nd:LMA/Nd:SA) operation at 1297 nm and 1306 nm for the 4F3/2 → 4I13/2 transition is demonstrated for the first time.

Iron(III)-Catalyzed Methanesulfonic-Acid-Mediated [3 + 2 + 1C] Annulation of Enaminones with 1,3-Dioxolane: Access to 2-Hydroxy-1,2-dihydropyridines.

An iron(III)-catalyzed methanesulfonic-acid-mediated [3 + 2 + 1C] annulation of enaminones assembling a 1,2-dihydropyridine (1,2-DHP) scaffold has been developed for the first time. This approach facilitates the rapid synthesis of 2-hydroxy-1,2-DHP derivatives in moderate to excellent yields with a broad substrate scope under mild conditions. The employment of 1,3-dioxolane as both a 1C synthon and solvent enables simultaneous incorporation of both a carbon atom and a hydroxy group into 1,2-DHPs.

Prediction Analysis of Integrative Quality Zones for W. T. Wang Under Climate Change: A Rare Medicinal Plant Endemic to China.

W. T. Wang, commonly known as Yanhusuo, is an important and rare medicinal plant resource in China.

[Research progress in pharmacological activities and pharmacokinetics of geniposidic acid].

Geniposidic acid(GA), a natural iridoid, exists in the roots, stems, leaves, flowers, bark, fruits, and seeds of medicinal plants of Rubiaceae, Eucommiaceae, and Plantaginaceae. Modern pharmacological studies have revealed that GA has multiple pharmacological activities, including organ-protective, anti-inflammatory, antioxidative, anti-osteoporosis, anti-neurodegenerative, and anti-cardiovascular effects. GA can enhance cell/organism defenses by upregulating key anti-inflammatory and antioxidant cytokines, while downregulating key node proteins in pro-inflammatory signaling pathways such as AhR and TLR4/MyD88, thereby exerting pharmacological effects such as organ protection.

[Caffeoylquinic acids from Erigeron breviscapus ameliorates cognitive impairment and mitochondrial dysfunction in AD by activating PINK1/Parkin-mediated mitophagy].

This study aimed to investigate the effects of caffeoylquinic acids from Erigeron breviscapus(EBCQA) on cognitive impairment and mitochondrial dysfunction in Alzheimer's disease(AD), and to explore its underlying mechanisms. The impacts of EBCQA on paralysis, β-amyloid(Aβ) oligomerization, and mRNA expression of mitophagy-related genes [PTEN-induced putative kinase 1(PINK1) homolog-encoding gene pink-1, Parkin homolog-encoding gene pdr-1, Bcl-2 interacting coiled-coil protein 1(Beclin 1) homolog-encoding gene bec-1, microtubule-associated protein 1 light chain 3(LC3) homolog-encoding gene lgg-1, autophagic adapter protein 62(p62) homolog-encoding gene sqst-1] were examined in the AD Caenorhabditis elegans CL4176 model, along with mitochondrial functions including adenosine triphosphate(ATP) content, enzyme activities of mitochondrial respiratory chain complexes Ⅰ,Ⅲ, and Ⅳ, and mitochondrial membrane potential. Additionally, the effects of EBCQA on the green fluorescent protein(GFP)/red fluorescent protein from Discosoma sp.

Five new clerodane diterpenoids from Callicarpa integerrima and their anti-inflammatory activity.

Five previously undescribed clerodane diterpenoids named calintegerinoids A-E (1-5), featuring 5/6 and 6/6 fused ring systems, were isolated from Callicarpa integerrima. Their structures were determined using modern spectroscopic techniques, including NMR, HR-ESI-MS, IR, UV, specific rotations, and ECD, supplemented by quantum chemical calculations and DP4+ analysis. Compared with the standard drug Andrographolide (IC 8.

Benefit-harm trade-offs of intensive blood pressure control versus standard blood pressure control on cardiovascular and renal outcomes: an individual participant data analysis of randomised controlled trials.

Background: Although intensive blood pressure control is recommended by major guidelines, its overall benefit-harm balance remains uncertain. In particular, it is unclear how net clinical benefit varies by blood pressure target and patient characteristics. We aimed to quantify the benefit-harm trade-offs of intensive blood pressure control versus standard blood pressure control.

From NaScGaQ (Q = S, Se) to KGaInS: substitution of Sc with In to achieve doubled birefringence.

The exploration of novel compounds with new crystal and electronic structures is essential for advancing the development of functional materials. Here, three novel isomorphic quaternary alkali-metal chalcogenides, AMQ (A = Na, K; M = Sc, Ga and In; Q = S, Se), with a new structure type have been obtained by a facile reactive flux assisted boron-chalcogen solid-state method, and adopt a 3 {[MQ]} open-framework architecture with A ions occupying the cavities to balance charges. Subtle modulation of the M-Q bonds induces a twofold enhancement in optical birefringence (Δ), observed from NaScGaQ (Q = S, Δ = 0.

Acupuncture for Rapid Pain Relief and Restoration of Motor Function in Acute Lateral Ankle Sprains: A Randomized Controlled Trial Protocol Based on Infrared Thermography.

Purpose: Acute lateral ankle sprain (ALAS) is a prevalent clinical sports injury disease, rapid relief of symptoms and return to normal functional activity are urgent needs of ALAS patients. The aim of this study is to observe the immediate therapeutic effect of acupuncture on ALAS patients in the short term and to evaluate the efficacy at different time points through a multidimensional assessment system, which is expected to provide a simple, rapid, safe and effective therapeutic option for ALAS patients.

Patients And Methods: This is a single-center, prospective, randomized clinical trial.

Literature review: Current trends and future prospects of digital vaccine supply chain support technology.

The digital vaccine supply chain (DVSC) harnesses modern information technology to track, monitor, and manage the entire vaccine process in real-time, ensuring vaccine quality and safety while enhancing the transparency and efficiency of the supply chain (SC). This paper undertakes a systematic literature review of research papers on DVSC support technology, adopting the Bibliometric-Systematic Literature Review (B-SLR) method. It addresses the gaps in previous research in this area and offers new ideas and perspectives for further applications.

Silver-Catalyzed Difluorocarbene Activation Enables Multicomponent Synthesis of δ,γ-Unsaturated β-Hydroxynitriles.

Herein, we report an efficient and general one-pot multicomponent strategy, innovatively developed for the construction of δ,γ-unsaturated β-hydroxy nitrile scaffolds. Using readily available aldehydes and ketones as starting materials and TMSCFBr as a difluorocarbene precursor, the transformation proceeds via tandem Aldol condensation, a difluorocarbene electrophilic reaction, and hydrolysis. Mechanistic studies revealed that the difluorocarbene activates the oxygen atom of the α,β-unsaturated carbonyl group through electrophilic orientation, significantly enhancing the electrophilicity of the carbonyl carbon, thereby driving the reaction to proceed with high selectivity via a 1,2-addition pathway.

Muscle-Bone Biochemical Crosstalk in Osteosarcopenia: Focusing on Mechanism and Potential Therapeutic Strategies.

Osteosarcopenia (OS) is a syndrome defined by the concurrent presence of sarcopenia and osteoporosis in the elderly population, which markedly elevates the risk of falls, fractures, and mortality. Recent studies demonstrate that disruption of muscle-bone biochemical crosstalk emerges as a key driver of OS pathogenesis, and that targeting pivotal mediators and pathways can concurrently restore musculoskeletal homeostasis. However, the precise molecular mechanisms and targeted therapeutic strategies remain inadequately explored.

Investigation of the toxic mechanism of aspartame on female infertility using network toxicology and molecular docking approaches.

Aspartame is a nonnutritive sweetener derived from phenylalanine and is widely used in food and beverages globally. In recent years, its safety, particularly the potential carcinogenic risks, has garnered significant attention; however, there has been relatively less focus on its potential infertility risks. This study employed network toxicology methods to construct an interaction network of aspartame and infertility-related targets and identify key targets and pathways.

Ozone dry deposition and chemical removal in the urban environment of Beijing: I. Chemical and meteorological controlling parameters.

Tropospheric ozone (O) is a major air pollutant that negatively affects human health and vegetation, and plays a central role in climate change and atmospheric chemistry. Current simulations of tropospheric O concentrations in climate and air-quality models are significantly limited by the inaccurate representation of O dry deposition rate-particularly in urban areas, where field measurements remain scarce. We hypothesize that O dry deposition in the urban environment is controlled by factors similar to those over vegetation, albeit via potentially different mechanisms.

Nano-enabled strategies for targeted immunotherapy in gastrointestinal cancers.

Gastrointestinal (GI) cancers remain a leading cause of global cancer morbidity and mortality, demanding novel therapeutic strategies that overcome existing limitations. Nanomedicine has recently emerged as a transformative approach, offering the potential to significantly enhance immunotherapy outcomes through precision targeting and modulation of tumour immune microenvironments. This review discusses the principal categories of precision-engineered nanoparticles-including lipid-based carriers, polymeric systems, protein-derived formulations, and metallic-hybrid composites-emphasising their capacity for targeted immune modulation and improved pharmacokinetic profiles.