Prognostic Value of a Novel Model for Hepatocellular Carcinoma Patients Undergoing Transarterial Chemoembolization.

Background: Hepatocellular carcinoma (HCC) patients who underwent transarterial chemoembolization (TACE) have heterogeneous clinical outcomes. Accurate prognosis prediction and risk stratification are crucial for individualized treatment. We sought to develop a novel prognostic model for overall survival (OS) that incorporated contemporary clinical and laboratory factors for estimating individual prognosis.

Literature review: Current trends and future prospects of digital vaccine supply chain support technology.

The digital vaccine supply chain (DVSC) harnesses modern information technology to track, monitor, and manage the entire vaccine process in real-time, ensuring vaccine quality and safety while enhancing the transparency and efficiency of the supply chain (SC). This paper undertakes a systematic literature review of research papers on DVSC support technology, adopting the Bibliometric-Systematic Literature Review (B-SLR) method. It addresses the gaps in previous research in this area and offers new ideas and perspectives for further applications.

A child of congenital muscular dystrophy-dystroglycanopathy with a novel variant in the gene: a case report and literature review.

Background: Dystroglycanopathy is a genetically heterogeneous group of rare muscular dystrophies that affect the brain, muscles, and eyes, primarily resulting from impaired glycosylation of α-dystroglycan. In this study, we identify and characterize a novel heterozygous gene variant causally associated with α-dystroglycanopathy.

Case Description: We present a case of a 1-year and 5-month-old female with elevated creatine kinase (CK) levels and seizures, along with global developmental delay, microphthalmia, hypotonia, and myasthenia.

FOXO1 contributes to cigarette smoke condensate-induced cellular senescence and fibrosis in lung fibroblasts through activating the TGF-β1/Smad2/3 signaling pathway.

Cigarette smoking is the most dominant factor contributing to chronic obstructive pulmonary disease (COPD). Fibroblasts are sensitive to cellular injury induced by cigarette smoke condensate (CSC). This study was devoted to discovering the potential target and exploring its regulatory mechanism in CSC-induced human fibroblasts.

Comprehensive Quality Evaluation of Viticis Fructus Based on Simultaneous Quantification of Nine Flavones and One Iridoid Glycoside by Ultra-High Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry and Chemometric Analysis.

Viticis fructus is the dry fruit of Vitex trifolia L. var. simplicifolia Cham.

Intercostobrachial nerve preservation during breast cancer surgery to prevent chronic postsurgical pain: A systematic review and meta-analysis of randomized controlled trials.

Background: Intercostobrachial nerve (ICBN) sacrifice during breast cancer surgery is associated with chronic postsurgical pain (CPSP), impaired sensory function, and reduced quality of life. The aim of this study was to assess the comparative effects of ICBN preservation vs. sacrifice after breast cancer surgery.

In the era of targeted therapy and immunotherapy: advances in the treatment of large B-cell lymphoma of immune-privileged sites.

Primary large B-cell lymphomas of immune-privileged sites (IP-LBCLs) include primary central nervous system large B-cell lymphoma (PCNSL), primary vitreoretinal large B-cell lymphoma (PVRL), and primary testicular large B-cell lymphoma (PTL). These tumors not only have a unique anatomical distribution but also exhibit specific biological and clinical characteristics. Given the high biological overlap between intravascular large B-cell lymphoma (IVLBCL) and IP-LBCLs, and the fact that IVLBCL is confined to the intravascular microenvironment, IVLBCL is currently included in the category of IP-LBCLs.

Odor contribution evaluation of six species of microalgae and corresponding odorants to whole fishy odor in drinking water source.

Disgusting fishy odor could break out inside oligotrophic drinking waterbody in winter with low temperature. In preceding study, six species of fishy odor-producing microalgae and totally twenty fishy odorants were identified in drinking water source of Tongyu River, however, contributions of odorants and microalgae to whole fishy odor were unclear. In this study, odor contribution of microalgae and corresponding odorant to whole fishy odor was evaluated comprehensively.

A rare case of vision loss caused by leptomeningeal metastasis of lung adenocarcinoma: a case report and literature review.

Leptomeningeal metastasis (LM) is a fatal complication with increasing incidence in patients with non-small cell lung cancer. Herein, we present the case of a patient who presented with complete vision loss due to LM and achieved a survival benefit from treatment with trametinib. The treatment was prescribed based on the detection of a BRAF non-V600E mutation in the cerebrospinal fluid (CSF).

IGF2-IGF1R signaling inhibition delays the growth of IGF2-high colorectal cancer by modulating MDSCs.

Approximately 22 % of human colorectal cancers (CRC) are characterized by IGF2 overexpression, and the tumor-promoting role of IGF2 has been widely reported. Despite promising preclinical results, IGF2 signaling inhibition therapy has exhibited limited efficacy in treating unselected patients with CRC. Recent evidence suggests that IGF2-high CRC are more sensitive to IGF2 signaling blockade therapy in immune-deficient mice, suggesting that IGF2-high CRC can benefit from IGF2 signaling blockade therapy.

Chlorophyll-Based Optogenetics to Control Membraneless Organelles.

Membraneless organelles (MLOs) formed via protein phase separation have garnered significant attention recently due to their relevance to cellular physiology and pathology. However, there is a lack of tools available to study their behavior and control their bioactivity in complex biological systems. This chapter describes a new optogenetic tool based on water-soluble chlorophyll protein (WSCP), a red light-induced singlet oxygen-generating protein, to control synthetic MLOs.

Immunogenicity and safety of SARS-CoV-2 recombinant protein vaccine (CHO cell) LYB001 as a heterologous booster following two- or three-dose inactivated COVID-19 vaccine in adults aged ≥18 years: interim results of a randomized, active-controlled, double-blinded, phase 3 trial.

Background: LYB001 is a recombinant protein COVID-19 vaccine displaying a receptor-binding domain (RBD) in a highly immunogenic array on virus-like particles (VLPs). This study assessed the immunogenicity and safety of LYB001 as a booster.

Research Design And Methods: In this randomized, active-controlled, double-blinded, phase 3 trial, participants aged ≥ 18 years received a booster with LYB001 or ZF2001 (Recombinant COVID-19 Vaccine).

Characteristics and potential human health risks of Paralytic Shellfish Toxins identified in eight species of bivalves from South Yellow Sea Mudflat.

The consumption of bivalves contaminated with paralytic shellfish toxins (PSTs) poses a serious risk to human health. However, the presence of PSTs in bivalves from the South Yellow Sea Mudflat remains unclear. This study comprehensively examined the characteristics and potential health risks of PSTs in eight species of bivalves from the South Yellow Sea Mudflat across four seasons.

Basilar Artery Tortuosity Increases the Risk of Persistent Dizziness and Unsteadiness After Posterior Circulation Infarction.

Background And Purpose: Basilar artery (BA) tortuosity is closely associated with posterior circulation infarction (PCI) and dizziness/unsteadiness. This study aims to determine the relationship between BA tortuosity and the outcome of dizziness and unsteadiness in PCI patients.

Method: This study prospectively recruited PCI patients presenting with dizziness and unsteadiness.

Breeding Maize Hybrids with Improved Drought Tolerance Using Genetic Transformation.

Drought is considered the main agricultural menace, limiting the successful realization of land potential, and thereby reducing crop productivity worldwide. Therefore, breeding maize hybrids with improved drought tolerance via genetic manipulation is necessary. Herein, the multiple bud clumps of elite inbred maize lines, DH4866, Qi319, Y478 and DH9938, widely used in China, were transformed with the gene encoding choline dehydrogenase (EC 1.

Abundance, characteristics and ecological risks of microplastics from South Yellow Sea Mudflat.

Microplastic (MP) pollution in global marine environments has been extensively reported and attracted significant concerns, but MP distribution in mudflat has rarely been studied. In this paper, the abundance, features and ecological risk of MP in South Yellow Sea Mudflat were investigated comprehensively. MP were both detected in waters (5.

Preparation, typical structural characteristics and relieving effects on osteoarthritis of squid cartilage type II collagen peptides.

The promoting effects of collagen and its derivatives on bone health have been uncovered. However, the structure and effects of type II collagen peptides from squid cartilage (SCIIP) on osteoarthritis still need to be clarified. In this study, SCIIP was prepared from squid throat cartilage with pretreatment by 0.

Research on distribution strategy of logistics enterprise alliance based on three-party evolution game.

Currently, collaborative distribution models have not reached the optimal state of carbon emissions. The cost of additional low-carbon expenditures and the problem of carbon data verification have led to the lack of motivation for reducing emissions among collaborative distribution enterprises. Therefore, how to incentivize them to adopt the low-carbon model is crucial for achieving low-carbon goal.

Serum 25-hydroxyvitamin D level and erectile dysfunction: a causal relationship? Findings from a two-sample Mendelian randomization study.

Background: Serum 25-hydroxyvitamin D level is associated with erectile dysfunction (ED) in observational studies. However, whether there is a causal association between them remains uncertain.

Objective: Conduct a two-sample Mendelian randomization (MR) analysis to investigate the causal effect between serum 25-hydroxyvitamin D level and ED risk.

Detection of sulphur(II) of carbon dots synthesized from residue.

The detection of anions using carbon dots (CDs) has received less attention compared to cations. Therefore, the present study aimed to develop a fluorescence sensor based on carbon dots (CDs) capable of detecting S in real water samples. The CDs were successfully prepared from the residues of a traditional Chinese herb, , which emitted green photoluminescence (PL) under ultraviolet light irradiation.

Genome-wide identification of ATG genes and their expression profiles under biotic and abiotic stresses in Fenneropenaeus chinensis.

Background: Autophagy is a conserved catabolic process in eukaryotes that contributes to cell survival in response to multiple stresses and is important for organism fitness. Extensive research has shown that autophagy plays a pivotal role in both viral infection and replication processes. Despite the increasing research dedicated to autophagy, investigations into shrimp autophagy are relatively scarce.

ZmNF-YA1 Contributes to Maize Thermotolerance by Regulating Heat Shock Response.

(maize) is a staple food, feed, and industrial crop. Heat stress is one of the major stresses affecting maize production and is usually accompanied by other stresses, such as drought. Our previous study identified a heterotrimer complex, ZmNF-YA1-YB16-YC17, in maize.