Machine learning-based model identifies a novel cuproptosis-related mitochondrial gene signature with a key role in the prognosis and treatment of lung adenocarcinoma.

Lung adenocarcinoma (LUAD) remains one of the most prevalent and lethal cancers globally, making it critical to understand the mechanisms driving its progression and improve prognosis. Moreover, cuproptosis and mitochondrial dysfunction may be involved in lung cancer. Therefore, the present study aimed to identify mitochondrial genes associated with cuproptosis to develop a prognostic model for patients with LUAD, with the potential to predict survival outcomes and responses to treatment.

Association between weight-adjusted waist index and severe periodontitis using NHANES 2009-2014.

The Weight-adjusted Waist Index (WWI) is a novel anthropometric indicator for assessing obesity. Given the well-established association between obesity and periodontitis, this cross-sectional clinical study aimed to investigate the relationship between WWI and severe periodontitis while evaluating its potential as a simple predictive marker for periodontitis. The study analyzed periodontal examination data and WWI measurements from participants in the 2009-2014 National Health and Nutrition Examination Survey (NHANES), employing weighted logistic regression, smoothed curve fitting, and subgroup analyses.

Intelligent generation and optimization of resources in music teaching reform based on artificial intelligence and deep learning.

In order to increase the effectiveness and personalization of music instruction, this paper aims to create a deep reinforcement learning (DRL)-based framework for creating music resources. Therefore, a Melody Generation Model in Music Education Based on Actor-Critic Framework (AC-MGME) is proposed. This model analyzes students' learning status in real time through AC-MGME algorithm, generates melodies that match their abilities, and enhances the polyphonic generation effect by using multi-label classification and attention mechanism.

Hierarchical Modulation in Cu-Aerogel Enables Breakthrough CO Electroreduction for Combating Stability-Efficiency-Selectivity Tradeoff.

Design of electrocatalyst combining low overpotential, high selectivity and stability for combating the stability-efficiency-selectivity tradeoff in CO electroreduction remains a crucial challenge. Herein, a hierarchical modulation strategy is proposed for the precise assembly of Boron (B) and Tin (Sn), resulting in novel copper (Cu)-aerogel (BSnCu3) structures with both structural and functional hierarchies for advanced CO electroreduction. Superficial assembled Tin creates Cu protective layer for high stability, the body assembled Boron improves the binding affinity to intermediates and shifts Cu d-band upward for enhanced charge transfer.

Sparse learned kernels for interpretable and efficient medical time series processing.

Rapid, reliable and accurate interpretation of medical time series signals is crucial for high-stakes clinical decision-making. Deep learning methods offered unprecedented performance in medical signal processing but at a cost: they were compute intensive and lacked interpretability. We propose sparse mixture of learned kernels (SMoLK), an interpretable architecture for medical time series processing.

Study of Dielectric-Modulated Buried Source Horizontally Double-Gate TFET-Based Biosensors.

In this paper, a dielectric-modulated buried source horizontally double-gate TFET-based (DM-BSHDG TFET) biosensors is proposed for detection of biomolecules. The channel partially encloses the buried source, and the drain half surrounds the channel. Horizontally double gate is located above the source and channel.

Comparison of four-dimensional CT and Sestamibi SPECTCT in the localization management of primary hyperparathyroidism.

Objective: Accurate preoperative imaging localization is paramount to the success of targeted parathyroidectomy for primary hyperparathyroidism (PHPT). Four-dimensional (4D) CT is a promising method for preoperative localization of the parathyroid, but studies on the performance of 4D CT and technetium 99 m-sestamibi SPECT/CT for the diagnosis of diseases of the parathyroid are limited.

Materials And Methods: To compare the diagnostic performance of sestamibi SPECT/CT and 4D-CT for preoperative localization in patients with PHPT in a single-institution from August 2017 to May 2024.

Alternating Current-Driven Bioredox Cycling Achieves in Situ Deep Mineralization of Nitroaromatic Pollutants in Sediments.

Nitroaromatic compound (NAC)-contaminated sediments pose threats to aquatic ecosystems. The challenges of low mass transfer in sediments and the recalcitrance of NACs to degradation limit the effectiveness of conventional bioremediation techniques. This study demonstrates the potential of alternating current (AC)-driven bioredox cycling to overcome these barriers by coupling in situ reduction-oxidation processes.

Maximizing Efficacy of Cancer Nanovaccines and Immune Cells Landscape in Responders and Non-Responders to Immunotherapy.

Adjuvants, formulations, and processing of tumor antigens (collection, lysis, purification, and oxidation) can affect the therapeutic efficacy of cancer vaccines. To maximize their efficacy, adjuvants and their combinations are investigated to prepare vaccines with whole tumor antigens. By comparing different nano/micro-vaccines, ≤ 400 nm and 2.

Comparative evaluation of porcine and bovine bone xenografts in bone grafting: a systematic review and meta-analysis.

Objective: To compare the efficacy of porcine bone xenografts (PBX) and bovine bone xenografts (BBX) in maxillary sinus floor augmentation (MSFA) and alveolar ridge preservation (ARP), focusing on histomorphometric and radiographic outcomes.

Materials And Methods: A comprehensive online search for relevant studies was conducted using PubMed, Cochrane Library, Web of Science, and Scopus, including literature published up to April 2025 (PROSPERO CRD42024628683). The percentage of newly formed bone (NFB) served as the primary outcome.

Exposure to benzotriazole UV stabilizer-329 at environmental concentrations induces neurotoxicity by affecting neurotransmission in Caenorhabditis elegans.

Benzotriazole UV stabilizer-329 (UV-329), a novel stabilizer used in polymers, has been detected in various environmental matrices and organisms, where it exerts toxic effects. However, the neurotoxic effects and underlying mechanisms of UV-329 remain largely unexplored. In this study, Caenorhabditis elegans was used as a model organism to investigate the neurotoxicity of UV-329 at environmental concentrations (0.

FOXM1 Promotes Non-Small Cell Lung Cancer Progression by Increasing CHEK1 Expression.

Objective: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-associated mortality. This study aimed to investigate the role of checkpoint kinase 1 (CHEK1) in NSCLC progression and its regulatory relationship with forkhead box protein M1 (FOXM1).

Methods: Transwell assays were used to evaluate the migration and invasion capabilities of NSCLC cells with either CHEK1 overexpression or knockdown.

Longitudinal alterations of gut mycobiota during 2 years after COVID-19 and its correlation with pulmonary sequela.

Unlabelled: Pulmonary sequelae associated with COVID-19 are an increasing concern. Emerging evidence suggests that gut dysbiosis may contribute to post-acute COVID-19 syndromes; yet, the specific link between gut mycobiota and pulmonary sequelae remains unclear. We conducted a prospective study with 46 COVID-19 patients and 37 healthy controls.

GPT-PPG: a GPT-based foundation model for photoplethysmography signals.

. This study aims to introduce a novel generative pre-trained transformer (GPT)-based foundation model specifically tailored to photoplethysmography (PPG) signals, enabling effective adaptation to various downstream biomedical tasks..

DRP2 promotes EMT and serves as a potential therapeutic target for LUAD treatment.

LUAD, a prevalent lung cancer with high mortality, has seen increased focus on molecular targeted therapies due to patient heterogeneity. Among these prospects, dystrophin-associated protein 2 (DRP2), a critical component of the dystrophin complex, underpins membrane-associated structures vital for intercellular interactions in vertebrates. Aberrations in DRP2 function have been linked to the occurrence and development of multiple diseases, prompting an inquiry into its potential link with LUAD progression.

Alternating current-powered bioelectrode for enhanced sulfide removal from sulfide-rich organic effluent.

Conventional biological wastewater treatments often struggle with efficient sulfide removal. This study presents an innovative and sustainable approach using an alternating current (AC)-powered bioelectrode to facilitate periodic microbial oxidation and reduction for sulfide removal from sulfide-rich organic effluents. The AC bioelectrode addressed the drawbacks of conventional direct current (DC) systems, demonstrating 93.

Inhalable myofibroblast targeting nanoparticles for synergistic treatment of pulmonary fibrosis.

Pulmonary fibrosis (PF) is a life-threatening interstitial lung disease, characterized by excessive fibroblast activation and collagen deposition, leading to progressive pulmonary function decline and limited therapeutic efficacy. Here, the inhalable, myofibroblast-targeted, and pH-responsive liposomes (FL-NI) were developed for effective codelivery of nintedanib, a mainstream antifibrotic drug in clinic, and siIL11, a small interfering RNA that silences the key profibrosis cytokine IL-11. Notably, FL-NI achieved a 117.

Identification of the role of MED6 in the development and prognosis of lung adenocarcinoma based on multi-omics profiling.

Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer. Recent studies have highlighted the importance of Mediator complex subunits in cancer, but their specific roles in LUAD are still unclear. The CRISPR-Cas9 loss-of-function data was used to assess gene dependency in cell growth.

Exploring the Links Between Rheumatoid Arthritis and Pulpal-Periapical Diseases: Insights from Meta-Analysis and Two-Sample Mendelian Randomization.

Introduction: Several clinical trials have investigated the relationship between rheumatoid arthritis (RA) and periapical periodontitis (AP), yielding inconsistent results. Our study aimed to synthesize clinical evidence through a meta-analysis and evaluate potential association using two-sample Mendelian randomization (TSM), which leverages genetic information for a more comprehensive perspective.

Methods: A systematic literature search was executed across PubMed, Web of Science, Scopus, and gray literature sources until February 20, 2025.

Leveraging advanced graph neural networks for the enhanced classification of post anesthesia states to aid surgical procedures.

Anesthesia plays a pivotal role in modern surgery by facilitating controlled states of unconsciousness. Precise control is crucial for safe and pain-free surgeries. Monitoring anesthesia depth accurately is essential to guide anesthesiologists, optimize drug usage, and mitigate postoperative complications.

Orange-red emissive organic-inorganic hybrid copper halide for white light-emitting diode application.

Organic-inorganic hybrid copper(I)-based metal halides (OIHCMHs) have emerged as promising alternatives to lead perovskites due to their exceptional optical properties. However, the lack of low-energy light-emitting compounds prohibits their further applications. Herein, we report an orange-red emissive (CHP)CuBr with a zero-dimensional structure.

Comparison of laser-guided technology and conventional manual percutaneous lung biopsy: a single-center retrospective study.

Background: Percutaneous lung biopsy (PLB) is currently widely utilized in the diagnosis and treatment of lung tumors, owing to its advantages of minimal trauma, high detection rate, and precise localization. However, traditional computed tomography (CT)-guided freehand PLB procedures often involve multiple puncture adjustments and a relatively high incidence of complications. The aim of this study is to investigate whether laser-guided technology can effectively reduce the operative time and incidence of complications.

Two-year follow-up of gut microbiota alterations in patients after COVID-19: from the perspective of gut enterotype.

Unlabelled: Gut microbiota dysbiosis plays a role in the pathogenesis of post-acute coronavirus disease (COVID-19); however, the long-term recovery of the gut microbiota following SARS-CoV-2 infection remains insufficiently understood. In this study, 239 fecal samples were collected from 87 COVID-19 patients during the acute phase, and at 6 months, 1 year, and 2 years post-discharge. An additional 48 fecal samples from non-COVID-19 controls were also analyzed.

Tripeptide DT-109 (Gly-Gly-Leu) attenuates atherosclerosis and vascular calcification in nonhuman primates.

Advanced atherosclerotic lesions and vascular calcification substantially increase the risk of cardiovascular events. However, effective strategies for preventing or treating advanced atherosclerosis and calcification are currently lacking. This study investigated the efficacy of DT-109 (Gly-Gly-Leu) in attenuating atherosclerosis and calcification in nonhuman primates, exploring its broader therapeutic potential.

Odor contribution evaluation of six species of microalgae and corresponding odorants to whole fishy odor in drinking water source.

Disgusting fishy odor could break out inside oligotrophic drinking waterbody in winter with low temperature. In preceding study, six species of fishy odor-producing microalgae and totally twenty fishy odorants were identified in drinking water source of Tongyu River, however, contributions of odorants and microalgae to whole fishy odor were unclear. In this study, odor contribution of microalgae and corresponding odorant to whole fishy odor was evaluated comprehensively.