Highly sensitive detection and mechanism study of tetracycline in water by CuFeO/NiCo-LDH heterojunction electrochemical sensor.

A CuFeO/NiCo-LDH heterojunction electrochemical sensor (LDH: layered double hydroxide) was developed for the sensitive detection of tetracycline (TC). The sensor was constructed by integrating ZIF-67-derived nanocage NiCo-LDH on nickel foam with CuFeO, forming a p-n heterojunction that enhanced electron transfer and TC adsorption. The sensor exhibited bilinear detection ranges (0.

Article I. metformin affects H1N1-induced apoptosis in lung epithelial cells by the miR-130a-5p-regulated PI3K/AKT signaling pathway.

Background: H1N1 influenza virus can cause diffuse alveolar damage, such as pneumonia and pulmonary fibrosis, when it infects the respiratory tract. Metformin not only improves chronic inflammation but also has direct anti-inflammatory effects. Therefore, the focus of this study was on the molecular mechanism and regulatory mechanism of metformin against influenza virus in alleviating lung disease.

Synthesis of cerium dioxide-calcium oxide composite antibacterial materials and their use for water treatment and dye degradation.

Bacterial infections have become a major challenge to global public health security. In this study, based on the concept of green synthesis, three cerium dioxide (CeO)-calcium oxide (CaO) composites (CS-CeO@CaO, CT-CeO@CaO, and CTD-CeO@CaO) were developed using chemical hydrothermal (CS), chrysanthemum tea impregnation (CT), and residue impregnation (CTD). Eggshell-derived calcium oxide was used as the carrier, in combination with the functional components of chrysanthemum tea and its residue extract.

Correction: Single-cell and spatial transcriptomics reveal a stress-induced EMT-like epithelial subset driving immune activation in silica-injured lung.

[This corrects the article DOI: 10.3389/fimmu.2025.

Perineural invasion and the "cold" tumor microenvironment in pancreatic cancer: mechanisms of crosstalk and therapeutic opportunities.

Pancreatic ductal adenocarcinoma (PDAC) remains a devastating malignancy characterized by profound lethality, aggressive local invasion, dismal prognosis, and significant resistance to existing therapies. Two critical biological features underpin the challenges in treating PDAC: extensive perineural invasion (PNI), the process by which cancer cells infiltrate and migrate along nerves, and a profoundly immunosuppressive, or "cold," tumor microenvironment (TME). PNI is not only a primary route for local tumor dissemination and recurrence but also a major contributor to the severe pain often experienced by patients.

Identification of sepsis biomarkers through glutamine metabolism-mediated immune regulation: a comprehensive analysis employing mendelian randomization, multi-omics integration, and machine learning.

Background: Sepsis is a global health challenge associated with high morbidity and mortality rates. Early diagnosis and treatment are challenging because of the limited understanding of its underlying mechanisms. This study aimed to identify biomarkers of sepsis through an integrated multi-method approach.

Controlling Schottky Barriers and Tunneling Resistances in Metal/CuSe Contacts via van der Waals Interlayers.

Electrode contact properties with two-dimensional (2D) channel materials decisively determine the nanodevice's overall performance. A recently synthesized semiconducting CuSe monolayer has emerged as a promising candidate for high-performance device channels due to its high carrier mobility, excellent environmental stability, and a reversible thermal-driven phase transition accompanied by a direct-to-indirect band-gap variation. Herein, to identify promising high-quality electrodes for CuSe, the contact properties with various metals (Al, Ag, Au, Ni, and Co), as well as the modulation effects of graphene and -BN interlayers, are systematically investigated based on first-principles calculations.

High Performance Monometallic Platinum Fuel Cell Catalyst Derived from Self-Hole-Confined Nanoparticles and Nitrogen-Anchored Single-Atoms.

Platinum and non-precious metal (PtM) alloy multimetallic catalysts have been developed to address the kinetically sluggish oxygen reduction reaction (ORR) occurring at the cathodes of proton exchange membrane fuel cells (PEMFCs). However, these catalysts inevitably suffer from poor lot-to-lot consistency of chemical compositions and structures during production, and the transition metal leaching in practical applications. Thus, the development of high-performance monometallic Pt catalysts using innovative nanoarchitectures has become important to address the technical challenges that hinder the widespread deployment of the PEMFCs.

Microorganisms in mosquitoes for controlling mosquito-borne viral diseases: from lab to field.

Mosquito-borne viral diseases pose a growing global health threat, with over half of the world's population living in high-risk areas. In the absence of effective vaccines or antiviral therapies for most mosquito-borne viruses, vector control remains the primary strategy. However, traditional insecticides face rising resistance and ecological concerns.

Interactions of extracellular polymeric substances with ferrihydrite and subsequent 17α-ethinylestradiol photodegradation: Impact of Fe(III)-EPS complexes formation.

Microbial-derived extracellular polymeric substances (EPS) and iron minerals are ubiquitous in aquatic environments, and they can influence the fate of organic micropollutants such as 17α-ethinylestradiol (EE2). However, the interactions between EPS and iron minerals, and their influence on EE2 photodegradation, are seldom addressed in the literature. This study explored the effects of EPS derived from different aerobic or anaerobic microbials on the reductive dissolution of ferrihydrite (Fhy) and subsequent EE2 photodegradation, with emphasis on the impact of Fe-EPS complexes formation.

Iron(III)-Catalyzed Methanesulfonic-Acid-Mediated [3 + 2 + 1C] Annulation of Enaminones with 1,3-Dioxolane: Access to 2-Hydroxy-1,2-dihydropyridines.

An iron(III)-catalyzed methanesulfonic-acid-mediated [3 + 2 + 1C] annulation of enaminones assembling a 1,2-dihydropyridine (1,2-DHP) scaffold has been developed for the first time. This approach facilitates the rapid synthesis of 2-hydroxy-1,2-DHP derivatives in moderate to excellent yields with a broad substrate scope under mild conditions. The employment of 1,3-dioxolane as both a 1C synthon and solvent enables simultaneous incorporation of both a carbon atom and a hydroxy group into 1,2-DHPs.

SrZnSiS: Shattering the 4.0 eV Threshold toward Dual-Optimized Bandgap and Second-Harmonic Generation.

Infrared (IR) nonlinear optical (NLO) crystals are crucial for mid-IR lasers, yet their intrinsic narrow band gaps cause low laser-induced damage thresholds (LIDTs) and detrimental two-photon absorption, thus limiting their widespread application. Herein, a synergistic strategy involving d-orbital exclusion and polarization motif construction is employed to synthesize novel chalcogenide SrZnSiS by introducing [SiS] and [ZnS] tetrahedral polarization subunits. Performance evaluation demonstrates that SrZnSiS breaks through the "4.

Prevalence and Risk Factors of Spirometry-Defined Small Airway Dysfunction in the High-Risk Population for COPD in Yunnan Province, China: A Population Based Cross-Sectional Study.

Purpose: Small airway dysfunction (SAD) is a key early marker of chronic obstructive pulmonary disease (COPD) development. While many studies have examined the link between SAD and early COPD, the epidemiology of SAD in high-risk COPD populations remains understudied.

Patients And Methods: This cross-sectional study utilized a multi-stage randomized cluster sampling method and recruited 11,095 adult residents aged ≥20 years from different elevations in Yunnan Province, China.

Fungal symbiont Mycena complements impaired nitrogen utilization in Gastrodia elata and supplies indole-3-acetic acid to facilitate its seed germination.

Nitrogen and auxin uptake plays pivotal roles in seed germination and development. Gastrodia elata, a fully mycoheterotrophic plant, depends entirely on its symbiotic association with Mycena for early growth and seed germination. The process by which Mycena enables the supply of nitrogen nutrients and auxin, which are deficient in G.

Biological detoxification and application of emerging control strategies of zearalenone in food.

Zearalenone (ZEA) is a mycotoxin produced by filamentous fungi of the Ascomycota phylum, widely present in grains such as corn and wheat. The global contamination of ZEA is becoming increasingly severe, with a significant rise in its detection rate in grains and animal feed, posing serious threats to the health of livestock and poultry, the safety of processed grain products, and human health. This paper reviews the residual risks of ZEA, particularly its significant effects on the reproductive system and liver.

Silencing CALB1 enhances prostate cancer radiosensitivity via calcium-mediated mitochondrial dysfunction and cellular senescence.

Background: Prostate cancer remains a leading cause of cancer-related deaths in men, with radioresistance limiting treatment efficacy. This study investigates the role of Calbindin 1 (CALB1), a calcium-binding protein regulated by miR-186-5p, in prostate cancer progression and radiation response.

Methods: CALB1 expression was analyzed using GEO and TCGA datasets, and the regulatory relationship with miR-186-5p was validated.

Unveiling the Mechanistic Origin of High Efficiency in Selective Reduction of NO by NH over Mn-W/CeO Catalysts: Sufficient Acidity and Appropriate Reducibility.

Achieving remarkable activity in selective catalytic reduction of NO by NH (NH-SCR) over CeO-based catalysts was crucial for their industrial application but still faces a tough challenge, mainly owing to the insufficient acidity and overoxidation ability. Herein, the surface acidity and reducibility of CeO catalysts were finely tuned over Mn-W/CeO to efficiently eliminate NO and reveal the mechanistic origin of superior catalytic properties. Systematic surface and structure analyses revealed that MnO interacted with WO species in the possible form of Mn-O-W, which could enhance the dispersion of WO over the CeO surface.

Combined flotation-oxygen pressure leaching process for treatment of copper smelting slag with a high oxidation rate and its kinetic study.

A process route combining flotation for recovering easily floatable sulfide copper minerals and oxygen pressure acid leaching (OPAL) was employed to comprehensively recover valuable metals (Cu, Mo, Fe, ) from copper smelting slag with a high oxidation degree. The oxidative leaching process selectively dissolved and recovered Cu and Mo while transforming Fe into leach residue, rendering it suitable as a raw material for iron and steel smelting. Under optimal conditions, the leaching recoveries for Cu and Mo reached 96.

A systematic review of protein post-translational modifications in sepsis.

Background: Sepsis originates from the host's dysregulated response to pathogens, and its pathophysiological mechanisms are extremely complex. Recent research has found that post-translational modifications (PTMs) can regulate gene transcription without altering the genetic sequence, thereby playing a key role in the occurrence and development of sepsis.

Objective: This review aims to systematically categorize the main types of PTMs and elucidate their roles in the pathogenesis of sepsis, thereby providing new perspectives for a deeper understanding of the complex pathophysiological processes of this disease.

Integrated Analysis of GC-MS-Based Metabolomics and Proteomics Reveals the Importance of Volatile Metabolite Stigmasterol in the Defence Response of Panax notoginseng Against Root Rot.

Root rot disease in Panax notoginseng, primarily caused by the pathogenic fungus Fusarium solani, significantly impacts the growth and production of this medicinal herb. To elucidate the defence mechanisms of P. notoginseng against root rot, we employed proteomics and gas chromatography-mass spectrometry (GC-MS)-based metabolomics analyses.

Advances on cyclodextrin-based supramolecular imprinted polymers and their extraction applications.

Over the past decade, cyclodextrins (CDs), as cyclic oligosaccharides, have emerged as pivotal supramolecular hosts in molecular imprinting field owing to their distinctive "hydrophobic cavity-hydrophilic shell" structure. The synergistic recognition effect of molecular imprinting sites and cyclodextrin cavity has led to the development of cyclodextrin-based supramolecular imprinted polymers (CD-SMIPs), which has attracted significant research attention. The hydrophobic cavity functions as a selective molecular "pocket", enabling precise encapsulation of target analytes through size and polarity matching while effectively excluding hydrophilic interferents in complex matrices.

Study of the early metabolic characteristics in patients undergoing sleeve gastrectomy for the treatment of obesity and type 2 diabetes mellitus (T2DM) using high-performance liquid chromatography combined with high-resolution mass spectrometry via metabolomics technology.

Objective: To investigate the impact of laparoscopic sleeve gastrectomy (SG) on plasma metabolites in obese patients with type 2 diabetes mellitus (T2DM) and identify key metabolites associated with weight loss. Subjects and.

Methods: Nineteen obese T2DM patients who underwent SG surgery were selected as the study participants.

Valley-Layer-Polarized Anomalous Hall Effect in a Two-Dimensional Multiferroic van der Waals Material.

Emerging phenomena such as the valley Hall effect and layer Hall effect, showing promise for next-generation electronics and valleytronic devices, have attracted considerable attention. However, most studies of the layer Hall effect have been restricted to antiferromagnetic or topological systems. Based on first-principles calculations, we establish a valley-layertronics framework and predict that two-dimensional ScI is a multiferroic material exhibiting substantial spontaneous valley polarization in both its monolayer (93.

Microstructure Design of Metal Selenides for Sodium-Ion Battery Anodes.

The advancement of sodium-ion batteries (SIBs) as next-generation energy storage systems is critically dependent on developing high-performance anode materials. Metal selenides have garnered significant attention as promising anode candidates due to their high theoretical capacities, yet their practical application is hampered by intrinsic issues such as large volume expansion, poor electrical conductivity, and structural pulverization during cycling. Engineering the microstructure of metal selenides offers a powerful avenue to overcome these limitations and unlock their full electrochemical potential.

Peptide codes for organ-selective mRNA delivery.

Organ-selective delivery of messenger RNA (mRNA) is critical for fulfilling the therapeutic potential of mRNA-based gene and protein replacement technologies. Despite clinical advances in the hepatic delivery of mRNA using lipid nanoparticles (LNPs), current strategies for extrahepatic-organ-selective mRNA delivery still have limitations. Here we report a peptide-encoded organ-selective targeting (POST) method for the delivery of mRNA to extrahepatic organs after systemic administration, which is based on the modular tuning of LNPs through surface engineering with specific amino acid sequences (POST codes).