Dissecting the microbial, physicochemical, and flavor dynamics of core and peel layers in Houhuo Daqu: Insights into quality regulation.

Houhuo Daqu (HHD) exhibits significant heterogeneity between its core and peel layers, yet their differences remain underexplored. This study integrates metagenomic sequencing and electronic sensory technologies to compare the physicochemical properties, microbial communities, and flavor profiles of HHD's core and peel. Results reveal distinct microbial communities and diversity between the layers.

Food Intake and Mental Health Among Middle School Students in Shandong Province: A Network Analysis.

Purpose: A network analysis model was used to investigate the network structure linking food intake and mental health among middle school students in Shandong Province from a specific symptom perspective.

Methods: A total of 6179 middle school students aged 11-18 years in Shandong Province were included in the study. The modified Chinese Diet Quality Questionnaire (DQQ) and Symptom Check List 90 (SCL-90) were used to estimate the status of food intake and mental health, respectively.

Prototheca wickerhamii Causing Toe Infection Presenting Initially as Gouty Arthritis: A Rare Case Report.

Prototheca, a genus of opportunistic pathogenic microalgae, can cause protothecosis in humans and animals, manifesting as cutaneous lesions or disseminated/systemic infections. This report describes a rare case of Prototheca wickerhamii toe infection in a 78-year-old Chinese male, presenting initially as gouty arthritis. The patient, who worked in fish farming with frequent water exposure, had a history of herpes zoster and hypertension.

Unraveling the pathogenicity role of the novel compound heterozygous mutations of MED25 gene in a Chinese patient with BVSYS.

Introduction: Mediator of RNA polymerase II transcription subunit 25 (), a crucial component of the transcriptional coactivator complex, plays a significant role in the transcription of most RNA polymerase II-dependent genes. Mutations in have been linked to various genetic syndromes, including Basel-Vanagaite-Smirin-Yosef Syndrome (BVSYS) and Intellectual Disability (ID). This study elucidated the molecular mechanism through which compound heterozygous mutations in the gene impaired pre-mRNA splicing, ultimately causing BVSYS.

Predicting 28-day mortality for patients with acute anterior circulation large vessel occlusion stroke following endovascular treatment in neurology intensive care units.

Background: The clinical utility of the National Institutes of Health Stroke Scale, Glasgow Coma Scale, and modified Rankin Scale scores in predicting prognosis is well established. However, whether the Acute Physiology and Chronic Health Evaluation System II (APACHE II) score can predict mortality in patients with large vessel occlusion stroke (LVOS) admitted to the neurology intensive care unit (NICU) following endovascular treatment (EVT) remains unclear. This study aims to evaluate the ability of the APACHE II score to predict mortality in post-EVT LVOS patients admitted to the NICU.

Regulating the Donor and Acceptor Interaction Mode in Metal-Organic Frameworks for HO Photosynthesis.

Development of novel photocatalysts for hydrogen peroxide (HO) production from water and oxygen is gathering great attention, but still suffers from inefficient photogenerated charge mobility. Reticular chemistry in metal-organic frameworks (MOFs) provides a promising platform to enhance the charge-transfer kinetics by assembling a donor-acceptor (D-A) system. Here, we designed and synthesized a series of D-A type MOFs (UiO-67-NB, UiO-67-PE/BB, and UiO-67-PE/NB) via regulating the interaction mode of donor and acceptor.

Multifunctional Nanozyme PDA-CrO for the Treatment of Osteoarthritis.

Introduction: Osteoarthritis (OA) is one of the major menaces to human health. Currently, no sufficiently effective medications are available to treat OA clinically. OA is an inflammatory joint disorder.

TM9SF1 as a Novel Prognostic Biomarker for Sepsis Severity and Mortality: A Longitudinal Study.

Background: Sepsis is a prevalent and detrimental condition in intensive care units (ICUs) and a leading cause of mortality. The present study evaluated the role and clinical importance of Transmembrane 9 superfamily member 1 (TM9SF1) as a potential indicator for the early detection of sepsis severity and prognosis.

Methods: This study included 118 patients with septic shock and 107 patients with sepsis, all of whom underwent follow-up assessments.

Fatal X-linked agammaglobulinemia complicated by septic shock: a case report and comprehensive review of novel BTK mutations.

X-linked agammaglobulinemia (XLA) is a rare primary immunodeficiency disorder caused by mutations in the Bruton tyrosine kinase (BTK) gene. This article presents a fatal case of a 20-year-old male with XLA complicated by septic shock due to infection, highlighting two novel BTK insertion mutations in exon 15 (NM_000061.3 exon15:c.

EdgeNeXt-SEDP for cervical adenocarcinoma HPV-associated and non-HPV-associated diagnosis and decision support.

Aims: Adenocarcinoma of the uterine cervix exhibits substantial biological and histological heterogeneity, with subtype-specific differences in prognosis and therapeutic response. Conventional classification-based on histopathology, immunohistochemistry, and molecular testing-remains subjective, labor-intensive, and challenging to standardize. This study introduces EdgeNeXt-SEDP, a lightweight deep-learning framework for automated differentiation of HPV-associated (HPVA) and non-HPV-associated (NHPVA) subtypes from histopathological whole-slide images (WSIs).

Genome-Wide Analysis of the Maize LBD Gene Family Reveals a Role for in the Development of Lateral Roots.

The growth and yield of the aboveground parts of maize ( L.) are closely associated with development of the root system. LBD (Lateral Organ Boundaries Domain) transcription factors are crucial for the regulation of lateral organ development in plants.

The association between adverse childhood experiences and chronic respiratory diseases in the Chinese middle-aged and elderly population.

Background: The relationship between adverse childhood experiences (ACEs) and respiratory diseases in the Chinese middle-aged and elderly population remains under explored. Furthermore, the potential moderating effects of social demographics factors and health-related behaviors on these associations have not been thoroughly investigated.

Methods: The association between ACEs and chronic respiratory diseases was evaluated using the validated China Health and Retirement Longitudinal Study(CHARLS)baseline questionnaire2, with data analyzed through a logistic regression model.

Deciphering icosahedra structural evolution with atomically precise silver nanoclusters.

Determining the atomic structure of nanoparticles (NPs) is critical for understanding their structural evolution and properties. However, controlling the growth of multiply-twinned metal NPs remains challenging because of numerous competing pathways. In this work, we report the synthesis of two giant silver icosahedral nanoclusters, [Ag(C≡CR1)] and [AgCl(C≡CR2)] (Ag and Ag, R1 =3,4,5-FCH and R2 = 4-CFCH), achieved through ligand engineering and kinetic control.

Operational thresholds of urease-mediated microbial cementation: Multivariate optimization and field validation in ambient groundwater environments.

Microbially induced calcium carbonate precipitation (MICP) provides a sustainable method for soil stabilization; however, its practical application is limited by rapid reaction kinetics that cause localized clogging and the reliance on energy-intensive environmental controls. This study develops a multivariate optimization framework for urease-inhibited MICP using N-(n-butyl)-thiophosphoric triamide (NBPT), with an emphasis on practical thresholds under ambient groundwater conditions. Five operational parameters-NBPT concentration, cementing solution concentration, bacteria-to-cement solution ratio, temperature, and pH-were systematically investigated through sand column tests and continuous urease activity monitoring.

Efficacy of photodynamic therapy for cervical intraepithelial neoplasia grade 3: a retrospective study.

Background: This study aimed to evaluate the histologic response rate of high-grade squamous intraepithelial lesion (HSIL), also referred to as cervical intraepithelial neoplasia 3 (CIN 3), following treatment with 5-aminolevulinic acid photodynamic therapy (ALA-PDT).

Method: A retrospective analysis was conducted on 49 patients diagnosed with CIN 3 and treated with ALA-PDT between March 2022 and December 2024. Patients received either ALA-PDT alone or in combination with the Loop Electrosurgical Excision Procedure (LEEP) or CO laser therapy.

Turn Waste into Treasure: Gas-Solid Photoreduction of NO in Flow for Separation-Free Ammonia Synthesis.

Photo/electrocatalytic ammonia (NH) synthesis via nitrous oxide (NO) reduction is challenged by low NO solubility in electrolytes, inefficient electron and proton supply, and the high cost of separating NH from dilute NH product solutions. In this study, we present a continuous, separation-free gas-solid photoreduction strategy for direct NH gas production from flue gas, enabled by dynamic band structure regulation of the photocatalyst. Comprehensive in situ characterization and theoretical analysis demonstrate that this approach utilizes photoexcited oxygen vacancies (PV) in TiO to generate high-energy electrons in deep conduction bands, thereby enhancing the reduction capacity, accelerating electron transfer, and lowering the activation energy for both HO dissociation and NO hydrogenation.

Multivalent mpox protein nanoparticle vaccines confer cross-protection against orthopoxvirus infection.

The outbreak of mpox since 2022 has driven the development of mpox virus (MPXV)-specific, subunit-based, next-generation vaccines, instead of the currently used live-attenuated vaccinia virus (VACV) vaccines. Here, we describe a self-assembling protein nanoparticle against MPXV using lumazine synthase to present viral surface proteins. Multivalent nanoparticles elicited broader and stronger immune responses against MPXV and provided superior heterologous protection in rodent models against lethal VACV challenges compared to monovalent formulations.

Combined Biologics and Exclusive Enteral Nutrition Promote Early Transmural Healing and Improve Long-Term Outcomes in Crohn's Disease: A Multicenter Retrospective Study.

Transmural healing (TH), a comprehensive therapeutic target in Crohn's disease (CD), is associated with reduced long-term complications. However, evidence on the role of exclusive enteral nutrition (EEN) in TH remains limited. This study aimed to evaluate the efficacy of biologics combined with 16-week EEN in achieving early TH and improving clinical outcomes.

From sting to STING: role of inflammation in wasp sting induced AKI - a narrative review.

Multiple wasp stings that induce acute kidney injury (AKI) pose a significant threat to human health. This review focuses on the roles and mechanisms of inflammation in wasp sting-induced AKI. Relevant clinical studies, although limited in scope, have reported elevated levels of various inflammatory mediators in patients.

Uterine torsion with fetal death in the third trimester: Case report.

Rationale: Uterine torsion is a rare obstetric complication that can easily lead to fetal death. The sudden onset and atypical clinical presentation make diagnosis very difficult.

Patient Concerns: We reported a case of uterine torsion in the third trimester of pregnancy, which was mainly characterized by severe abdominal pain and shock.

Mapping Current Research Status and Emerging Frontiers of T-Cell Exhaustion: A Comprehensive Data-Mining-Based Study.

Background: T-cell exhaustion (Tex) represents a distinct immunological state characterized by the progressive functional deterioration of T cells under persistent antigenic stimulation. In recent years, the field of Tex research has attracted considerable attention, accompanied by a dramatic surge in related scientific literature. This study employed bibliometric methods to conduct a comprehensive analysis of Tex-related publications.

Eukaryotic initiation factors: central factor associating mRNA translational plasticity during neuropathic pain progression.

Neuropathic pain causes plasticity in the nervous system, which is often associated with altered protein synthesis. Proteins are the key executors of cellular functions, and their alteration is closely related to the occurrence of neuropathic pain. Protein synthesis is a finely regulated process involving the interaction of multiple biomolecules.

Clinical characteristics and caloric testing in patients with light or heavy cupula of the horizontal semicircular canal.

Objectives: Persistent direction-changing positional nystagmus (DCPN) and null point (NP) are characteristic of cupulopathy of the horizontal semicircular canal (HSC). The cupulopathy can manifest as HSC-light cupula (HSC-Lcu) (geotropic DCPN) and HSC-heavy cupula (HSC-Hcu) (apogeotropic DCPN) in the supine roll test (SRT). Whether the affected side of cupulopathy could be based on the nystagmus intensity in the SRT is controversial.