Efficacy evaluation of neuromuscular blocking agents as adjuncts to intravenous regional anesthesia: a meta-analysis of randomized controlled trials.

Purpose: To evaluate the efficacy of neuromuscular blocking agents (NMBAs) as adjuncts to intravenous regional anesthesia (IVRA).

Methods: Two researchers independently searched PUBMED, EMBASE, the Cochrane Library databases, and CBM for randomized controlled trials assessing the efficacy of NMBAs as adjuvants in IVRA.

Results: This meta-analysis included 420 patients from 7 randomized controlled trials.

Resilience driven EV coordination in multiple microgrids using distributed deep reinforcement learning.

By integrating electric vehicles (EVs), the multi-microgrids (MMGs) can significantly enhance their resilient operation capabilities. However, existing works face challenges in formulating optimal routing and scheduling strategies for EVs, due to the spatial-temporal uncertainty of the distribution and transportation networks, as well as incomplete information. This paper addresses the coordination problem of EVs for the resilience enhancement of MMGs, using a distributed multi-agent deep reinforcement learning approach to minimize the load-shedding cost.

Bimetallic nanozyme-mediated dual ferroptosis/cuproptosis synergy potentiates immunotherapy in bladder cancer.

Immunotherapy for bladder cancer remains limited by immunosuppressive tumor microenvironment (TME) and low immunogenicity. Here, we developed a TME-responsive bimetallic porous nanozyme, Fe/Cu-HPC@GOx/PEG, to synergistically induce dual ferroptosis/cuproptosis and amplify antitumor immunity. The nanozyme integrates Fe-Cu bimetal catalytic centers within a hierarchical porous carbon framework, enabling glucose oxidase (GOx)-triggered H₂O₂ generation and subsequent Fenton/Fenton-like reactions.

Sleep patterns and risk of new-onset hypertension and cardiovascular disease in prehypertensive adults: The UK Biobank Study.

Objective: This study aimed to investigate the relationship between comprehensive sleep patterns and the incidence of new-onset hypertension (HTN) and cardiovascular disease (CVD) in individuals with prehypertension.

Methods: This analysis included 118,523 baseline participants from the UK Biobank (2006-2010) with follow-up through 31 December 2021. A sleep pattern included chronotype, sleep duration, insomnia, snoring, and excessive daytime sleepiness.

Preoperative MRI-based radiomics analysis of intra- and peritumoral regions for predicting CD3 expression in early cervical cancer.

The study investigates the correlation between CD3 T-cell expression levels and cervical cancer (CC) while developing a magnetic resonance (MR) imaging-based radiomics model for preoperative prediction of CD3 T-cell expression levels. Prognostic correlations between CD3D, CD3E, and CD3G gene expressions and various cancers were analyzed using the Cancer Genome Atlas (TCGA) database. Protein-protein interaction (PPI) analysis via the STRING database identified associations between these genes and T lymphocyte activity.

Social media addiction as the central mediating variable to explore the mechanism between physical exercise and sleep quality.

In recent years, the sleep quality of college students has garnered increasing attention from scholars. Physical activity, as a healthy lifestyle, has been extensively investigated in relation to the sleep quality of college students. However, the psychological mechanisms underlying this relationship warrant further exploration.

The roles of loneliness and self-control in the association between social avoidance and nomophobia among college students.

Nomophobia has become an increasingly common mental health concern among college students. While prior research has examined various factors contributing to nomophobia, the relationships among social avoidance, loneliness, and self-control within the Chinese context remain underexplored. This study aims to investigate the impact of social avoidance on nomophobia, with a particular focus on the parallel mediating roles of loneliness and self-control.

Stem cell therapy for diabetes: Advances, prospects, and challenges.

Diabetes mellitus, a global epidemic, represents a major public health threat. Stem cell therapy, with its regenerative capacity, has emerged as a promising approach for diabetes mellitus management. This paper reviews recent advancements, prospects, and challenges in stem cell-based treatments for diabetes mellitus, focusing on the applications of induced pluripotent stem cells and mesenchymal stem cells, the development of pancreatic islet organoids, and the potential for personalized medicine.

A short recorded pulse dataset for vascular age prediction in China.

Early assessment of cardiovascular disease risk plays an important role in preventing cardiovascular disease, vascular age (VA) is an important indicator for early screening of cardiovascular disease risk. This study presents a pulse signal-based dataset for VA prediction. The dataset comprises 226 subjects with 1364 pulse cycles, spanning both sexes (49.

C20orf27 promotes hepatocellular carcinoma progression via NT5E.

Liver cancer is one of the most lethal human malignancies in the world. Although great efforts have been made to develop novel therapeutic targets, effective drug targeting remains limited. C20orf27, located on human chromosome 20, is a gene whose function has not been fully elucidated.

Synthesis and biological activity of neopeltolide and analogs.

Neopeltolide, a macrolide natural product of marine origin, was initially isolated from a deep-sea sponge belonging to the Neopeltidae family. This compound has garnered significant attention due to its intriguing structural complexity and remarkable biological potency. Since its discovery, the scientific community has reported over twenty distinct total syntheses, formal syntheses, and fragment syntheses of this natural product, along with developing more than eighty neopeltolide analogues with their corresponding biological evaluations.

Efficacy Analysis of TACE Combined with Lenvatinib and PD-1 Inhibitors in the Treatment of Hepatitis B Virus-Related Unresectable Hepatocellular Carcinoma.

Background: To explore the impact of hepatitis B virus (HBV) DNA on the efficacy of triple therapy [transarterial chemoembolization (TACE), lenvatinib, and programmed cell death protein-1 (PD-1) inhibitors] in the treatment of HBV-related unresectable hepatocellular carcinoma (u-HCC).

Methods: We retrospectively collected clinical data on triple therapy for HBV-related u-HCC from January 2020 to January 2024 at Xiangyang Central Hospital. Patients with HBV-DNA ≤ 1000 IU/mL were designated the low HBV-DNA level group, and patients with HBV-DNA > 1000 IU/mL were designated the high HBV-DNA level group.

A mini-review on the health risks associated with sodium p-perfluorous nonenoxybenzene sulfonate exposure.

Sodium p-perfluorous nonenoxybenzene sulfonate (OBS) is an alternative to perfluoroalkyl substance (PFAS), primarily used as surfactant in various industrial and commercial applications. Due to the presence of both perfluorinated carbon tail and sulfonate functional group in its molecular structure, OBS exhibits exceptional chemical stability and resistance to environmental degradation. Recent environmental monitoring studies have detected OBS in soil, surface and groundwater, across diverse geographic regions, indicating that human populations are inevitably exposed to this pollutant through multiple environmental pathways.

Invasive pulmonary cryptococcosis mimicking metastatic lung cancer: A case report and review of literature.

Background: Worldwide, there has been a steady increase in the number of cases of pulmonary cryptococcosis diagnosed in immunocompetent patients, where symptoms can range from mild to severe. Clinical and radiological distinction of disease may be made when compared with immunodeficient cases and in those presenting with primary lung carcinoma. In the latter case confusion can lead to initial misdiagnosis and delayed treatment.

Advancing the Stability of Carbon-Based Catalysts for Long-Lasting Oxygen Reduction Reactions.

Achieving high-performance carbon-based catalysts for the oxygen reduction reaction (ORR) is pivotal for advancing sustainable energy technologies. Despite significant advancements in ORR activity, the intrinsic instability of carbon frameworks and active sites under harsh operating conditions remains a fundamental challenge. Although the degradation of carbon under ORR conditions has long been recognized, previous reviews and research works dominantly focus on improving catalytic activity, whereas the stability issue, which is decisive for practical applications, is largely neglected or treated superficially, thus impeding the commercialization of carbon ORR catalysts.

Non-monotonic response of macrophages to mechanical stretch impacts skin wound healing.

Background: The skin is subjected to constant mechanical stress in both healthy and wounded states. Macrophages play crucial roles in skin homeostasis and in all stages of the wound healing process. However, the effects of static mechanical stretch (MS) on macrophages and the subsequent consequences on skin cells remain largely unclear.

Association of Reproductive Factors with Osteoarthritis and the Mediating Effect of Body Mass Index Among Postmenopausal Women.

Osteoarthritis (OA) is the leading cause of disability worldwide, with a higher prevalence and severity of functional impairment observed in women over the age of 50. However, the reasons for this gender disparity are not well understood. This study aims to investigate the potential association between reproductive factors and OA prevalence in postmenopausal women, as well as whether body mass index (BMI) mediates this relationship.

Role of the renin-angiotensin-aldosterone system in sepsis and its therapeutic targets.

An imbalance in the host's response to infection causes sepsis, a potentially fatal condition. Sepsis may advance to septic shock, organ dysfunction (including the brain, liver, lung, kidney, and heart), skeletal muscle atrophy, and an array of severe complications. The renin-angiotensin-aldosterone system (RAAS) undergoes significant alterations during sepsis, and the expression of its principal bioactive components is closely associated with the prognosis of patients with sepsis.

Preparation process and properties of polyurethane/phosphogypsum-modified asphalt and its mixtures.

The preparation process parameters and composition of polyurethane/phosphogypsum-modified asphalt were studied to achieve comprehensive utilization of phosphogypsum and reduce asphalt pavement costs while ensuring performance compliance. Additionally, the aging resistances of the modified asphalt and its mixtures were investigated. The results showed that the order of the influence of the different preparation process parameters on the performance of modified asphalt is preparation temperature, storage time, reaction time, and shear rate.

Distinct roles of HMOX1 on tumor epithelium and macrophage for regulation of immune microenvironment in ovarian cancer.

Background: Ferroptosis has been implicated in the regulation of the tumor immune environment; however, its precise effect on immune checkpoint inhibitors remains contradictory.

Objective: To elucidate the "double-edged sword effect" of a key ferroptosis-related factor in regulating the immune microenvironment.

Methods: This study utilized single-cell RNA sequencing (scRNA-seq) analysis to characterize the tumor microenvironment in ovarian cancer samples from immunotherapy cohorts.

Current Status and Influencing Factors of Death Preparedness in Advanced Cancer Patients Based on the PRECEDE-PROCEED Model: A Cross-Sectional Study.

Background: Death preparedness is an important prerequisite for improving the quality of life and the quality of death in advanced cancer patients. However, research on the level of death preparedness in patients is insufficient, and there is little understanding of the current status and influencing factors of death preparedness in advanced cancer patients.

Aim: This study aims to assess the current status of death preparedness and its influencing factors in advanced cancer patients.

Taxifolin Inhibits Platelet Activation and Thrombosis by Regulating the PI3K/Akt and MAPK Signaling Pathways.

Excessive platelet activation plays a pivotal role in the development of cardiovascular disease. Taxifolin is a natural dihydroflavonol compound with antioxidant properties. However, its mechanism of action on platelets and thrombosis remains unclear.

Cellular leiomyoma: A 10-year retrospective analysis of clinical features, and recurrence risk.

Objectives: In this study, we aimed to compare the clinical characteristics of cellular leiomyoma (CL) with those of typical uterine leiomyoma (UL) and explore recurrence risk factors in patients with CL myomectomy.

Study Design: In this retrospective cohort study, we analyzed medical records of patients diagnosed with CL (n = 102) and UL (n = 105) who underwent surgery between January 2013 and May 2023. Postoperative prognosis was assessed through patient follow-up until June 2024.

Unveiling the role of localized polaronic mid-gap states in enhanced carrier transfer in TiO/BiVO heterojunctions under visible light irradiation.

TiO/BiVO heterojunctions are considered to be one of the most promising materials for photocatalysts due to their extended carrier lifetime, high visible light response, and good stability. However, while Type-II TiO/BiVO heterojunctions are well-studied, the fundamental mechanism behind the Type-I configurations remains unclear, particularly regarding their unexpected high photocatalytic activity despite theoretically unfavorable band alignment. Herein, we reveal that localized polaronic mid-gap states (SP states) can mediate efficient charge transfer and recombination in TiO/BiVO using time-resolved photoluminescence (PL) spectroscopy and transient absorption spectroscopy (TAS), providing direct experimental evidence of this mechanism.