Multifunctional Nanozyme PDA-CrO for the Treatment of Osteoarthritis.

Introduction: Osteoarthritis (OA) is one of the major menaces to human health. Currently, no sufficiently effective medications are available to treat OA clinically. OA is an inflammatory joint disorder.

Substantial reductions in black carbon from both fossil fuels and biomass burning during China's Clean Air Action.

Black carbon (BC) aerosols exacerbate air pollution and climate warming, but their climatic impacts and sources are poorly constrained by bottom-up emission inventories (EIs). China's Clean Air Action (CAA), which was launched in 2013, provides an excellent opportunity for investigating interannual variations in source contributions and validate the accuracy of EIs. Here, we present an 11-y (2008-2018) record of the BC concentration and its source-diagnostic radiocarbon (C) and stable carbon isotope (C) signatures at a receptor site in the Pearl River Delta (PRD) region, South China.

Reduced level of BMI1 inhibits trophoblast proliferation and migration via the epigenetic enhancement of CSTA and TGFB2 in spontaneous abortion.

Introduction: Spontaneous abortion is the loss of a pregnancy before the 28th week of gestation in China. The precise mechanisms leading to spontaneous abortion remain largely unclear.

Methods: The expression of BMI1 in normal pregnancy and SA villous tissues was detected by qRT-PCR and immunofluorescence staining.

Review of the wolf spider genus Dahl, 1908 from China (Araneae, Lycosidae).

The genus Dahl, 1908 from China is reviewed, including five species: Zyuzin & Marusik, 1988, (Clerck, 1757), (Marusik, 1993), (♂♀) and (♂♀). and are recorded from China for the first time. Detailed descriptions are presented, along with photos of the habitus and copulatory organs, and a distribution map.

Lactiplantibacillus plantarum fermentation enhances the antidepressant effects of Hemerocallis citrina Baroni in chronic restraint stress mice.

Ethnopharmacological Relevance: Hemerocallis citrina Baroni (H. citrina), referred to as 'Forgetting Sadness Grass,' is a traditional Chinese medicine (TCM) known for its antidepressant effects. Fermentation is an ancient processing method for TCM.

Base-controlled regio-divergent C-H bond functionalization.

The choice of appropriate directing groups, catalysts, ligands, bases, and solvents to give different regioisomers from the same precursors can improve the efficiency and atom economy in synthetic organic chemistry, while minimizing costs and expanding know chemical space. Base-controlled regio-divergent C-H bond functionalization is an important control strategy in organic synthesis, with the advantages of being operationally simple, and using cheap and available bases with low-toxicity that are easily separable. This highlight is classified into three sections: base-controlled, base-controlled transition metal-catalysed and base-controlled photocatalytic regio-divergent C-H bond functionalization.

Synthetic Biology-Based Strategy for Nanomedicine Design.

Nanomedicines have demonstrated significant potential in disease diagnosis and therapy, revolutionizing traditional drug development patterns. Recently, inspired by both natural and engineering principles, synthetic biology integrates the complexity of biological systems with the precision of engineering to design and create novel biological components, devices, and systems. This convergence of synthetic biology and nanomedicine has led to the emergence of a new concept: synthetic biological nanomedicine.

Assembly of Genetically Engineered Ionizable Protein Nanocage-based Nanozymes for Intracellular Superoxide Scavenging.

Nanozymes play a pivotal role in mitigating excessive oxidative stress, however, determining their specific enzyme-mimicking activities for intracellular free radical scavenging is challenging due to endo-lysosomal entrapment. In this study, we employ a genetic engineering strategy to generate ionizable ferritin nanocages (iFTn), enabling their escape from endo-lysosomes and entry into the cytoplasm. Specifically, ionizable repeated Histidine-Histidine-Glutamic acid (9HE) sequences are genetically incorporated into the outer surface of human heavy chain FTn, followed by the assembly of various chain-like nanostructures via a two-armed polyethylene glycol (PEG).

Identification of the cysteine-rich transmembrane module CYSTM family in upland cotton and functional analysis of GhCYSTM5_A in cold and drought stresses.

Abiotic stress poses adverse impacts on cotton production, raising demands for a better understanding of stress-response mechanisms and developing strategies to improve plant performance to cope with stress. CYSTM (Cysteine-rich transmembrane module) is a widely distributed and conserved family in eukaryotes that performs potential functions in stress tolerance. However, CYSTM genes and their role in stress response is uncharacterized in cotton.

Rational Design of Genetically Engineered Mitochondrial-Targeting Nanozymes for Alleviating Myocardial Ischemic-Reperfusion Injury.

The development of mitochondria-targeting nanozymes holds significant promise for treating myocardial ischemia-reperfusion (IR) injury but faces significant biological barriers. To overcome these obstacles, we herein utilized genetically engineered ferritin nanocages (i.e.

The Influence of Electrolytes on the Performance of Self-Powered Photoelectrochemical Photodetector Based on -GaO Nanorods.

Photodetectors have a wide range of applications across various fields. Self-powered photodetectors that do not require external energy have garnered significant attention. The photoelectrochemical type of photodetector is a self-powered device that is both simple to fabricate and offers high performance.

Ruptured giant omphalocele with congenital short small intestine: a case report.

We herein present a case of a ruptured giant omphalocele with congenital short small intestine. Vacuum-sealing drainage and carboxymethylcellulose silver dressing promoted wound healing after repair, avoided abdominal compartment syndrome, and reduced the risks of multiple procedures. We review the perioperative management of omphaloceles in congenital short small intestines.

Peer or tutor? The congruity effects of service robot role and service type on usage intention.

The invention of service robots has reduced the labor cost and improved enterprises' efficiency and service quality. However, it is still difficult to enhance consumers' intention to use robot-by-robot design efficiently. Based on social roles of anthropomorphic cues, service robots can be divided into peer (e.

Mechanistic insights into phosphoactivation of SLAC1 in guard cell signaling.

Stomata in leaves regulate gas (carbon dioxide and water vapor) exchange and water transpiration between plants and the atmosphere. SLow Anion Channel 1 (SLAC1) mediates anion efflux from guard cells and plays a crucial role in controlling stomatal aperture. It serves as a central hub for multiple signaling pathways in response to environmental stimuli, with its activity regulated through phosphorylation via various plant protein kinases.

Versatile Design of NO-Generating Proteolipid Nanovesicles for Alleviating Vascular Injury.

Vascular injury is central to the pathogenesis and progression of cardiovascular diseases, however, fostering alternative strategies to alleviate vascular injury remains a persisting challenge. Given the central role of cell-derived nitric oxide (NO) in modulating the endogenous repair of vascular injury, NO-generating proteolipid nanovesicles (PLV-NO) are designed that recapitulate the cell-mimicking functions for vascular repair and replacement. Specifically, the proteolipid nanovesicles (PLV) are versatilely fabricated using membrane proteins derived from different types of cells, followed by the incorporation of NO-generating nanozymes capable of catalyzing endogenous donors to produce NO.

Greatly isolated heterogeneous circulating tumor cells using hybrid engineered cell membrane-camouflaged magnetic nanoparticles.

Background: Circulating tumor cells (CTCs) are considered as a useful biomarker for early cancer diagnosis, which play a crucial role in metastatic process. Unfortunately, the tumor heterogeneity and extremely rare occurrence rate of CTCs among billions of interfering leukocytes seriously hamper the sensitivity and purity of CTCs isolation.

Methods: To address these, we firstly used microfluidic chips to detect the broad-spectrum of triple target combination biomarkers in CTCs of 10 types of cancer patients, including EpCAM, EGFR and Her2.

Aspartyl proteases identified as candidate genes of a fiber length QTL, qFL, that regulates fiber length in cotton (Gossypium hirsutum L.).

GhAP genes were identified as the candidates involved in cotton fiber length under the scope of fine mapping a stable fiber length QTL, qFL. Moreover, the transcription factor GhWRKY40 positively regulated GhAP3 to decrease fiber length. Fiber length (FL) is an economically important fiber quality trait.

Structure and activation mechanism of the rice Salt Overly Sensitive 1 (SOS1) Na/H antiporter.

Salinity is one of the most severe abiotic stresses that adversely affect plant growth and agricultural productivity. The plant Na/H antiporter Salt Overly Sensitive 1 (SOS1) located in the plasma membrane extrudes excess Na out of cells in response to salt stress and confers salt tolerance. However, the molecular mechanism underlying SOS1 activation remains largely elusive.

Antifouling modification for high-performance isolation of circulating tumor cells.

Circulating tumor cells (CTCs), which shed from solid tumor tissue into blood circulatory system, have attracted wide attention as a biomarker in the early diagnosis and prognosis of cancer. Given their potential significance in clinics, many platforms have been developed to separate CTCs. However, the high-performance isolation of CTCs remains significant challenges including achieving the sensitivity and specificity necessary due to their extreme rarity and severe biofouling in blood, such as billions of background cells and various proteins.

WeiTsing, a pericycle-expressed ion channel, safeguards the stele to confer clubroot resistance.

Plant roots encounter numerous pathogenic microbes that often cause devastating diseases. One such pathogen, Plasmodiophora brassicae (Pb), causes clubroot disease and severe yield losses on cruciferous crops worldwide. Here, we report the isolation and characterization of WeiTsing (WTS), a broad-spectrum clubroot resistance gene from Arabidopsis.

Comparing the impact of comprehensive care with conventional care in children with congenital heart disease: a systematic review and meta-analysis.

Background: This study compares the impact of comprehensive care and conventional care on interventional therapy in children with congenital heart disease and to provide a reference basis for clinical care.

Methods: Clinical randomized controlled trials (RCTs) examining care during interventional therapy in children with congenital heart disease were identified in the PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang databases using a combination of subject terms and free terms. The retrieval time was from the establishment of the database to November 27th, 2022.

[Protective effect of breviscapine against brain injury induced by intrauterine inflammation in preterm rats and its mechanism].

Objectives: To study the protective effect of breviscapine against brain injury induced by intrauterine inflammation in preterm rats and its mechanism.

Methods: A preterm rat model of brain injury caused by intrauterine inflammation was prepared by intraperitoneal injections of lipopolysaccharide in pregnant rats. The pregnant rats and preterm rats were respectively randomly divided into 5 groups: control, model, low-dose breviscapine (45 mg/kg), high-dose breviscapine (90 mg/kg), and high-dose breviscapine (90 mg/kg)+ML385 [a nuclear factor erythroid 2-related factor 2 (Nrf2) inhibitor, 30 mg/kg] (=10 each).

Tumor Cell Nanovaccines Based on Genetically Engineered Antibody-Anchored Membrane.

Despite the promise in whole-tumor cell vaccines, a key challenge is to overcome the lack of costimulatory signals. Here, agonistic-antibody-boosted tumor cell nanovaccines are reported by genetically engineered antibody-anchored membrane (AAM) technology, capable of effectively activating costimulatory pathways. Specifically, the AAM can be stably constructed following genetic engineering of tumor cell membranes with anti-CD40 single chain variable fragment (scFv), an agonistic antibody to induce costimulatory signals.

Study on shock vibration analysis and foundation reinforcement of large ball mill.

The vibration of the ball mill foundation will seriously affect the operation stability of the ball mill. According to the connection relationship between the ball mill and the foundation, the mill-foundation transient shock model is established. The effects of shock force, concrete grade and shock angle on the transient response of the foundation were studied.