The renoprotective anti-hyperuricemia effect of Cornus officinalis extract in hyperuricemia rats based on network pharmacology and multiple omics.

Ethnopharmacological Relevance: Corus officinalis Siebold & Zucc belongs to the genus Cornus in the Cornaceae family, and was first recorded in the "Shennong Herbal Classic", now has been included in "according to the tradition of both food and Chinese herbal medicines", consist of kidney and liver tonifying, antioxidant substances including cycloid glycosides, flavonoids, polyphenols, organic acids, etc. AIM OF THE STUDY: This study was aimed at discovering the mechanism underlying the anti-hyperemia effect of Cor in rats, particularly its protective effect against liver and kidney dysfunction caused by HUA.

Materials And Methods: In this study, the effect of Cor extract against HUA was verified in rats, subsequently, network pharmacology combined with non-targeted metabolomic were performed to investigate its composition characteristics, and further multi-omics studies and molecular validation were performed to reveal molecular mechanism both in vivo and in vitro.

Effects of Geniposide on Cerebral Ischemia/Reperfusion-Induced Neuron Damage by Inhibiting Autophagy via cGAS-STING.

Aim Of The Study: This study aimed to investigate the protective effects of Geniposide (GEN) against cerebral ischemia-reperfusion injury by targeting the cGAS-STING pathway and modulating autophagy in neuronal cells.

Materials And Methods: In vivo middle cerebral artery occlusion/reperfusion (MCAO/R) model and an in vitro oxygen-glucose deprivation/reperfusion (OGD/R) model to mimic the pathology of cerebral ischemic stroke in humans. Behavioral tests, tissue staining to assess neurological deficits and tissue damage in mice.

Dual-self-learning co-evolutionary algorithm for energy-efficient flexible job shop scheduling problem with processing- transportation composite robots.

The processing-transportation composite robots, with their dual functions of processing and transportation, as well as comprehensive robot-machine interactions, have been widely and efficiently applied in the manufacturing industry, leading to a continuous increase in energy consumption. Hence, this work focuses on investigating robot-machine integrated energy-efficient scheduling in flexible job shop environments. To address the new problem, an innovative mixed-integer linear programming model and a novel dual-self-learning co-evolutionary algorithm are proposed, aimed at minimizing the total energy consumption and makespan.

Robust tracking control of uncertain autoloaders by implicit Lyapunov method and scleronomic Lagrangian mechanics-informed neural network.

The autoloader is a key subsystem in modern main battle tanks, mainly responsible for ammunition transfer, loading, and resupply. However, it often suffers from uncertainties induced by base oscillations, leading to potential instability. While various control strategies have been proposed, most rely on prior knowledge of such oscillations.

Transition-Metal-Free Aluminosilicate Small-Pore Zeolites Upgrade Methane to Light Olefins.

Upgrading methane to value-added chemicals is significant but still challenging. Well-designed catalysts are required to activate methane. Extensive efforts have been dedicated to the catalytic conversion of methane over transition-metal-containing catalysts.

Research Progress on the Effects of Anthocyanins on Cognitive Function and Their Underlying Mechanisms.

Introduction: This review aims to systematically investigate the existing research on the effects of anthocyanins on cognitive functions and their underlying mechanisms involved. It provides detailed insights into their development and potential applications.

Method: An extensive review and analysis of various animal experiments and human studies were performed using databases, such as Web of Science, Sci-Hub, EI, ScienceDirect, and PubMed.

Application of Dental Pulp Stem Cell-Derived Intracellular Vesicles for Diabetic Wound Healing.

Unlabelled: Diabetic wounds represent a significant clinical and economic burden, affecting both patients and health care systems. While current therapeutic approaches, such as negative pressure wound therapy, offer benefits, their limitations necessitate alternative strategies. Newly discovered dental pulp stem cell-derived intracellular vesicles have emerged as a promising candidate in regenerative medicine due to their therapeutic potential.

Exploration of the Mechanism of Action of in the Treatment of Liver Cancer Based on Network Pharmacology, Molecular Docking and in vitro Validation.

Purpose: The anti-tumor effects of , as a medicinal and dietary Chinese medicine, have long been documented. However, the mechanism of action for its therapeutic effect has not been fully elucidated.

Methods: The chemical constituents of were screened using PubMed, CNKI, and Wanfang databases.

Unlocking Strategic Metals from Zinc Smelting Dust: Ultrasound-ClO Synergy and Atomic-Scale Leaching Mechanisms.

This study proposes an innovative ultrasonic-assisted ClO oxidative leaching (UCL) process for Zn, In, and Ge synergistic recovery from zinc smelting dust (ZSD). Laser ablation inductively coupled plasma time-of-flight mass spectrometry reveals the synergistic association of In/Ge and Cu in sphalerite, which breaks through the limitations of the traditional characterization techniques for trace element analysis in ZSD. Through appropriate process parameters(0.

The multi-dimensional regulatory mechanism of Sirt6 in heart health: From cell death pathways to targeted therapy for cardiovascular diseases.

Sirtuin 6 (Sirt6) is a member of the Sirtuin family, exhibiting histone deacetylase and ADP-ribosyltransferase activity. This enzyme is involved in several pathways, such as epigenetic regulation and inflammation control. It is essential for preserving cardiac equilibrium and postponing the emergence of cardiovascular disorders.

A comorbidity of cardiac atherosclerotic disease with cardiac myxomas being concomitantly treated by coronary artery bypass grafting coupling with tumor resection: a case report.

Introduction And Importance: Cardiac atherosclerotic disease (CAD), the leading cause to cardiovascular disease-related death, coexisting with cardiac myxoma, the commonest benign primary cardiac neoplasm, is rare. The treatment of the comorbidity is complicated due to the rarity and inexperience.

Case Presentation: A 65-year old male patient with intermittent chest tightness and shortness of breath for 10 years was admitted for further work-up.

Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis.

Background: To assess the clinical benefits of Selenium (Se) supplementation in patients with Hashimoto thyroiditis (HT).

Methods: Eight databases were searched for randomized controlled trials. The outcomes of interest were thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4).

Endovascular embolization for ruptured intracranial aneurysms: efficacy and effects on oxidative stress levels.

Objective: This study aimed to investigate the efficacy of endovascular embolization in treating ruptured intracranial aneurysms (RIAs).

Methods: RIA patients (n = 89) were grouped according to different surgical methods. The control group (n = 42) received aneurysm clipping surgery, whereas the observation group (n = 47) received endovascular embolization.

Attitudes and opinions of pharmacy undergraduates towards the integration of innovation and entrepreneurship programs into professional education.

Background: Innovation and entrepreneurship (I&E) ability has been defined as one of the key elements and expected outcomes of personal and professional development among pharmacy students. As an emerging trend in pharmacy undergraduate training, the organic integration of I&E elements in professional education offers a critical means to cultivate high-quality pharmacy professionals. However, the current methods of doing so have not incorporated adequate consultation with pharmacy undergraduates, who are key stakeholders in I&E and professional education.

Design, synthesis, and anti-inflammatory activity studies of indanone derivatives containing cinnamic acid skeleton.

Reactive oxygen species (ROS), as small-molecule signaling intermediates, are geynthesis and activity of aurone and indanone derivatinerated by immune and somatic cells in response to damage, infection, or stimulation. During the inflammatory response, ROS participate in the activation of the NF-κB pathway, leading to the upregulation of pro-inflammatory cytokines. Inflammatory mediators serve as key regulatory and effector molecules that initiate, amplify, and coordinate the inflammatory process and contribute to the resolution of inflammation at later stages.

Differential expression of microRNA-3127-5p and its molecular mechanisms in polycystic ovary syndrome.

Introduction: The present study was undertaken to elucidate the expression status and molecular mechanism underlying microRNA-3127-5p (miR-3127-5p) in polycystic ovary syndrome (PCOS).

Material And Methods: A total of 50 PCOS and 50 non-PCOS patients were recruited as research subjects. Quantitative real-time polymerase chain reaction was employed to assess the relative abundances of miR-3127-5p in serum, cumulus cells (CCs), and granulosa cells (GCs) from PCOS patients.

Integrated electrochemical biosensor featuring nanoforest hierarchical architectures and catalytic hairpin amplification for breast cancer diagnosis.

MicroRNAs (miRNAs) serves as a crucial biomarker for early cancer diagnosis, and dual-target miRNA detection significantly enhances diagnostic accuracy. However, the uncontrollable uniformity of multi-capture probe modifications, limited electrode sites, and high sample consumption restrict the advancement of electrochemical biosensors in clinical diagnostics. In this work, an integrated microdroplet chip electrochemical biosensor has been ingeniously developed, including TiO nanorods modified by Au nanoparticles vertically arranged on the FTO as the working electrode, which exhibits high electron transfer efficiency and abundant anchoring sites for capture probes; A Y-shaped probe was designed with one end immobilized via Au-S covalent bonding while the two free arms enabled simultaneous dual-target miRNA recognition; By employing Au/TiO-FTO as both the substrate for a custom micro-detection chamber and the working electrode, coupled with catalytic hairpin assembly (CHA), the sensor achieves ultrahigh-precision trace-level detection of dual miRNAs.

Validation and Refinement of Scores to Predict Stroke Risk: Prospective Cohort Study.

Background: In China, the "8+2" stroke risk score has been widely used to identify individuals at high risk of stroke, despite insufficient evidence confirming its predictive ability for stroke events.

Objective: We aimed to validate the risk score's ability to predict the risk of stroke within a 10-year timeframe in community cohort populations and to optimize the scoring method to improve its predictive accuracy.

Methods: By reviewing previous literature to obtain the parameters for constructing the logistic regression model and the Rothman-Keller model, the risk threshold points of the models were determined using a sample of 100,000 participants.

Preparation and evaluation of immediate and modified release tablets contained diphenidol hydrochloride.

Motion sickness (MS) is a common phenomenon in life and nearly all individuals will experience MS at least once in their lives. Diphenidol hydrochloride (DPN) is widely used in China for the pharmacotherapy of MS at the dosages of 25 mg every 6-8 h as needed. The conventional DPN tablets may present inconvenience for individuals embarking on extended sea voyages, as they require multiple daily doses.

Stirring speed optimization for improved microalgal-bacterial granular sludge morphology and performance in complex organic wastewater treatment.

This study investigated the morphology regulation and pollutant removal performance of microalgal-bacterial granular sludge (MBGS) under different organic carbon conditions, specifically comparing simple and complex organics. Results showed that MBGS proliferated faster under complex organics conditions due to filamentous cyanobacteria dominance, requiring a higher stirring speed (300 rpm, 0.128 Pa) to inhibit excessive growth and maintain stability.

EdgeNeXt-SEDP for cervical adenocarcinoma HPV-associated and non-HPV-associated diagnosis and decision support.

Aims: Adenocarcinoma of the uterine cervix exhibits substantial biological and histological heterogeneity, with subtype-specific differences in prognosis and therapeutic response. Conventional classification-based on histopathology, immunohistochemistry, and molecular testing-remains subjective, labor-intensive, and challenging to standardize. This study introduces EdgeNeXt-SEDP, a lightweight deep-learning framework for automated differentiation of HPV-associated (HPVA) and non-HPV-associated (NHPVA) subtypes from histopathological whole-slide images (WSIs).

Biodegradable Quercetin-Incorporated Poly(Lactic Acid)/Chitosan Functional Films: A Study of the Properties and Application in Enhancing Fish Preservation.

Traditional plastic packaging materials have brought serious environmental pollution and a number of health risks; so the development of biodegradable polymers as an alternative has received increasing attention. Here, active packaging materials with antioxidant, antimicrobial, and biodegradable properties were prepared using poly(lactic acid) (PLA) and chitosan loaded with quercetin. The experimental results demonstrate that the PLA/chitosan/quercetin film achieved an impressive ABTS radical scavenging rate of up to 98.