A cohort study on the association of dietary inflammatory index and a posteriori dietary patterns with lung cancer risk.

This study aimed to explore the relationship between dietary patterns and the risk of lung cancer by combining the a priori Dietary Inflammatory Index (DII) with a posteriori dietary patterns identified through factor analysis using a prospective cohort study. A total of 189,561 participants from the UK Biobank were included. Dietary intake was assessed using a 24-hour dietary recall questionnaire.

Hierarchical signal amplification for regional infectious disease risk assessment: A multidimensional approach from urban China.

Background: Infectious disease surveillance systems face methodological limitations in early warning capabilities, particularly in integrating correlated indicators, assessing healthcare system impacts, and synthesizing diverse data streams into actionable intelligence. We aimed to develop and validate a hierarchical signal amplification algorithm generating daily risk scores for regional infectious disease assessment.

Methods: In this retrospective observational study in Chongqing, China (population 32.

Investigation of a Thunderstorm Asthma Event - Chongqing Municipality, China, April 2024.

What Is Already Known About This Topic?: Thunderstorm asthma (TA) is triggered by specific severe convective weather conditions and elevated airborne allergen concentrations, leading to a rapid increase in asthma cases within a short period. Three TA incidents have been previously reported in China, occurring in Shaanxi, Ningxia, and Inner Mongolia.

What Is Added By This Report?: We report the first documented thunderstorm asthma event (TAE) in Chongqing, China, and conducted a case-control study revealing that allergic rhinitis is an independent risk factor among susceptible individuals.

Epidemiology of human respiratory tract infection in Chongqing, China after COVID-19-based on surveillance data encompassing 17 respiratory pathogens.

Background: Respiratory tract infections (RTIs) are an important public health concern, and SARS-CoV-2 affects the epidemic pattern of RTIs globally. National multipathogenic surveillance for RTIs was conducted in mid-October 2023. However, baseline data on the pathogen spectrum of RTIs in Chongqing, China, before mid-October 2023 are limited.

Effect of Life's Essential 8 and Exposure to Solid Fuels for Cooking on Cardiovascular Disease Risk.

Background: Few studies have examined the association between Life's Essential 8 (LE8) scores and cardiovascular disease (CVD) risk in less-developed countries. In this study we aimed to assess the relationship between LE8 levels and CVD and evaluate whether LE8 modifies the association between exposure to solid cooking fuels and CVD.

Methods: A cross-sectional analysis was conducted using data extracted from the China Multi-Ethnic Cohort.

Etiological mechanisms underlying the hazard factors and inflammatory bowel disease: a prospective cohort study.

Inflammatory bowel disease (IBD) is a progressively advancing immune-mediated disorder characterized by intricate pathophysiological features. Despite extensive research, the mechanisms linking various risk factors to the development of IBD remain incompletely understood. We conducted analyses within a prospective cohort of unrelated European individuals, utilizing data from the UK Biobank.

Increased depth of pancreas incisure on computed tomography as an independent predictor for T2DM.

We aim to identify CT-based biomarkers in the pancreas for predicting both the presence and prognosis of T2DM. Between January and December 2021, a population of 2246 subjects undertaken health-check were recruited. Between January 2023 and June 2024, another 244 hospitalized patients with T2DM were recruited.

Circulating gamma-glutamyl transpeptidase, systemic inflammation biomarkers and risk of lung cancer in the UK biobank prospective cohort study.

Epidemiological evidence on the association between Gamma-glutamyl transpeptidase (GGT) and lung cancer risk is limited. Meanwhile, whether inflammation can modify the association of GGT-lung cancer remains unknown. We assessed the relationship of GGT-lung cancer and modification effects of inflammation biomarkers in 412,634 participants from UK Biobank using Cox models and interactive analysis.

Investigation of human infection with H5N6 avian influenza cases in Sichuan Province from 2014 to 2024: a retrospective study.

Objective: The objective is to examine the epidemiology and clinical features of human cases infected with H5N6 avian influenza in Sichuan Province from 2014 to 2024, and to offer guidance for the prevention and management of human infections with H5N6 avian influenza.

Methods: Epidemiological survey reports of H5N6 avian influenza cases in Sichuan Province from 2014 to 2024 were compiled, and the epidemiological context and characteristics of 16 human cases infected with H5N6 avian influenza in the province were summarized and analyzed using descriptive epidemiological methods.

Results: From 2014, when the initial human case ofH5N6 infection was documented in Sichuan Province, to 2024, there have been 16 human cases of H5N6 avian influenza in the region, resulting in 12 fatalities and a case fatality rate of 75%.

Salt-assisted liquid-liquid microextraction-programmed temperature vaporizer-gas chromatography-tandem Q-Exactive Orbitrap mass spectrometry for simultaneous analysis of sixteen nitrosamines in drinking water.

The prevalence of carcinogenic N-nitrosamines formed as byproducts during water treatment was public health of significant concern. The salt-assisted liquid-liquid microextraction (SALLME) combined with gas chromatography-tandem Q-Exactive Orbitrap mass spectrometry, employing programmed temperature vaporization-large volume injection (PTV-LVI) was developed for the determination of sixteen N-nitrosamines. The Plackett-Burman Design and Response Surface Methodology were applied to optimize the PTV-LVI parameters and sample pretreatment procedures.

Exploring the role of cathepsins in sarcopenia-related traits: Insights from a Mendelian randomization study.

Sarcopenia, a degenerative loss of skeletal muscle mass, strength, and function, poses a significant public health issue, particularly among aging populations. Cathepsins have recently emerged as key regulators of muscle metabolism and potential contributors to sarcopenia. This study employed Mendelian randomization (MR) to elucidate the causal relationships between 10 specific cathepsins and sarcopenia-related phenotypes, particularly appendicular lean mass (ALM) and handgrip strength, to identify potential therapeutic targets for sarcopenia intervention.

The influence of common exercise on the prevalence of hypertension.

Background: Numerous studies have shown that physical activity can effectively reduce blood pressure. And exercise is a physical activity that we can control, so which kind of exercise modalities is more closely related to the prevalence of hypertension needs further research.

Methods: This study's data came from the baseline survey of the China Multi-Ethnic Cohort.

Predictive modeling of eye lens dose in interventional radiology: a polynomial regression approach to cumulative fluoroscopy dose.

Objectives: This study aimed to investigate the relationship between cumulative fluoroscopy dose and eye lens radiation dose among interventional radiologists, and to develop a predictive model to enhance occupational radiation safety.

Methods: We collected data from interventional radiologists, focusing on cumulative fluoroscopy dose during procedures and corresponding eye lens doses. A quadratic polynomial regression model was developed to assess the non-linear relationship between cumulative fluoroscopy dose and eye lens dose.

Detection of the mpox virus using a robust recombinase-aided amplification-based approach.

In 2022, a global outbreak of mpox was anticipated, with several cases reported in non-endemic countries in early May. Given the challenge of distinguishing the mpox virus (MPXV) from other pathogens based solely on symptoms, there is an urgent need for prompt and reliable MPXV detection methods. In this study, we developed assays using recombinase-aided amplification (RAA) to identify MPXV and evaluated their applicability with clinical samples.

Mediation effect and metabolic pathways of gut microbiota in the associations between lifestyles and dyslipidemia.

Whether the role of gut microbial features lies in the pathways from lifestyles to dyslipidemia remains unclear. In this cross-sectional study, we conducted a metagenome-wide association analysis and fecal metabolomic profiling in 994 adults from the China Multi-Ethnic cohort. A total of 26 microbial species were identified as mediators between lifestyle factors and risk for dyslipidemia.

Association between occupational health literacy and generalized anxiety disorder among couriers: A cross-sectional survey based in China.

BackgroundOccupational health literacy is crucial for the health of the working population. Couriers have more mental health problems compared to other populations.ObjectiveThis study aimed to examine the mediating effect of occupational stress and depressive symptoms between occupational health literacy and generalized anxiety disorder.

[Study on comorbidity between post-traumatic stress disorder and depressive symptoms in firefighters].

To analyze the epidemiological characteristics of comorbidity of post-traumatic stress disorder and depression symptoms among active firefighters, and explore its influencing factors. In November 2021, a cross-sectional study was conducted using a combination of convenience sampling and cluster sampling. Active firefighters were selected as the research subjects for a questionnaire survey.

[Structural equation analysis and modeling of upper limb WMSDs and their adverse ergonomic factors].

To explore the structural relationship between WMSDs in the upper limbs and various risk factors in the occupational population in China, based on a large sample epidemiological survey and structural equation analysis, and to establish a structural equation model, so as to lay a foundation for the prevention and control of such diseases. The Chinese version of the Musculoskeletal Disorders Electronic Questionnaire was used to conduct a nationwide survey on the prevalence of WMSDs in the upper extremity. Six factors related to WMSDs in the upper extremity were extracted by the classification standard of adverse ergonomic factors and their source and confirmatory factor analysis, including work organization, work type, upper extremity work posture, individual factors, upper extremity fatigue and upper extremity WMSDs.

Gaseous air pollution exposure and depression in middle-aged and elderly adults: evidence from a Chinese cohort.

Increasing research has investigated the impact of atmospheric gaseous air pollution on depression. However, the results have exhibited inconsistencies, and the majority of studies have focused on the impact of long- or short-term exposures. The aim of the study was to investigate the impact of intermediate-term exposure to gaseous air pollution on depression in middle-aged and older adults.

Correlates of the sexual and reproductive health service utilization among older people living with HIV in China: Findings from the sexual well-being (SWELL) Study.

Objectives: Sexual and reproductive health (SRH) is vital to personal overall well-being, this study aims to explore the SRH service utilization and its correlates among older people living with HIV (PLHIV) in China.

Study Design: Cross-sectional study.

Methods: We conducted a cross-sectional study to collect data from older PLHIV aged 50 and above in HIV/AIDS treatment hospitals in China.

Mixed adverse ergonomic factors exposure in relation to work-related musculoskeletal disorders: a multicenter cross-sectional study of Chinese medical personnel.

Exposure to adverse ergonomic factors is associated with elevated risk of work-related musculoskeletal disorders (WMSDs) in medical personnel. We aimed to reveal how different adverse ergonomic factors act individually and in combination to influence the risk of WMSDs in medical personnel. From June 2018 to December 2020, we applied multistage cluster random sampling to select a total of 6,099 medical personnel from 54 hospitals in 12 cities in China.

Urban pertussis epidemiological patterns in a highly vaccinated megacity: Policy impacts and control strategies in Chongqing, China, 2005-2024.

Objectives: Despite high vaccination coverage, pertussis resurgence in megacities challenges conventional control strategies. We investigated epidemiological patterns and policy impacts in a densely populated urban setting in Chongqing, China.

Methods: Using population-based surveillance data (2005-2024) from Chongqing (population 32.

Hexavalent chromium and cellular senescence: A comprehensive analysis from chromate-exposed occupational population and chromate-inhaled mouse model.

Cellular senescence may predominantly drive the progression of early subclinical injury under conditions of low-dose, long-term occupational exposure. However, previous research has largely overlooked the cellular senescence induced by hexavalent chromium [Cr(VI)]. To bridge the gap, 304 workers from a chromate facility were enrolled, and a mouse model was used to confirm the effects of Cr(VI) on cellular senescence.

Emerging zoonotic potential of H4N1 avian influenza virus: enhanced human receptor binding and replication via novel mutations.

Background: Avian influenza virus (AIV), a zoonotic pathogen found worldwide, includes multiple subtypes, one of which is the H4 subtype frequently detected in wild birds and poultry. Despite its prevalence, research on H4 subtype AIV has been scarce, with a focus predominantly on the H4N2 and H4N6 subtypes. The zoonotic potential of H4N1 has not been investigated to date.

Spatial-temporal evolution patterns of influenza incidence in plateau regions from 2009 to 2023.

Objectives: This study used (Geographic Information System) GIS technology to analyze the spatiotemporal distribution of influenza incidence in Qinghai from 2009 to 2023, based on influenza surveillance data.

Methods: This study first accessed the influenza data sets of Qinghai Province from 2009 to 2023 through the Chinese Infectious Disease Surveillance System. Subsequently, trend charts of influenza incidence in each city and prefecture were employed to illustrate the trends of influenza incidence during the period from 2009 to 2023.