Enhancing CO Adsorption Capacity through FeO/CaO Ratio Engineering in Simulated Fly Ash-Derived Zeolite Synthesis through Gradient Oxide Modulation.

Zeolite synthesis from fly ash offers recycling and environmental benefits for carbon dioxide capture, but varying fly ash composition from different sources has different compositions, leading to inconsistent adsorption results. To achieve high CO adsorption performance and stability in zeolite synthesis from fly ash systems, this study established an element-controlled simulated fly ash system with Ca/Fe gradient differences. Hydrothermal synthesis yielded zeolites with optimized oxide ratios for CO adsorption.

Decoding coal-induced pulmonary endothelial injury using single-cell omics.

Pulmonary endothelial injury is a critical factor in the pathogenesis and progression of coal pneumoconiosis. However, the precise mechanisms underlying this injury remain poorly understood. To address this, we established a coal pneumoconiosis mouse model by chronic intranasal coal dust exposure over 9 months.

An improving spectral PTF for mining area soil water content prediction: combining 2D correlation spectroscopy and soil-crop indicators with ResGRU.

Conventional methods for soil sampling and soil water content (SWC) measurement are often labor-intensive and time-consuming. The Pedo-transfer function (PTF) integrating soil spectroscopy with soil physicochemical properties provides a more efficient approach for SWC estimation. However, existing studies highlight regional limitations in the accuracy of PTFs across diverse geographical regions.

METTL1-mediated mG methylation of mRNA promotes macrophage inflammatory responses and multiple organ injury.

RNA modifications regulate phenotype and function of macrophages by regulating RNA translation, splicing, and stability. However, the role of -methylguanosine (mG) modification in macrophages and inflammation remains unexplored. In this study, we observed elevated levels of the methyltransferase METTL1 and mG modifications in macrophages from mouse and human tissues during acute kidney injury (AKI).

Correction: Single-cell and spatial transcriptomics reveal a stress-induced EMT-like epithelial subset driving immune activation in silica-injured lung.

[This corrects the article DOI: 10.3389/fimmu.2025.

The mechanism of NK cell expression of RANKL/RANK/OPG pathway in mouse models of femoral head necrosis.

This study aimed to investigate the role of natural killer (NK) cells in the RANKL/RANK/OPG pathway in osteonecrosis of the femoral head (ONFH). C57 mice were categorized into a control group, an observation group (10 mice each), and an experimental group comprising 4 NK cell knockout mice. A hormone-induced femoral head necrosis model was created by administering lipopolysaccharide combined with methylprednisolone for 8 weeks to the experimental and control groups.

Study on Failure Characteristics and Fracture Susceptibility of Surrounding Rock Under True Triaxial Stress.

To investigate the failure behavior and cracking mechanisms in surrounding rock, a true triaxial experimental system and digital imaging were employed to perform compression tests on sandstone specimens containing preexisting flaws. Experimental results revealed the propagation characteristics of microfractures under stress concentration conditions and their correlation with failure patterns. Furthermore, a fracture propagation model was implemented to evaluate the susceptibility of surrounding rock to failure.

Binary Rhodium Atom Catalyst for Selective Catalytic Conversion of Methane to Methanol.

Using monometallic catalysts to selectively catalyze methane to methanol while suppressing the formation of liquid-phase overoxide products is beneficial for industrial applications. However, the balance between yield and selectivity over monometallic active sites remains challenging. This work proposes a strategy anchoring binary rhodium species to influence their surface dispersion properties.

Hydrophilicity and Zincophilicity Coincorporated Zwitterionic Additives for High-Performance Zinc Metal Batteries.

Despite the potential of Zn metal batteries (ZMBs) due to their low cost, environmental benefits, and favorable Zn/Zn redox potential, challenges such as low Zn utilization and parasitic reactions hinder their performance. These issues arise from the thermodynamic instability of the Zn anode and high-desolvation energy barriers. To overcome these challenges, this study investigates two zwitterionic compounds with hydrophilic and zincophilic functional groups, BES (N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid) and MES (2-(N-morpholino)ethanesulfonic acid), selecting BES as the optimal electrolyte additive.

Antimicrobial Resistance Mechanisms in Carbapenem-Resistant Clinical Strains Isolated in Shanghai, China.

Carbapenems, as the preferred treatment for multidrug-resistant , are increasingly facing issues of insufficient therapeutic efficacy. This study aims to investigate the antimicrobial resistance mechanisms of clinical isolates to carbapenems. The whole genome sequencing revealed various β-lactamase genes, including the intrinsic genes and , as well as the acquired (n = 6), and (n = 10) in 40 carbapenem-resistant (CRPA) isolates.

Enhancement of flame-retardancy and self-extinguishing in cellulose paper by bio-based phytic acid chelate-mediated interfacial assembly of Mg(OH)₂.

Cellulose-based paper, widely used in cultural heritage preservation and art, suffers from inherent flammability. Conventional phosphorus-based flame retardants, derived from depleting phosphate ores, necessitate sustainable alternatives. This study introduces an innovative layer-by-layer assembly strategy to fabricate biomass-derived MH-P@Mn and MH-P@Ni core-shell flame retardants.

Roof collapse in a retained top coal roadway induced by high-energy seismic events: implications from a case study.

Fully mechanized top-coal caving inevitably results in a certain thickness of retained coal above the roadway, which compromises roof stability and increases the difficulty of roof management. This study presents a dynamic disaster phenomenon in the Binchang mining area of China, where high-energy seismic events (HESEs) induced roof collapse in roadways with retained top coal. Disaster characteristic analysis indicates that in high-stress zones, the support system in roadways with retained top coal gradually deteriorates under mining-induced stress loading, and HESEs lead to roof support failure and roof collapse.

Synergistic Effect of Guanidinium and Tertiary Amine Groups on Boosting Gene Delivery.

The lack of safe and efficient delivery vectors remains a major bottleneck in nucleic acid therapeutics, limiting clinical translation. In this study, by incorporating the synergistic effects of guanidinium and tertiary amine functional groups, a new versatile branched poly-(β-amino ester) (PAE)-based delivery system was designed and developed, resulting in enhanced nucleic acid (DNA/mRNA) delivery. The synergistic interactions between these functional groups were systematically analyzed using 2D-NMR, AFM, TEM, and photophysical characterization.

Sub-ppb Methane Detection via EMD-Wavelet Adaptive Thresholding in Wavelength Modulation TDLAS: A Hybrid Denoising Approach for Trace Gas Sensing.

Wavelength modulation-tunable diode laser absorption spectroscopy (WM-TDLAS) is a critical tool for gas detection. However, noise in second harmonic signals degrades detection performance. This study presents a hybrid denoising algorithm combining Empirical Mode Decomposition (EMD) and wavelet adaptive thresholding to enhance WM-TDLAS performance.

MBTPS1: a membrane-bound transcription factor protease implicated in the pathogenesis of several skin and skeletal disorders.

The MBTPS1 gene, which is located on chromosome 16q24, encodes the membrane-bound transcription factor protease site-1 (MBTPS1), commonly referred to as site-1 protease (S1P). S1P can process a variety of substrates independently or in conjunction with membrane-bound transcription factor protease site-2 (MBTPS2, also known as S2P), including sterol regulatory element binding proteins (SREBPs), activating transcription factor 6 (ATF6) and cyclic-AMP responsive element‑binding protein 3 (CREB3). Variants in the MBTPS1 gene can lead to multiple clinically distinct disorders with different phenotypes, including spondyloepiphyseal dysplasia of Kondo-Fu type (SEDKF), Cataract, alopecia, oral mucosal disorder, and psoriasis-like (CAOP) syndrome, and Silver-Russell-like syndrome (SRS).

Amidinium versus Ammonium Ligands for Thermal Stability and Efficiency Boost in CsPbI Perovskite Solar Cells.

Inorganic CsPbI perovskite solar cells (PSCs) hold notable promise but suffer from instability in maintaining the photoactive black phase under ambient and thermal conditions; this work systematically investigates the impacts of phenylenediamine dihydrochloride (PPD·2HCl, containing ammonium groups) and terephthalimidamide dihydrochloride (TPID·2HCl, featuring amidinium groups) ligands on device performance and stability, with a focus on dissecting TPID's thermal stabilization mechanisms. While both ligands enhance room-temperature phase stability via surface defect passivation, TPID·2HCl-treated devices exhibit superior thermal resilience: its amidinium group features delocalized electron density across the N-C-N skeleton, strengthening coordination with undercoordinated sites and mitigating lattice distortion under heat; thermogravimetric analysis (TGA) shows TPID·2HCl decomposes at ∼350 °C with gradual mass loss, surpassing PPD·2HCl's rapid degradation at ∼300 °C; density functional theory (DFT) calculations reveal TPID binds more strongly to the CsPbI surface (adsorption energy: -1.51 eV vs -1.

Prevalence of head and face actinic keratosis among older community residents aged ≥60 years in Shanghai: a cross-sectional study.

Background: Actinic keratosis (AK), as a key indicator of skin cancer risk, is vital for understanding the skin health status of the elderly population. However, the epidemiological data on the prevalence of AK among community residents in Shanghai remain limited. This study aimed to investigate the prevalence of AK in older Shanghai residents and explore the associated factors.

Implementing Undergraduate Medical Education Reform to Enhance Problem-Solving and Practical Skills.

Background: Undergraduate medical education in China faces significant gaps in integrating theory with practice, with 32.7% of graduates requiring remedial procedural training.

Objective: To implement and evaluate a competency-based reform targeting problem-solving and practical skills.

Bioinspired prussian blue nanopesticides with triple-stimuli-responsive gates for ecology-adaptive pest management.

The escalating complexity of pest dynamics, characterized by intensifying seasonal pressures and unpredictable acute outbreaks, necessitates advanced agrochemicals capable of dynamically adapting to ecological rhythms. Inspired by the dual-phase biocontrol strategy of parasitoid wasps (immediate paralysis and sustained suppression), we engineered a Prussian blue (PB)-based nanopesticide (PAPP) with spatiotemporally decoupled release modes. Architecturally, the system integrates pH-responsive PB (alkaline-triggered disintegration) cores with thermosensitive poly(N-isopropylacrylamide) (PNIPAM, heat-induced volumetric transition) nanohydrogel gates, achieving dual-modal pest management: alkaline-triggered burst avermectin (AVM) release (91.

KYNU is a potential metabolic-related biomarker for nasopharyngeal carcinoma by Raman spectroscopy, metabolomics, and transcriptomics analysis.

Background: Nasopharyngeal carcinoma (NPC) is a malignant tumor with high incidence in Southeast Asia and Southern China, characterized by difficulties in early diagnosis and high recurrence rates after treatment. Metabolic reprogramming plays a crucial role in the development and progression of tumors. In-depth studies on the metabolic characteristics and molecular mechanisms of NPC are essential to identify novel diagnostic and therapeutic targets.

Optimizing spore germination and unveiling impermeability mechanisms in microbial self-healing concrete.

This study investigated the impact of key factors on spore germination of , a self-healing bacterium for concrete, and elucidated its impermeability mechanism to provide theoretical and practical guidance for advanced self-healing concrete development. Controlled experiments determined optimal germination conditions: 2 g/L microcapsule concentration, pH 8, and 1 g/L inosine, yielding peak germination efficiency that highlights parameter synergies. Thermal stimulation for 3 minutes effectively triggered germination, presenting a practical activation approach.

Green emitting nitrogen-doped carbon dots as a dual recognition platform for sensitive and selective detection of 2,4,6-trinitrotoluene and glucose in wastewater.

Carbon dots (CDs) have been widely employed to fabricate various fluorescent chemosensors owing to their favorable photo-physicochemical properties and versatile surface modification feasibility. However, reports on CDs as a dual recognition platform for sensitive and selective detection of different analytes are very limited. In this study, highly negatively charged green emitting nitrogen-doped CDs were synthesized by a hydrothermal approach using 1,3,6-trinitropyrene and ascorbic acid as precursors, which subsequently self-assembled with positively charged methylviologen (MV) and polyethyleneimine (PEI) to form CDs-MV and CDs-PEI nanocomposites, respectively, by electrostatic interaction and hydrogen bond.

Revealing simultaneous enrichment and degradation mechanism of organic molecules driven by TENG via SERS.

Self-powered degradation (SPD) driven by the triboelectric nanogenerator (TENG) has attracted significant attention. However, the effects of TENG on the migration of organic molecules have not been fully explored. Herein, a simultaneous enrichment and degradation mechanism of organic molecules around the electrode in the TENG electric field is proposed by surface enhancement of Raman scattering (SERS).

Real time wire rope detection method based on Rockchip RK3588.

In the era of fully mechanized and automated coal mine production, the need for autonomous fault detection and intelligent identification of wire ropes has become increasingly critical. Conventional model training and algorithmic computations rely on server-based systems, requiring significant computational resources. This study proposes a real-time wire rope detection system utilizing the Rockchip RK3588 platform.

PD-L1/ITGB4 Axis Modulates Sensitivity of Hepatocellular Carcinoma to Sorafenib via FAK/AKT/mTOR Signaling Pathway.

Background: Hepatocellular carcinoma (HCC) frequently develops resistance to sorafenib, a first-line treatment for advanced HCC. While PD-L1 contributes to immune evasion and direct tumor survival, its role in modulating sorafenib resistance via non-immunological pathways remains unclear. This study investigates the PD-L1/ITGB4 axis in regulating sorafenib sensitivity.